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Entry version 158 (10 Feb 2021)
Sequence version 1 (01 Jun 2002)
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Protein

NADH-ubiquinone oxidoreductase chain 5

Gene

Mt-nd5

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransportUniRule annotationARBA annotation
LigandNADUniRule annotation, UbiquinoneUniRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 5UniRule annotation (EC:7.1.1.2UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Mt-nd5Imported
Synonyms:mt-Co3Imported, mt-Nd4lImported, NADH5Imported, ND5Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates if the gene coding for the protein originates from the hydrogenosome, the mitochondrion, the nucleomorph, different plastids or a plasmid. The absence of this section means that the gene is located in one of the main chromosomal element(s).<p><a href='/help/encoded_on' target='_top'>More...</a></p>Encoded oniMitochondrionImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus

Organism-specific databases

Rat genome database

More...
RGDi
620560, Mt-nd5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei32 – 55HelicalUniRule annotationAdd BLAST24
Transmembranei84 – 105HelicalUniRule annotationAdd BLAST22
Transmembranei117 – 134HelicalUniRule annotationAdd BLAST18
Transmembranei141 – 160HelicalUniRule annotationAdd BLAST20
Transmembranei172 – 191HelicalUniRule annotationAdd BLAST20
Transmembranei242 – 260HelicalUniRule annotationAdd BLAST19
Transmembranei272 – 293HelicalUniRule annotationAdd BLAST22
Transmembranei367 – 385HelicalUniRule annotationAdd BLAST19
Transmembranei405 – 431HelicalUniRule annotationAdd BLAST27
Transmembranei452 – 471HelicalUniRule annotationAdd BLAST20
Transmembranei483 – 503HelicalUniRule annotationAdd BLAST21
Transmembranei585 – 603HelicalUniRule annotationAdd BLAST19

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Sequence analysisAdd BLAST18
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501509936219 – 609NADH-ubiquinone oxidoreductase chain 5Sequence analysisAdd BLAST591

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q8SEZ0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000029971, Expressed in cerebellum and 21 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8SEZ0, baseline and differential

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini65 – 121Proton_antipo_NInterPro annotationAdd BLAST57
Domaini134 – 417Proton_antipo_MInterPro annotationAdd BLAST284
Domaini421 – 600NADH5_CInterPro annotationAdd BLAST180

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the complex I subunit 5 family.UniRule annotationARBA annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixUniRule annotationARBA annotation

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_007100_6_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
GVGIMSF

Database of Orthologous Groups

More...
OrthoDBi
526738at2759

TreeFam database of animal gene trees

More...
TreeFami
TF342974

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010934, NADH_DH_su5_C
IPR003945, NADHpl_OxRdtase_5
IPR001750, ND/Mrp_mem
IPR001516, Proton_antipo_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06455, NADH5_C, 1 hit
PF00361, Proton_antipo_M, 1 hit
PF00662, Proton_antipo_N, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01974, NDH_I_L, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8SEZ0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNMMTSSILM ILILLTTPII ISMTNLPKLI DFPSYATSSI KFSFLLSLLP
60 70 80 90 100
LLLFFHHNTE YMITNWHWLT INSIKLTMSF KIDYFSILFL SVALFVTWSI
110 120 130 140 150
MQFSSWYMHS DPHINRFIKY LMMFLITMLI LTSANNLFQL FIGWEGVGIM
160 170 180 190 200
SFLLIGWWYG RADANTAALQ AILYNRVGDI GFILAMTWFC LNMNSWELQQ
210 220 230 240 250
IFLTNTNNLV PLTGLLIAAT GKSAQFGLHP WLPSAMEGPT PVSALLHSST
260 270 280 290 300
MVVAGIFLMI RFHPLTSNNS TIMTAMLCLG AITTLFTAIC ALTQNDIKKI
310 320 330 340 350
VAFSTSSQLG LMMVTLGINQ PYLAFLHICT HAFFKAMLFM CSGSIIHSLN
360 370 380 390 400
DEQDIRKMGN MMKAMPFTSS CLIIGSLALT GMPFLTGFYS KDLIIEAINT
410 420 430 440 450
CNTNAWALMI TLIATSMTAV YSMRIIYFVT MTKPRYSPLI TINENNPNLI
460 470 480 490 500
NPIKRLALGS ILAGFLISLN IPPTNIQILT MPWHLKMTAL LITILGFAIA
510 520 530 540 550
LELNNLTLNL SMSKPTKLSS FSTSLGYYPP IMHRIIPQKT LNSSYKLSLN
560 570 580 590 600
LLDLIWLEKT IPKSTSITQT QLSKMMSNQK GLIKLYFLSF LITISLIFIL

HTLNPEWFQ
Length:609
Mass (Da):68,618
Last modified:June 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1C876639DC556967
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY769440 Genomic DNA Translation: AAV31049.1
DQ673907 Genomic DNA Translation: ABG11771.1
DQ673909 Genomic DNA Translation: ABG11797.1
DQ673910 Genomic DNA Translation: ABG11811.1
DQ673912 Genomic DNA Translation: ABG11836.1
DQ673913 Genomic DNA Translation: ABG11849.1
DQ673914 Genomic DNA Translation: ABG11862.1
DQ673915 Genomic DNA Translation: ABG11875.1
DQ673917 Genomic DNA Translation: ABG11901.1
FJ919761 Genomic DNA Translation: ACP50316.1
FJ919762 Genomic DNA Translation: ACP50329.1
FJ919763 Genomic DNA Translation: ACP50342.1
FJ919764 Genomic DNA Translation: ACP50355.1
FJ919765 Genomic DNA Translation: ACP50368.1
FJ919766 Genomic DNA Translation: ACP50381.1
FJ919767 Genomic DNA Translation: ACP50394.1
FJ919768 Genomic DNA Translation: ACP50407.1
FJ919769 Genomic DNA Translation: ACP50420.1
GU997610 Genomic DNA Translation: ADE05962.1
GU997611 Genomic DNA Translation: ADE05975.1
GU997608 Genomic DNA Translation: ADE05988.1
JX105355 Genomic DNA Translation: AFN06288.1
JX105356 Genomic DNA Translation: AFN06301.1
KF011917 Genomic DNA Translation: AGS12831.1
KJ939360 Genomic DNA Translation: AIU45585.1
KJ939361 Genomic DNA Translation: AIU45598.1
KM009112 Genomic DNA Translation: AIU45611.1
KM009113 Genomic DNA Translation: AIU45624.1
KM009114 Genomic DNA Translation: AIU45637.1
KM114603 Genomic DNA Translation: AIU45650.1
KM114604 Genomic DNA Translation: AIU45663.1
KM114605 Genomic DNA Translation: AIU45676.1
KM114606 Genomic DNA Translation: AIU45689.1
KM114607 Genomic DNA Translation: AIU45702.1
KM114608 Genomic DNA Translation: AIU45715.1
KM577635 Genomic DNA Translation: AIY51552.1
KM657952 Genomic DNA Translation: AIZ58332.1
KM657953 Genomic DNA Translation: AIZ58345.1
KP100657 Genomic DNA Translation: AJE26540.1
KM820831 Genomic DNA Translation: AJE61349.1
KM820833 Genomic DNA Translation: AJE61375.1
KM820834 Genomic DNA Translation: AJE61388.1
KM820835 Genomic DNA Translation: AJE61401.1
KM820837 Genomic DNA Translation: AJE61414.1
KP233827 Genomic DNA Translation: AJJ48759.1
KP241960 Genomic DNA Translation: AJK29991.1
KP244683 Genomic DNA Translation: AJK30567.1
AJ428514 Genomic DNA Translation: CAD21569.1

NCBI Reference Sequences

More...
RefSeqi
YP_665639.1, NC_001665.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
26202

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:26202

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY769440 Genomic DNA Translation: AAV31049.1
DQ673907 Genomic DNA Translation: ABG11771.1
DQ673909 Genomic DNA Translation: ABG11797.1
DQ673910 Genomic DNA Translation: ABG11811.1
DQ673912 Genomic DNA Translation: ABG11836.1
DQ673913 Genomic DNA Translation: ABG11849.1
DQ673914 Genomic DNA Translation: ABG11862.1
DQ673915 Genomic DNA Translation: ABG11875.1
DQ673917 Genomic DNA Translation: ABG11901.1
FJ919761 Genomic DNA Translation: ACP50316.1
FJ919762 Genomic DNA Translation: ACP50329.1
FJ919763 Genomic DNA Translation: ACP50342.1
FJ919764 Genomic DNA Translation: ACP50355.1
FJ919765 Genomic DNA Translation: ACP50368.1
FJ919766 Genomic DNA Translation: ACP50381.1
FJ919767 Genomic DNA Translation: ACP50394.1
FJ919768 Genomic DNA Translation: ACP50407.1
FJ919769 Genomic DNA Translation: ACP50420.1
GU997610 Genomic DNA Translation: ADE05962.1
GU997611 Genomic DNA Translation: ADE05975.1
GU997608 Genomic DNA Translation: ADE05988.1
JX105355 Genomic DNA Translation: AFN06288.1
JX105356 Genomic DNA Translation: AFN06301.1
KF011917 Genomic DNA Translation: AGS12831.1
KJ939360 Genomic DNA Translation: AIU45585.1
KJ939361 Genomic DNA Translation: AIU45598.1
KM009112 Genomic DNA Translation: AIU45611.1
KM009113 Genomic DNA Translation: AIU45624.1
KM009114 Genomic DNA Translation: AIU45637.1
KM114603 Genomic DNA Translation: AIU45650.1
KM114604 Genomic DNA Translation: AIU45663.1
KM114605 Genomic DNA Translation: AIU45676.1
KM114606 Genomic DNA Translation: AIU45689.1
KM114607 Genomic DNA Translation: AIU45702.1
KM114608 Genomic DNA Translation: AIU45715.1
KM577635 Genomic DNA Translation: AIY51552.1
KM657952 Genomic DNA Translation: AIZ58332.1
KM657953 Genomic DNA Translation: AIZ58345.1
KP100657 Genomic DNA Translation: AJE26540.1
KM820831 Genomic DNA Translation: AJE61349.1
KM820833 Genomic DNA Translation: AJE61375.1
KM820834 Genomic DNA Translation: AJE61388.1
KM820835 Genomic DNA Translation: AJE61401.1
KM820837 Genomic DNA Translation: AJE61414.1
KP233827 Genomic DNA Translation: AJJ48759.1
KP241960 Genomic DNA Translation: AJK29991.1
KP244683 Genomic DNA Translation: AJK30567.1
AJ428514 Genomic DNA Translation: CAD21569.1
RefSeqiYP_665639.1, NC_001665.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PRIDEiQ8SEZ0

Genome annotation databases

GeneIDi26202
KEGGirno:26202

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4540
RGDi620560, Mt-nd5

Phylogenomic databases

HOGENOMiCLU_007100_6_0_1
OMAiGVGIMSF
OrthoDBi526738at2759
TreeFamiTF342974

Gene expression databases

BgeeiENSRNOG00000029971, Expressed in cerebellum and 21 other tissues
ExpressionAtlasiQ8SEZ0, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR010934, NADH_DH_su5_C
IPR003945, NADHpl_OxRdtase_5
IPR001750, ND/Mrp_mem
IPR001516, Proton_antipo_N
PfamiView protein in Pfam
PF06455, NADH5_C, 1 hit
PF00361, Proton_antipo_M, 1 hit
PF00662, Proton_antipo_N, 1 hit
TIGRFAMsiTIGR01974, NDH_I_L, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ8SEZ0_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8SEZ0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2002
Last sequence update: June 1, 2002
Last modified: February 10, 2021
This is version 158 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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