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Entry version 57 (02 Dec 2020)
Sequence version 1 (01 Jun 2002)
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Protein

Peptidoglycan hydrolase gp181

Gene
N/A
Organism
Pseudomonas phage phiKZ
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Exolysin that catalyzes the cleavage of the host peptidoglycans during virus entry.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>pH dependencei

Optimum pH is 6.2.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAntimicrobial, Bacteriolytic enzyme
Biological processDegradation of host cell envelope components during virus entry, Degradation of host peptidoglycans during virus entry, Virus entry into host cell

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
GH23, Glycoside Hydrolase Family 23

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Peptidoglycan hydrolase gp181Curated
Alternative name(s):
Gene product 181Curated
Short name:
Gp181
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPseudomonas phage phiKZImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri169683 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesDuplodnaviriaHeunggongviraeUroviricotaCaudoviricetesCaudoviralesMyoviridaePhikzvirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiPseudomonas aeruginosa [TaxID: 287]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002098 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Virion

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004329761 – 2237Peptidoglycan hydrolase gp181Add BLAST2237

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q8SCY1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8SCY1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1880 – 2042Peptidoglycan hydrolase activityAdd BLAST163

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C-terminus contains the peptidoglycan hydrolase activity.1 Publication

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR023346, Lysozyme-like_dom_sf
IPR008258, Transglycosylase_SLT_dom_1

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01464, SLT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53955, SSF53955, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8SCY1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKKVTLPKG QTGATGTTLG QAGNILDLSD VDDIFGDTPK AKKGSPVTEF
60 70 80 90 100
FNGIKQGLFD SVKPQQALKA FMRSAAPDGF SRMFGVYEDT MSTIRDVKDS
110 120 130 140 150
VERTSASDLL FLTREAQDLA VKLKDKVPAS VFDRLNNRLE SQIENYKYAE
160 170 180 190 200
DSNRNYKEIR RRMEAERDED ELKSAIDQVT LVQRDLAIKA EQGEVKRFAI
210 220 230 240 250
GQAERGIRDK VSADRFDWMA KAMGQTVDNL SKLASYNEQV NYSIQKKGLE
260 270 280 290 300
IQFRSMLHLR KIAQQTEATM ELLNNGFAAL VRNTGIPDHK KSSMKDLVGF
310 320 330 340 350
NAAQRVSSSF VDNAIQTLPN FLGNFGSAVT NNATRFANEN IRNFADAVRA
360 370 380 390 400
GNMFGADAWE NRYNIAGQFA GSYLGDWTRN SVIPVLGRMA RPGIERFSNN
410 420 430 440 450
YLGGRHNQAS YLLDNFPAWT QEYMNNYQNT YGARGILRDI MAPFIPQFTL
460 470 480 490 500
QDRLKTGSYQ TIGQDSGFNQ LTQRTIVEAI PGYLSRLLQE TRMIRTGRDD
510 520 530 540 550
ITREVFDLST GSFMSVEDSA ANTERRLVSR STVRGVSGAL TDVLEAFDPN
560 570 580 590 600
KELSIDARKA LTERLIRDAN MNKRFDPEAY ARAGGYDRSK VSGETIKELT
610 620 630 640 650
EYIKRQYNIG ADGRMASTNE NFARRQEIST LFLDVRNFSR DPIKEIERLT
660 670 680 690 700
NAGKTDQLRE MGIIITEQGI DRINYPRIWE LMSSEVKYEG WGNDNPFDRY
710 720 730 740 750
SDTPPSDNGG PEQLSPLGDQ NNPHFIGPMY QSQTERKMRQ AQEQVIRASK
760 770 780 790 800
LAQEQANKGY DYAQQKVSLA TDYVRDNVPN QFSELRRNVN IPASMNFGDL
810 820 830 840 850
RDQLYGQAGD MYSRAVNYSN QLNGYSDIIN QSIADLYTKA NTFTPVIKGM
860 870 880 890 900
DFLNGNLIDI NTGMIVEKIS DITGEIKNQA GITVVTAQEV ATGLYNQRGD
910 920 930 940 950
LLTKATDIAS QLRDKAAQIA GDARERLTQG LDNVSDMAKD WYIPGREEAV
960 970 980 990 1000
ILGRDLLAGE YIDTATNQII TNLKDAKGTI INRAGDVVVT AQELAKGLIR
1010 1020 1030 1040 1050
SDGFNLRRNI ADTSNWIQRN VLGGGSTTQK IFNAMGTVAN KAKDFTIGLG
1060 1070 1080 1090 1100
KDILSNRDAY LPGMLKPVLQ KVKLKAGEYY TTAGNLLKSF DEINGPVLDR
1110 1120 1130 1140 1150
DGNIVVDEEQ ISELINSDGS KHTAAKSKGL FRTGLGNLAR GYANMSMRYW
1160 1170 1180 1190 1200
KWLGKKSVDT AKGMAGLGYK LLGSPFKKRF SAFTGKVETQ IDKKALDTTT
1210 1220 1230 1240 1250
DQLLAGIWEE LRNQKPDANK PRRGSWQDLT SRVSDTLNGK NNGDEETTES
1260 1270 1280 1290 1300
KGLFGKLGDT LKNIFGKKKG DEEDEGLLED LGLGGKKGGK WAAARQILGR
1310 1320 1330 1340 1350
GALAIGGGAL STAAAYASFG GTGASTNDKL AGAAIVTSNP IMWALKDFLI
1360 1370 1380 1390 1400
KPVLGWRGSQ KFKDDLISYR MMQYGATTTD QMNKVTELEQ LVSSVATRGG
1410 1420 1430 1440 1450
DASFDVRALN ARDIIKIFGY GADDGPAIMR LANWIDFRFK PIFEAWLKGL
1460 1470 1480 1490 1500
SKINRSDVDI SEVDSKVPNE LKGQLIRSVS FPYEGNTPYL VLNNPFGEED
1510 1520 1530 1540 1550
LSIDVASIQM KEKELLNKYS ATEKTSVAPK ATSSSFKEST TDVINDTITT
1560 1570 1580 1590 1600
IKSKSTDITN WFRDSTIGKA IKAVSPVESI RKMVTTTVDT IIPKANASDS
1610 1620 1630 1640 1650
LTSLQALRVH AYGMQGLDLA AVNGLLSIES LVNDKMRVAN GKATYTGDIE
1660 1670 1680 1690 1700
ELIKWTGQAF GMVTTSDGPD RVKVVDWLYR RFLPVFKAFI VTARSVSTSI
1710 1720 1730 1740 1750
TLSQIETLTA TQRVQIANAI MGATDDEGIS IWKAPSIFNI VGDMDSVEDL
1760 1770 1780 1790 1800
AKISLDEIKK EAETEVAEAP GKSKSAQIAG KNDAASGRSF ASRIIDNVKS
1810 1820 1830 1840 1850
TFNSATTKVT NWMENTSARV SQVIGRAREG VTDTYYTAKY KLGAGGELTP
1860 1870 1880 1890 1900
TGQTYGQLAT GNGGVWENIP MPQSNKSRDA AQATFKAVSE MTGVPVELLN
1910 1920 1930 1940 1950
IFCGIESSFN YNAKAPTSSA AGWFQFIKST WKGMLAKYGA KFGIPADDEN
1960 1970 1980 1990 2000
GSLRFDPRIN ALMGAMFLRD NYEYLENALG RAPTDVDLYL AHFMGPAGAR
2010 2020 2030 2040 2050
KFLTRDQNSI GAEIFPDQAR ANRSIFFKTD GSARTLGEIY QVMENKVAKF
2060 2070 2080 2090 2100
RTGGGKNANS QSLGKPKSTE ELMNDAATAK QKDMATDKEL IGGAADTSIT
2110 2120 2130 2140 2150
DSSNNKIGLG KIMSGMASPL RTNAPSMMLP GAPSSATDVS SGQQPVVDTG
2160 2170 2180 2190 2200
AATQATVRAS QIEEQRKVVT SQDKAMLDIA SEQLSVLKQF HADILNYIKN
2210 2220 2230
KAANPSAQTG QEQANTIAPS QRPGRVVDNR PLPIRLR
Length:2,237
Mass (Da):245,758
Last modified:June 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6CA92E901B372F04
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF399011 Genomic DNA Translation: AAL83082.1

NCBI Reference Sequences

More...
RefSeqi
NP_803747.1, NC_004629.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1258330

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
vg:1258330

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF399011 Genomic DNA Translation: AAL83082.1
RefSeqiNP_803747.1, NC_004629.1

3D structure databases

SMRiQ8SCY1
ModBaseiSearch...

Protein family/group databases

CAZyiGH23, Glycoside Hydrolase Family 23

Proteomic databases

PRIDEiQ8SCY1

Genome annotation databases

GeneIDi1258330
KEGGivg:1258330

Family and domain databases

InterProiView protein in InterPro
IPR023346, Lysozyme-like_dom_sf
IPR008258, Transglycosylase_SLT_dom_1
PfamiView protein in Pfam
PF01464, SLT, 1 hit
SUPFAMiSSF53955, SSF53955, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEXLYS_BPDPK
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8SCY1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2015
Last sequence update: June 1, 2002
Last modified: December 2, 2020
This is version 57 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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