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Protein

Aldehyde dehydrogenase family 2 member B7, mitochondrial

Gene

ALDH2B7

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Possesses activity on acetaldehyde and glycolaldehyde in vitro.1 Publication

Catalytic activityi

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei202Transition state stabilizerBy similarity1
Active sitei301Proton acceptorPROSITE-ProRule annotation1
Active sitei335NucleophilePROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi278 – 283NADBy similarity6

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

BioCyciARA:AT1G23800-MONOMER
ReactomeiR-ATH-380612 Metabolism of serotonin
R-ATH-5365859 RA biosynthesis pathway
R-ATH-70350 Fructose catabolism
R-ATH-71384 Ethanol oxidation

Names & Taxonomyi

Protein namesi
Recommended name:
Aldehyde dehydrogenase family 2 member B7, mitochondrial (EC:1.2.1.3)
Short name:
ALDH2b
Gene namesi
Name:ALDH2B7
Synonyms:ALDH3
Ordered Locus Names:At1g23800
ORF Names:F5O8.33, F5O8.35
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G23800
TAIRilocus:2034855 AT1G23800

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 34Mitochondrion1 PublicationAdd BLAST34
ChainiPRO_000025605735 – 534Aldehyde dehydrogenase family 2 member B7, mitochondrialAdd BLAST500

Proteomic databases

PaxDbiQ8S528
PRIDEiQ8S528

Expressioni

Gene expression databases

ExpressionAtlasiQ8S528 baseline and differential
GenevisibleiQ8S528 AT

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi3702.AT1G23800.1

Structurei

3D structure databases

ProteinModelPortaliQ8S528
SMRiQ8S528
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2450 Eukaryota
COG1012 LUCA
HOGENOMiHOG000271505
InParanoidiQ8S528
KOiK00128
OMAiRHVMIKH
OrthoDBiEOG0936062U
PhylomeDBiQ8S528

Family and domain databases

Gene3Di3.40.309.10, 1 hit
3.40.605.10, 2 hits
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR016163 Ald_DH_C
IPR016160 Ald_DH_CS_CYS
IPR029510 Ald_DH_CS_GLU
IPR016162 Ald_DH_N
IPR015590 Aldehyde_DH_dom
PfamiView protein in Pfam
PF00171 Aldedh, 1 hit
SUPFAMiSSF53720 SSF53720, 1 hit
PROSITEiView protein in PROSITE
PS00070 ALDEHYDE_DEHYDR_CYS, 1 hit
PS00687 ALDEHYDE_DEHYDR_GLU, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8S528-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASRRVSSLL SRSFMSSSRS IFSLRGMNRG AQRYSNLAAA VENTITPPVK
60 70 80 90 100
VEHTQLLIGG RFVDAVSGKT FPTLDPRNGE VIAQVSEGDA EDVNRAVAAA
110 120 130 140 150
RKAFDEGPWP KMTAYERSKI LFRFADLIEK HNDEIAALET WDNGKPYEQS
160 170 180 190 200
AQIEVPMLAR VFRYYAGWAD KIHGMTMPGD GPHHVQTLHE PIGVAGQIIP
210 220 230 240 250
WNFPLLMLSW KLGPALACGN TVVLKTAEQT PLSALLVGKL LHEAGLPDGV
260 270 280 290 300
VNIVSGFGAT AGAAIASHMD VDKVAFTGST DVGKIILELA SKSNLKAVTL
310 320 330 340 350
ELGGKSPFIV CEDADVDQAV ELAHFALFFN QGQCCCAGSR TFVHERVYDE
360 370 380 390 400
FVEKAKARAL KRNVGDPFKS GIEQGPQVDS EQFNKILKYI KHGVEAGATL
410 420 430 440 450
QAGGDRLGSK GYYIQPTVFS DVKDDMLIAT DEIFGPVQTI LKFKDLDEVI
460 470 480 490 500
ARANNSRYGL AAGVFTQNLD TAHRLMRALR VGTVWINCFD VLDASIPFGG
510 520 530
YKMSGIGREK GIYSLNNYLQ VKAVVTSLKN PAWL
Length:534
Mass (Da):58,153
Last modified:October 31, 2006 - v2
Checksum:iC709B0E539E52C31
GO

Sequence cautioni

The sequence AAC98035 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAL99612 differs from that shown. Reason: Frameshift at positions 303 and 309.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF348416 mRNA Translation: AAL99612.1 Frameshift.
AC005990 Genomic DNA Translation: AAC98035.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE30433.1
AY035139 mRNA Translation: AAK59643.1
AY113912 mRNA Translation: AAM44960.1
PIRiC86372
RefSeqiNP_564204.1, NM_102228.4
UniGeneiAt.22317

Genome annotation databases

EnsemblPlantsiAT1G23800.1; AT1G23800.1; AT1G23800
GeneIDi838991
GrameneiAT1G23800.1; AT1G23800.1; AT1G23800
KEGGiath:AT1G23800

Similar proteinsi

Entry informationi

Entry nameiAL2B7_ARATH
AccessioniPrimary (citable) accession number: Q8S528
Secondary accession number(s): Q94C67, Q9ZUB6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: July 18, 2018
This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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