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Entry version 113 (18 Sep 2019)
Sequence version 1 (01 Jun 2002)
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Protein

Exocyst complex component SEC5A

Gene

SEC5A

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane during regulated or polarized secretion. Involved in polarized cell growth and organ morphogenesis. During cytokinesis, involved in cell plate initiation, cell plate maturation and formation of new primary cell wall. Probable component of an exocyst subcomplex specifically involved in autophagy-related, Golgi-independent membrane traffic to the vacuole. Regulates autophagosome formation and autophagy-related Golgi-independent import into the vacuole.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processExocytosis, Transport

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.F.2.1.3 the octameric exocyst (exocyst) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Exocyst complex component SEC5A1 Publication
Short name:
AtSec5a1 Publication
Alternative name(s):
Exocyst complex component 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SEC5A1 Publication
Ordered Locus Names:At1g76850Imported
ORF Names:F7O12.2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT1G76850

The Arabidopsis Information Resource

More...
TAIRi
locus:2030056 AT1G76850

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

No visible phenotype under normal growth conditions, but the double mutant sec5a-1 and sec5b-1 is male gametophytic lethal due to defect in pollen germination and pollen tube growth.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001189231 – 1090Exocyst complex component SEC5AAdd BLAST1090

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei180PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8S3U9

PRoteomics IDEntifications database

More...
PRIDEi
Q8S3U9

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8S3U9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8S3U9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8S3U9 AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The exocyst complex is composed of SEC3, SEC5, SEC6, SEC8, SEC10, EXO70A1 and EXO84B.

Interacts with SEC3A and EXO70B1. Binds to EXO70H1 AND EXO70B2 (PubMed:21199889).

3 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
29239, 4 interactors

Protein interaction database and analysis system

More...
IntActi
Q8S3U9, 4 interactors

STRING: functional protein association networks

More...
STRINGi
3702.AT1G76850.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8S3U9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SEC5 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2347 Eukaryota
ENOG410XSY3 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000029908

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8S3U9

KEGG Orthology (KO)

More...
KOi
K17637

Identification of Orthologs from Complete Genome Data

More...
OMAi
EWKSPNK

Database of Orthologous Groups

More...
OrthoDBi
97000at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8S3U9

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016159 Cullin_repeat-like_dom_sf
IPR029175 EXOC2/Sec5
IPR039481 EXOC2/Sec5_N_dom

The PANTHER Classification System

More...
PANTHERi
PTHR13043 PTHR13043, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15469 Sec5, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF74788 SSF74788, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8S3U9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSDSNDLDE DELLQMALKE QAKRDLTYQK PPSSSARKPV ANLVQQPRQQ
60 70 80 90 100
KPVAAAAAPP KKSAAAVRKP SMDEDEESEV ELLSISSGDD DLEREREIGG
110 120 130 140 150
SSGGAGRGRG SDVREKGRAR KEDDGAWDGG EPDCWKRVNE AELARRVRDM
160 170 180 190 200
RESRTAPVVQ KVEGKAPAPG KKVALTSLQS LPRGMECIDP LKLGIIDNKT
210 220 230 240 250
LRLITESSGS PSKAEKVDNT LREKLVYFSD HFDPKLFLSR IHQDTTAADL
260 270 280 290 300
EAGALGLKSD LKGRNLQRKQ LVKDNFDCFV SCKTTIDDIE SKLKRIEEDP
310 320 330 340 350
EGSGTTHLFN CMKSVTSRAN LAFEPLFERQ AQAEKIRSVQ GMLQRFRTLF
360 370 380 390 400
NLPSIIRSSI SKGEYDLAVR EYKKAKSIAL PSHVNILKRV LEEVEKVMLE
410 420 430 440 450
FKGTLYKSME DPKIDFTSLE NTVRLLLELE PESDPVWHYL NVQNHRIHGL
460 470 480 490 500
LEKCTYDHEA RVEILRNDTH EKAISDAKWQ QIQQNGVSYS DTASSNENNA
510 520 530 540 550
VQVDLQSVEF PSEEIDILKG RYIKRLTAVL VHHIPVFWKT AISIFSGKFA
560 570 580 590 600
KSSQVTDTSA NKAEEKVTEA RYSTHSLEEV AGMIRKTISV YEAKVNSTFC
610 620 630 640 650
DFDESCILRP FMSDAINEVS KACQAFEAKE STPHSAVVAL RKIQAEITKI
660 670 680 690 700
YIQRLCSWMR ASTEGISKEE TWIPVSILER NRSPYAISYL PLAFRSVIVS
710 720 730 740 750
GMEQVNLMIL SVKSEAAKSE DMFAQIEEII ISVRLAFLNC FLDFAAHLEQ
760 770 780 790 800
IGADLSQSTS RQDNWKNGYS DEHQEEPSAN TYGSVIDPHR RLLMVLSNIG
810 820 830 840 850
YCKDELASEL YNKFKYTWLQ SRDKNEDSSD LQDLIMSFSG LGEKVLEHYT
860 870 880 890 900
FAKANLIRTA ATNYLLDSGI QWGSAPQVKG IRDAAVELLH TLVAVHAEVF
910 920 930 940 950
AGAKPLLDKI LGVLIEGLID TFLSVVEENR SSDLRSIDAN GFCQLMFELE
960 970 980 990 1000
YFETVLYSYF TSAATESLKS LQGTVLEIAI ESISEAVETP GHNRRPTRGS
1010 1020 1030 1040 1050
EDTVSDDKQS VSADDLLALT KQCSNELLQQ ELERTRVNTA CFAESAPLES
1060 1070 1080 1090
TPPLPKATYS SFRGSMDSPS RNYRGSQSSG SPINARPRRR
Length:1,090
Mass (Da):121,902
Last modified:June 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9E0C29580CBE3AD8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti384 – 388Missing in AAG51148 (PubMed:11130712).Curated5

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF479278 mRNA Translation: AAL87121.1
AC079283 Genomic DNA Translation: AAG51148.1
CP002684 Genomic DNA Translation: AEE35895.1
AK118540 mRNA Translation: BAC43143.1
BT005978 mRNA Translation: AAO64913.1
AK230372 mRNA Translation: BAF02171.1

Protein sequence database of the Protein Information Resource

More...
PIRi
C96797

NCBI Reference Sequences

More...
RefSeqi
NP_177811.2, NM_106336.4

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT1G76850.1; AT1G76850.1; AT1G76850

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
844020

Gramene; a comparative resource for plants

More...
Gramenei
AT1G76850.1; AT1G76850.1; AT1G76850

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT1G76850

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF479278 mRNA Translation: AAL87121.1
AC079283 Genomic DNA Translation: AAG51148.1
CP002684 Genomic DNA Translation: AEE35895.1
AK118540 mRNA Translation: BAC43143.1
BT005978 mRNA Translation: AAO64913.1
AK230372 mRNA Translation: BAF02171.1
PIRiC96797
RefSeqiNP_177811.2, NM_106336.4

3D structure databases

SMRiQ8S3U9
ModBaseiSearch...

Protein-protein interaction databases

BioGridi29239, 4 interactors
IntActiQ8S3U9, 4 interactors
STRINGi3702.AT1G76850.1

Protein family/group databases

TCDBi1.F.2.1.3 the octameric exocyst (exocyst) family

PTM databases

iPTMnetiQ8S3U9

Proteomic databases

PaxDbiQ8S3U9
PRIDEiQ8S3U9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G76850.1; AT1G76850.1; AT1G76850
GeneIDi844020
GrameneiAT1G76850.1; AT1G76850.1; AT1G76850
KEGGiath:AT1G76850

Organism-specific databases

AraportiAT1G76850
TAIRilocus:2030056 AT1G76850

Phylogenomic databases

eggNOGiKOG2347 Eukaryota
ENOG410XSY3 LUCA
HOGENOMiHOG000029908
InParanoidiQ8S3U9
KOiK17637
OMAiEWKSPNK
OrthoDBi97000at2759
PhylomeDBiQ8S3U9

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q8S3U9

Gene expression databases

ExpressionAtlasiQ8S3U9 baseline and differential
GenevisibleiQ8S3U9 AT

Family and domain databases

InterProiView protein in InterPro
IPR016159 Cullin_repeat-like_dom_sf
IPR029175 EXOC2/Sec5
IPR039481 EXOC2/Sec5_N_dom
PANTHERiPTHR13043 PTHR13043, 1 hit
PfamiView protein in Pfam
PF15469 Sec5, 1 hit
SUPFAMiSSF74788 SSF74788, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSEC5A_ARATH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8S3U9
Secondary accession number(s): Q0WL36, Q541W6, Q9C6K6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: June 1, 2002
Last modified: September 18, 2019
This is version 113 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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