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Entry version 121 (12 Aug 2020)
Sequence version 1 (01 Jun 2002)
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Protein

Phosphatidylinositol 4-phosphate 5-kinase 8

Gene

PIP5K8

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
ARA:AT1G60890-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phosphatidylinositol 4-phosphate 5-kinase 8 (EC:2.7.1.68)
Short name:
AtPIP5K8
Alternative name(s):
1-phosphatidylinositol 4-phosphate kinase 8
Diphosphoinositide kinase 8
PtdIns(4)P-5-kinase 8
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PIP5K8
Ordered Locus Names:At1g60890
ORF Names:T7P1.4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT1G60890

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001854801 – 769Phosphatidylinositol 4-phosphate 5-kinase 8Add BLAST769

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8RY89

PRoteomics IDEntifications database

More...
PRIDEi
Q8RY89

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
234956 [Q8RY89-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8RY89

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8RY89, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8RY89, AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
27605, 1 interactor

STRING: functional protein association networks

More...
STRINGi
3702.AT1G60890.2

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8RY89

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati16 – 38MORN 1Add BLAST23
Repeati39 – 61MORN 2Add BLAST23
Repeati62 – 84MORN 3Add BLAST23
Repeati85 – 107MORN 4Add BLAST23
Repeati108 – 130MORN 5Add BLAST23
Repeati131 – 153MORN 6Add BLAST23
Repeati154 – 176MORN 7Add BLAST23
Repeati177 – 198MORN 8Add BLAST22
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini344 – 765PIPKPROSITE-ProRule annotationAdd BLAST422

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni725 – 746Activation loopBy similarityAdd BLAST22

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0229, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004312_6_4_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8RY89

KEGG Orthology (KO)

More...
KOi
K00889

Identification of Orthologs from Complete Genome Data

More...
OMAi
PPHCSIN

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8RY89

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.800.10, 1 hit
3.30.810.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003409, MORN
IPR017163, PIno-4-P-5_kinase_pln
IPR023610, PInositol-4-P-5-kinase
IPR027483, PInositol-4-P-5-kinase_C
IPR002498, PInositol-4-P-5-kinase_core
IPR027484, PInositol-4-P-5-kinase_N

The PANTHER Classification System

More...
PANTHERi
PTHR23086, PTHR23086, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02493, MORN, 8 hits
PF01504, PIP5K, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF037274, PIP5K_plant_prd, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00698, MORN, 8 hits
SM00330, PIPKc, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51455, PIPK, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 1 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoform i produced by alternative splicing. AlignAdd to basket
Note: A number of isoforms are produced. According to EST sequences.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8RY89-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
METRPAERVF SNGDVYSGQL KGTLPHGKGK YAWPDGIIYE GDWEEGKISG
60 70 80 90 100
RGKLMWSSGA KYEGDFSGGY LHGFGTLTSP DGSVYAGAWR MNVRHGLGRK
110 120 130 140 150
EYCNSDVYDG SWREGLQDGS GSYSWYNGNR FIGNWKKGKM SGRGVMSWAN
160 170 180 190 200
GDLFNGFWLN GLRHGSGVYK YADGGFYFGT WSRGLKDGSG VFYPAGSKHP
210 220 230 240 250
SLKKWHRHFG YDDTGNFLLS HNSTINIDDL RTSKAVSRSL SELTTTSGLT
260 270 280 290 300
RTSERYPDDY WSTSDPPRDF MHHGPSSKSA RSVDSGQSEI RDKNPIVFER
310 320 330 340 350
EYMQGVLIKE RIMSSIDMSH RARPLNLTKE VTVSACVSFL GGKWNHYLML
360 370 380 390 400
NLQLGIRYTV GKITPVPPRE VRASDFSERA RIMMFFPRNG SQYTPPHKSI
410 420 430 440 450
DFDWKDYCPM VFRNLREMFK LDAADYMMSI CGDDGLREIS SPGKSGSIFY
460 470 480 490 500
LSHDDRFVIK TLKRSELKVL LRMLPRYYEH VGDYENTLIT KFFGVHRIKL
510 520 530 540 550
KWGKKVRFVV MGNMFCTELK IHRRYDLKGS TQGRYTEKNK IGEKTTLKDL
560 570 580 590 600
DLAYEFHMDK LLREALFKQI ILDCSFLESL QILDYSLLLG LHFRAPDPLT
610 620 630 640 650
DILEPPNEMS DQESDSVGSV DVNLPREPSI PPKGLLMVTH EPNSVNTAPG
660 670 680 690 700
PHIRGSTLRA FSVGEKEVDL ILPGTARLRV QLGVNMPAQA HHKLGQDNEE
710 720 730 740 750
SGTVELFEVY DVVVYMGIID ILQEYNMKKK VEHTCKSMKY DPMTISAIEP
760
TLYSKRFIDF LLKVFPEKA
Length:769
Mass (Da):87,403
Last modified:June 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2E8A045211FB39A3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F4HRM3F4HRM3_ARATH
Phosphatidylinositol 4-phosphate 5-...
At1g60890, T7P1.4, T7P1_4
781Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAG51639 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC018908 Genomic DNA Translation: AAG51639.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE33744.1
AY074507 mRNA Translation: AAL69491.1
AY133824 mRNA Translation: AAM91758.1

Protein sequence database of the Protein Information Resource

More...
PIRi
D96634

NCBI Reference Sequences

More...
RefSeqi
NP_176286.2, NM_104770.5 [Q8RY89-1]

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT1G60890.1; AT1G60890.1; AT1G60890 [Q8RY89-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
842381

Gramene; a comparative resource for plants

More...
Gramenei
AT1G60890.1; AT1G60890.1; AT1G60890 [Q8RY89-1]

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT1G60890

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC018908 Genomic DNA Translation: AAG51639.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE33744.1
AY074507 mRNA Translation: AAL69491.1
AY133824 mRNA Translation: AAM91758.1
PIRiD96634
RefSeqiNP_176286.2, NM_104770.5 [Q8RY89-1]

3D structure databases

SMRiQ8RY89
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi27605, 1 interactor
STRINGi3702.AT1G60890.2

PTM databases

iPTMnetiQ8RY89

Proteomic databases

PaxDbiQ8RY89
PRIDEiQ8RY89
ProteomicsDBi234956 [Q8RY89-1]

Genome annotation databases

EnsemblPlantsiAT1G60890.1; AT1G60890.1; AT1G60890 [Q8RY89-1]
GeneIDi842381
GrameneiAT1G60890.1; AT1G60890.1; AT1G60890 [Q8RY89-1]
KEGGiath:AT1G60890

Organism-specific databases

AraportiAT1G60890

Phylogenomic databases

eggNOGiKOG0229, Eukaryota
HOGENOMiCLU_004312_6_4_1
InParanoidiQ8RY89
KOiK00889
OMAiPPHCSIN
PhylomeDBiQ8RY89

Enzyme and pathway databases

BioCyciARA:AT1G60890-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q8RY89

Gene expression databases

ExpressionAtlasiQ8RY89, baseline and differential
GenevisibleiQ8RY89, AT

Family and domain databases

Gene3Di3.30.800.10, 1 hit
3.30.810.10, 2 hits
InterProiView protein in InterPro
IPR003409, MORN
IPR017163, PIno-4-P-5_kinase_pln
IPR023610, PInositol-4-P-5-kinase
IPR027483, PInositol-4-P-5-kinase_C
IPR002498, PInositol-4-P-5-kinase_core
IPR027484, PInositol-4-P-5-kinase_N
PANTHERiPTHR23086, PTHR23086, 1 hit
PfamiView protein in Pfam
PF02493, MORN, 8 hits
PF01504, PIP5K, 1 hit
PIRSFiPIRSF037274, PIP5K_plant_prd, 1 hit
SMARTiView protein in SMART
SM00698, MORN, 8 hits
SM00330, PIPKc, 1 hit
PROSITEiView protein in PROSITE
PS51455, PIPK, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPI5K8_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8RY89
Secondary accession number(s): Q9C962
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: June 1, 2002
Last modified: August 12, 2020
This is version 121 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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