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Entry version 144 (07 Oct 2020)
Sequence version 1 (01 Jun 2002)
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Protein

Aminopeptidase P2

Gene

APP2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.By similarity EC:3.4.11.9

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei147SubstrateBy similarity1
Binding sitei486Substrate; via tele nitrogenBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi506Manganese 1By similarity1
Metal bindingi517Manganese 1By similarity1
Metal bindingi517Manganese 2By similarity1
Metal bindingi580Manganese 2; via tele nitrogenBy similarity1
Binding sitei580Substrate; via tele nitrogenBy similarity1
Binding sitei589Substrate; via tele nitrogenBy similarity1
Metal bindingi614Manganese 2By similarity1
Binding sitei614SubstrateBy similarity1
Metal bindingi628Manganese 1By similarity1
Metal bindingi628Manganese 2By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAminopeptidase, Hydrolase, Metalloprotease, Protease
LigandManganese, Metal-binding

Protein family/group databases

MEROPS protease database

More...
MEROPSi
M24.A04

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Aminopeptidase P21 Publication (EC:3.4.11.9By similarity)
Short name:
AtAPP21 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:APP21 Publication
Ordered Locus Names:At3g05350Imported
ORF Names:T12H1.32Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT3G05350

The Arabidopsis Information Resource

More...
TAIRi
locus:2096319, AT3G05350

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chloroplast, Plastid

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 79ChloroplastSequence analysisAdd BLAST79
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000044415680 – 710Aminopeptidase P2Add BLAST631

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8RY11

PRoteomics IDEntifications database

More...
PRIDEi
Q8RY11

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
244479

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8RY11, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

By similarity

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q8RY11, 2 interactors

STRING: functional protein association networks

More...
STRINGi
3702.AT3G05350.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8RY11

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase M24B family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2413, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_011781_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8RY11

KEGG Orthology (KO)

More...
KOi
K01262

Identification of Orthologs from Complete Genome Data

More...
OMAi
YRPGKWG

Database of Orthologous Groups

More...
OrthoDBi
417805at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8RY11

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01085, APP, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.350.10, 2 hits
3.90.230.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029149, Creatin/AminoP/Spt16_NTD
IPR036005, Creatinase/aminopeptidase-like
IPR000587, Creatinase_N
IPR000994, Pept_M24
IPR033740, Pept_M24B
IPR032416, Peptidase_M24_C

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01321, Creatinase_N, 1 hit
PF00557, Peptidase_M24, 1 hit
PF16188, Peptidase_M24_C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53092, SSF53092, 1 hit
SSF55920, SSF55920, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q8RY11-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIPLTLSSPS LNRLVLSTSR YSHSLFLSNF NSLSLIHRKL PYKPLFGARC
60 70 80 90 100
HASSSSSSSS SFTAKSSKEI RKAQTKVVVD EKLSSIRRLF SEPGVGIDAY
110 120 130 140 150
IIPSQDAHQS EFIAECYARR AYISGFTGSA GTAVVTKDKA ALWTDGRYFL
160 170 180 190 200
QAEKQLNSSW ILMRAGNPGV PTASEWIADV LAPGGRVGID PFLFSADAAE
210 220 230 240 250
ELKEVIAKKN HELVYLYNVN LVDEIWKDSR PKPPSRQIRI HDLKYAGLDV
260 270 280 290 300
ASKLLSLRNQ IMDAGTSAIV ISMLDEIAWV LNLRGSDVPH SPVMYAYLIV
310 320 330 340 350
EVDQAQLFVD NSKVTVEVKD HLKNAGIELR PYDSILQGID SLAARGAQLL
360 370 380 390 400
MDPSTLNVAI ISTYKSACER YSRNFESEAK VKTKFTDSSS GYTANPSGIY
410 420 430 440 450
MQSPISWAKA IKNDAELKGM KNSHLRDAAA LAHFWAWLEE EVHKNANLTE
460 470 480 490 500
VDVADRLLEF RSMQDGFMDT SFDTISGSGA NGAIIHYKPE PESCSRVDPQ
510 520 530 540 550
KLFLLDSGAQ YVDGTTDITR TVHFSEPSAR EKECFTRVLQ GHIALDQAVF
560 570 580 590 600
PEGTPGFVLD GFARSSLWKI GLDYRHGTGH GVGAALNVHE GPQSISFRYG
610 620 630 640 650
NMTPLQNGMI VSNEPGYYED HAFGIRIENL LHVRDAETPN RFGGATYLGF
660 670 680 690 700
EKLTFFPIQT KMVDVSLLSD TEVDWLNSYH AEVWEKVSPL LEGSTTQQWL
710
WNNTRPLAKP
Length:710
Mass (Da):78,709
Last modified:June 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9C888095DEFDB0A1
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF27041 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC009177 Genomic DNA Translation: AAF27041.1 Sequence problems.
CP002686 Genomic DNA Translation: AEE74224.1
AY079018 mRNA Translation: AAL84973.1
BT001080 mRNA Translation: AAN46861.1

NCBI Reference Sequences

More...
RefSeqi
NP_187186.5, NM_111408.7

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT3G05350.1; AT3G05350.1; AT3G05350

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
819699

Gramene; a comparative resource for plants

More...
Gramenei
AT3G05350.1; AT3G05350.1; AT3G05350

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT3G05350

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009177 Genomic DNA Translation: AAF27041.1 Sequence problems.
CP002686 Genomic DNA Translation: AEE74224.1
AY079018 mRNA Translation: AAL84973.1
BT001080 mRNA Translation: AAN46861.1
RefSeqiNP_187186.5, NM_111408.7

3D structure databases

SMRiQ8RY11
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ8RY11, 2 interactors
STRINGi3702.AT3G05350.1

Protein family/group databases

MEROPSiM24.A04

Proteomic databases

PaxDbiQ8RY11
PRIDEiQ8RY11
ProteomicsDBi244479

Genome annotation databases

EnsemblPlantsiAT3G05350.1; AT3G05350.1; AT3G05350
GeneIDi819699
GrameneiAT3G05350.1; AT3G05350.1; AT3G05350
KEGGiath:AT3G05350

Organism-specific databases

AraportiAT3G05350
TAIRilocus:2096319, AT3G05350

Phylogenomic databases

eggNOGiKOG2413, Eukaryota
HOGENOMiCLU_011781_2_1_1
InParanoidiQ8RY11
KOiK01262
OMAiYRPGKWG
OrthoDBi417805at2759
PhylomeDBiQ8RY11

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q8RY11

Gene expression databases

ExpressionAtlasiQ8RY11, baseline and differential

Family and domain databases

CDDicd01085, APP, 1 hit
Gene3Di3.40.350.10, 2 hits
3.90.230.10, 1 hit
InterProiView protein in InterPro
IPR029149, Creatin/AminoP/Spt16_NTD
IPR036005, Creatinase/aminopeptidase-like
IPR000587, Creatinase_N
IPR000994, Pept_M24
IPR033740, Pept_M24B
IPR032416, Peptidase_M24_C
PfamiView protein in Pfam
PF01321, Creatinase_N, 1 hit
PF00557, Peptidase_M24, 1 hit
PF16188, Peptidase_M24_C, 1 hit
SUPFAMiSSF53092, SSF53092, 1 hit
SSF55920, SSF55920, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAMPP2_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8RY11
Secondary accession number(s): Q9MA84
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 23, 2018
Last sequence update: June 1, 2002
Last modified: October 7, 2020
This is version 144 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families
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