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Entry version 143 (16 Oct 2019)
Sequence version 1 (01 Jun 2002)
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Protein

WD repeat-containing protein PCN

Gene

PCN

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in auxin signaling pathway. Required for embryo development and meristem organization. Functions in the auxin pathway, integrating auxin signaling in the organization and maintenance of the shoot apical meristem (SAM) and root apical meristem (RAM).1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
WD repeat-containing protein PCNCurated
Alternative name(s):
Protein POPCORN1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PCN1 Publication
Ordered Locus Names:At4g07410Imported
ORF Names:F28D6.14Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT4G07410

The Arabidopsis Information Resource

More...
TAIRi
locus:2124377 AT4G07410

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Temperature-sensitive phenotype. Defective in embryo development and embryo lethality when grown at 22 degrees Celsius. Embryo lethality phenotype rescued when grown at 29 degrees Celsius. Germination of temperature-rescued pcn mutant seeds give plants with small and narrow-shaped leaves, abnormal leaf vein patterns, altered flowering organs and defects in the root apical meristem (RAM).1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004432531 – 815WD repeat-containing protein PCNAdd BLAST815

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8RXU6

PRoteomics IDEntifications database

More...
PRIDEi
Q8RXU6

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8RXU6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

During early phases of embryogenesis, expressed in all the cells of the embryo proper and the suspensor until the 32-cell embryo stage. At the heart stage, expression completely disappears in the suspensor, but remains in the embryo proper. After germination, expressed in shoot apical meristem (SAM), leaf primordia, root apical meristem (RAM), and lateral root primordia.1 Publication

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8RXU6 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
3702.AT4G07410.1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati11 – 50WD 1Sequence analysisAdd BLAST40
Repeati58 – 103WD 2Sequence analysisAdd BLAST46
Repeati146 – 190WD 3Sequence analysisAdd BLAST45
Repeati196 – 235WD 4Sequence analysisAdd BLAST40
Repeati244 – 284WD 5Sequence analysisAdd BLAST41
Repeati287 – 326WD 6Sequence analysisAdd BLAST40
Repeati381 – 421WD 7Sequence analysisAdd BLAST41
Repeati529 – 568WD 8Sequence analysisAdd BLAST40

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2048 Eukaryota
ENOG410XQNR LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000015194

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8RXU6

KEGG Orthology (KO)

More...
KOi
K14548

Identification of Orthologs from Complete Genome Data

More...
OMAi
PRRFQEF

Database of Orthologous Groups

More...
OrthoDBi
376282at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8RXU6

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00400 WD40, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320 WD40, 8 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978 SSF50978, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8RXU6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLEYRCSSVD WKPSPVVALA NSSDDSQVAA AREDGSLEIW LVSPGAVGWH
60 70 80 90 100
CQLTIHGDPN SRISSLAWCC SPSIGLPSGR LFSSSIDGSI SEWDLFDLKQ
110 120 130 140 150
KIVLESIGIS IWQMALAPIS GFSSDVEGIK NGYLSEKSND EEEIGSEEDG
160 170 180 190 200
SDSDEFHEKS EEEIDRILAA ACDDGCVRLY RISNLEKLTY YRSLPRVSGR
210 220 230 240 250
ALSVTWSPDA KRIFSGSSDG LIRCWDATSC HEVYRITAGL GGLGSSSEIC
260 270 280 290 300
VWSLLSLRCS VLVSGDSTGT VQFWDSEHGT LLEAHSNHKG DVNTLAAAPS
310 320 330 340 350
HNRVFSAGAD GQVILYKLSG STNGSQDLKP SSSQKWDYIG YVKAHTHDIR
360 370 380 390 400
ALTVAVPISR EDPFPDDILP DKASRKHRKK GKPVDFTYHK WAHLGVPMLI
410 420 430 440 450
SAGDDAKLFA YSIQEFTKFS PHDICPAPQR IPMQMVHNSM FNKTSLLLVQ
460 470 480 490 500
GISTLDILRL NISSDSSGRA STKSLVRVKS RDARKIICSA ISNTGSHFAY
510 520 530 540 550
SDQIGPSLFE LKKNEFTKCP WSVSRRRLPE LPFAHSMIFS SDCSRLIIAG
560 570 580 590 600
HDRRIYTIDI SSLELVYAFT PSREEHEGEA PTPKEPPITK LFTSSDGQWL
610 620 630 640 650
AAINCFGDIY VFNLETQRQH WFISRLDGAS VTAAGFHPWN NNALVISTSS
660 670 680 690 700
NQVFAFDVEA RQLGKWSLLN TYVLPKRYQE FPGEVLGLSF SPSPNSSSVI
710 720 730 740 750
VYSSRAKCLI DFGKPVEEDE EYDLPNGNLS KTLEGKLVNL GLKKGKGTNR
760 770 780 790 800
KRRLDEYQLE GKSNERKNFE ILPSNHPVLF VGHLSKNSIL VIEKPWMDVV
810
KSLDNQPVDR HIFGT
Length:815
Mass (Da):90,270
Last modified:June 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC5A1ABCA0CA1AD85
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8MRY7A8MRY7_ARATH
Transducin family protein / WD-40 r...
PCN POPCORN, At4g07410, F28D6.14, F28D6_14
702Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD48948 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAB81111 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF147262 Genomic DNA Translation: AAD48948.1 Sequence problems.
AL161505 Genomic DNA Translation: CAB81111.1 Sequence problems.
CP002687 Genomic DNA Translation: AEE82567.1
AY080667 mRNA Translation: AAL86343.1
AY133764 mRNA Translation: AAM91698.1

Protein sequence database of the Protein Information Resource

More...
PIRi
C85072

NCBI Reference Sequences

More...
RefSeqi
NP_567317.2, NM_116813.4

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT4G07410.1; AT4G07410.1; AT4G07410

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
826172

Gramene; a comparative resource for plants

More...
Gramenei
AT4G07410.1; AT4G07410.1; AT4G07410

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT4G07410

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF147262 Genomic DNA Translation: AAD48948.1 Sequence problems.
AL161505 Genomic DNA Translation: CAB81111.1 Sequence problems.
CP002687 Genomic DNA Translation: AEE82567.1
AY080667 mRNA Translation: AAL86343.1
AY133764 mRNA Translation: AAM91698.1
PIRiC85072
RefSeqiNP_567317.2, NM_116813.4

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi3702.AT4G07410.1

PTM databases

iPTMnetiQ8RXU6

Proteomic databases

PaxDbiQ8RXU6
PRIDEiQ8RXU6

Genome annotation databases

EnsemblPlantsiAT4G07410.1; AT4G07410.1; AT4G07410
GeneIDi826172
GrameneiAT4G07410.1; AT4G07410.1; AT4G07410
KEGGiath:AT4G07410

Organism-specific databases

AraportiAT4G07410
TAIRilocus:2124377 AT4G07410

Phylogenomic databases

eggNOGiKOG2048 Eukaryota
ENOG410XQNR LUCA
HOGENOMiHOG000015194
InParanoidiQ8RXU6
KOiK14548
OMAiPRRFQEF
OrthoDBi376282at2759
PhylomeDBiQ8RXU6

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q8RXU6

Gene expression databases

ExpressionAtlasiQ8RXU6 baseline and differential

Family and domain databases

Gene3Di2.130.10.10, 3 hits
InterProiView protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 1 hit
SMARTiView protein in SMART
SM00320 WD40, 8 hits
SUPFAMiSSF50978 SSF50978, 2 hits
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPCN_ARATH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8RXU6
Secondary accession number(s): Q9S9X3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 28, 2018
Last sequence update: June 1, 2002
Last modified: October 16, 2019
This is version 143 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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