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Entry version 126 (02 Jun 2021)
Sequence version 1 (01 Jun 2002)
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Protein

Fumarylacetoacetase

Gene

FAH

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Converts fumarylacetoacetate to acetoacetate and fumarate (PubMed:22980205).

Involved in tyrosine catabolic pathway. Catalyzes the final step in the tyrosine degradation pathway (PubMed:22980205, PubMed:23743712, PubMed:27097641).

3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=2.7 µM for 4-fumarylacetoacetate1 Publication

    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: L-phenylalanine degradation

    This protein is involved in step 6 of the subpathway that synthesizes acetoacetate and fumarate from L-phenylalanine.Curated This subpathway is part of the pathway L-phenylalanine degradation, which is itself part of Amino-acid degradation.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetoacetate and fumarate from L-phenylalanine, the pathway L-phenylalanine degradation and in Amino-acid degradation.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi131CalciumBy similarity1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei138Proton acceptorBy similarity1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei147SubstrateBy similarity1
    Metal bindingi204CalciumBy similarity1
    Metal bindingi206CalciumBy similarity1
    Metal bindingi238CalciumBy similarity1
    Metal bindingi238MagnesiumBy similarity1
    Binding sitei245SubstrateBy similarity1
    Binding sitei249SubstrateBy similarity1
    Metal bindingi258MagnesiumBy similarity1
    Metal bindingi262MagnesiumBy similarity1
    Binding sitei355SubstrateBy similarity1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    • fumarylacetoacetase activity Source: TAIR
    • metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    • cell death Source: TAIR
    • homogentisate catabolic process Source: TAIR
    • L-phenylalanine catabolic process Source: GO_Central
    • tyrosine catabolic process Source: TAIR

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionHydrolase
    Biological processPhenylalanine catabolism, Tyrosine catabolism
    LigandCalcium, Magnesium, Metal-binding

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    ARA:AT1G12050-MONOMER

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    3.7.1.2, 399

    UniPathway: a resource for the exploration and annotation of metabolic pathways

    More...
    UniPathwayi
    UPA00139;UER00341

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    FumarylacetoacetaseCurated (EC:3.7.1.21 Publication)
    Alternative name(s):
    Fumarylacetoacetate hydrolase1 Publication
    Short name:
    AtFAH1 Publication
    Protein SHORT-DAY SENSITIVE CELL DEATH 11 Publication
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:FAH1 Publication
    Synonyms:SSCD11 Publication
    Ordered Locus Names:At1g12050Imported
    ORF Names:F12F1.8Imported
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

    Organism-specific databases

    Arabidopsis Information Portal

    More...
    Araporti
    AT1G12050

    The Arabidopsis Information Resource

    More...
    TAIRi
    locus:2008845, AT1G12050

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    <p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

    Spontaneous cell death phenotype under short-day conditions.1 Publication

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004420481 – 421FumarylacetoacetaseAdd BLAST421

    Proteomic databases

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q8RW90

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q8RW90

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    222377

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    Gene expression databases

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q8RW90, baseline and differential

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    STRING: functional protein association networks

    More...
    STRINGi
    3702.AT1G12050.1

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q8RW90

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the FAH family.Curated

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG2843, Eukaryota

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_026207_2_0_1

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q8RW90

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    PNWLHIP

    Database of Orthologous Groups

    More...
    OrthoDBi
    980065at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q8RW90

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    2.30.30.230, 1 hit
    3.90.850.10, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR005959, Fumarylacetoacetase
    IPR011234, Fumarylacetoacetase-like_C
    IPR036663, Fumarylacetoacetase_C_sf
    IPR015377, Fumarylacetoacetase_N
    IPR036462, Fumarylacetoacetase_N_sf

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR43069, PTHR43069, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF01557, FAA_hydrolase, 1 hit
    PF09298, FAA_hydrolase_N, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF56529, SSF56529, 1 hit
    SSF63433, SSF63433, 1 hit

    TIGRFAMs; a protein family database

    More...
    TIGRFAMsi
    TIGR01266, fum_ac_acetase, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    Q8RW90-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MALLKSFIDV GSDSHFPIQN LPYGVFKPES NSTPRPAVAI GDLVLDLSAI
    60 70 80 90 100
    SEAGLFDGLI LKDADCFLQP NLNKFLAMGR PAWKEARSTL QRILSSNEPI
    110 120 130 140 150
    LRDNDVLRRK SFHQMSKVEM IVPMVIGDYT DFFASMHHAK NCGLMFRGPE
    160 170 180 190 200
    NAINPNWFRL PIAYHGRASS IVISGTDIIR PRGQGHPQGN SEPYFGPSKK
    210 220 230 240 250
    LDFELEMAAV VGPGNELGKP IDVNNAADHI FGLLLMNDWS ARDIQAWEYV
    260 270 280 290 300
    PLGPFLGKSF GTTISPWIVT LDALEPFGCQ APKQDPPPLP YLAEKESVNY
    310 320 330 340 350
    DISLEVQLKP SGRDDSCVIT KSNFQNLYWT ITQQLAHHTV NGCNLRPGDL
    360 370 380 390 400
    LGTGTISGPE PDSYGCLLEL TWNGQKPLSL NGTTQTFLED GDQVTFSGVC
    410 420
    KGDGYNVGFG TCTGKIVPSP P
    Length:421
    Mass (Da):46,095
    Last modified:June 1, 2002 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i14F8458045893FAC
    GO

    <p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence AAC17611 differs from that shown. Reason: Erroneous gene model prediction.Curated

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AC002131 Genomic DNA Translation: AAC17611.1 Sequence problems.
    CP002684 Genomic DNA Translation: AEE28830.1
    AY094010 mRNA Translation: AAM16166.1

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    F86255

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_172669.2, NM_101077.6

    Genome annotation databases

    Ensembl plant genome annotation project

    More...
    EnsemblPlantsi
    AT1G12050.1; AT1G12050.1; AT1G12050

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    837757

    Gramene; a comparative resource for plants

    More...
    Gramenei
    AT1G12050.1; AT1G12050.1; AT1G12050

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    ath:AT1G12050

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AC002131 Genomic DNA Translation: AAC17611.1 Sequence problems.
    CP002684 Genomic DNA Translation: AEE28830.1
    AY094010 mRNA Translation: AAM16166.1
    PIRiF86255
    RefSeqiNP_172669.2, NM_101077.6

    3D structure databases

    SMRiQ8RW90
    ModBaseiSearch...

    Protein-protein interaction databases

    STRINGi3702.AT1G12050.1

    Proteomic databases

    PaxDbiQ8RW90
    PRIDEiQ8RW90
    ProteomicsDBi222377

    Genome annotation databases

    EnsemblPlantsiAT1G12050.1; AT1G12050.1; AT1G12050
    GeneIDi837757
    GrameneiAT1G12050.1; AT1G12050.1; AT1G12050
    KEGGiath:AT1G12050

    Organism-specific databases

    AraportiAT1G12050
    TAIRilocus:2008845, AT1G12050

    Phylogenomic databases

    eggNOGiKOG2843, Eukaryota
    HOGENOMiCLU_026207_2_0_1
    InParanoidiQ8RW90
    OMAiPNWLHIP
    OrthoDBi980065at2759
    PhylomeDBiQ8RW90

    Enzyme and pathway databases

    UniPathwayiUPA00139;UER00341
    BioCyciARA:AT1G12050-MONOMER
    BRENDAi3.7.1.2, 399

    Miscellaneous databases

    Protein Ontology

    More...
    PROi
    PR:Q8RW90

    Gene expression databases

    ExpressionAtlasiQ8RW90, baseline and differential

    Family and domain databases

    Gene3Di2.30.30.230, 1 hit
    3.90.850.10, 1 hit
    InterProiView protein in InterPro
    IPR005959, Fumarylacetoacetase
    IPR011234, Fumarylacetoacetase-like_C
    IPR036663, Fumarylacetoacetase_C_sf
    IPR015377, Fumarylacetoacetase_N
    IPR036462, Fumarylacetoacetase_N_sf
    PANTHERiPTHR43069, PTHR43069, 1 hit
    PfamiView protein in Pfam
    PF01557, FAA_hydrolase, 1 hit
    PF09298, FAA_hydrolase_N, 1 hit
    SUPFAMiSSF56529, SSF56529, 1 hit
    SSF63433, SSF63433, 1 hit
    TIGRFAMsiTIGR01266, fum_ac_acetase, 1 hit

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFAH_ARATH
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8RW90
    Secondary accession number(s): O65374
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2017
    Last sequence update: June 1, 2002
    Last modified: June 2, 2021
    This is version 126 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families
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