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Entry version 123 (11 Dec 2019)
Sequence version 1 (01 Jun 2002)
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Protein

Calpain-type cysteine protease DEK1

Gene

DEK1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Essential protease involved in epiderm development. Required for aleurone cell development in the endosperm probably by maintaining and restricting the aleurone and embryonic epidermal L1 cell-layer fates as well as meristems organization. Involved in the maintenance of adaxial/abaxial axis information in developing leaves, probably by regulating cell proliferation and expansion. Does not need calcium ions to be active. Required for the formation of giant cells in sepals by determining cell fate and promoting endoreplication.5 Publications

Miscellaneous

Although homology to other calpains is high within the protease domain, the lack of calcium-binding sites suggests that this protein is a protease that may not be activated by calcium ions.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1761By similarity1
Active sitei1919By similarity1
Active sitei1939By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • calcium-dependent cysteine-type endopeptidase activity Source: GO_Central
  • cysteine-type peptidase activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Hydrolase, Protease, Thiol protease

Protein family/group databases

MEROPS protease database

More...
MEROPSi
C02.019

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Calpain-type cysteine protease DEK1 (EC:3.4.22.-)
Alternative name(s):
Phytocalpain DEK1
Protein DEFECTIVE KERNEL 1
Short name:
AtDEK1
Protein EMBRYO DEFECTIVE 1275
Protein EMBRYO DEFECTIVE 80
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DEK1
Synonyms:EMB1275, EMB80
Ordered Locus Names:At1g55350
ORF Names:F7A10.23
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT1G55350

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini33 – 69ExtracellularSequence analysisAdd BLAST37
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei70 – 90Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini91 – 94CytoplasmicSequence analysis4
Transmembranei95 – 115Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini116 – 126ExtracellularSequence analysisAdd BLAST11
Transmembranei127 – 147Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini148 – 163CytoplasmicSequence analysisAdd BLAST16
Transmembranei164 – 184Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini185 – 235ExtracellularSequence analysisAdd BLAST51
Transmembranei236 – 256Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini257 – 263CytoplasmicSequence analysis7
Transmembranei264 – 284Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini285 – 293ExtracellularSequence analysis9
Transmembranei294 – 314Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini315 – 319CytoplasmicSequence analysis5
Transmembranei320 – 340Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini341 – 615ExtracellularSequence analysisAdd BLAST275
Transmembranei616 – 636Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini637 – 652CytoplasmicSequence analysisAdd BLAST16
Transmembranei653 – 673Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini674 – 686ExtracellularSequence analysisAdd BLAST13
Transmembranei687 – 707Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini708 – 711CytoplasmicSequence analysis4
Transmembranei712 – 732Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini733 – 760ExtracellularSequence analysisAdd BLAST28
Transmembranei761 – 782Helical; Name=13Sequence analysisAdd BLAST22
Topological domaini783 – 813CytoplasmicSequence analysisAdd BLAST31
Transmembranei814 – 834Helical; Name=14Sequence analysisAdd BLAST21
Topological domaini835 – 844ExtracellularSequence analysis10
Transmembranei845 – 865Helical; Name=15Sequence analysisAdd BLAST21
Topological domaini866 – 878CytoplasmicSequence analysisAdd BLAST13
Transmembranei879 – 899Helical; Name=16Sequence analysisAdd BLAST21
Topological domaini900 – 912ExtracellularSequence analysisAdd BLAST13
Transmembranei913 – 933Helical; Name=17Sequence analysisAdd BLAST21
Topological domaini934 – 936CytoplasmicSequence analysis3
Transmembranei937 – 957Helical; Name=18Sequence analysisAdd BLAST21
Topological domaini958 – 971ExtracellularSequence analysisAdd BLAST14
Transmembranei972 – 992Helical; Name=19Sequence analysisAdd BLAST21
Topological domaini993 – 1006CytoplasmicSequence analysisAdd BLAST14
Transmembranei1007 – 1027Helical; Name=20Sequence analysisAdd BLAST21
Topological domaini1028 – 1050ExtracellularSequence analysisAdd BLAST23
Transmembranei1051 – 1071Helical; Name=21Sequence analysisAdd BLAST21
Topological domaini1072 – 2151CytoplasmicSequence analysisAdd BLAST1080

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Endoplasmic reticulum, Endosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Defective embryo arrested at preglobular/globular stage. Disturbed endosperm lacking the aleurone-like peripheral cell layer and unorganized embryo development displaying irregular mitotic divisions in the embryo proper and suspensor. In a partially disrupted phenotype, impaired meristems organization characterized by vacuolated cells, abnormal cotyledon epiderm made of chloroplast-containing cells, and radialized leaves.6 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1761C → S: Loss of activity. 1 Publication1
Mutagenesisi2106R → C in dek1-4; near absence of giant cells in sepals due to a reduced endoreduplication. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 32Sequence analysisAdd BLAST32
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000042343733 – 2151Calpain-type cysteine protease DEK1Add BLAST2119
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000042343833 – ?

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Autocatalytic proteolytic cleavage leading to the production of mainly cytoplasmic localized subproducts of about 85 and 120 kDa.

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8RVL2

PRoteomics IDEntifications database

More...
PRIDEi
Q8RVL2

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8RVL2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Mostly expressed in meristems and organ primordia. Expressed at low levels in young and germinating seeds at 10 ppm and in seedling roots at 67 ppm. Present in most tissues at a low level.2 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Mostly observed in vegetative, inflorescence and floral meristems as well as in young leaf and floral organ primordia. Strongly expressed in developing ovules and during early embryogenesis. Expressed evenly throughout the endosperm and the embryo in developing seed. Present in the embryo proper, but excluded from the suspensor, until the late heart stage, and fades out later, especially in the hypocotyl region, to be present at low levels throughout walking-stick embryos. Accumulates at the margins and in the tips of cotyledons and lateral organs, in the apical meristem, in a subset of cells at the root pole and in a restricted number of cells within the presumptive vasculature of the hypocotyls. Also detected during early endosperm development, prior to cellularization.2 Publications

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8RVL2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8RVL2 AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
27206, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q8RVL2, 1 interactor

STRING: functional protein association networks

More...
STRINGi
3702.AT1G55350.5

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1407 – 1600Calpain catalytic 1PROSITE-ProRule annotationAdd BLAST194
Domaini1695 – 1997Calpain catalytic 2PROSITE-ProRule annotationAdd BLAST303

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi369 – 485Ser-richAdd BLAST117
Compositional biasi1595 – 1636Asp-richAdd BLAST42

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The transmembrane regions are not required for calpain activity but may play regulatory roles.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase C2 family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0045 Eukaryota
ENOG410XP0B LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000030613

Identification of Orthologs from Complete Genome Data

More...
OMAi
IYVCRIY

Database of Orthologous Groups

More...
OrthoDBi
23957at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8RVL2

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00214 Calpain_III, 1 hit
cd00044 CysPc, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR033883 C2_III
IPR022684 Calpain_cysteine_protease
IPR022682 Calpain_domain_III
IPR022683 Calpain_III
IPR036213 Calpain_III_sf
IPR013320 ConA-like_dom_sf
IPR038765 Papain-like_cys_pep_sf
IPR000169 Pept_cys_AS
IPR001300 Peptidase_C2_calpain_cat

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01067 Calpain_III, 1 hit
PF00648 Peptidase_C2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00704 CALPAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00720 calpain_III, 1 hit
SM00230 CysPc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49758 SSF49758, 1 hit
SSF49899 SSF49899, 1 hit
SSF54001 SSF54001, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50203 CALPAIN_CAT, 1 hit
PS00139 THIOL_PROTEASE_CYS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 1 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoform i produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms may exist.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8RVL2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEGDERGVLL ACVISGTLFT VFGSGSFWIL WAVNWRPWRL YSWIFARKWP
60 70 80 90 100
KVLQGPQLDI LCGVLSLFAW IVVVSPIAIL IGWGSWLIVI LDRHIIGLAI
110 120 130 140 150
IMAGTALLLA FYSIMLWWRT QWQSSRAVAL LLLLGVALLC AYELCAVYVT
160 170 180 190 200
AGAHASQQYS PSGFFFGVSA IALAINMLFI CRMVFNGNGL DVDEYVRRAY
210 220 230 240 250
KFAYSDCIEV GPVACLPEPP DPNELYPRQT SRASHLGLLY LGSLVVLLAY
260 270 280 290 300
SVLYGLTARE SRWLGGITSA AVIVLDWNIG ACLYGFKLLQ NRVLALFVAG
310 320 330 340 350
ISRLFLICFG IHYWYLGHCI SYIFVASVLS GAAVSRHLSI TDPSAARRDA
360 370 380 390 400
LQSTVIRLRE GFRRKEQNSS SSSSDGCGSS IKRSSSIDAG HTGCTNEANR
410 420 430 440 450
TAESCTADNL TRTGSSQEGI NSDKSEESGR PSLGLRSSSC RSVVQEPEAG
460 470 480 490 500
TSYFMDKVSD QNNTLVVCSS SGLDSQGYES STSNSANQQL LDMNLALAFQ
510 520 530 540 550
DQLNNPRIAS ILKKKAKEGD LELTNLLQDK GLDPNFAVML KEKNLDPTIL
560 570 580 590 600
ALLQRSSLDA DRDHRDNTDI TIIDSNSVDN TLPNQISLSE ELRLRGLEKW
610 620 630 640 650
LKLSRLLLHH VAGTPERAWG LFSLVFILET IIVAIFRPKT ITIINSSHQQ
660 670 680 690 700
FEFGFSVLLL SPVVCSIMAF LRSLQVEEMA LTSKSRKYGF VAWLLSTSVG
710 720 730 740 750
LSLSFLSKSS VLLGISLTVP LMAACLSIAV PIWMHNGYQF WVPQLSCGDQ
760 770 780 790 800
ARDLRSPRIK GFILWICVVL FAGSVISLGA IISAKPLDDL KYKLFSAREN
810 820 830 840 850
NVTSPYTSSV YLGWAMSSGI ALVVTAILPI VSWFATYRFS HSSAVCLMIF
860 870 880 890 900
SVVLVAFCGT SYLEVVKSRD DQLPTKGDFL AALLPLACIP ALLSLCCGMV
910 920 930 940 950
KWKDDCWILS RGVYVFFSIG LLLLFGAIAA VIAVKPWTIG VSFLLVLFLM
960 970 980 990 1000
VVTIGVIHLW ASNNFYLTRK QTSFVCFLAL LLGLAAFLLG WHQDKAFAGA
1010 1020 1030 1040 1050
SVGYFTFLSL LAGRALAVLL SPPIVVYSPR VLPVYVYDAH ADCGKNVSAA
1060 1070 1080 1090 1100
FLVLYGIALA TEGWGVVASL IIYPPFAGAA VSAITLVVAF GFAVSRPCLT
1110 1120 1130 1140 1150
LEMMEVAVRF LSKDTIVQAI SRSATKTRNA LSGTYSAPQR SASSAALLVG
1160 1170 1180 1190 1200
DPSAMRDKAG NFVLPRDDVM KLRDRLRNEE RVAGSIFYKM QCRKGFRHEP
1210 1220 1230 1240 1250
PTNVDYRRDM CAHARVLALE EAIDTEWVYM WDKFGGYLLL LLGLTAKAER
1260 1270 1280 1290 1300
VQDEVRLRLF LDSIGFSDLS ARKISKWKPE DRRQFEIIQE SYLREKEMEE
1310 1320 1330 1340 1350
ESLMQRREEE GRGKERRKAL LEKEERKWKE IEASLIPSIP NAGSREAAAM
1360 1370 1380 1390 1400
AAAIRAVGGD SVLEDSFARE RVSGIARRIR TAQLERRAQQ TGISGAVCVL
1410 1420 1430 1440 1450
DDEPMISGKH CGQMDSSVCQ SQKISFSVTA MIQSDSGPVC LFGTEFQKKV
1460 1470 1480 1490 1500
CWEILVAGSE QGIEAGQVGL RLITKGERQT TVAREWYIGA TSITDGRWHT
1510 1520 1530 1540 1550
VTITIDADAG EATCYIDGGF DGYQNGLPLS IGSAIWEQGA EVWLGVRPPI
1560 1570 1580 1590 1600
DVDAFGRSDS DGVESKMHIM DVFLWGKCLS EEEAASLHAA IGMADLDMID
1610 1620 1630 1640 1650
LSDDNWQWTD SPPRVDGWDS DPADVDLYDR DDVDWDGQYS SGRKRRSGRD
1660 1670 1680 1690 1700
FVMSVDSFAR RHRKPRMETQ EDINQRMRSV ELAVKEALSA RGDKQFTDQE
1710 1720 1730 1740 1750
FPPNDRSLFV DTQNPPSKLQ VVSEWMRPDS IVKENGSDSR PCLFSGDANP
1760 1770 1780 1790 1800
SDVCQGRLGD CWFLSAVAVL TEVSRISEVI ITPEYNEEGI YTVRFCIQGE
1810 1820 1830 1840 1850
WVPVVIDDWI PCESPGKPAF ATSRKLNELW VSMVEKAYAK LHGSYEALEG
1860 1870 1880 1890 1900
GLVQDALVDL TGGAGEEIDL RSAQAQIDLA SGRLWSQLLR FKQEGFLLGA
1910 1920 1930 1940 1950
GSPSGSDVHV SSSGIVQGHA YSVLQVREVD GHRLVQIRNP WANEVEWNGP
1960 1970 1980 1990 2000
WSDSSPEWTD RMKHKLKHVP QSKEGIFWMS WQDFQIHFRS IYVCRVYPRE
2010 2020 2030 2040 2050
MRYSVNGQWR GYSAGGCQDY SSWHQNPQFR LRATGSDASL PIHVFITLTQ
2060 2070 2080 2090 2100
GVGFSRTTPG FRNYQSSHDS QLFYIGLRIL KTRGRRAAYN IFLHESVGGT
2110 2120 2130 2140 2150
DYVNSREISC EMVLDPDPKG YTIVPTTIHP GEEAPFVLSV FTKASIVLEA

L
Length:2,151
Mass (Da):238,264
Last modified:June 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i50D571D7446A5609
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F4I0A4F4I0A4_ARATH
Calpain-type cysteine protease fami...
DEK1 ATDEK1, DEFECTIVE KERNEL 1, EMB1275, EMB80, embryo defective 1275
2,179Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAG51565 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY061803 mRNA Translation: AAL38186.1
AC027034 Genomic DNA Translation: AAG51565.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE33232.1
CP002684 Genomic DNA Translation: AEE33233.1
CP002684 Genomic DNA Translation: AEE33234.1
CP002684 Genomic DNA Translation: AEE33235.1
CP002684 Genomic DNA Translation: ANM58867.1
AY050822 mRNA Translation: AAK92757.1
AY074514 mRNA Translation: AAL67128.1

Protein sequence database of the Protein Information Resource

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PIRi
G96595

NCBI Reference Sequences

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RefSeqi
NP_001319240.1, NM_001333706.1 [Q8RVL2-1]
NP_001321273.1, NM_001333707.1 [Q8RVL2-1]
NP_175932.2, NM_104411.4 [Q8RVL2-1]
NP_850966.1, NM_180635.1 [Q8RVL2-1]
NP_850967.1, NM_180636.1 [Q8RVL2-1]

Genome annotation databases

Ensembl plant genome annotation project

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EnsemblPlantsi
AT1G55350.1; AT1G55350.1; AT1G55350 [Q8RVL2-1]
AT1G55350.2; AT1G55350.2; AT1G55350 [Q8RVL2-1]
AT1G55350.3; AT1G55350.3; AT1G55350 [Q8RVL2-1]
AT1G55350.4; AT1G55350.4; AT1G55350 [Q8RVL2-1]
AT1G55350.6; AT1G55350.6; AT1G55350 [Q8RVL2-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
841981

Gramene; a comparative resource for plants

More...
Gramenei
AT1G55350.1; AT1G55350.1; AT1G55350 [Q8RVL2-1]
AT1G55350.2; AT1G55350.2; AT1G55350 [Q8RVL2-1]
AT1G55350.3; AT1G55350.3; AT1G55350 [Q8RVL2-1]
AT1G55350.4; AT1G55350.4; AT1G55350 [Q8RVL2-1]
AT1G55350.6; AT1G55350.6; AT1G55350 [Q8RVL2-1]

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
ath:AT1G55350

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Seed defective Arabidopsis mutants

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY061803 mRNA Translation: AAL38186.1
AC027034 Genomic DNA Translation: AAG51565.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE33232.1
CP002684 Genomic DNA Translation: AEE33233.1
CP002684 Genomic DNA Translation: AEE33234.1
CP002684 Genomic DNA Translation: AEE33235.1
CP002684 Genomic DNA Translation: ANM58867.1
AY050822 mRNA Translation: AAK92757.1
AY074514 mRNA Translation: AAL67128.1
PIRiG96595
RefSeqiNP_001319240.1, NM_001333706.1 [Q8RVL2-1]
NP_001321273.1, NM_001333707.1 [Q8RVL2-1]
NP_175932.2, NM_104411.4 [Q8RVL2-1]
NP_850966.1, NM_180635.1 [Q8RVL2-1]
NP_850967.1, NM_180636.1 [Q8RVL2-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi27206, 2 interactors
IntActiQ8RVL2, 1 interactor
STRINGi3702.AT1G55350.5

Protein family/group databases

MEROPSiC02.019

PTM databases

iPTMnetiQ8RVL2

Proteomic databases

PaxDbiQ8RVL2
PRIDEiQ8RVL2

Genome annotation databases

EnsemblPlantsiAT1G55350.1; AT1G55350.1; AT1G55350 [Q8RVL2-1]
AT1G55350.2; AT1G55350.2; AT1G55350 [Q8RVL2-1]
AT1G55350.3; AT1G55350.3; AT1G55350 [Q8RVL2-1]
AT1G55350.4; AT1G55350.4; AT1G55350 [Q8RVL2-1]
AT1G55350.6; AT1G55350.6; AT1G55350 [Q8RVL2-1]
GeneIDi841981
GrameneiAT1G55350.1; AT1G55350.1; AT1G55350 [Q8RVL2-1]
AT1G55350.2; AT1G55350.2; AT1G55350 [Q8RVL2-1]
AT1G55350.3; AT1G55350.3; AT1G55350 [Q8RVL2-1]
AT1G55350.4; AT1G55350.4; AT1G55350 [Q8RVL2-1]
AT1G55350.6; AT1G55350.6; AT1G55350 [Q8RVL2-1]
KEGGiath:AT1G55350

Organism-specific databases

AraportiAT1G55350

Phylogenomic databases

eggNOGiKOG0045 Eukaryota
ENOG410XP0B LUCA
HOGENOMiHOG000030613
OMAiIYVCRIY
OrthoDBi23957at2759
PhylomeDBiQ8RVL2

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q8RVL2

Gene expression databases

ExpressionAtlasiQ8RVL2 baseline and differential
GenevisibleiQ8RVL2 AT

Family and domain databases

CDDicd00214 Calpain_III, 1 hit
cd00044 CysPc, 1 hit
InterProiView protein in InterPro
IPR033883 C2_III
IPR022684 Calpain_cysteine_protease
IPR022682 Calpain_domain_III
IPR022683 Calpain_III
IPR036213 Calpain_III_sf
IPR013320 ConA-like_dom_sf
IPR038765 Papain-like_cys_pep_sf
IPR000169 Pept_cys_AS
IPR001300 Peptidase_C2_calpain_cat
PfamiView protein in Pfam
PF01067 Calpain_III, 1 hit
PF00648 Peptidase_C2, 1 hit
PRINTSiPR00704 CALPAIN
SMARTiView protein in SMART
SM00720 calpain_III, 1 hit
SM00230 CysPc, 1 hit
SUPFAMiSSF49758 SSF49758, 1 hit
SSF49899 SSF49899, 1 hit
SSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS50203 CALPAIN_CAT, 1 hit
PS00139 THIOL_PROTEASE_CYS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDEK1_ARATH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8RVL2
Secondary accession number(s): Q8VXW6, Q949X8, Q9C8A6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 18, 2013
Last sequence update: June 1, 2002
Last modified: December 11, 2019
This is version 123 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  3. Peptidase families
    Classification of peptidase families and list of entries
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