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Entry version 101 (22 Apr 2020)
Sequence version 2 (18 Sep 2013)
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Protein

Calpain-type cysteine protease DEK1

Gene

DEK1

Organism
Zea mays (Maize)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Essential protease involved in epiderm development. Required for aleurone cell development in the endosperm probably by maintaining and restricting the aleurone and embryonic epidermal L1 cell-layer fates as well as meristems organization. Involved in the maintenance of adaxial/abaxial axis information in developing leaves, probably by regulating cell proliferation and expansion. Does not need calcium ions to be active.3 Publications

Miscellaneous

Although homology to other calpains is high within the protease domain, the lack of calcium-binding sites suggests that this protein is a protease that may not be activated by calcium ions.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1769By similarity1
Active sitei1927By similarity1
Active sitei1947By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • calcium-dependent cysteine-type endopeptidase activity Source: GO_Central
  • cysteine-type peptidase activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Hydrolase, Protease, Thiol protease

Protein family/group databases

MEROPS protease database

More...
MEROPSi
C02.019

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Calpain-type cysteine protease DEK1 (EC:3.4.22.-)
Alternative name(s):
Phytocalpain DEK1
Protein DEFECTIVE KERNEL 1
Short name:
ZmDEK1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DEK1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiZea mays (Maize)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri4577 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogonodaeAndropogoneaeTripsacinaeZea
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007305 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Maize Genetics and Genomics Database

More...
MaizeGDBi
12148

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini34 – 70ExtracellularSequence analysisAdd BLAST37
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei71 – 91Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini92 – 95CytoplasmicSequence analysis4
Transmembranei96 – 116Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini117 – 127ExtracellularSequence analysisAdd BLAST11
Transmembranei128 – 148Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini149 – 164CytoplasmicSequence analysisAdd BLAST16
Transmembranei165 – 185Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini186 – 236ExtracellularSequence analysisAdd BLAST51
Transmembranei237 – 257Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini258 – 264CytoplasmicSequence analysis7
Transmembranei265 – 285Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini286 – 294ExtracellularSequence analysis9
Transmembranei295 – 315Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini316 – 320CytoplasmicSequence analysis5
Transmembranei321 – 341Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini342 – 623ExtracellularSequence analysisAdd BLAST282
Transmembranei624 – 644Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini645 – 660CytoplasmicSequence analysisAdd BLAST16
Transmembranei661 – 681Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini682 – 694ExtracellularSequence analysisAdd BLAST13
Transmembranei695 – 715Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini716 – 719CytoplasmicSequence analysis4
Transmembranei720 – 740Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini741 – 770ExtracellularSequence analysisAdd BLAST30
Transmembranei771 – 791Helical; Name=13Sequence analysisAdd BLAST21
Topological domaini792 – 822CytoplasmicSequence analysisAdd BLAST31
Transmembranei823 – 843Helical; Name=14Sequence analysisAdd BLAST21
Topological domaini844 – 853ExtracellularSequence analysis10
Transmembranei854 – 874Helical; Name=15Sequence analysisAdd BLAST21
Topological domaini875 – 887CytoplasmicSequence analysisAdd BLAST13
Transmembranei888 – 908Helical; Name=16Sequence analysisAdd BLAST21
Topological domaini909 – 921ExtracellularSequence analysisAdd BLAST13
Transmembranei922 – 942Helical; Name=17Sequence analysisAdd BLAST21
Topological domaini943 – 946CytoplasmicSequence analysis4
Transmembranei947 – 967Helical; Name=18Sequence analysisAdd BLAST21
Topological domaini968 – 981ExtracellularSequence analysisAdd BLAST14
Transmembranei982 – 1002Helical; Name=19Sequence analysisAdd BLAST21
Topological domaini1003 – 1016CytoplasmicSequence analysisAdd BLAST14
Transmembranei1017 – 1037Helical; Name=20Sequence analysisAdd BLAST21
Topological domaini1038 – 1060ExtracellularSequence analysisAdd BLAST23
Transmembranei1061 – 1081Helical; Name=21Sequence analysisAdd BLAST21
Topological domaini1082 – 2159CytoplasmicSequence analysisAdd BLAST1078

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Endoplasmic reticulum, Endosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Loss of aleurone cells leading to white grains. Embryos arrest at the juvenile globoid stage and are devoid of shoot structures.2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1769C → S: Loss of activity. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 33Sequence analysisAdd BLAST33
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000042343934 – 2159Calpain-type cysteine protease DEK1Add BLAST2126
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000042344034 – ?By similarity

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1371PhosphoserineBy similarity1
Modified residuei1376PhosphoserineBy similarity1
Modified residuei1665PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Autocatalytic proteolytic cleavage leading to the production of mainly cytoplasmic localized subproducts of about 85 and 120 kDa.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8RVL1

PRoteomics IDEntifications database

More...
PRIDEi
Q8RVL1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in most tissues at low levels ranging from 30 to 55 ppm. Present in all endosperm cells at transcript level, but confined to aleurones at protein level.2 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

In endosperm, accumulates during early developmental stages and declines near maturity. In embryos, levels peak at middevelopment with highest expression in the embryonic axis. Also present in young pericarp and immature ear tip and base.1 Publication

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8RVL1 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
4577.GRMZM2G321753_P01

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8RVL1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1417 – 1609Calpain catalytic 1PROSITE-ProRule annotationAdd BLAST193
Domaini1703 – 2005Calpain catalytic 2PROSITE-ProRule annotationAdd BLAST303

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi370 – 493Ser-richAdd BLAST124
Compositional biasi1248 – 1254Poly-Leu7

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The transmembrane regions are not required for calpain activity but may play regulatory roles.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase C2 family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0045 Eukaryota
ENOG410XP0B LUCA

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00044 CysPc, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR022682 Calpain_domain_III
IPR022683 Calpain_III
IPR036213 Calpain_III_sf
IPR013320 ConA-like_dom_sf
IPR038765 Papain-like_cys_pep_sf
IPR000169 Pept_cys_AS
IPR001300 Peptidase_C2_calpain_cat

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01067 Calpain_III, 1 hit
PF00648 Peptidase_C2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00720 calpain_III, 1 hit
SM00230 CysPc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49758 SSF49758, 1 hit
SSF49899 SSF49899, 1 hit
SSF54001 SSF54001, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50203 CALPAIN_CAT, 1 hit
PS00139 THIOL_PROTEASE_CYS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 27 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8RVL1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEGEGHHGVV LACSICGFLF AVLSPFSFWV LWAVNWRPWR LYSWIYARKW
60 70 80 90 100
PTYVQGPQLS TLCSLLTLCA WLVVISPIAV LLVWGSVLIA LMERNIIGLA
110 120 130 140 150
VIMAGVALLL SFYSIMLWWR TQWQSSEAVA YLLLLAVCLL CAYDFCAIYV
160 170 180 190 200
TAGASASELN SPSGFFFGVS VISLAINMLF ICKILFNVSG FDVDEYVRRS
210 220 230 240 250
YKFAYSDCVE VAPVSCSPEP PDPSELYMTK SSRVKHLGLL YISSLLVLVG
260 270 280 290 300
YSILYGLTSK EARWLGALTS VAVVILDWNL GLCSFRFELL KSRMIVLFVA
310 320 330 340 350
GTSRAFLVSF GVHYWYLGHC ISYAFVASVL LSAAVSSWLS ISNPSVARID
360 370 380 390 400
ALRSTVIKLR EGFRRKGQNS SSNSSEGCGS SVKRSSGSVE AGQNGNAMDS
410 420 430 440 450
MYRSNSQSDG VNWSSIPFDR SNSCQEGRSS DKNIDSARAS LAHRSNSCLS
460 470 480 490 500
AVQDSETAVV SVDRHGDPIT SLVCSSSGLE SHGCEPSGSA TTSGNQQLLD
510 520 530 540 550
LNLAAIFQDR LNDPRISSML KKNGGLGDVE LANLLQDKGL DPNFSYMLKD
560 570 580 590 600
KVMDPRILAL LQRSSLDADR EHQDDVDVTA TDSDRLDTTI ANQISLSEEL
610 620 630 640 650
RRSGLEKWLN ISRLIFHHLA GSPIRAFIVF TVMFIIETAT VAIYRPETIK
660 670 680 690 700
VINATHEQFE FGFSILLLSP VVCSIMAFIW SLRAEEMLMT SKPQKYGFIA
710 720 730 740 750
WLLSTCVGLF LSFLSKSSVI LGLSLTVPLM VACLSFAVPI WIRNGYSFWI
760 770 780 790 800
PGREFANREN VSQAPGEKER ALFVITIAVF TASIIGLGAI VSAKPLDALG
810 820 830 840 850
YKGWDADKNS SYSPYATSMY LGWALSSTIA VITTGLIPIV AWFATYRFSP
860 870 880 890 900
SSAICVGLFA TVLVSFCGAS YWGVVNSRED GVPLKADFLA ALLPLLCIPA
910 920 930 940 950
FFSLFTGLYK WKDDDWKISR GVYLFVGMGM LLLFGAVAAV IVTIRPWTVG
960 970 980 990 1000
VACLVAILFL VFVIGVIHYW TSNNFYLTRT QMLLVCSIAF LLALAAFLMG
1010 1020 1030 1040 1050
LFHGKPFVGA SIGYFSFIFL LTGRALTVLL SPPIVVYSPR VLPVYVYDAH
1060 1070 1080 1090 1100
ADSAKNVSYA FLILYGIALA TEVWGVIASL IMNPPFVGAG VSATTLVIAF
1110 1120 1130 1140 1150
SFAVSRPCLT LKMMEDAVHF LSKDTVVQAM SRSANKTRNA ISGTYSAPQR
1160 1170 1180 1190 1200
SASSAALLVG DPALTLDRAG NFVLPRADVM KLRDRLRNEE IAAGSFLCGV
1210 1220 1230 1240 1250
KDCLLICPQS LSNIDYRRNM CAHARILALE EAIDTEWVYM WDKFGGYLLL
1260 1270 1280 1290 1300
LLGLTAKAEQ IQDEVRLRLF LDSIGLSDLS AKEIKKWMPE DRRQFELIQE
1310 1320 1330 1340 1350
SYIREKEMEE EALMQRREEE GKGRERRRAL LEREERKWKE LEISLLSSIP
1360 1370 1380 1390 1400
NTGSRDAAAM AAAVRAVGGD SALEDSFARD RVSSIANHIR KAQLARRAEQ
1410 1420 1430 1440 1450
TGIPGTICIL DDEPRSTGRH CGELDLCLCQ SQKVTLSIAV MVQPVSGPVC
1460 1470 1480 1490 1500
LFGSEFQKVC WEILVAGSEQ GMEAGQVGLR LVTKGERMTT VAKEWNIGAS
1510 1520 1530 1540 1550
SIADGRWHLV TVTLDADLGE ATSFIDGVYD GYQNGLPLPT DNGIWEPGTD
1560 1570 1580 1590 1600
IWVGARPPMD LDAFGRSDSE GSDSKMQIMD AFLWGRCLSE DEVTVLHTAM
1610 1620 1630 1640 1650
SPAEYGFFDL APGDAWHGSY SARVDDWESE EAYELYDQGD VEWDGQYSSG
1660 1670 1680 1690 1700
RKRPVHDAVA IDLDSFARRP RKPRFETRDE VNQRMLSVER AVRDALIAKG
1710 1720 1730 1740 1750
ERNFTDQEFP PEDRSLFVDP MNPPLKLQVV SEWMRPSDIA KDISISCQPC
1760 1770 1780 1790 1800
LFSGSVNSSD VCQGRLGDCW FLSAVAVLTE MSRISEVIIT PEYNDEGIYT
1810 1820 1830 1840 1850
VRFCIQGEWV AVVVDDWIPC ESPGKPAFAT SRKQNELWVS ILEKAYAKLH
1860 1870 1880 1890 1900
GSYEALEGGL VQDALVDLTG GAGEEIDMRS PQAQLDLASG RLWSQLLHFK
1910 1920 1930 1940 1950
QEGFLLGAGS PSGSDAHISS SGIVQGHAYS ILQVREVDGH KLIQIRNPWA
1960 1970 1980 1990 2000
NEVEWNGPWS DSSPEWTERM KHKLMHVPQS KNGVFWMSWQ DFQIHFRSIY
2010 2020 2030 2040 2050
VCRVYPPEMR YSVHGQWRGY NAGGCQDYDS WHQNPQYRLR VTGRDALYPV
2060 2070 2080 2090 2100
HVFITLTQGV GFSRKTNGFR NYQSSHDSSM FYIGMRILKT QGCRAAYNIY
2110 2120 2130 2140 2150
MHESAGGTDY VNSREISCEL VLDPYPKGYT IVPTTIHPGE EAPFVLSVFS

KASIRLEAV
Length:2,159
Mass (Da):239,106
Last modified:September 18, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i041D8974E4BA0AA5
GO
Isoform 2 (identifier: Q8RVL1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1877: Missing.

Show »
Length:282
Mass (Da):32,209
Checksum:iAED88901ABBBFCB1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 27 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1D6JZV9A0A1D6JZV9_MAIZE
Calpain-type cysteine protease DEK1
ZEAMMB73_Zm00001d028818
2,159Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1D6JZW0A0A1D6JZW0_MAIZE
Calpain-type cysteine protease DEK1
ZEAMMB73_Zm00001d028818
1,720Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1D6JZU7A0A1D6JZU7_MAIZE
Calpain-type cysteine protease DEK1
ZEAMMB73_Zm00001d028818
2,125Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1D6JZU9A0A1D6JZU9_MAIZE
Calpain-type cysteine protease DEK1
ZEAMMB73_Zm00001d028818
2,095Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1D6JZU5A0A1D6JZU5_MAIZE
Calpain-type cysteine protease DEK1
ZEAMMB73_Zm00001d028818
1,817Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1D6JZU8A0A1D6JZU8_MAIZE
Calpain-type cysteine protease DEK1
ZEAMMB73_Zm00001d028818
1,783Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1D6JZV5A0A1D6JZV5_MAIZE
Calpain-type cysteine protease DEK1
ZEAMMB73_Zm00001d028818
1,753Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1D6JZW4A0A1D6JZW4_MAIZE
Calpain-type cysteine protease DEK1
ZEAMMB73_Zm00001d028818
1,640Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1D6JZW8A0A1D6JZW8_MAIZE
Calpain-type cysteine protease DEK1
ZEAMMB73_Zm00001d028818
1,762Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1D6JZX0A0A1D6JZX0_MAIZE
Calpain-type cysteine protease DEK1
ZEAMMB73_Zm00001d028818
1,420Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti92M → L in AAL38189 (PubMed:11929961).Curated1
Sequence conflicti127E → K in AAL38189 (PubMed:11929961).Curated1
Sequence conflicti138C → G in AAL38189 (PubMed:11929961).Curated1
Sequence conflicti398M → T in AAL38189 (PubMed:11929961).Curated1
Sequence conflicti469I → T in AAL38189 (PubMed:11929961).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0478711 – 1877Missing in isoform 2. 2 PublicationsAdd BLAST1877

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AY061806 mRNA Translation: AAL38189.1
CM007647 Genomic DNA No translation available.
BT035904 mRNA Translation: ACF80909.1

NCBI Reference Sequences

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RefSeqi
NP_001105528.1, NM_001112058.1
XP_008648830.1, XM_008650608.1

Genome annotation databases

Ensembl plant genome annotation project

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EnsemblPlantsi
Zm00001d028818_T053; Zm00001d028818_P053; Zm00001d028818 [Q8RVL1-2]
Zm00001d028818_T057; Zm00001d028818_P057; Zm00001d028818 [Q8RVL1-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
542509

Gramene; a comparative resource for plants

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Gramenei
Zm00001d028818_T053; Zm00001d028818_P053; Zm00001d028818 [Q8RVL1-2]
Zm00001d028818_T057; Zm00001d028818_P057; Zm00001d028818 [Q8RVL1-2]

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
zma:542509

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY061806 mRNA Translation: AAL38189.1
CM007647 Genomic DNA No translation available.
BT035904 mRNA Translation: ACF80909.1
RefSeqiNP_001105528.1, NM_001112058.1
XP_008648830.1, XM_008650608.1

3D structure databases

SMRiQ8RVL1
ModBaseiSearch...

Protein-protein interaction databases

STRINGi4577.GRMZM2G321753_P01

Protein family/group databases

MEROPSiC02.019

Proteomic databases

PaxDbiQ8RVL1
PRIDEiQ8RVL1

Genome annotation databases

EnsemblPlantsiZm00001d028818_T053; Zm00001d028818_P053; Zm00001d028818 [Q8RVL1-2]
Zm00001d028818_T057; Zm00001d028818_P057; Zm00001d028818 [Q8RVL1-2]
GeneIDi542509
GrameneiZm00001d028818_T053; Zm00001d028818_P053; Zm00001d028818 [Q8RVL1-2]
Zm00001d028818_T057; Zm00001d028818_P057; Zm00001d028818 [Q8RVL1-2]
KEGGizma:542509

Organism-specific databases

MaizeGDBi12148

Phylogenomic databases

eggNOGiKOG0045 Eukaryota
ENOG410XP0B LUCA

Gene expression databases

ExpressionAtlasiQ8RVL1 baseline and differential

Family and domain databases

CDDicd00044 CysPc, 1 hit
InterProiView protein in InterPro
IPR022682 Calpain_domain_III
IPR022683 Calpain_III
IPR036213 Calpain_III_sf
IPR013320 ConA-like_dom_sf
IPR038765 Papain-like_cys_pep_sf
IPR000169 Pept_cys_AS
IPR001300 Peptidase_C2_calpain_cat
PfamiView protein in Pfam
PF01067 Calpain_III, 1 hit
PF00648 Peptidase_C2, 1 hit
SMARTiView protein in SMART
SM00720 calpain_III, 1 hit
SM00230 CysPc, 1 hit
SUPFAMiSSF49758 SSF49758, 1 hit
SSF49899 SSF49899, 1 hit
SSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS50203 CALPAIN_CAT, 1 hit
PS00139 THIOL_PROTEASE_CYS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDEK1_MAIZE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8RVL1
Secondary accession number(s): B4FFL6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 18, 2013
Last sequence update: September 18, 2013
Last modified: April 22, 2020
This is version 101 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Peptidase families
    Classification of peptidase families and list of entries
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