UniProtKB - Q8RQE9 (RPOB_THET8)
Protein
DNA-directed RNA polymerase subunit beta
Gene
rpoB
Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Functioni
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Catalytic activityi
- EC:2.7.7.6UniRule annotation
GO - Molecular functioni
- DNA binding Source: UniProtKB-UniRule
- DNA-directed 5'-3' RNA polymerase activity Source: UniProtKB-UniRule
- ribonucleoside binding Source: InterPro
GO - Biological processi
- transcription, DNA-templated Source: UniProtKB-UniRule
Keywordsi
Molecular function | Nucleotidyltransferase, Transferase |
Biological process | Transcription |
Names & Taxonomyi
Protein namesi | Recommended name: DNA-directed RNA polymerase subunit betaUniRule annotation (EC:2.7.7.6UniRule annotation)Short name: RNAP subunit betaUniRule annotation Alternative name(s): RNA polymerase subunit betaUniRule annotation Transcriptase subunit betaUniRule annotation |
Gene namesi | Name:rpoBUniRule annotation Ordered Locus Names:TTHA1813 |
Organismi | Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) |
Taxonomic identifieri | 300852 [NCBI] |
Taxonomic lineagei | Bacteria › Deinococcus-Thermus › Deinococci › Thermales › Thermaceae › Thermus › |
Proteomesi |
|
Pathology & Biotechi
Chemistry databases
DrugBanki | DB08266, Methyl [(1E,5R)-5-{3-[(2E,4E)-2,5-dimethyl-2,4-octadienoyl]-2,4-dioxo-3,4-dihydro-2H-pyran-6-yl}hexylidene]carbamate DB08226, Myxopyronin B DB04788, Tagetitoxin |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047985 | 1 – 1119 | DNA-directed RNA polymerase subunit betaAdd BLAST | 1119 |
Interactioni
Subunit structurei
The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
Protein-protein interaction databases
DIPi | DIP-47011N |
IntActi | Q8RQE9, 7 interactors |
STRINGi | 300852.55773195 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q8RQE9 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q8RQE9 |
Family & Domainsi
Sequence similaritiesi
Belongs to the RNA polymerase beta chain family.UniRule annotation
Phylogenomic databases
eggNOGi | COG0085, Bacteria |
HOGENOMi | CLU_000524_4_1_0 |
OMAi | FMTWEGY |
PhylomeDBi | Q8RQE9 |
Family and domain databases
CDDi | cd00653, RNA_pol_B_RPB2, 1 hit |
Gene3Di | 2.30.150.10, 1 hit 2.40.270.10, 1 hit 2.40.50.150, 1 hit 3.90.1110.10, 1 hit |
HAMAPi | MF_01321, RNApol_bact_RpoB, 1 hit |
InterProi | View protein in InterPro IPR042107, DNA-dir_RNA_pol_bsu_ext_1_sf IPR019462, DNA-dir_RNA_pol_bsu_external_1 IPR015712, DNA-dir_RNA_pol_su2 IPR007120, DNA-dir_RNAP_su2_dom IPR037033, DNA-dir_RNAP_su2_hyb_sf IPR010243, RNA_pol_bsu_bac IPR007121, RNA_pol_bsu_CS IPR007644, RNA_pol_bsu_protrusion IPR007642, RNA_pol_Rpb2_2 IPR037034, RNA_pol_Rpb2_2_sf IPR007645, RNA_pol_Rpb2_3 IPR007641, RNA_pol_Rpb2_7 IPR014724, RNA_pol_RPB2_OB-fold |
PANTHERi | PTHR20856, PTHR20856, 1 hit |
Pfami | View protein in Pfam PF04563, RNA_pol_Rpb2_1, 1 hit PF04561, RNA_pol_Rpb2_2, 1 hit PF04565, RNA_pol_Rpb2_3, 1 hit PF10385, RNA_pol_Rpb2_45, 1 hit PF00562, RNA_pol_Rpb2_6, 1 hit PF04560, RNA_pol_Rpb2_7, 1 hit |
TIGRFAMsi | TIGR02013, rpoB, 1 hit |
PROSITEi | View protein in PROSITE PS01166, RNA_POL_BETA, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8RQE9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEIKRFGRIR EVIPLPPLTE IQVESYRRAL QADVPPEKRE NVGIQAAFRE
60 70 80 90 100
TFPIEEEDKG KGGLVLDFLE YRLGEPPFPQ DECREKDLTY QAPLYARLQL
110 120 130 140 150
IHKDTGLIKE DEVFLGHIPL MTEDGSFIIN GADRVIVSQI HRSPGVYFTP
160 170 180 190 200
DPARPGRYIA SIIPLPKRGP WIDLEVEPNG VVSMKVNKRK FPLVLLLRVL
210 220 230 240 250
GYDQETLARE LGAYGELVQG LMDESVFAMR PEEALIRLFT LLRPGDPPKR
260 270 280 290 300
DKAVAYVYGL IADPRRYDLG EAGRYKAEEK LGIRLSGRTL ARFEDGEFKD
310 320 330 340 350
EVFLPTLRYL FALTAGVPGH EVDDIDHLGN RRIRTVGELM TDQFRVGLAR
360 370 380 390 400
LARGVRERML MGSEDSLTPA KLVNSRPLEA AIREFFSRSQ LSQFKDETNP
410 420 430 440 450
LSSLRHKRRI SALGPGGLTR ERAGFDVRDV HRTHYGRICP VETPEGANIG
460 470 480 490 500
LITSLAAYAR VDELGFIRTP YRRVVGGVVT DEVVYMTATE EDRYTIAQAN
510 520 530 540 550
TPLEGNRIAA ERVVARRKGE PVIVSPEEVE FMDVSPKQVF SVNTNLIPFL
560 570 580 590 600
EHDDANRALM GSNMQTQAVP LIRAQAPVVM TGLEERVVRD SLAALYAEED
610 620 630 640 650
GEVAKVDGNR IVVRYEDGRL VEYPLRRFYR SNQGTALDQR PRVVVGQRVR
660 670 680 690 700
KGDLLADGPA SENGFLALGQ NVLVAIMPFD GYNFEDAIVI SEELLKRDFY
710 720 730 740 750
TSIHIERYEI EARDTKLGPE RITRDIPHLS EAALRDLDEE GVVRIGAEVK
760 770 780 790 800
PGDILVGRTS FKGESEPTPE ERLLRSIFGE KARDVKDTSL RVPPGEGGIV
810 820 830 840 850
VRTVRLRRGD PGVELKPGVR EVVRVYVAQK RKLQVGDKLA NRHGNKGVVA
860 870 880 890 900
KILPVEDMPH LPDGTPVDVI LNPLGVPSRM NLGQILETHL GLAGYFLGQR
910 920 930 940 950
YISPIFDGAK EPEIKELLAQ AFEVYFGKRK GEGFGVDKRE VEVLRRAEKL
960 970 980 990 1000
GLVTPGKTPE EQLKELFLQG KVVLYDGRTG EPIEGPIVVG QMFIMKLYHM
1010 1020 1030 1040 1050
VEDKMHARST GPYSLITQQP LGGKAQFGGQ RFGEMEVWAL EAYGAAHTLQ
1060 1070 1080 1090 1100
EMLTLKSDDI EGRNAAYEAI IKGEDVPEPS VPESFRVLVK ELQALALDVQ
1110
TLDEKDNPVD IFEGLASKR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB083789 Genomic DNA Translation: BAB89400.1 AP008226 Genomic DNA Translation: BAD71636.1 |
RefSeqi | WP_011228935.1, NC_006461.1 YP_145079.1, NC_006461.1 |
Genome annotation databases
EnsemblBacteriai | BAD71636; BAD71636; BAD71636 |
GeneIDi | 3169736 |
KEGGi | ttj:TTHA1813 |
PATRICi | fig|300852.9.peg.1784 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB083789 Genomic DNA Translation: BAB89400.1 AP008226 Genomic DNA Translation: BAD71636.1 |
RefSeqi | WP_011228935.1, NC_006461.1 YP_145079.1, NC_006461.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1IW7 | X-ray | 2.60 | C/M | 1-1119 | [»] | |
1SMY | X-ray | 2.70 | C/M | 1-1119 | [»] | |
1ZYR | X-ray | 3.00 | C/M | 1-1119 | [»] | |
2A68 | X-ray | 2.50 | C/M | 1-1119 | [»] | |
2A69 | X-ray | 2.50 | C/M | 1-1119 | [»] | |
2A6E | X-ray | 2.80 | C/M | 1-1119 | [»] | |
2A6H | X-ray | 2.40 | C/M | 1-1119 | [»] | |
2BE5 | X-ray | 2.40 | C/M | 1-1119 | [»] | |
2CW0 | X-ray | 3.30 | C/M | 1-1119 | [»] | |
2O5I | X-ray | 2.50 | C/M | 1-1119 | [»] | |
2O5J | X-ray | 3.00 | C/M | 1-1119 | [»] | |
2PPB | X-ray | 3.00 | C/M | 1-1119 | [»] | |
3AOH | X-ray | 4.10 | C/H/M | 1-1119 | [»] | |
3AOI | X-ray | 4.30 | C/H/M | 1-1119 | [»] | |
3DXJ | X-ray | 3.00 | C/M | 1-1119 | [»] | |
3EQL | X-ray | 2.70 | C/M | 1-1119 | [»] | |
3WOD | X-ray | 3.60 | C | 1-1119 | [»] | |
3WOE | X-ray | 2.35 | A/C | 703-830 | [»] | |
3WOF | X-ray | 3.30 | A/C/E/G/I/K/M/O/Q/S/U/W | 703-830 | [»] | |
4G7H | X-ray | 2.90 | C/M | 1-1119 | [»] | |
4G7O | X-ray | 2.99 | C/M | 1-1119 | [»] | |
4G7Z | X-ray | 3.82 | C/M | 1-1119 | [»] | |
4GZY | X-ray | 3.51 | C | 1-1119 | [»] | |
4GZZ | X-ray | 4.29 | C | 1-1119 | [»] | |
4MQ9 | X-ray | 3.35 | C | 1-1119 | [»] | |
4OIN | X-ray | 2.80 | C | 1-1119 | [»] | |
4OIO | X-ray | 3.10 | C | 1-1119 | [»] | |
4OIP | X-ray | 3.40 | C | 1-1119 | [»] | |
4OIQ | X-ray | 3.62 | C | 1-1119 | [»] | |
4OIR | X-ray | 3.10 | C | 1-1119 | [»] | |
4Q4Z | X-ray | 2.90 | C | 1-1119 | [»] | |
4Q5S | X-ray | 3.00 | C | 1-1119 | [»] | |
4WQS | X-ray | 4.31 | C/M | 1-1119 | [»] | |
4WQT | X-ray | 4.40 | C/H/M | 1-1119 | [»] | |
5D4C | X-ray | 3.28 | C/M | 1-1119 | [»] | |
5D4D | X-ray | 3.00 | C/M | 1-1119 | [»] | |
5D4E | X-ray | 3.08 | C/M | 1-1119 | [»] | |
5E17 | X-ray | 3.20 | C | 1-1119 | [»] | |
5E18 | X-ray | 3.30 | C | 1-1119 | [»] | |
5I2D | X-ray | 4.41 | C/N | 1-1119 | [»] | |
5TMC | X-ray | 2.71 | C | 1-1119 | [»] | |
5TMF | X-ray | 3.00 | C | 1-1119 | [»] | |
5VO8 | X-ray | 3.30 | C | 1-1119 | [»] | |
5VOI | X-ray | 2.80 | C | 1-1119 | [»] | |
5X21 | X-ray | 3.32 | C | 1-1119 | [»] | |
5X22 | X-ray | 3.35 | C/M | 1-1119 | [»] | |
5XJ0 | X-ray | 4.00 | C | 1-1119 | [»] | |
6ASG | X-ray | 3.80 | C | 1-1119 | [»] | |
6KQD | X-ray | 3.30 | C/M | 1-1119 | [»] | |
6KQE | X-ray | 3.30 | C | 1-1119 | [»] | |
6KQF | X-ray | 2.45 | C | 1-1119 | [»] | |
6KQG | X-ray | 2.78 | C | 1-1119 | [»] | |
6KQH | X-ray | 3.18 | C | 1-1119 | [»] | |
6KQL | X-ray | 2.89 | C | 1-1119 | [»] | |
6KQM | X-ray | 3.20 | C | 1-1119 | [»] | |
6KQN | X-ray | 3.49 | C | 1-1119 | [»] | |
6L74 | X-ray | 3.12 | C | 1-1119 | [»] | |
6LTS | X-ray | 3.45 | C | 1-1119 | [»] | |
6OVR | X-ray | 2.84 | C | 1-1119 | [»] | |
6OVY | X-ray | 3.00 | C | 1-1119 | [»] | |
6OW3 | X-ray | 2.77 | C | 1-1119 | [»] | |
6OY5 | X-ray | 3.10 | C | 1-1119 | [»] | |
6OY6 | X-ray | 3.10 | C | 1-1119 | [»] | |
6OY7 | X-ray | 3.04 | C | 1-1119 | [»] | |
6P70 | X-ray | 3.05 | C | 1-1119 | [»] | |
6P71 | X-ray | 2.92 | C | 1-1119 | [»] | |
6WOX | X-ray | 3.14 | C | 1-1119 | [»] | |
6WOY | X-ray | 3.00 | C | 1-1119 | [»] | |
SMRi | Q8RQE9 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
DIPi | DIP-47011N |
IntActi | Q8RQE9, 7 interactors |
STRINGi | 300852.55773195 |
Chemistry databases
DrugBanki | DB08266, Methyl [(1E,5R)-5-{3-[(2E,4E)-2,5-dimethyl-2,4-octadienoyl]-2,4-dioxo-3,4-dihydro-2H-pyran-6-yl}hexylidene]carbamate DB08226, Myxopyronin B DB04788, Tagetitoxin |
Genome annotation databases
EnsemblBacteriai | BAD71636; BAD71636; BAD71636 |
GeneIDi | 3169736 |
KEGGi | ttj:TTHA1813 |
PATRICi | fig|300852.9.peg.1784 |
Phylogenomic databases
eggNOGi | COG0085, Bacteria |
HOGENOMi | CLU_000524_4_1_0 |
OMAi | FMTWEGY |
PhylomeDBi | Q8RQE9 |
Miscellaneous databases
EvolutionaryTracei | Q8RQE9 |
PROi | PR:Q8RQE9 |
Family and domain databases
CDDi | cd00653, RNA_pol_B_RPB2, 1 hit |
Gene3Di | 2.30.150.10, 1 hit 2.40.270.10, 1 hit 2.40.50.150, 1 hit 3.90.1110.10, 1 hit |
HAMAPi | MF_01321, RNApol_bact_RpoB, 1 hit |
InterProi | View protein in InterPro IPR042107, DNA-dir_RNA_pol_bsu_ext_1_sf IPR019462, DNA-dir_RNA_pol_bsu_external_1 IPR015712, DNA-dir_RNA_pol_su2 IPR007120, DNA-dir_RNAP_su2_dom IPR037033, DNA-dir_RNAP_su2_hyb_sf IPR010243, RNA_pol_bsu_bac IPR007121, RNA_pol_bsu_CS IPR007644, RNA_pol_bsu_protrusion IPR007642, RNA_pol_Rpb2_2 IPR037034, RNA_pol_Rpb2_2_sf IPR007645, RNA_pol_Rpb2_3 IPR007641, RNA_pol_Rpb2_7 IPR014724, RNA_pol_RPB2_OB-fold |
PANTHERi | PTHR20856, PTHR20856, 1 hit |
Pfami | View protein in Pfam PF04563, RNA_pol_Rpb2_1, 1 hit PF04561, RNA_pol_Rpb2_2, 1 hit PF04565, RNA_pol_Rpb2_3, 1 hit PF10385, RNA_pol_Rpb2_45, 1 hit PF00562, RNA_pol_Rpb2_6, 1 hit PF04560, RNA_pol_Rpb2_7, 1 hit |
TIGRFAMsi | TIGR02013, rpoB, 1 hit |
PROSITEi | View protein in PROSITE PS01166, RNA_POL_BETA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RPOB_THET8 | |
Accessioni | Q8RQE9Primary (citable) accession number: Q8RQE9 Secondary accession number(s): Q5SHB7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 16, 2004 |
Last sequence update: | June 1, 2002 | |
Last modified: | December 2, 2020 | |
This is version 130 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families