UniProtKB - Q8RQE8 (RPOC_THET8)
Protein
DNA-directed RNA polymerase subunit beta'
Gene
rpoC
Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Functioni
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.UniRule annotation
Catalytic activityi
- EC:2.7.7.6UniRule annotation
Cofactori
Protein has several cofactor binding sites:- Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit.UniRule annotation
- Zn2+UniRule annotationNote: Binds 2 Zn2+ ions per subunit.UniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 58 | Zinc 1UniRule annotation | 1 | |
Metal bindingi | 60 | Zinc 1UniRule annotation | 1 | |
Metal bindingi | 73 | Zinc 1UniRule annotation | 1 | |
Metal bindingi | 76 | Zinc 1UniRule annotation | 1 | |
Metal bindingi | 739 | MagnesiumUniRule annotation | 1 | |
Metal bindingi | 741 | MagnesiumUniRule annotation | 1 | |
Metal bindingi | 743 | MagnesiumUniRule annotation | 1 | |
Metal bindingi | 1112 | Zinc 2UniRule annotation | 1 | |
Metal bindingi | 1194 | Zinc 2UniRule annotation | 1 | |
Metal bindingi | 1201 | Zinc 2UniRule annotation | 1 | |
Metal bindingi | 1204 | Zinc 2UniRule annotation | 1 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-UniRule
- DNA-directed 5'-3' RNA polymerase activity Source: UniProtKB-UniRule
- magnesium ion binding Source: UniProtKB-UniRule
- zinc ion binding Source: UniProtKB-UniRule
GO - Biological processi
- transcription, DNA-templated Source: UniProtKB-UniRule
Keywordsi
Molecular function | Nucleotidyltransferase, Transferase |
Biological process | Transcription |
Ligand | Magnesium, Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: DNA-directed RNA polymerase subunit beta'UniRule annotation (EC:2.7.7.6UniRule annotation)Short name: RNAP subunit beta'UniRule annotation Alternative name(s): RNA polymerase subunit beta'UniRule annotation Transcriptase subunit beta'UniRule annotation |
Gene namesi | Name:rpoCUniRule annotation Ordered Locus Names:TTHA1812 |
Organismi | Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) |
Taxonomic identifieri | 300852 [NCBI] |
Taxonomic lineagei | Bacteria › Deinococcus-Thermus › Deinococci › Thermales › Thermaceae › Thermus › |
Proteomesi |
|
Pathology & Biotechi
Chemistry databases
DrugBanki | DB08266, Methyl [(1E,5R)-5-{3-[(2E,4E)-2,5-dimethyl-2,4-octadienoyl]-2,4-dioxo-3,4-dihydro-2H-pyran-6-yl}hexylidene]carbamate DB08226, Myxopyronin B DB04788, Tagetitoxin |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000067820 | 1 – 1524 | DNA-directed RNA polymerase subunit beta'Add BLAST | 1524 |
Interactioni
Subunit structurei
The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
UniRule annotationBinary interactionsi
Q8RQE8
With | #Exp. | IntAct |
---|---|---|
rpoA [Q5SHR6] | 4 | EBI-2106930,EBI-2106870 |
Protein-protein interaction databases
DIPi | DIP-47007N |
IntActi | Q8RQE8, 5 interactors |
STRINGi | 300852.55773194 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q8RQE8 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q8RQE8 |
Family & Domainsi
Sequence similaritiesi
Belongs to the RNA polymerase beta' chain family.UniRule annotation
Phylogenomic databases
eggNOGi | COG0086, Bacteria |
HOGENOMi | CLU_000524_3_1_0 |
OMAi | YRNIRVE |
PhylomeDBi | Q8RQE8 |
Family and domain databases
Gene3Di | 1.10.132.30, 1 hit 1.10.274.100, 1 hit |
HAMAPi | MF_01322, RNApol_bact_RpoC, 1 hit |
InterProi | View protein in InterPro IPR012754, DNA-dir_RpoC_beta_prime IPR000722, RNA_pol_asu IPR006592, RNA_pol_N IPR007080, RNA_pol_Rpb1_1 IPR007066, RNA_pol_Rpb1_3 IPR042102, RNA_pol_Rpb1_3_sf IPR007083, RNA_pol_Rpb1_4 IPR007081, RNA_pol_Rpb1_5 IPR038120, Rpb1_funnel_sf |
Pfami | View protein in Pfam PF04997, RNA_pol_Rpb1_1, 2 hits PF00623, RNA_pol_Rpb1_2, 1 hit PF04983, RNA_pol_Rpb1_3, 1 hit PF05000, RNA_pol_Rpb1_4, 1 hit PF04998, RNA_pol_Rpb1_5, 2 hits |
SMARTi | View protein in SMART SM00663, RPOLA_N, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8RQE8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKKEVRKVRI ALASPEKIRS WSYGEVEKPE TINYRTLKPE RDGLFDERIF
60 70 80 90 100
GPIKDYECAC GKYKRQRFEG KVCERCGVEV TKSIVRRYRM GHIELATPAA
110 120 130 140 150
HIWFVKDVPS KIGTLLDLSA TELEQVLYFS KYIVLDPKGA ILNGVPVEKR
160 170 180 190 200
QLLTDEEYRE LRYGKQETYP LPPGVDALVK DGEEVVKGQE LAPGVVSRLD
210 220 230 240 250
GVALYRFPRR VRVEYVKKER AGLRLPLAAW VEKEAYKPGE ILAELPEPYL
260 270 280 290 300
FRAEEEGVVE LKELEEGAFL VLRREDEPVA TYFLPVGMTP LVVHGEIVEK
310 320 330 340 350
GQPLAEAKGL LRMPRQVRAA QVEAEEEGET VYLTLFLEWT EPKDYRVQPH
360 370 380 390 400
MNVVVPEGAR VEAGDKIVAA IDPEEEVIAE AEGVVHLHEP ASILVVKARV
410 420 430 440 450
YPFEDDVEVS TGDRVAPGDV LADGGKVKSD VYGRVEVDLV RNVVRVVESY
460 470 480 490 500
DIDARMGAEA IQQLLKELDL EALEKELLEE MKHPSRARRA KARKRLEVVR
510 520 530 540 550
AFLDSGNRPE WMILEAVPVL PPDLRPMVQV DGGRFATSDL NDLYRRLINR
560 570 580 590 600
NNRLKKLLAQ GAPEIIIRNE KRMLQEAVDA LLDNGRRGAP VTNPGSDRPL
610 620 630 640 650
RSLTDILSGK QGRFRQNLLG KRVDYSGRSV IVVGPQLKLH QCGLPKRMAL
660 670 680 690 700
ELFKPFLLKK MEEKGIAPNV KAARRMLERQ RDIKDEVWDA LEEVIHGKVV
710 720 730 740 750
LLNRAPTLHR LGIQAFQPVL VEGQSIQLHP LVCEAFNADF DGDQMAVHVP
760 770 780 790 800
LSSFAQAEAR IQMLSAHNLL SPASGEPLAK PSRDIILGLY YITQVRKEKK
810 820 830 840 850
GAGLEFATPE EALAAHERGE VALNAPIKVA GRETSVGRLK YVFANPDEAL
860 870 880 890 900
LAVAHGIVDL QDVVTVRYMG KRLETSPGRI LFARIVAEAV EDEKVAWELI
910 920 930 940 950
QLDVPQEKNS LKDLVYQAFL RLGMEKTARL LDALKYYGFT FSTTSGITIG
960 970 980 990 1000
IDDAVIPEEK KQYLEEADRK LLQIEQAYEM GFLTDRERYD QILQLWTETT
1010 1020 1030 1040 1050
EKVTQAVFKN FEENYPFNPL YVMAQSGARG NPQQIRQLCG LRGLMQKPSG
1060 1070 1080 1090 1100
ETFEVPVRSS FREGLTVLEY FISSHGARKG GADTALRTAD SGYLTRKLVD
1110 1120 1130 1140 1150
VTHEIVVREA DCGTTNYISV PLFQPDEVTR SLRLRKRADI EAGLYGRVLA
1160 1170 1180 1190 1200
REVEVLGVRL EEGRYLSMDD VHLLIKAAEA GEIQEVPVRS PLTCQTRYGV
1210 1220 1230 1240 1250
CQKCYGYDLS MARPVSIGEA VGIVAAQSIG EPGTQLTMRT FHTGGVAGAA
1260 1270 1280 1290 1300
DITQGLPRVI ELFEARRPKA KAVISEIDGV VRIEETEEKL SVFVESEGFS
1310 1320 1330 1340 1350
KEYKLPKEAR LLVKDGDYVE AGQPLTRGAI DPHQLLEAKG PEAVERYLVE
1360 1370 1380 1390 1400
EIQKVYRAQG VKLHDKHIEI VVRQMMKYVE VTDPGDSRLL EGQVLEKWDV
1410 1420 1430 1440 1450
EALNERLIAE GKTPVAWKPL LMGVTKSALS TKSWLSAASF QNTTHVLTEA
1460 1470 1480 1490 1500
AIAGKKDELI GLKENVILGR LIPAGTGSDF VRFTQVVDQK TLKAIEEARK
1510 1520
EAVEAKERPA ARRGVKREQP GKQA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB083790 Genomic DNA Translation: BAB89401.1 AP008226 Genomic DNA Translation: BAD71635.1 |
RefSeqi | WP_011228934.1, NC_006461.1 YP_145078.1, NC_006461.1 |
Genome annotation databases
EnsemblBacteriai | BAD71635; BAD71635; BAD71635 |
GeneIDi | 3169754 |
KEGGi | ttj:TTHA1812 |
PATRICi | fig|300852.9.peg.1783 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB083790 Genomic DNA Translation: BAB89401.1 AP008226 Genomic DNA Translation: BAD71635.1 |
RefSeqi | WP_011228934.1, NC_006461.1 YP_145078.1, NC_006461.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1IW7 | X-ray | 2.60 | D/N | 1-1524 | [»] | |
1SMY | X-ray | 2.70 | D/N | 1-1524 | [»] | |
1ZYR | X-ray | 3.00 | D/N | 1-1524 | [»] | |
2A68 | X-ray | 2.50 | D/N | 1-1524 | [»] | |
2A69 | X-ray | 2.50 | D/N | 1-1524 | [»] | |
2A6E | X-ray | 2.80 | D/N | 1-1524 | [»] | |
2A6H | X-ray | 2.40 | D/N | 1-1524 | [»] | |
2BE5 | X-ray | 2.40 | D/N | 1-1524 | [»] | |
2CW0 | X-ray | 3.30 | D/N | 1-1524 | [»] | |
2O5I | X-ray | 2.50 | D/N | 1-1524 | [»] | |
2O5J | X-ray | 3.00 | D/N | 1-1524 | [»] | |
2PPB | X-ray | 3.00 | D/N | 1-1524 | [»] | |
3AOH | X-ray | 4.10 | D/I/N | 1-1524 | [»] | |
3AOI | X-ray | 4.30 | D/I/N | 1-1524 | [»] | |
3DXJ | X-ray | 3.00 | D/N | 1-1524 | [»] | |
3EQL | X-ray | 2.70 | D/N | 1-1524 | [»] | |
3WOD | X-ray | 3.60 | D | 1-1524 | [»] | |
4G7H | X-ray | 2.90 | D/N | 1-1524 | [»] | |
4G7O | X-ray | 2.99 | D/N | 1-1524 | [»] | |
4G7Z | X-ray | 3.82 | D/N | 1-1524 | [»] | |
4GZY | X-ray | 3.51 | D | 1-1524 | [»] | |
4GZZ | X-ray | 4.29 | D | 1-1524 | [»] | |
4MQ9 | X-ray | 3.35 | D | 1-1524 | [»] | |
4OIN | X-ray | 2.80 | D | 1-1524 | [»] | |
4OIO | X-ray | 3.10 | D | 1-1524 | [»] | |
4OIP | X-ray | 3.40 | D | 1-1524 | [»] | |
4OIQ | X-ray | 3.62 | D | 1-1524 | [»] | |
4OIR | X-ray | 3.10 | D | 1-1524 | [»] | |
4Q4Z | X-ray | 2.90 | D | 1-1524 | [»] | |
4Q5S | X-ray | 3.00 | D | 1-1524 | [»] | |
4WQS | X-ray | 4.31 | D/N | 1-1524 | [»] | |
4WQT | X-ray | 4.40 | D/I/N | 1-1524 | [»] | |
5D4C | X-ray | 3.28 | D/N | 1-1524 | [»] | |
5D4D | X-ray | 3.00 | D/N | 1-1524 | [»] | |
5D4E | X-ray | 3.08 | D/N | 1-1524 | [»] | |
5E17 | X-ray | 3.20 | D | 1-1524 | [»] | |
5E18 | X-ray | 3.30 | D | 1-1524 | [»] | |
5I2D | X-ray | 4.41 | D/O | 1-1524 | [»] | |
5TMC | X-ray | 2.71 | D | 1-1524 | [»] | |
5TMF | X-ray | 3.00 | D | 1-1524 | [»] | |
5VO8 | X-ray | 3.30 | D | 1-1524 | [»] | |
5VOI | X-ray | 2.80 | D | 1-1524 | [»] | |
5X21 | X-ray | 3.32 | D | 1-1524 | [»] | |
5X22 | X-ray | 3.35 | D/N | 1-1524 | [»] | |
5XJ0 | X-ray | 4.00 | D | 1-1524 | [»] | |
6ASG | X-ray | 3.80 | D | 1-1524 | [»] | |
6KQD | X-ray | 3.30 | D/N | 1-1524 | [»] | |
6KQE | X-ray | 3.30 | D | 1-1524 | [»] | |
6KQF | X-ray | 2.45 | D | 1-1524 | [»] | |
6KQG | X-ray | 2.78 | D | 1-1524 | [»] | |
6KQH | X-ray | 3.18 | D | 1-1524 | [»] | |
6KQL | X-ray | 2.89 | D | 1-1524 | [»] | |
6KQM | X-ray | 3.20 | D | 1-1524 | [»] | |
6KQN | X-ray | 3.49 | D | 1-1524 | [»] | |
6L74 | X-ray | 3.12 | D | 1-1524 | [»] | |
6LTS | X-ray | 3.45 | D | 1-1524 | [»] | |
6M6A | electron microscopy | 5.00 | D | 1-1524 | [»] | |
6M6B | electron microscopy | 4.10 | D | 1-1524 | [»] | |
6M6C | electron microscopy | 3.10 | D | 1-1524 | [»] | |
6OVR | X-ray | 2.84 | D | 1-1524 | [»] | |
6OVY | X-ray | 3.00 | D | 1-1524 | [»] | |
6OW3 | X-ray | 2.77 | D | 1-1524 | [»] | |
6OY5 | X-ray | 3.10 | D | 1-1524 | [»] | |
6OY6 | X-ray | 3.10 | D | 1-1502 | [»] | |
6OY7 | X-ray | 3.04 | D | 1-1524 | [»] | |
6P70 | X-ray | 3.05 | D | 1-1524 | [»] | |
6P71 | X-ray | 2.92 | D | 1-1524 | [»] | |
6WOX | X-ray | 3.14 | D | 1-1505 | [»] | |
6WOY | X-ray | 3.00 | D | 1-1505 | [»] | |
SMRi | Q8RQE8 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
DIPi | DIP-47007N |
IntActi | Q8RQE8, 5 interactors |
STRINGi | 300852.55773194 |
Chemistry databases
DrugBanki | DB08266, Methyl [(1E,5R)-5-{3-[(2E,4E)-2,5-dimethyl-2,4-octadienoyl]-2,4-dioxo-3,4-dihydro-2H-pyran-6-yl}hexylidene]carbamate DB08226, Myxopyronin B DB04788, Tagetitoxin |
Genome annotation databases
EnsemblBacteriai | BAD71635; BAD71635; BAD71635 |
GeneIDi | 3169754 |
KEGGi | ttj:TTHA1812 |
PATRICi | fig|300852.9.peg.1783 |
Phylogenomic databases
eggNOGi | COG0086, Bacteria |
HOGENOMi | CLU_000524_3_1_0 |
OMAi | YRNIRVE |
PhylomeDBi | Q8RQE8 |
Miscellaneous databases
EvolutionaryTracei | Q8RQE8 |
PROi | PR:Q8RQE8 |
Family and domain databases
Gene3Di | 1.10.132.30, 1 hit 1.10.274.100, 1 hit |
HAMAPi | MF_01322, RNApol_bact_RpoC, 1 hit |
InterProi | View protein in InterPro IPR012754, DNA-dir_RpoC_beta_prime IPR000722, RNA_pol_asu IPR006592, RNA_pol_N IPR007080, RNA_pol_Rpb1_1 IPR007066, RNA_pol_Rpb1_3 IPR042102, RNA_pol_Rpb1_3_sf IPR007083, RNA_pol_Rpb1_4 IPR007081, RNA_pol_Rpb1_5 IPR038120, Rpb1_funnel_sf |
Pfami | View protein in Pfam PF04997, RNA_pol_Rpb1_1, 2 hits PF00623, RNA_pol_Rpb1_2, 1 hit PF04983, RNA_pol_Rpb1_3, 1 hit PF05000, RNA_pol_Rpb1_4, 1 hit PF04998, RNA_pol_Rpb1_5, 2 hits |
SMARTi | View protein in SMART SM00663, RPOLA_N, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RPOC_THET8 | |
Accessioni | Q8RQE8Primary (citable) accession number: Q8RQE8 Secondary accession number(s): Q5SHB8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 16, 2004 |
Last sequence update: | June 1, 2002 | |
Last modified: | April 7, 2021 | |
This is version 135 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families