UniProtKB - Q8RPQ2 (DPS2_BACAN)
Protein
DNA protection during starvation protein 2
Gene
dps2
Organism
Bacillus anthracis
Status
Functioni
Protects DNA from oxidative damage by sequestering intracellular Fe2+ ion and storing it in the form of Fe3+ oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe2+ ions, which prevents hydroxyl radical production by the Fenton reaction (By similarity). It is capable of binding and sequestering Fe2+ ion. Does not bind DNA.By similarity
Catalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 27 | Iron 1; shared with dodecameric partner1 Publication | 1 | |
Metal bindingi | 54 | Iron 11 Publication | 1 | |
Metal bindingi | 58 | Iron 11 Publication | 1 | |
Metal bindingi | 58 | Iron 21 Publication | 1 |
GO - Molecular functioni
- DNA binding Source: TIGR
- ferric iron binding Source: InterPro
- oxidoreductase activity, oxidizing metal ions Source: InterPro
GO - Biological processi
- cellular iron ion homeostasis Source: UniProtKB-KW
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Iron storage |
Ligand | Iron, Metal-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:dps2 Synonyms:dlp1 Ordered Locus Names:BA_5290, GBAA_5290, BAS4914 |
Organismi | Bacillus anthracis |
Taxonomic identifieri | 1392 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group |
Proteomesi |
|
Subcellular locationi
- Cytoplasm By similarity
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000253327 | 1 – 146 | DNA protection during starvation protein 2Add BLAST | 146 |
Interactioni
Subunit structurei
The 12 subunits form a hollow sphere into which the mineral iron core of up to 500 Fe3+ can be deposited (By similarity). Homododecamer.
By similarity1 PublicationProtein-protein interaction databases
STRINGi | 260799.BAS4914 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q8RPQ2 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q8RPQ2 |
Family & Domainsi
Domaini
12 di-nuclear ferroxidase centers are located at the interfaces between subunits related by 2-fold symmetry axes.
Sequence similaritiesi
Belongs to the Dps family.Curated
Phylogenomic databases
eggNOGi | COG0783, Bacteria |
HOGENOMi | CLU_098183_2_2_9 |
Family and domain databases
CDDi | cd01043, DPS, 1 hit |
Gene3Di | 1.20.1260.10, 1 hit |
InterProi | View protein in InterPro IPR002177, DPS_DNA-bd IPR023188, DPS_DNA-bd_CS IPR012347, Ferritin-like IPR009078, Ferritin-like_SF IPR008331, Ferritin_DPS_dom |
PANTHERi | PTHR42932, PTHR42932, 1 hit |
Pfami | View protein in Pfam PF00210, Ferritin, 1 hit |
PIRSFi | PIRSF005900, Dps, 1 hit |
PRINTSi | PR01346, HELNAPAPROT |
SUPFAMi | SSF47240, SSF47240, 1 hit |
PROSITEi | View protein in PROSITE PS00818, DPS_1, 1 hit PS00819, DPS_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8RPQ2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNKQVIEVLN KQVADWSVLF TKLHNFHWYV KGPQFFTLHE KFEELYTESA
60 70 80 90 100
THIDEIAERI LAIGGKPVAT MKEYLEISSI QEAAYGETAE GMVEAIMKDY
110 120 130 140
EMMLVELKKG MEIAQNSDDE MTSDLLLGIY TELEKHAWML RAFLNQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF374268 Genomic DNA Translation: AAM18635.1 AE016879 Genomic DNA Translation: AAP28955.1 AE017334 Genomic DNA Translation: AAT34421.1 AE017225 Genomic DNA Translation: AAT57205.1 |
RefSeqi | NP_847469.1, NC_003997.3 WP_001041890.1, NZ_WXXJ01000014.1 YP_031155.1, NC_005945.1 |
Genome annotation databases
EnsemblBacteriai | AAP28955; AAP28955; BA_5290 AAT34421; AAT34421; GBAA_5290 AAT57205; AAT57205; BAS4914 |
GeneIDi | 45024903 56689251 |
KEGGi | ban:BA_5290 bar:GBAA_5290 bat:BAS4914 |
PATRICi | fig|198094.11.peg.5251 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF374268 Genomic DNA Translation: AAM18635.1 AE016879 Genomic DNA Translation: AAP28955.1 AE017334 Genomic DNA Translation: AAT34421.1 AE017225 Genomic DNA Translation: AAT57205.1 |
RefSeqi | NP_847469.1, NC_003997.3 WP_001041890.1, NZ_WXXJ01000014.1 YP_031155.1, NC_005945.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1JI5 | X-ray | 2.50 | A/B/C/D | 4-145 | [»] | |
SMRi | Q8RPQ2 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 260799.BAS4914 |
Protocols and materials databases
DNASUi | 1084783 |
Genome annotation databases
EnsemblBacteriai | AAP28955; AAP28955; BA_5290 AAT34421; AAT34421; GBAA_5290 AAT57205; AAT57205; BAS4914 |
GeneIDi | 45024903 56689251 |
KEGGi | ban:BA_5290 bar:GBAA_5290 bat:BAS4914 |
PATRICi | fig|198094.11.peg.5251 |
Phylogenomic databases
eggNOGi | COG0783, Bacteria |
HOGENOMi | CLU_098183_2_2_9 |
Miscellaneous databases
EvolutionaryTracei | Q8RPQ2 |
Family and domain databases
CDDi | cd01043, DPS, 1 hit |
Gene3Di | 1.20.1260.10, 1 hit |
InterProi | View protein in InterPro IPR002177, DPS_DNA-bd IPR023188, DPS_DNA-bd_CS IPR012347, Ferritin-like IPR009078, Ferritin-like_SF IPR008331, Ferritin_DPS_dom |
PANTHERi | PTHR42932, PTHR42932, 1 hit |
Pfami | View protein in Pfam PF00210, Ferritin, 1 hit |
PIRSFi | PIRSF005900, Dps, 1 hit |
PRINTSi | PR01346, HELNAPAPROT |
SUPFAMi | SSF47240, SSF47240, 1 hit |
PROSITEi | View protein in PROSITE PS00818, DPS_1, 1 hit PS00819, DPS_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DPS2_BACAN | |
Accessioni | Q8RPQ2Primary (citable) accession number: Q8RPQ2 Secondary accession number(s): Q6HR83, Q6KKJ8, Q81XE7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 17, 2006 |
Last sequence update: | June 1, 2002 | |
Last modified: | February 10, 2021 | |
This is version 132 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families