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UniProtKB - Q8RP52 (Q8RP52_STRPY)
Protein
Signal peptidase I
Gene
lepA
Organism
Streptococcus pyogenes
Status
Functioni
Catalytic activityi
- Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.UniRule annotation EC:3.4.21.89
GO - Molecular functioni
- serine-type endopeptidase activity Source: UniProtKB-EC
GO - Biological processi
- signal peptide processing Source: InterPro
Keywordsi
Molecular function | Hydrolase, ProteaseUniRule annotation |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:lepAImported |
Organismi | Streptococcus pyogenesImported |
Taxonomic identifieri | 1314 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus |
Subcellular locationi
Plasma membrane
- Cell membrane ARBA annotation; Single-pass type II membrane protein ARBA annotation
Other locations
- Membrane UniRule annotationARBA annotation; Single-pass type II membrane protein UniRule annotationARBA annotation
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 20 – 44 | HelicalUniRule annotationAdd BLAST | 25 |
Keywords - Cellular componenti
MembraneStructurei
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixUniRule annotationFamily and domain databases
CDDi | cd06530, S26_SPase_I, 1 hit |
InterProi | View protein in InterPro IPR036286, LexA/Signal_pep-like_sf IPR000223, Pept_S26A_signal_pept_1 IPR019533, Peptidase_S26 |
PANTHERi | PTHR43390, PTHR43390, 1 hit |
Pfami | View protein in Pfam PF10502, Peptidase_S26, 1 hit |
PRINTSi | PR00727, LEADERPTASE |
SUPFAMi | SSF51306, SSF51306, 1 hit |
TIGRFAMsi | TIGR02227, sigpep_I_bact, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8RP52-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTNYLNRLNE NPLFKAFIRL VLKISIIGFL GYILFQYVFG VMIVNTNQMS
60 70 80 90 100
PAVSAGDGVL YYRLTDRYHI NDVVVYEVDN TLKVGRIAAQ AGDEVSFTQE
110 120 130 140 150
GGLLINGHPP EKEVPYLTYP HSSGPNFPYK VPTGTYFILN DYREERLDSR
160 170
YYGALPINQI KGKISTLLRV RGI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF447492 Genomic DNA Translation: AAL86407.1 |
RefSeqi | WP_002987832.1, NZ_WXZG01000003.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF447492 Genomic DNA Translation: AAL86407.1 |
RefSeqi | WP_002987832.1, NZ_WXZG01000003.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4K8W | X-ray | 1.67 | A | 45-173 | [»] | |
ModBasei | Search... | |||||
SWISS-MODEL-Workspacei | Submit a new modelling project... | |||||
PDBe-KBi | Search... |
Family and domain databases
CDDi | cd06530, S26_SPase_I, 1 hit |
InterProi | View protein in InterPro IPR036286, LexA/Signal_pep-like_sf IPR000223, Pept_S26A_signal_pept_1 IPR019533, Peptidase_S26 |
PANTHERi | PTHR43390, PTHR43390, 1 hit |
Pfami | View protein in Pfam PF10502, Peptidase_S26, 1 hit |
PRINTSi | PR00727, LEADERPTASE |
SUPFAMi | SSF51306, SSF51306, 1 hit |
TIGRFAMsi | TIGR02227, sigpep_I_bact, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q8RP52_STRPY | |
Accessioni | Q8RP52Primary (citable) accession number: Q8RP52 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 1, 2002 |
Last sequence update: | June 1, 2002 | |
Last modified: | January 19, 2022 | |
This is version 95 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |