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UniProtKB - Q8RN04 (C5B3_AMYOR)
Protein
Cytochrome P450 165B3
Gene
cyp165B3
Organism
Amycolatopsis orientalis (Nocardia orientalis)
Status
Functioni
Involved in the coupling of aromatic side chains of the heptapeptide of vancomycin.
Cofactori
: vancomycin biosynthesis Pathwayi
This protein is involved in the pathway vancomycin biosynthesis, which is part of Antibiotic biosynthesis.View all proteins of this organism that are known to be involved in the pathway vancomycin biosynthesis and in Antibiotic biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 347 | Iron (heme axial ligand) | 1 |
GO - Molecular functioni
- heme binding Source: InterPro
- iron ion binding Source: InterPro
- monooxygenase activity Source: UniProtKB-KW
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Source: InterPro
GO - Biological processi
- vancomycin biosynthetic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Monooxygenase, Oxidoreductase |
Ligand | Heme, Iron, Metal-binding |
Enzyme and pathway databases
UniPathwayi | UPA00162 |
Names & Taxonomyi
Protein namesi | Recommended name: Cytochrome P450 165B3 (EC:1.14.-.-)Alternative name(s): Vancomycin biosynthesis protein OxyB |
Gene namesi | Name:cyp165B3 Synonyms:oxyB |
Organismi | Amycolatopsis orientalis (Nocardia orientalis)Imported |
Taxonomic identifieri | 31958 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Pseudonocardiales › Pseudonocardiaceae › Amycolatopsis |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000052239 | 1 – 398 | Cytochrome P450 165B3Add BLAST | 398 |
Interactioni
Protein-protein interaction databases
DIPi | DIP-61594N |
IntActi | Q8RN04, 2 interactors |
STRINGi | 1125971.ASJB01000062_gene4400 |
Chemistry databases
BindingDBi | Q8RN04 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q8RN04 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q8RN04 |
Family & Domainsi
Sequence similaritiesi
Belongs to the cytochrome P450 family.Curated
Phylogenomic databases
eggNOGi | COG2124, Bacteria |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR002397, Cyt_P450_B IPR017972, Cyt_P450_CS IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00359, BP450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8RN04-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSEDDPRPLH IRRQGLDPAD ELLAAGALTR VTIGSGADAE THWMATAHAV
60 70 80 90 100
VRQVMGDHQQ FSTRRRWDPR DEIGGKGIFR PRELVGNLMD YDPPEHTRLR
110 120 130 140 150
RKLTPGFTLR KMQRMAPYIE QIVNDRLDEM ERAGSPADLI AFVADKVPGA
160 170 180 190 200
VLCELVGVPR DDRDMFMKLC HGHLDASLSQ KRRAALGDKF SRYLLAMIAR
210 220 230 240 250
ERKEPGEGMI GAVVAEYGDD ATDEELRGFC VQVMLAGDDN ISGMIGLGVL
260 270 280 290 300
AMLRHPEQID AFRGDEQSAQ RAVDELIRYL TVPYSPTPRI AREDLTLAGQ
310 320 330 340 350
EIKKGDSVIC SLPAANRDPA LAPDVDRLDV TREPIPHVAF GHGVHHCLGA
360 370 380 390
ALARLELRTV FTELWRRFPA LRLADPAQDT EFRLTTPAYG LTELMVAW
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF486630 Genomic DNA Translation: AAL90878.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF486630 Genomic DNA Translation: AAL90878.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1LFK | X-ray | 1.70 | A | 1-398 | [»] | |
1LG9 | X-ray | 2.00 | A | 1-398 | [»] | |
1LGF | X-ray | 2.20 | A | 1-398 | [»] | |
SMRi | Q8RN04 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
DIPi | DIP-61594N |
IntActi | Q8RN04, 2 interactors |
STRINGi | 1125971.ASJB01000062_gene4400 |
Chemistry databases
BindingDBi | Q8RN04 |
ChEMBLi | CHEMBL1075039 |
Phylogenomic databases
eggNOGi | COG2124, Bacteria |
Enzyme and pathway databases
UniPathwayi | UPA00162 |
Miscellaneous databases
EvolutionaryTracei | Q8RN04 |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR002397, Cyt_P450_B IPR017972, Cyt_P450_CS IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00359, BP450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | C5B3_AMYOR | |
Accessioni | Q8RN04Primary (citable) accession number: Q8RN04 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 19, 2003 |
Last sequence update: | June 1, 2002 | |
Last modified: | June 2, 2021 | |
This is version 74 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structureDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families