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UniProtKB - Q8RHX3 (KDD_FUSNN)
Protein
L-erythro-3,5-diaminohexanoate dehydrogenase
Gene
kdd
Organism
Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355)
Status
Functioni
Involved in the anaerobic fermentation of lysine. Catalyzes the oxidative deamination of L-erythro-3,5-diaminohexanoate (3,5-DAH) to 3-keto-5-aminohexanoate (KAH). It can use NAD or NADP.
2 PublicationsCatalytic activityi
- (3S,5S)-3,5-diaminohexanoate + H2O + NAD+ = (5S)-5-amino-3-oxohexanoate + H+ + NADH + NH4+2 PublicationsEC:1.4.1.112 Publications
Kineticsi
- KM=3.2 µM for 3,5-DAH (with NAD as cofactor)1 Publication
- KM=197.8 µM for 3,5-DAH (with NADP as cofactor)1 Publication
- Vmax=4.1 nmol/min/µg enzyme with 3,5-DAH as substrate (with NAD as cofactor)1 Publication
- Vmax=4.5 nmol/min/µg enzyme with 3,5-DAH as substrate (with NADP as cofactor)1 Publication
: L-lysine degradation via acetate pathway Pathwayi
This protein is involved in the pathway L-lysine degradation via acetate pathway, which is part of Amino-acid degradation.1 Publication1 PublicationView all proteins of this organism that are known to be involved in the pathway L-lysine degradation via acetate pathway and in Amino-acid degradation.
GO - Molecular functioni
- L-erythro-3,5-diaminohexanoate dehydrogenase activity Source: UniProtKB-EC
GO - Biological processi
- L-lysine catabolic process to acetate Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Oxidoreductase |
Ligand | NAD, NADP |
Enzyme and pathway databases
BioCyci | FNUC190304:G1FZS-364-MONOMER |
UniPathwayi | UPA00870 |
Names & Taxonomyi
Protein namesi | Recommended name: L-erythro-3,5-diaminohexanoate dehydrogenase1 Publication (EC:1.4.1.112 Publications)Alternative name(s): 3,5-diaminohexanoate dehydrogenase1 Publication |
Gene namesi | Name:kdd1 Publication Ordered Locus Names:FN1867 |
Organismi | Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355) |
Taxonomic identifieri | 190304 [NCBI] |
Taxonomic lineagei | Bacteria › Fusobacteria › Fusobacteriales › Fusobacteriaceae › Fusobacterium › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000416981 | 1 – 345 | L-erythro-3,5-diaminohexanoate dehydrogenaseAdd BLAST | 345 |
Interactioni
Subunit structurei
Homodimer.
2 PublicationsProtein-protein interaction databases
STRINGi | 190304.FN1867 |
Structurei
3D structure databases
AlphaFoldDBi | Q8RHX3 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Sequence similaritiesi
Belongs to the KDD family.Curated
Phylogenomic databases
eggNOGi | COG0604, Bacteria |
HOGENOMi | CLU_826176_0_0_0 |
OMAi | GKMQNPV |
Family and domain databases
InterProi | View protein in InterPro IPR036291, NAD(P)-bd_dom_sf |
SUPFAMi | SSF51735, SSF51735, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8RHX3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKKGCKYGTH RVIEPAGVLP QPAKKISNDM EIFSNEILID VIALNIDSAS
60 70 80 90 100
FTQIEEEAGH DVEKVKAKIK EIVAERGKMQ NPVTGSGGML IGTVEKIGDD
110 120 130 140 150
LVGKTDLKVG DKIATLVSLS LTPLRIDEII NIKPEIDRVE IKGKAILFES
160 170 180 190 200
GIYAVLPKDM PENLALAALD VAGAPAQVAK LVKPCQSVAI LGSAGKSGML
210 220 230 240 250
CAYEAVKRVG PTGKVIGVVR NDKEKALLQR VSDKVKIVIA DATKPMDVLH
260 270 280 290 300
AVLEANDAKE VDVAINCVNV PNTEMSTILP VKEFGIAYFF SMATGFSKAA
310 320 330 340
LGAEGVGKDI TMIVGNGYTV DHAAITLEEL RESAVLREIF NEIYL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE009951 Genomic DNA Translation: AAL93966.1 |
RefSeqi | NP_602667.1, NC_003454.1 |
Genome annotation databases
EnsemblBacteriai | AAL93966; AAL93966; FN1867 |
KEGGi | fnu:FN1867 |
PATRICi | fig|190304.8.peg.343 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE009951 Genomic DNA Translation: AAL93966.1 |
RefSeqi | NP_602667.1, NC_003454.1 |
3D structure databases
AlphaFoldDBi | Q8RHX3 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 190304.FN1867 |
Genome annotation databases
EnsemblBacteriai | AAL93966; AAL93966; FN1867 |
KEGGi | fnu:FN1867 |
PATRICi | fig|190304.8.peg.343 |
Phylogenomic databases
eggNOGi | COG0604, Bacteria |
HOGENOMi | CLU_826176_0_0_0 |
OMAi | GKMQNPV |
Enzyme and pathway databases
UniPathwayi | UPA00870 |
BioCyci | FNUC190304:G1FZS-364-MONOMER |
Family and domain databases
InterProi | View protein in InterPro IPR036291, NAD(P)-bd_dom_sf |
SUPFAMi | SSF51735, SSF51735, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | KDD_FUSNN | |
Accessioni | Q8RHX3Primary (citable) accession number: Q8RHX3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 18, 2012 |
Last sequence update: | June 1, 2002 | |
Last modified: | May 25, 2022 | |
This is version 93 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families