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Protein

Fructose-bisphosphate aldolase class 1

Gene

fda

Organism
Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / CIP 101130 / JCM 8532 / LMG 13131)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 4 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgi)
  3. ATP-dependent 6-phosphofructokinase (pfkA)
  4. Fructose-bisphosphate aldolase class 1 (fda)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei176Proton acceptorUniRule annotation1
Active sitei213Schiff-base intermediate with dihydroxyacetone-PUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processGlycolysis
LigandSchiff base

Enzyme and pathway databases

BioCyciFNUC190304:G1FZS-919-MONOMER
UniPathwayiUPA00109; UER00183

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase class 1UniRule annotation (EC:4.1.2.13UniRule annotation)
Alternative name(s):
Fructose-bisphosphate aldolase class I
Short name:
FBP aldolaseUniRule annotation
Gene namesi
Name:fdaUniRule annotation
Ordered Locus Names:FN0322
OrganismiFusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / CIP 101130 / JCM 8532 / LMG 13131)
Taxonomic identifieri190304 [NCBI]
Taxonomic lineageiBacteriaFusobacteriaFusobacterialesFusobacteriaceaeFusobacterium
Proteomesi
  • UP000002521 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002169001 – 295Fructose-bisphosphate aldolase class 1Add BLAST295

Proteomic databases

PRIDEiQ8RGH3

Interactioni

Protein-protein interaction databases

STRINGi190304.FN0322

Structurei

3D structure databases

ProteinModelPortaliQ8RGH3
SMRiQ8RGH3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I fructose-bisphosphate aldolase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105WYW Bacteria
COG3588 LUCA
HOGENOMiHOG000073502
InParanoidiQ8RGH3
KOiK01623
OMAiVFGTKER

Family and domain databases

Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00729 FBP_aldolase_1, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR000741 FBA_I
IPR023014 FBA_I_Gram+-type
PfamiView protein in Pfam
PF00274 Glycolytic, 1 hit

Sequencei

Sequence statusi: Complete.

Q8RGH3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNEKLEKMRN GKGFIAALDQ SGGSTPKALK LYGVNENEYS NDKEMFDLIH
60 70 80 90 100
KMRTRIIKSP AFNESKILGA ILFEQTMDSK IDGKYTADFL WEEKKVLPFL
110 120 130 140 150
KIDKGLNDLD ADGVQTMKPN PTLADLLKRA NERHIFGTKM RSVIKKASPA
160 170 180 190 200
GIARVVEQQF EVAAQVVAAG LIPIIEPEVD INNVDKVQCE EILRDEIRKH
210 220 230 240 250
LNALPETSNV MLKLTLPTVE NLYEEFTKHP RVVRVVALSG GYSREKANDI
260 270 280 290
LSKNKGVIAS FSRALTEGLS AQQTDEEFNK TLAASIDGIY EASVK
Length:295
Mass (Da):32,896
Last modified:June 1, 2002 - v1
Checksum:i492DA50FBAC26495
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009951 Genomic DNA Translation: AAL94528.1
RefSeqiNP_603229.1, NC_003454.1
WP_005901613.1, NC_003454.1

Genome annotation databases

EnsemblBacteriaiAAL94528; AAL94528; FN0322
GeneIDi991677
KEGGifnu:FN0322
PATRICifig|190304.8.peg.902

Similar proteinsi

Entry informationi

Entry nameiALF1_FUSNN
AccessioniPrimary (citable) accession number: Q8RGH3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: June 1, 2002
Last modified: February 28, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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