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Entry version 122 (07 Apr 2021)
Sequence version 1 (01 Jun 2002)
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Protein

Carbamoyltransferase

Gene

HypF

Organism
Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Thermoanaerobacter tengcongensis)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: [NiFe] hydrogenase maturation

This protein is involved in the pathway [NiFe] hydrogenase maturation, which is part of Protein modification.ARBA annotation
View all proteins of this organism that are known to be involved in the pathway [NiFe] hydrogenase maturation and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei26PROSITE-ProRule annotation1
Active sitei44PROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi114Zinc 1Combined sources1
Metal bindingi117Zinc 1Combined sources1
Metal bindingi136Zinc 1Combined sources1
Metal bindingi139Zinc 1Combined sources1
Metal bindingi164Zinc 2Combined sources1
Metal bindingi167Zinc 2Combined sources1
Metal bindingi186Zinc 2Combined sources1
Metal bindingi189Zinc 2Combined sources1
Metal bindingi483Iron; via tele nitrogenCombined sources1
Metal bindingi487Iron; via tele nitrogenCombined sources1
Metal bindingi507IronCombined sources1
Metal bindingi734IronCombined sources1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolasePROSITE-ProRule annotation, LigaseARBA annotation
LigandIronCombined sources, Metal-binding, Zinc

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00335

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
CarbamoyltransferaseUniRule annotation (EC:6.2.-.-UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HypFImported
Ordered Locus Names:TTE0131Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Thermoanaerobacter tengcongensis)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri273068 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeCaldanaerobacter
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000555 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi200 ↔ 207Combined sources

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
273068.TTE0131

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8RDB0

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini11 – 97Acylphosphatase-likeInterPro annotationAdd BLAST87
Domaini202 – 386YrdC-likeInterPro annotationAdd BLAST185

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the acylphosphatase family.ARBA annotation
Belongs to the carbamoyltransferase HypF family.UniRule annotationARBA annotation

Keywords - Domaini

Zinc-fingerARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG0068, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_009164_0_0_9

Identification of Orthologs from Complete Genome Data

More...
OMAi
VQHHYAH

Database of Orthologous Groups

More...
OrthoDBi
48295at2

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001792, Acylphosphatase-like_dom
IPR036046, Acylphosphatase-like_dom_sf
IPR017968, Acylphosphatase_CS
IPR043129, ATPase_NBD
IPR004421, Carbamoyltransferase_HypF
IPR017945, DHBP_synth_RibB-like_a/b_dom
IPR041440, HypF_C
IPR006070, YrdC-like_dom
IPR011125, Znf_HypF

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00708, Acylphosphatase, 1 hit
PF17788, HypF_C, 1 hit
PF01300, Sua5_yciO_yrdC, 1 hit
PF07503, zf-HYPF, 2 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF006256, CMPcnvr_hdrg_mat, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53067, SSF53067, 1 hit
SSF54975, SSF54975, 1 hit
SSF55821, SSF55821, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00143, hypF, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00150, ACYLPHOSPHATASE_1, 1 hit
PS51160, ACYLPHOSPHATASE_3, 1 hit
PS51163, YRDC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8RDB0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVRGRVPQIQ ARQINIFGIV QGVGFRPFVF NIAQKYNLKG IVYNNSSGLY
60 70 80 90 100
IEVEGEEKDI EAFIREIKEN PPSLSVIDEI QVREVEVKEY KDFKIVGSKE
110 120 130 140 150
DGGFVPVSPD MGVCEDCLRE LKDPKDRRYR YPFINCTNCG PRFSIIEDIP
160 170 180 190 200
YDRAKTSMKV FPMCEKCSRE YHDPHDRRFH AQPVACFDCG PSLSFVGEGC
210 220 230 240 250
FDDEIKCVAK ALKEGKIVAI KGIGGFHLAV NALDDEAVAT LRRRKKRYGK
260 270 280 290 300
PFAVMMRDVE EVKKYCIVSP EEERLLLSQR RPIVLLKKKG EKLAKGIADD
310 320 330 340 350
LDTLGVMLPY APIHYLLMEE IDFPIVMTSG NVSEEPICKD NEEALEKLKD
360 370 380 390 400
IADVFLLNNR DIVNRIDDSV TSFNAGAERI IRRARGYAPQ PILLKKEVKA
410 420 430 440 450
SILAVGGFYK NTFCMTKGHY AFISHHIGDL DNEKAFNYYI EQIERYKKLF
460 470 480 490 500
RVDPEVVAHD MHKGYLSTQY AKSLDLPKIE VQHHHAHIAS CMAEHNLDEK
510 520 530 540 550
VIGIAYDGTG YGTDGNVWGA EILVCDLKSF ERIAHLKYKP LPGNELAIKK
560 570 580 590 600
IYRTALGFIF DNISFYKNFV EQVDSRELDI ILKQIDRKIN TAYVSSMGRF
610 620 630 640 650
FDAVAALIGV RKEVLFEGQA AMELESLMAE SEEYYEYEIL KEDRYVIDPE
660 670 680 690 700
LILRQIYEDY MKGFEKSYIS AKFHNTVVNF TYDLANLIRK ETGINKVVLS
710 720 730 740 750
GGSFQNRYLL RRLIEKLSLS GFEVYSNSKV PCNDGGISLG QAVIANKILE

G
Length:751
Mass (Da):85,546
Last modified:June 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1CEDA490F16E6AF7
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE008691 Genomic DNA Translation: AAM23435.1

NCBI Reference Sequences

More...
RefSeqi
WP_011024637.1, NC_003869.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAM23435; AAM23435; TTE0131

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
tte:TTE0131

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008691 Genomic DNA Translation: AAM23435.1
RefSeqiWP_011024637.1, NC_003869.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3VTHX-ray2.00A/B1-751[»]
3VTIX-ray2.56A/B1-751[»]
SMRiQ8RDB0
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

STRINGi273068.TTE0131

Genome annotation databases

EnsemblBacteriaiAAM23435; AAM23435; TTE0131
KEGGitte:TTE0131

Phylogenomic databases

eggNOGiCOG0068, Bacteria
HOGENOMiCLU_009164_0_0_9
OMAiVQHHYAH
OrthoDBi48295at2

Enzyme and pathway databases

UniPathwayiUPA00335

Family and domain databases

InterProiView protein in InterPro
IPR001792, Acylphosphatase-like_dom
IPR036046, Acylphosphatase-like_dom_sf
IPR017968, Acylphosphatase_CS
IPR043129, ATPase_NBD
IPR004421, Carbamoyltransferase_HypF
IPR017945, DHBP_synth_RibB-like_a/b_dom
IPR041440, HypF_C
IPR006070, YrdC-like_dom
IPR011125, Znf_HypF
PfamiView protein in Pfam
PF00708, Acylphosphatase, 1 hit
PF17788, HypF_C, 1 hit
PF01300, Sua5_yciO_yrdC, 1 hit
PF07503, zf-HYPF, 2 hits
PIRSFiPIRSF006256, CMPcnvr_hdrg_mat, 1 hit
SUPFAMiSSF53067, SSF53067, 1 hit
SSF54975, SSF54975, 1 hit
SSF55821, SSF55821, 1 hit
TIGRFAMsiTIGR00143, hypF, 1 hit
PROSITEiView protein in PROSITE
PS00150, ACYLPHOSPHATASE_1, 1 hit
PS51160, ACYLPHOSPHATASE_3, 1 hit
PS51163, YRDC, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ8RDB0_CALS4
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8RDB0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2002
Last sequence update: June 1, 2002
Last modified: April 7, 2021
This is version 122 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Reference proteomeImported
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