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Protein

Chemotaxis response regulator protein-glutamate methylesterase

Gene

cheB

Organism
Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Thermoanaerobacter tengcongensis)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the modulation of the chemotaxis system; catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR.UniRule annotation

Catalytic activityi

Protein L-glutamate O5-methyl ester + H2O = protein L-glutamate + methanol.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei177UniRule annotation1
Active sitei204UniRule annotation1
Active sitei303UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processChemotaxis

Enzyme and pathway databases

BioCyciTTEN273068:G1FZJ-1097-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Chemotaxis response regulator protein-glutamate methylesteraseUniRule annotation (EC:3.1.1.61UniRule annotation)
Gene namesi
Name:cheBUniRule annotation
Ordered Locus Names:TTE1035
OrganismiCaldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Thermoanaerobacter tengcongensis)
Taxonomic identifieri273068 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeCaldanaerobacter
Proteomesi
  • UP000000555 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001580331 – 367Chemotaxis response regulator protein-glutamate methylesteraseAdd BLAST367

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei574-aspartylphosphateUniRule annotation1

Post-translational modificationi

Phosphorylated by CheA. Phosphorylation suppresses the inhibitory activity of the N-terminal domain.UniRule annotation

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi273068.TTE1035

Structurei

3D structure databases

ProteinModelPortaliQ8RAZ3
SMRiQ8RAZ3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 123Response regulatoryPROSITE-ProRule annotationAdd BLAST118
Domaini165 – 361CheB-type methylesteraseUniRule annotationAdd BLAST197

Domaini

The N-terminal regulatory domain inhibits the activity of the C-terminal effector domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CMP Bacteria
COG2201 LUCA
HOGENOMiHOG000151423
KOiK03412
OMAiAMVKIRQ
OrthoDBiPOG091H045J

Family and domain databases

CDDicd16432 CheB_Rec, 1 hit
cd00156 REC, 1 hit
Gene3Di3.40.50.180, 1 hit
HAMAPiMF_00099 CheB_methylest, 1 hit
InterProiView protein in InterPro
IPR035909 CheB_C
IPR011006 CheY-like_superfamily
IPR008248 Sig_transdc_resp-reg_CheB
IPR000673 Sig_transdc_resp-reg_Me-estase
IPR001789 Sig_transdc_resp-reg_receiver
PfamiView protein in Pfam
PF01339 CheB_methylest, 1 hit
PF00072 Response_reg, 1 hit
PIRSFiPIRSF000876 RR_chemtxs_CheB, 1 hit
SMARTiView protein in SMART
SM00448 REC, 1 hit
SUPFAMiSSF52172 SSF52172, 1 hit
SSF52738 SSF52738, 1 hit
PROSITEiView protein in PROSITE
PS50122 CHEB, 1 hit
PS50110 RESPONSE_REGULATORY, 1 hit

Sequencei

Sequence statusi: Complete.

Q8RAZ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKKIRVLVV DDSAFMRRCL KDILENEEDM EVIDTARDGN EAVKKAVELR
60 70 80 90 100
PDVITLDINM PVMDGLTALQ YIMSLAPCPV VIISSLSTEG ALTTFEALEL
110 120 130 140 150
GAVDFVAKPG GTVSLGIKQL ADEIVSKVRI AALSNKELLS SSRNFKKLLK
160 170 180 190 200
RRNQEVTRKV YENKISKKEI VVVIGVSTGG PKTLMEILPY LPSDFPAAVL
210 220 230 240 250
VVQHMPPGFT QSFAQRLDQS CNLKVKEAED KAFIEPGTVI IAKGGWHLVV
260 270 280 290 300
ERDSRSSKLI TRLTQKPEET LYKPSINVTM KSVLENVDGR NIIGILLTGM
310 320 330 340 350
GDDGADMMVE IRKRGGLTIA ESQETAIVYG MPRAAVERGG AEIVAPAYKI
360
SDILLKKVNE YARTSEY
Length:367
Mass (Da):40,350
Last modified:June 1, 2002 - v1
Checksum:i612272BBC543DEA6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008691 Genomic DNA Translation: AAM24289.1
RefSeqiWP_011025403.1, NC_003869.1

Genome annotation databases

EnsemblBacteriaiAAM24289; AAM24289; TTE1035
KEGGitte:TTE1035

Entry informationi

Entry nameiCHEB_CALS4
AccessioniPrimary (citable) accession number: Q8RAZ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: June 1, 2002
Last modified: February 28, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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