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UniProtKB - Q8R5M8 (CADM1_MOUSE)

Entry version 160 (25 May 2022)
Sequence version 2 (26 Jun 2007)
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Protein

Cell adhesion molecule 1

Gene

Cadm1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates homophilic cell-cell adhesion in a Ca2+-independent manner (PubMed:12202822, PubMed:12799182, PubMed:12826663).

Also mediates heterophilic cell-cell adhesion with CADM3 and NECTIN3 in a Ca2+-independent manner (PubMed:12826663).

Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ T-cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM1 in vivo (PubMed:15811952).

In mast cells, may mediate attachment to and promote communication with nerves (By similarity).

CADM1, together with MITF, is essential for development and survival of mast cells in vivo (PubMed:15158462, PubMed:16605125).

By interacting with CRTAM and thus promoting the adhesion between CD8+ T-cells and CD8+ dendritic cells, regulates the retention of activated CD8+ T-cell within the draining lymph node (PubMed:19752223).

Required for the intestinal retention of intraepithelial CD4+ CD8+ T-cells and, to a lesser extent, intraepithelial and lamina propria CD8+ T-cells and CD4+ T-cells (PubMed:24687959).

Interaction with CRTAM promotes the adhesion to gut-associated CD103+ dendritic cells, which may facilitate the expression of gut-homing and adhesion molecules on T-cells and the conversion of CD4+ T-cells into CD4+ CD8+ T-cells (PubMed:24687959).

Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly (PubMed:12202822, PubMed:23209303).

May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons (PubMed:15707673).

May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa (PubMed:12606335, PubMed:16612000).

By similarity12 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processApoptosis, Cell adhesion, Differentiation, Immunity, Spermatogenesis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-418990, Adherens junctions interactions
R-MMU-420597, Nectin/Necl trans heterodimerization

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cell adhesion molecule 1
Alternative name(s):
Immunoglobulin superfamily member 4
Short name:
IgSF4
Nectin-like protein 2
Short name:
NECL-2
Spermatogenic immunoglobulin superfamily
Short name:
SgIgSF
Synaptic cell adhesion molecule
Short name:
SynCAM
Tumor suppressor in lung cancer 1
Short name:
TSLC-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Cadm1Imported
Synonyms:Igsf41 Publication, Necl2, Ra175, Syncam1 Publication, SynCam1Curated, Tslc1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1889272, Cadm1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSMUSG00000032076

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini48 – 388ExtracellularSequence analysisAdd BLAST341
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei389 – 409HelicalSequence analysisAdd BLAST21
Topological domaini410 – 456CytoplasmicSequence analysisAdd BLAST47

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Male mice are infertile, due to a defect at the spermatid stage of spermatogenesis, and show oligoasthenoteratozoospermia with almost no mature motile spermatozoa in the epididymis (PubMed:16382161, PubMed:16611999, PubMed:16612000). Heterozygous males and females and homozygous null females are fertile and have no overt developmental defects (PubMed:16382161, PubMed:16611999, PubMed:16612000). In the small intestine mucosa and under steady-state conditions, severe reduction in the number of intraepithelial CD4+ CD8+ T-cells and, partial reduction in the number of lamina propria and intraepithelial CD8+ and CD4+ T-cells (PubMed:24687959).4 Publications

Keywords - Diseasei

Tumor suppressor

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 47Sequence analysisAdd BLAST47
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000029196948 – 456Cell adhesion molecule 1Sequence analysisAdd BLAST409

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi67 ↔ 127PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi70N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi104N-linked (GlcNAc...) asparagine3 Publications1
Glycosylationi116N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi168N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi169 ↔ 223PROSITE-ProRule annotation
Disulfide bondi270 ↔ 316PROSITE-ProRule annotation
Glycosylationi307N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi311N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei436PhosphothreonineCombined sources1
Modified residuei448PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.4 Publications
Glycosylation at Asn-70 and Asn-104 promotes adhesive binding and synapse induction.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8R5M8

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8R5M8

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8R5M8

PeptideAtlas

More...PeptideAtlasi		Q8R5M8

PRoteomics IDEntifications database

More...PRIDEi		Q8R5M8

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		281746 [Q8R5M8-1]
281747 [Q8R5M8-2]
281748 [Q8R5M8-3]
281749 [Q8R5M8-4]
281750 [Q8R5M8-5]
281751 [Q8R5M8-6]
281752 [Q8R5M8-7]

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		2199, 4 N-Linked glycans (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q8R5M8, 6 sites, 4 N-linked glycans (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8R5M8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8R5M8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed dominantly in epithelial cells but not expressed in fibroblast cells (at protein level) (PubMed:12826663). Expressed in the T-cell area of lymph nodes, specifically in CD8+ and CD4- CD8- dendritic cells (at protein level) (PubMed:19752223). Expressed in CD8+ dendritic cells in the spleen (at protein level) (PubMed:19752223). Expressed in CD103+ dendritic cells in the small intestine lamina propria and mesenteric lymph nodes (at protein level) (PubMed:24687959). Expressed in brain, lung, kidney, testis, heart, spleen and liver, but not expressed in skeletal muscle (PubMed:12242005, PubMed:12606335, PubMed:12202822).6 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in spermatogenic cells during early spermatogenesis. Expression increases in intermediate spermatogonia through to zygotene spermatocytes but becomes diminished in the steps from early pachytene spermatocytes through to round spermatids. After meiosis, expression reappears in spermatids and is present in elongating spermatids until spermiation. Not detected in Sertoli cells.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000032076, Expressed in retina and 326 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8R5M8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8R5M8, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (via Ig-like V-type domain) (By similarity).

Interacts with FARP1 (PubMed:23209303).

Interacts (via Ig-like V-type domain) with CRTAM (via Ig-like V-type domain); the interaction competes with CRTAM homodimerization and CADM1 homodimerization (PubMed:15811952, PubMed:15781451).

Interacts (via C-terminus) with EPB41L3/DAL1 (By similarity). The interaction with EPB41L3/DAL1 may act to anchor CADM1 to the actin cytoskeleton (By similarity).

Interacts (via C-terminus) with MPP2 (via PDZ domain) (By similarity).

Interacts (via C-terminus) with MPP3 (via PDZ domain) (By similarity).

Interacts (via C-terminus) with PALS2 (via PDZ domain) (PubMed:12826663).

By similarity4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		207729, 16 interactors

Protein interaction database and analysis system

More...IntActi		Q8R5M8, 3 interactors

Molecular INTeraction database

More...MINTi		Q8R5M8

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000083073

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8R5M8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q8R5M8

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8R5M8

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini48 – 142Ig-like V-typeSequence analysisAdd BLAST95
Domaini147 – 241Ig-like C2-type 1Sequence analysisAdd BLAST95
Domaini246 – 332Ig-like C2-type 2Sequence analysisAdd BLAST87

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The cytoplasmic domain appears to play a critical role in proapoptosis and tumor suppressor activity in NSCLC.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the nectin family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502R1KU, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156093

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_047574_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8R5M8

Identification of Orthologs from Complete Genome Data

More...OMAi		TYDRMYT

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8R5M8

TreeFam database of animal gene trees

More...TreeFami		TF334317

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013162, CD80_C2-set
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR013106, Ig_V-set
IPR003585, Neurexin-like

Pfam protein domain database

More...Pfami		View protein in Pfam
PF08205, C2-set_2, 1 hit
PF07686, V-set, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00294, 4.1m, 1 hit
SM00409, IG, 3 hits
SM00408, IGc2, 3 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48726, SSF48726, 3 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50835, IG_LIKE, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 11 Publication (identifier: Q8R5M8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASAVLPSGS QCAAAAAVAA AAAPPGLRLR LLLLLLSAAA LIPTGDGQNL 
        60         70         80         90        100
FTKDVTVIEG EVATISCQVN KSDDSVIQLL NPNRQTIYFR DFRPLKDSRF 
       110        120        130        140        150
QLLNFSSSEL KVSLTNVSIS DEGRYFCQLY TDPPQESYTT ITVLVPPRNL 
       160        170        180        190        200
MIDIQKDTAV EGEEIEVNCT AMASKPATTI RWFKGNKELK GKSEVEEWSD 
       210        220        230        240        250
MYTVTSQLML KVHKEDDGVP VICQVEHPAV TGNLQTQRYL EVQYKPQVHI 
       260        270        280        290        300
QMTYPLQGLT REGDAFELTC EAIGKPQPVM VTWVRVDDEM PQHAVLSGPN 
       310        320        330        340        350
LFINNLNKTD NGTYRCEASN IVGKAHSDYM LYVYDPPTTI PPPTTTTTTT 
       360        370        380        390        400
TTTTTTILTI ITDTTATTEP AVHDSRAGEE GTIGAVDHAV IGGVVAVVVF 
       410        420        430        440        450
AMLCLLIILG RYFARHKGTY FTHEAKGADD AADADTAIIN AEGGQNNSEE 

KKEYFI
Length:456
Mass (Da):49,788
Last modified:June 26, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3226E86C04161C7F
GO
Isoform 24 Publications (identifier: Q8R5M8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     364-374: Missing.

Show »
Length:445
Mass (Da):48,664
Checksum:iC5D5A070DAF70E55
GO
Isoform 31 Publication (identifier: Q8R5M8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     336-363: Missing.

Show »
Length:428
Mass (Da):46,903
Checksum:iB10DFF1A2B893573
GO
Isoform 42 Publications (identifier: Q8R5M8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     336-374: Missing.

Show »
Length:417
Mass (Da):45,779
Checksum:i98500180D37845C2
GO
Isoform 52 Publications (identifier: Q8R5M8-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     335-336: DP → GT
     337-456: Missing.

Show »
Length:336
Mass (Da):37,155
Checksum:i9EF3D8B8BE5E8F72
GO
Isoform 61 Publication (identifier: Q8R5M8-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-150: Missing.
     355-365: Missing.

Show »
Length:295
Mass (Da):32,459
Checksum:iF557E3FAF8174671
GO
Isoform 71 Publication (identifier: Q8R5M8-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-150: Missing.
     336-352: Missing.

Show »
Length:289
Mass (Da):31,922
Checksum:iFC718DBCCEA8C452
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PYN1E9PYN1_MOUSE
Cell adhesion molecule 1
Cadm1
474Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E0CY16E0CY16_MOUSE
Cell adhesion molecule 1
Cadm1
390Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A668KLV1A0A668KLV1_MOUSE
Cell adhesion molecule 1
Cadm1
361Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1L1SS08A0A1L1SS08_MOUSE
Cell adhesion molecule 1
Cadm1
63Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC67243 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti8S → C in AAN01614 (PubMed:12202822).Curated1
Sequence conflicti8S → C in BAD30018 (Ref. 7) Curated1
Sequence conflicti266F → L in BAA87914 (PubMed:12799182).Curated1
Sequence conflicti266F → L in BAA87915 (PubMed:12799182).Curated1
Sequence conflicti315R → P in BAA87914 (PubMed:12799182).Curated1
Sequence conflicti315R → P in BAA87915 (PubMed:12799182).Curated1
Sequence conflicti330M → I in BAA87914 (PubMed:12799182).Curated1
Sequence conflicti330M → I in BAA87915 (PubMed:12799182).Curated1
Sequence conflicti356T → S in AAN01614 (PubMed:12202822).Curated1
Sequence conflicti356T → S in BAD30018 (Ref. 7) Curated1
Sequence conflicti429D → N in BAB83501 (PubMed:12799182).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0524631 – 150Missing in isoform 6 and isoform 7. 3 PublicationsAdd BLAST150
Alternative sequenceiVSP_052464335 – 336DP → GT in isoform 5. 3 Publications2
Alternative sequenceiVSP_052465336 – 374Missing in isoform 4. 2 PublicationsAdd BLAST39
Alternative sequenceiVSP_052466336 – 363Missing in isoform 3. 2 PublicationsAdd BLAST28
Alternative sequenceiVSP_052467336 – 352Missing in isoform 7. 2 PublicationsAdd BLAST17
Alternative sequenceiVSP_052468337 – 456Missing in isoform 5. 3 PublicationsAdd BLAST120
Alternative sequenceiVSP_052469355 – 365Missing in isoform 6. 2 PublicationsAdd BLAST11
Alternative sequenceiVSP_052470364 – 374Missing in isoform 2. 4 PublicationsAdd BLAST11

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF434663 mRNA Translation: AAL86736.1
AF539424 mRNA Translation: AAN01614.1
AB021964 mRNA Translation: BAA87914.1
AB021965 mRNA Translation: BAA87915.1
AB064265 mRNA Translation: BAB83501.2
AY351388 mRNA Translation: AAQ02381.1
AF061260 mRNA Translation: AAC67243.1 Frameshift.
AB092414 mRNA Translation: BAC66173.1
AB183399 mRNA Translation: BAD30018.1
AB183400 mRNA Translation: BAD30019.1
AB183401 mRNA Translation: BAD30020.1
AB183402 mRNA Translation: BAD30021.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS23147.1 [Q8R5M8-4]
CCDS23148.1 [Q8R5M8-2]
CCDS23149.1 [Q8R5M8-1]
CCDS23150.1 [Q8R5M8-3]

NCBI Reference Sequences

More...RefSeqi		NP_001020771.1, NM_001025600.1 [Q8R5M8-4]
NP_061240.3, NM_018770.3 [Q8R5M8-2]
NP_997558.2, NM_207675.2 [Q8R5M8-1]
NP_997559.1, NM_207676.2 [Q8R5M8-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000034581; ENSMUSP00000034581; ENSMUSG00000032076 [Q8R5M8-4]
ENSMUST00000085909; ENSMUSP00000083073; ENSMUSG00000032076 [Q8R5M8-1]
ENSMUST00000114547; ENSMUSP00000110194; ENSMUSG00000032076 [Q8R5M8-2]
ENSMUST00000114548; ENSMUSP00000110195; ENSMUSG00000032076 [Q8R5M8-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		54725

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:54725

UCSC genome browser

More...UCSCi		uc009phn.1, mouse [Q8R5M8-5]
uc009pho.1, mouse [Q8R5M8-1]
uc009phq.1, mouse [Q8R5M8-3]
uc009phr.1, mouse [Q8R5M8-4]
uc009phs.1, mouse [Q8R5M8-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF434663 mRNA Translation: AAL86736.1
AF539424 mRNA Translation: AAN01614.1
AB021964 mRNA Translation: BAA87914.1
AB021965 mRNA Translation: BAA87915.1
AB064265 mRNA Translation: BAB83501.2
AY351388 mRNA Translation: AAQ02381.1
AF061260 mRNA Translation: AAC67243.1 Frameshift.
AB092414 mRNA Translation: BAC66173.1
AB183399 mRNA Translation: BAD30018.1
AB183400 mRNA Translation: BAD30019.1
AB183401 mRNA Translation: BAD30020.1
AB183402 mRNA Translation: BAD30021.1
CCDSiCCDS23147.1 [Q8R5M8-4]
CCDS23148.1 [Q8R5M8-2]
CCDS23149.1 [Q8R5M8-1]
CCDS23150.1 [Q8R5M8-3]
RefSeqiNP_001020771.1, NM_001025600.1 [Q8R5M8-4]
NP_061240.3, NM_018770.3 [Q8R5M8-2]
NP_997558.2, NM_207675.2 [Q8R5M8-1]
NP_997559.1, NM_207676.2 [Q8R5M8-3]

3D structure databases

AlphaFoldDBiQ8R5M8
SMRiQ8R5M8
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi207729, 16 interactors
IntActiQ8R5M8, 3 interactors
MINTiQ8R5M8
STRINGi10090.ENSMUSP00000083073

PTM databases

GlyConnecti2199, 4 N-Linked glycans (1 site)
GlyGeniQ8R5M8, 6 sites, 4 N-linked glycans (1 site)
iPTMnetiQ8R5M8
PhosphoSitePlusiQ8R5M8

Proteomic databases

jPOSTiQ8R5M8
MaxQBiQ8R5M8
PaxDbiQ8R5M8
PeptideAtlasiQ8R5M8
PRIDEiQ8R5M8
ProteomicsDBi281746 [Q8R5M8-1]
281747 [Q8R5M8-2]
281748 [Q8R5M8-3]
281749 [Q8R5M8-4]
281750 [Q8R5M8-5]
281751 [Q8R5M8-6]
281752 [Q8R5M8-7]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		Q8R5M8, 1 sequenced antibody

Antibodypedia a portal for validated antibodies

More...Antibodypediai		32257, 661 antibodies from 40 providers

The DNASU plasmid repository

More...DNASUi		54725

Genome annotation databases

EnsembliENSMUST00000034581; ENSMUSP00000034581; ENSMUSG00000032076 [Q8R5M8-4]
ENSMUST00000085909; ENSMUSP00000083073; ENSMUSG00000032076 [Q8R5M8-1]
ENSMUST00000114547; ENSMUSP00000110194; ENSMUSG00000032076 [Q8R5M8-2]
ENSMUST00000114548; ENSMUSP00000110195; ENSMUSG00000032076 [Q8R5M8-3]
GeneIDi54725
KEGGimmu:54725
UCSCiuc009phn.1, mouse [Q8R5M8-5]
uc009pho.1, mouse [Q8R5M8-1]
uc009phq.1, mouse [Q8R5M8-3]
uc009phr.1, mouse [Q8R5M8-4]
uc009phs.1, mouse [Q8R5M8-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		23705
MGIiMGI:1889272, Cadm1
VEuPathDBiHostDB:ENSMUSG00000032076

Phylogenomic databases

eggNOGiENOG502R1KU, Eukaryota
GeneTreeiENSGT00940000156093
HOGENOMiCLU_047574_2_1_1
InParanoidiQ8R5M8
OMAiTYDRMYT
PhylomeDBiQ8R5M8
TreeFamiTF334317

Enzyme and pathway databases

ReactomeiR-MMU-418990, Adherens junctions interactions
R-MMU-420597, Nectin/Necl trans heterodimerization

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		54725, 2 hits in 74 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Cadm1, mouse

Protein Ontology

More...PROi		PR:Q8R5M8
RNActiQ8R5M8, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000032076, Expressed in retina and 326 other tissues
ExpressionAtlasiQ8R5M8, baseline and differential
GenevisibleiQ8R5M8, MM

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR013162, CD80_C2-set
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR013106, Ig_V-set
IPR003585, Neurexin-like
PfamiView protein in Pfam
PF08205, C2-set_2, 1 hit
PF07686, V-set, 1 hit
SMARTiView protein in SMART
SM00294, 4.1m, 1 hit
SM00409, IG, 3 hits
SM00408, IGc2, 3 hits
SUPFAMiSSF48726, SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835, IG_LIKE, 3 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCADM1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8R5M8
Secondary accession number(s): Q6F3J3
, Q7TNL1, Q80VG4, Q8K3T6, Q8R4L1, Q9QYL5, Q9QYL6, Q9Z2H8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: June 26, 2007
Last modified: May 25, 2022
This is version 160 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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