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Protein

Protein Wnt-9a

Gene

Wnt9a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). Required for normal timing of IHH expression during embryonic bone development, normal chondrocyte maturation and for normal bone mineralization during embryonic bone development (PubMed:16818445). Plays a redundant role in maintaining joint integrity (PubMed:16818445).By similarityCurated1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processWnt signaling pathway

Enzyme and pathway databases

ReactomeiR-MMU-3238698 WNT ligand biogenesis and trafficking

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-9a
Alternative name(s):
Protein Wnt-14
Gene namesi
Name:Wnt9a
Synonyms:Wnt141 Publication
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2446084 Wnt9a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Disruption phenotypei

Mutant mice die during the first 12 hours after birth. Heart, lung, liver, intestinal tract, kidney and brain appear grossly normal, but the mice display skeletal abnormalities, with slightly shortened long bones in their limbs. The region of bone mineralization is reduced in scapula, humerus, ileum and femur. Besides, hyoid bone and atlas are hypoplastic. In the scull, the supraoccipital bone shows reduced mineralization, with increased distance between the frontal bones. The basioccipital bone displays an abnormal shape and is smaller than in wild-type. Ectopic cartilage nodules are detected within the skull midline sutures. Ectopic cartilaginous material is detected in the interfrontal and sagittal suture regions between the frontal and parietal bones. In neonate forelimbs, the synovial fold contains cells with a chondrocyte-like appearance. Mutant mice display also partial joint fusions between the navicular and intermediate cuneiform tarsal elements in the foot, and between wrist carpal elements.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000004145630 – 365Protein Wnt-9aAdd BLAST336

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi93 ↔ 104By similarity
Glycosylationi103N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi141 ↔ 149By similarity
Disulfide bondi151 ↔ 168By similarity
Disulfide bondi215 ↔ 229By similarity
Disulfide bondi217 ↔ 224By similarity
Lipidationi221O-palmitoleoyl serine; by PORCNBy similarity1
Disulfide bondi313 ↔ 324By similarity
Disulfide bondi339 ↔ 354By similarity
Disulfide bondi341 ↔ 351By similarity
Disulfide bondi346 ↔ 347By similarity

Post-translational modificationi

Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein

Proteomic databases

MaxQBiQ8R5M2
PaxDbiQ8R5M2
PRIDEiQ8R5M2

PTM databases

iPTMnetiQ8R5M2
PhosphoSitePlusiQ8R5M2

Expressioni

Tissue specificityi

Expressed in adult brain, lung, skeletal muscle, heart, and 17-day embryo.1 Publication

Gene expression databases

BgeeiENSMUSG00000000126 Expressed in 237 organ(s), highest expression level in mesenchyme of handplate
CleanExiMM_WNT9A
ExpressionAtlasiQ8R5M2 baseline and differential
GenevisibleiQ8R5M2 MM

Interactioni

Subunit structurei

Forms a soluble 1:1 complex with AFM; this prevents oligomerization and is required for prolonged biological activity. The complex with AFM may represent the physiological form in body fluids.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi229787, 3 interactors
STRINGi10090.ENSMUSP00000104411

Structurei

3D structure databases

ProteinModelPortaliQ8R5M2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3913 Eukaryota
ENOG410XQZ1 LUCA
GeneTreeiENSGT00690000101857
HOGENOMiHOG000039529
HOVERGENiHBG001595
InParanoidiQ8R5M2
KOiK01064
OrthoDBiEOG091G0OFF
PhylomeDBiQ8R5M2

Family and domain databases

InterProiView protein in InterPro
IPR005817 Wnt
IPR013303 Wnt9a
IPR018161 Wnt_CS
PANTHERiPTHR12027 PTHR12027, 1 hit
PTHR12027:SF75 PTHR12027:SF75, 1 hit
PfamiView protein in Pfam
PF00110 wnt, 1 hit
PRINTSiPR01894 WNT14PROTEIN
PR01349 WNTPROTEIN
SMARTiView protein in SMART
SM00097 WNT1, 1 hit
PROSITEiView protein in PROSITE
PS00246 WNT1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8R5M2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLDGSLLARW LAAAFGLTLL LAALRPSAAY FGLTGSEPLT ILPLTLETEA
60 70 80 90 100
AAQAHYKACD RLKLERKQRR MCRRDPGVAE TLVEAVSMSA LECQYQFRFE
110 120 130 140 150
RWNCTLEGRY RASLLKRGFK ETAFLYAISS AGLTHALAKA CSAGRMERCT
160 170 180 190 200
CDEAPDLENR EAWQWGGCGD NLKYSSKFVK EFLGRRSSKD LRARVDFHNN
210 220 230 240 250
LVGVKVIKAG VETTCKCHGV SGSCTVRTCW RQLAPFHEVG KHLKHKYETS
260 270 280 290 300
LKVGSTTNEA TGEAGAISPP RGRASGSGGG DPLPRTPELV HLDDSPSFCL
310 320 330 340 350
AGRFSPGTAG RRCHREKNCE SICCGRGHNT QSRVVTRPCQ CQVRWCCYVE
360
CRQCTQREEV YTCKG
Length:365
Mass (Da):40,388
Last modified:June 1, 2002 - v1
Checksum:iC6EBBE1897D2FA8A
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3JS28J3JS28_MOUSE
Protein Wnt
Wnt9a
365Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB072311 mRNA Translation: BAB84710.1
CCDSiCCDS36169.1
RefSeqiNP_647459.1, NM_139298.2
UniGeneiMm.218794

Genome annotation databases

EnsembliENSMUST00000108783; ENSMUSP00000104411; ENSMUSG00000000126
GeneIDi216795
KEGGimmu:216795
UCSCiuc007jdq.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB072311 mRNA Translation: BAB84710.1
CCDSiCCDS36169.1
RefSeqiNP_647459.1, NM_139298.2
UniGeneiMm.218794

3D structure databases

ProteinModelPortaliQ8R5M2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi229787, 3 interactors
STRINGi10090.ENSMUSP00000104411

PTM databases

iPTMnetiQ8R5M2
PhosphoSitePlusiQ8R5M2

Proteomic databases

MaxQBiQ8R5M2
PaxDbiQ8R5M2
PRIDEiQ8R5M2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000108783; ENSMUSP00000104411; ENSMUSG00000000126
GeneIDi216795
KEGGimmu:216795
UCSCiuc007jdq.1 mouse

Organism-specific databases

CTDi7483
MGIiMGI:2446084 Wnt9a

Phylogenomic databases

eggNOGiKOG3913 Eukaryota
ENOG410XQZ1 LUCA
GeneTreeiENSGT00690000101857
HOGENOMiHOG000039529
HOVERGENiHBG001595
InParanoidiQ8R5M2
KOiK01064
OrthoDBiEOG091G0OFF
PhylomeDBiQ8R5M2

Enzyme and pathway databases

ReactomeiR-MMU-3238698 WNT ligand biogenesis and trafficking

Miscellaneous databases

PROiPR:Q8R5M2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000000126 Expressed in 237 organ(s), highest expression level in mesenchyme of handplate
CleanExiMM_WNT9A
ExpressionAtlasiQ8R5M2 baseline and differential
GenevisibleiQ8R5M2 MM

Family and domain databases

InterProiView protein in InterPro
IPR005817 Wnt
IPR013303 Wnt9a
IPR018161 Wnt_CS
PANTHERiPTHR12027 PTHR12027, 1 hit
PTHR12027:SF75 PTHR12027:SF75, 1 hit
PfamiView protein in Pfam
PF00110 wnt, 1 hit
PRINTSiPR01894 WNT14PROTEIN
PR01349 WNTPROTEIN
SMARTiView protein in SMART
SM00097 WNT1, 1 hit
PROSITEiView protein in PROSITE
PS00246 WNT1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiWNT9A_MOUSE
AccessioniPrimary (citable) accession number: Q8R5M2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: June 1, 2002
Last modified: October 10, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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