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Protein

Nucleolar protein 6

Gene

Nol6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • rRNA processing Source: GO_Central
  • tRNA export from nucleus Source: GO_Central

Keywordsi

Molecular functionRNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleolar protein 6
Alternative name(s):
Nucleolar RNA-associated protein
Short name:
Nrap
Gene namesi
Name:Nol6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2140151 Nol6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002156481 – 1152Nucleolar protein 6Add BLAST1152

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei65PhosphoserineBy similarity1
Modified residuei292PhosphoserineBy similarity1
Modified residuei817PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8R5K4
PaxDbiQ8R5K4
PeptideAtlasiQ8R5K4
PRIDEiQ8R5K4

PTM databases

iPTMnetiQ8R5K4
PhosphoSitePlusiQ8R5K4

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSMUSG00000028430 Expressed in 232 organ(s), highest expression level in cardiac ventricle
CleanExiMM_NOL6
GenevisibleiQ8R5K4 MM

Interactioni

Subunit structurei

Probably associated with rRNA.By similarity

Protein-protein interaction databases

BioGridi230928, 4 interactors
IntActiQ8R5K4, 1 interactor
STRINGi10090.ENSMUSP00000030138

Structurei

3D structure databases

ProteinModelPortaliQ8R5K4
SMRiQ8R5K4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili92 – 128Sequence analysisAdd BLAST37

Sequence similaritiesi

Belongs to the NRAP family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2054 Eukaryota
ENOG410XPP9 LUCA
GeneTreeiENSGT00390000018619
HOVERGENiHBG052644
InParanoidiQ8R5K4
KOiK14544
OMAiVWNQLAN
OrthoDBiEOG091G01Z2
PhylomeDBiQ8R5K4

Family and domain databases

InterProiView protein in InterPro
IPR005554 Nrap
IPR035082 Nrap_D1
IPR035367 Nrap_D2
IPR035368 Nrap_D3
IPR035369 Nrap_D4
IPR035370 Nrap_D5
IPR035371 Nrap_D6
PANTHERiPTHR17972 PTHR17972, 1 hit
PfamiView protein in Pfam
PF03813 Nrap, 1 hit
PF17403 Nrap_D2, 1 hit
PF17404 Nrap_D3, 1 hit
PF17405 Nrap_D4, 1 hit
PF17406 Nrap_D5, 1 hit
PF17407 Nrap_D6, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8R5K4-1) [UniParc]FASTAAdd to basket
Also known as: Alpha, Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPSAGERPAV KMGPAPAGEQ HRRATEDPEV MELAFEGMDK EKAPSRKRAR
60 70 80 90 100
TEPPAEGLLQ PVNLSREELY KEPTNEELNR LRETEILFHS TLLRLQVEEL
110 120 130 140 150
LKEVRLSEKK KERIDNFLKE VTKRIQKVPP VPEAELTDQS WLPAGVRVPL
160 170 180 190 200
HQVPYAVKGS FRFRPPSQIT VVGSYLLDTC MRPDINVDVA VTMPREILQD
210 220 230 240 250
KDGLNQRYFR KRALYLAHLA YHLAQDPLFS SVRFSYMSGC HLKPSLLLRP
260 270 280 290 300
HGKDERLVTV RLLPCPPLDF FRPCRLLPTK NNVRSAWYRG QSCPDYEPPT
310 320 330 340 350
PHYNTWILQD VALETHMHLL ASVLGSAQGL KDGVALLKVW LRQRELDKGL
360 370 380 390 400
GGFNGFIISM LVAFLVSKRK IHTTMSGYQV LRSVLQFLAT TDLTINGISF
410 420 430 440 450
SLSSDPSLPT LAEFHQLFAV VFVDPSGRLN LCADVTASTY NQVQYEAELS
460 470 480 490 500
MALLDSKADD GFQLLLMTPK PMIQAFDHVV HLHPLSRLQA SCHQLKLWPE
510 520 530 540 550
LQDNGGDYVS AALGPLTNIL VQGLGCRLHL LAHSRPPVPE WSINQDPPKH
560 570 580 590 600
KDAGTLTLGF LFRPEGLTSV IDLGPEADKP EAADFRQFWG TRSELRRFQD
610 620 630 640 650
GAIREAVVWE AESLFEKRLI PHQVVTHLLA LHADIPDTCI QYVGGFLDAL
660 670 680 690 700
IQNPKEISST GEEALALAVR CYDDLSRLLW GLEGLPLTVS AVQGAHPVLR
710 720 730 740 750
YTEVFPPAPV RPAYSFYNRL QELASLLPRP DKPCPAYVEP MTVVCHLEGS
760 770 780 790 800
GQWPQDAEAV QRVRAAFQLR LAEVLTQEHR LQCCATATHT DVLKDGFVFR
810 820 830 840 850
IRVAYQREPQ ILKEVRSPEG MVSLRDTPAS LRLERDTKLL PLLTSALHGL
860 870 880 890 900
QQQYPAYSGV ARLAKRWVRA QLLGEGFTDE SLDLLAASLF LHPEPFTPPS
910 920 930 940 950
VPQVGFLRFL YLVSTFDWKN NPLIVNLNGE LTAEEQVGIR SSFLAARTQL
960 970 980 990 1000
PVMVIITPQD RRSSVWTQDG PSAQILQQLV SLAAEALPIL EKQLMDPRGP
1010 1020 1030 1040 1050
GDIRTVFRPP FDMYDVLIHL TPRHIPRHRQ AVDPPVASFC RGLLAEPGPS
1060 1070 1080 1090 1100
SLMPVLGYDP PQLYLAQLRE AFEDLALFFY DQHGGEVIGV LWKPSSFQPQ
1110 1120 1130 1140 1150
PFKASSIKGR MVVSQGGELV MLPNIEAILE DFAVLGEGLV QAVEARSERW

TV
Length:1,152
Mass (Da):129,228
Last modified:September 11, 2007 - v2
Checksum:i187243E352C68C80
GO
Isoform 2 (identifier: Q8R5K4-2) [UniParc]FASTAAdd to basket
Also known as: Beta, Short

The sequence of this isoform differs from the canonical sequence as follows:
     1062-1065: QLYL → LSLL
     1066-1152: Missing.

Note: No experimental confirmation available.
Show »
Length:1,065
Mass (Da):119,519
Checksum:iD0D770806912B4D3
GO

Sequence cautioni

The sequence AAH19981 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH21856 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAL74401 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAL74402 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti254D → V in BAE38917 (PubMed:16141072).Curated1
Sequence conflicti740P → L in BAE38917 (PubMed:16141072).Curated1
Sequence conflicti815V → M in BAE38917 (PubMed:16141072).Curated1
Sequence conflicti1055V → I in BAE38917 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0135331062 – 1065QLYL → LSLL in isoform 2. 1 Publication4
Alternative sequenceiVSP_0135341066 – 1152Missing in isoform 2. 1 PublicationAdd BLAST87

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF361077 mRNA Translation: AAL74401.1 Different initiation.
AF361078 mRNA Translation: AAL74402.1 Different initiation.
AK053117 mRNA Translation: BAC35271.1
AK155818 mRNA Translation: BAE33447.1
AK166650 mRNA Translation: BAE38917.1
AL954379 Genomic DNA No translation available.
BC019981 mRNA Translation: AAH19981.1 Different initiation.
BC021856 mRNA Translation: AAH21856.1 Different initiation.
BC059820 mRNA Translation: AAH59820.2
CCDSiCCDS38715.1 [Q8R5K4-1]
RefSeqiNP_631982.2, NM_139236.3 [Q8R5K4-1]
UniGeneiMm.285797

Genome annotation databases

EnsembliENSMUST00000030138; ENSMUSP00000030138; ENSMUSG00000028430 [Q8R5K4-1]
GeneIDi230082
KEGGimmu:230082
UCSCiuc008sii.1 mouse [Q8R5K4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF361077 mRNA Translation: AAL74401.1 Different initiation.
AF361078 mRNA Translation: AAL74402.1 Different initiation.
AK053117 mRNA Translation: BAC35271.1
AK155818 mRNA Translation: BAE33447.1
AK166650 mRNA Translation: BAE38917.1
AL954379 Genomic DNA No translation available.
BC019981 mRNA Translation: AAH19981.1 Different initiation.
BC021856 mRNA Translation: AAH21856.1 Different initiation.
BC059820 mRNA Translation: AAH59820.2
CCDSiCCDS38715.1 [Q8R5K4-1]
RefSeqiNP_631982.2, NM_139236.3 [Q8R5K4-1]
UniGeneiMm.285797

3D structure databases

ProteinModelPortaliQ8R5K4
SMRiQ8R5K4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230928, 4 interactors
IntActiQ8R5K4, 1 interactor
STRINGi10090.ENSMUSP00000030138

PTM databases

iPTMnetiQ8R5K4
PhosphoSitePlusiQ8R5K4

Proteomic databases

EPDiQ8R5K4
PaxDbiQ8R5K4
PeptideAtlasiQ8R5K4
PRIDEiQ8R5K4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030138; ENSMUSP00000030138; ENSMUSG00000028430 [Q8R5K4-1]
GeneIDi230082
KEGGimmu:230082
UCSCiuc008sii.1 mouse [Q8R5K4-1]

Organism-specific databases

CTDi65083
MGIiMGI:2140151 Nol6

Phylogenomic databases

eggNOGiKOG2054 Eukaryota
ENOG410XPP9 LUCA
GeneTreeiENSGT00390000018619
HOVERGENiHBG052644
InParanoidiQ8R5K4
KOiK14544
OMAiVWNQLAN
OrthoDBiEOG091G01Z2
PhylomeDBiQ8R5K4

Enzyme and pathway databases

ReactomeiR-MMU-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Miscellaneous databases

ChiTaRSiNol6 mouse
PROiPR:Q8R5K4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028430 Expressed in 232 organ(s), highest expression level in cardiac ventricle
CleanExiMM_NOL6
GenevisibleiQ8R5K4 MM

Family and domain databases

InterProiView protein in InterPro
IPR005554 Nrap
IPR035082 Nrap_D1
IPR035367 Nrap_D2
IPR035368 Nrap_D3
IPR035369 Nrap_D4
IPR035370 Nrap_D5
IPR035371 Nrap_D6
PANTHERiPTHR17972 PTHR17972, 1 hit
PfamiView protein in Pfam
PF03813 Nrap, 1 hit
PF17403 Nrap_D2, 1 hit
PF17404 Nrap_D3, 1 hit
PF17405 Nrap_D4, 1 hit
PF17406 Nrap_D5, 1 hit
PF17407 Nrap_D6, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNOL6_MOUSE
AccessioniPrimary (citable) accession number: Q8R5K4
Secondary accession number(s): Q3TL75
, Q3U1P8, Q6PAN8, Q8C6V4, Q8R5K3, Q8VCG0, Q8WTY7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: September 11, 2007
Last modified: November 7, 2018
This is version 115 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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