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Entry version 163 (02 Jun 2021)
Sequence version 3 (27 Jul 2011)
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Protein

Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3

Gene

Arap3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Acts preferentially on ARF5 and on RHOA.

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-194840, Rho GTPase cycle

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3
Alternative name(s):
Centaurin-delta-3
Short name:
Cnt-d3
Dual specificity Rho- and Arf-GTPase-activating protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Arap3
Synonyms:Centd3, Drag1, Kiaa4097
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2147274, Arap3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi938R → L: Loss of Rho GAP activity. Enhances cell spreading. 1 Publication1
Mutagenesisi1399Y → F: Strongly reduces phosphorylation by CSK; when associated with F-1404. 1 Publication1
Mutagenesisi1404Y → F: Strongly reduces phosphorylation by CSK; when associated with F-1399. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000742161 – 1538Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3Add BLAST1538

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1344PhosphothreonineCombined sources1
Modified residuei1399Phosphotyrosine1 Publication1
Modified residuei1404PhosphotyrosineCombined sources1 Publication1
Modified residuei1438PhosphoserineBy similarity1
Modified residuei1474PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Tyrosine phosphorylated at a low basal level. PDGF treatment stimulates phosphorylation. Tyrosine phosphorylation is increased in cells that are in the process of becoming attached to a substrate and that start spreading and flattening.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8R5G7

PRoteomics IDEntifications database

More...
PRIDEi
Q8R5G7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
296280 [Q8R5G7-1]
296281 [Q8R5G7-2]
296282 [Q8R5G7-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8R5G7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8R5G7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000024451, Expressed in granulocyte and 246 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8R5G7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8R5G7, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via SAM domain) with INPPL1/SHIP2.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
223164, 6 interactors

Protein interaction database and analysis system

More...
IntActi
Q8R5G7, 5 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000035662

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8R5G7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8R5G7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini4 – 68SAMPROSITE-ProRule annotationAdd BLAST65
Domaini282 – 374PH 1PROSITE-ProRule annotationAdd BLAST93
Domaini389 – 478PH 2PROSITE-ProRule annotationAdd BLAST90
Domaini479 – 606Arf-GAPPROSITE-ProRule annotationAdd BLAST128
Domaini671 – 785PH 3PROSITE-ProRule annotationAdd BLAST115
Domaini795 – 901PH 4PROSITE-ProRule annotationAdd BLAST107
Domaini903 – 1084Rho-GAPPROSITE-ProRule annotationAdd BLAST182
Domaini1113 – 1206Ras-associatingPROSITE-ProRule annotationAdd BLAST94
Domaini1219 – 1321PH 5PROSITE-ProRule annotationAdd BLAST103

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni72 – 97DisorderedSequence analysisAdd BLAST26
Regioni125 – 149DisorderedSequence analysisAdd BLAST25
Regioni215 – 242DisorderedSequence analysisAdd BLAST28
Regioni1425 – 1538DisorderedSequence analysisAdd BLAST114

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi220 – 241Basic and acidic residuesSequence analysisAdd BLAST22
Compositional biasi1425 – 1443Polar residuesSequence analysisAdd BLAST19
Compositional biasi1467 – 1481Polar residuesSequence analysisAdd BLAST15
Compositional biasi1508 – 1538Pro residuesSequence analysisAdd BLAST31

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1117, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158869

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002900_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8R5G7

Identification of Orthologs from Complete Genome Data

More...
OMAi
TLNTMEM

Database of Orthologous Groups

More...
OrthoDBi
98944at2759

TreeFam database of animal gene trees

More...
TreeFami
TF105769

Family and domain databases

Conserved Domains Database

More...
CDDi
cd04385, RhoGAP_ARAP, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.150.50, 1 hit
1.10.555.10, 1 hit
2.30.29.30, 3 hits
3.30.40.160, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037278, ARFGAP/RecO
IPR001164, ArfGAP_dom
IPR038508, ArfGAP_dom_sf
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR000159, RA_dom
IPR008936, Rho_GTPase_activation_prot
IPR037858, RhoGAP_ARAP
IPR000198, RhoGAP_dom
IPR001660, SAM
IPR013761, SAM/pointed_sf
IPR029071, Ubiquitin-like_domsf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01412, ArfGap, 1 hit
PF00169, PH, 2 hits
PF00788, RA, 1 hit
PF00620, RhoGAP, 1 hit
PF07647, SAM_2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00405, REVINTRACTNG

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00105, ArfGap, 1 hit
SM00233, PH, 5 hits
SM00324, RhoGAP, 1 hit
SM00454, SAM, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47769, SSF47769, 1 hit
SSF48350, SSF48350, 1 hit
SSF54236, SSF54236, 1 hit
SSF57863, SSF57863, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50115, ARFGAP, 1 hit
PS50003, PH_DOMAIN, 3 hits
PS50200, RA, 1 hit
PS50238, RHOGAP, 1 hit
PS50105, SAM_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8R5G7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAPQDLDIA VWLALVHLEQ YADTFRRHGL ATAGAAQHLG HEELRHLGIS
60 70 80 90 100
ATGHRKRILR LLRAGSAEGF LDSHLDNTME PTPSPAPDAQ PPKPVPKPRT
110 120 130 140 150
VFGLSNPATA QRPGLSPIFW DPEVSRNSEC TQRSSPLLPS SSEQPSVPNT
160 170 180 190 200
MEMMPNAIYF GLDLRGRAQA AQDVTPDSSQ ATVPTPAFRP TTGTVHIMDP
210 220 230 240 250
GCLYYGVQPV GIPGASDRRD GRGVCQERAE HRQDLETRED AGYASLELPG
260 270 280 290 300
DSILSLPTQD AETSDDLISP YASFSSTADR PVPLLSGWLD KLSPQGNYVF
310 320 330 340 350
QRRFVQFNGR SLMYFGSDKD PFPKGVIPLT AIEMTRSSKD NKFQVITGQR
360 370 380 390 400
VFVFRTESEA QRDLWCSTLQ SCLKEQRLLG HPRPPHPPRP LRTGTLELRG
410 420 430 440 450
HKAKVFAALI PGELALYKSE QAFSLGIGIC FIELQGCSVR ETKSRSFDLL
460 470 480 490 500
TPHRCFSFTA ESGGARQSWA AALQEAVTET LSDYEVAEKV WSNPANRHCA
510 520 530 540 550
DCRASRPDWA AVNLGVVICK QCAGQHRALG SGISKVQSLK LDTSVWSNEI
560 570 580 590 600
VQLFIVLGND RANCFWAGAL PPGEGLHPDS APGPRGEFIS RKYKLGLFRK
610 620 630 640 650
PHPRHPDHSQ LLQALCAAMA GPNLLKNMAQ LLCVETSEGE EPLSPSALNG
660 670 680 690 700
SLLSLLPSDS PGVYNEVVVP ATYRGFLYCG SISNKAGAPP LRRGRDAPPR
710 720 730 740 750
LWCVLGAALE MFASESSPEP LSLLQPQDIV CLGVSPPPAD PGDLDRFPFS
760 770 780 790 800
FELILTGGRI QHFATDGADS LEAWISAVGK WFSPLSCHQL LGPGLLRMGR
810 820 830 840 850
LWLRSPSHAG LAPGLWLSGF GLLRGDHLFL CPAPGPGPPA PEDMVHLRRL
860 870 880 890 900
QEISVVSAAD TPDKKEHLVL VETGRTLYLQ GEGRLDFAAW NTAIGGAAGG
910 920 930 940 950
GGTGLQEQQM SRGDIPIIVD ACISFVTQHG LRLEGVYRKG GARARSLRLL
960 970 980 990 1000
AEFRRDARSV KLRPREHFVE DVTDTLKRFF RELDDPVTSA RLLPRWREAA
1010 1020 1030 1040 1050
ELSQKNQRLE KYKEVISCLP RVNRRTLATL IGHLYRVQKC ASLNQMCTRN
1060 1070 1080 1090 1100
LALLFAPSVF QTDGRGEHEV RVLQELIDGY ISVFDIDSDQ AAQIDLEVSL
1110 1120 1130 1140 1150
ITTWKDVQLS QAGDLIMEVY IEQQLPDNCV TLKVSPTLTA EELTNQVLEM
1160 1170 1180 1190 1200
RGAASGTDLW VTFEILEHGE LERPLHPKEK VLEQALQWCQ LPEPCSASLL
1210 1220 1230 1240 1250
LRKVSMAHAG CLFTGVRRES PRVGLLRCRE EPPRLLGNRF QERFFLVRGR
1260 1270 1280 1290 1300
CLLLLKEKKS SKPEREWSLE GAKVYLGIRK KLKPPTLWGF TLILEKMHLC
1310 1320 1330 1340 1350
LSCMDEEEMW DWTTSILKAQ HDDQQSVVLR RRSSSDLARQ KFGTMPLLPI
1360 1370 1380 1390 1400
RGDDSGATLL SANQTLRRLH NRRTLSMFFP MKSPQGSVEE QDELEEPVYE
1410 1420 1430 1440 1450
EPVYEEVGAF PELTKDTTFS STWEWSAKSD PSLTSQRSFD QPPLSKASML
1460 1470 1480 1490 1500
GHEERIPDPP PGPPSKSSSQ ARGSLEEQLL QELNNLILRK GEPASCPESS
1510 1520 1530
SQPTSPQAPS PTSLPTPTPS LPTQPPCTSN PPSSQPLT
Length:1,538
Mass (Da):169,741
Last modified:July 27, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD7E55C57FD4B83ED
GO
Isoform 2 (identifier: Q8R5G7-2) [UniParc]FASTAAdd to basket
Also known as: ARAP3 delta-SAM

The sequence of this isoform differs from the canonical sequence as follows:
     1-78: Missing.

Show »
Length:1,460
Mass (Da):161,171
Checksum:iC00130DB36CA8116
GO
Isoform 3 (identifier: Q8R5G7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-618: Missing.
     1446-1538: KASMLGHEER...SNPPSSQPLT → GPSPFVCTMKSLKEGEG

Show »
Length:844
Mass (Da):94,043
Checksum:i5742FA191BD0F796
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A494BA60A0A494BA60_MOUSE
Arf-GAP with Rho-GAP domain, ANK re...
Arap3
47Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494BAF2A0A494BAF2_MOUSE
Arf-GAP with Rho-GAP domain, ANK re...
Arap3
154Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494BA67A0A494BA67_MOUSE
Arf-GAP with Rho-GAP domain, ANK re...
Arap3
124Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAL78678 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAD90507 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti144Q → H in AAH68145 (PubMed:15489334).Curated1
Sequence conflicti167R → Q in AAL78677 (PubMed:15546919).Curated1
Sequence conflicti167R → Q in AAL78678 (PubMed:15546919).Curated1
Sequence conflicti1304M → T in AAL78677 (PubMed:15546919).Curated1
Sequence conflicti1304M → T in AAL78678 (PubMed:15546919).Curated1
Sequence conflicti1500S → P in AAL78677 (PubMed:15546919).Curated1
Sequence conflicti1500S → P in AAL78678 (PubMed:15546919).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0150021 – 618Missing in isoform 3. 1 PublicationAdd BLAST618
Alternative sequenceiVSP_0150031 – 78Missing in isoform 2. 1 PublicationAdd BLAST78
Alternative sequenceiVSP_0150041446 – 1538KASML…SQPLT → GPSPFVCTMKSLKEGEG in isoform 3. 1 PublicationAdd BLAST93

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF469621 mRNA Translation: AAL78677.1
AF469622 mRNA Translation: AAL78678.1 Different initiation.
AC121886 Genomic DNA No translation available.
AC129315 Genomic DNA No translation available.
BC068145 mRNA Translation: AAH68145.1
AK220486 mRNA Translation: BAD90507.1 Different initiation.

The Consensus CDS (CCDS) project

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CCDSi
CCDS29196.1 [Q8R5G7-1]
CCDS89225.1 [Q8R5G7-2]

NCBI Reference Sequences

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RefSeqi
NP_001192265.1, NM_001205336.1 [Q8R5G7-2]
NP_631945.2, NM_139206.2 [Q8R5G7-1]
XP_006525552.1, XM_006525489.1 [Q8R5G7-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000042944; ENSMUSP00000035662; ENSMUSG00000024451 [Q8R5G7-1]
ENSMUST00000237272; ENSMUSP00000157868; ENSMUSG00000024451 [Q8R5G7-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
106952

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:106952

UCSC genome browser

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UCSCi
uc008erq.2, mouse [Q8R5G7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF469621 mRNA Translation: AAL78677.1
AF469622 mRNA Translation: AAL78678.1 Different initiation.
AC121886 Genomic DNA No translation available.
AC129315 Genomic DNA No translation available.
BC068145 mRNA Translation: AAH68145.1
AK220486 mRNA Translation: BAD90507.1 Different initiation.
CCDSiCCDS29196.1 [Q8R5G7-1]
CCDS89225.1 [Q8R5G7-2]
RefSeqiNP_001192265.1, NM_001205336.1 [Q8R5G7-2]
NP_631945.2, NM_139206.2 [Q8R5G7-1]
XP_006525552.1, XM_006525489.1 [Q8R5G7-1]

3D structure databases

SMRiQ8R5G7
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi223164, 6 interactors
IntActiQ8R5G7, 5 interactors
STRINGi10090.ENSMUSP00000035662

PTM databases

iPTMnetiQ8R5G7
PhosphoSitePlusiQ8R5G7

Proteomic databases

PaxDbiQ8R5G7
PRIDEiQ8R5G7
ProteomicsDBi296280 [Q8R5G7-1]
296281 [Q8R5G7-2]
296282 [Q8R5G7-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
27363, 111 antibodies

The DNASU plasmid repository

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DNASUi
106952

Genome annotation databases

EnsembliENSMUST00000042944; ENSMUSP00000035662; ENSMUSG00000024451 [Q8R5G7-1]
ENSMUST00000237272; ENSMUSP00000157868; ENSMUSG00000024451 [Q8R5G7-2]
GeneIDi106952
KEGGimmu:106952
UCSCiuc008erq.2, mouse [Q8R5G7-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
64411
MGIiMGI:2147274, Arap3

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
Search...

Phylogenomic databases

eggNOGiKOG1117, Eukaryota
GeneTreeiENSGT00940000158869
HOGENOMiCLU_002900_1_0_1
InParanoidiQ8R5G7
OMAiTLNTMEM
OrthoDBi98944at2759
TreeFamiTF105769

Enzyme and pathway databases

ReactomeiR-MMU-194840, Rho GTPase cycle

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
106952, 0 hits in 52 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Arap3, mouse

Protein Ontology

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PROi
PR:Q8R5G7
RNActiQ8R5G7, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000024451, Expressed in granulocyte and 246 other tissues
ExpressionAtlasiQ8R5G7, baseline and differential
GenevisibleiQ8R5G7, MM

Family and domain databases

CDDicd04385, RhoGAP_ARAP, 1 hit
Gene3Di1.10.150.50, 1 hit
1.10.555.10, 1 hit
2.30.29.30, 3 hits
3.30.40.160, 1 hit
InterProiView protein in InterPro
IPR037278, ARFGAP/RecO
IPR001164, ArfGAP_dom
IPR038508, ArfGAP_dom_sf
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR000159, RA_dom
IPR008936, Rho_GTPase_activation_prot
IPR037858, RhoGAP_ARAP
IPR000198, RhoGAP_dom
IPR001660, SAM
IPR013761, SAM/pointed_sf
IPR029071, Ubiquitin-like_domsf
PfamiView protein in Pfam
PF01412, ArfGap, 1 hit
PF00169, PH, 2 hits
PF00788, RA, 1 hit
PF00620, RhoGAP, 1 hit
PF07647, SAM_2, 1 hit
PRINTSiPR00405, REVINTRACTNG
SMARTiView protein in SMART
SM00105, ArfGap, 1 hit
SM00233, PH, 5 hits
SM00324, RhoGAP, 1 hit
SM00454, SAM, 1 hit
SUPFAMiSSF47769, SSF47769, 1 hit
SSF48350, SSF48350, 1 hit
SSF54236, SSF54236, 1 hit
SSF57863, SSF57863, 1 hit
PROSITEiView protein in PROSITE
PS50115, ARFGAP, 1 hit
PS50003, PH_DOMAIN, 3 hits
PS50200, RA, 1 hit
PS50238, RHOGAP, 1 hit
PS50105, SAM_DOMAIN, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiARAP3_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8R5G7
Secondary accession number(s): E9QMK7
, Q5DTN4, Q6NVF1, Q8R5G6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: July 27, 2011
Last modified: June 2, 2021
This is version 163 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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