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Protein

Beta-centractin

Gene

Actr1b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome (By similarity).By similarity

GO - Molecular functioni

Keywordsi

LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-2132295 MHC class II antigen presentation
R-MMU-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-centractin
Alternative name(s):
Actin-related protein 1B
Short name:
ARP1B
Gene namesi
Name:Actr1b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1917446 Actr1b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000890611 – 376Beta-centractinAdd BLAST376

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei4Nitrated tyrosineCombined sources1

Keywords - PTMi

Acetylation, Nitration

Proteomic databases

EPDiQ8R5C5
MaxQBiQ8R5C5
PaxDbiQ8R5C5
PeptideAtlasiQ8R5C5
PRIDEiQ8R5C5

2D gel databases

UCD-2DPAGEiQ8R5C5

PTM databases

iPTMnetiQ8R5C5
PhosphoSitePlusiQ8R5C5

Expressioni

Gene expression databases

BgeeiENSMUSG00000037351 Expressed in 282 organ(s), highest expression level in cerebellum
CleanExiMM_ACTR1B
ExpressionAtlasiQ8R5C5 baseline and differential
GenevisibleiQ8R5C5 MM

Interactioni

Protein-protein interaction databases

BioGridi230579, 30 interactors
IntActiQ8R5C5, 32 interactors
MINTiQ8R5C5
STRINGi10090.ENSMUSP00000047326

Structurei

3D structure databases

ProteinModelPortaliQ8R5C5
SMRiQ8R5C5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the actin family. ARP1 subfamily.Curated

Phylogenomic databases

eggNOGiKOG0676 Eukaryota
COG5277 LUCA
GeneTreeiENSGT00760000118957
HOGENOMiHOG000233340
HOVERGENiHBG003771
InParanoidiQ8R5C5
KOiK16575
OMAiISAPNER
OrthoDBiEOG091G08LD
PhylomeDBiQ8R5C5
TreeFamiTF300420

Family and domain databases

InterProiView protein in InterPro
IPR004000 Actin
IPR020902 Actin/actin-like_CS
IPR004001 Actin_CS
IPR029909 Arp1
PANTHERiPTHR11937 PTHR11937, 1 hit
PTHR11937:SF195 PTHR11937:SF195, 1 hit
PfamiView protein in Pfam
PF00022 Actin, 1 hit
PRINTSiPR00190 ACTIN
SMARTiView protein in SMART
SM00268 ACTIN, 1 hit
PROSITEiView protein in PROSITE
PS00432 ACTINS_2, 1 hit
PS01132 ACTINS_ACT_LIKE, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8R5C5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MESYDIIANQ PVVIDNGSGV IKAGFAGDQI PKYCFPNYVG RPKHMRVMAG
60 70 80 90 100
ALEGDLFIGP KAEEHRGLLT IRYPMEHGVV RDWNDMERIW QYVYSKDQLQ
110 120 130 140 150
TFSEEHPVLL TEAPLNPSKN REKAAEVFFE TFNVPALFIS MQAVLSLYAT
160 170 180 190 200
GRTTGVVLDS GDGVTHAVPI YEGFAMPHSI MRVDIAGRDV SRYLRLLLRK
210 220 230 240 250
EGADFHTSAE FEVVRTIKER ACYLSINPQK DEALETEKVQ YTLPDGSTLD
260 270 280 290 300
VGPARFRAPE LLFQPDLVGD ESEGLHEVLA FAIHKSDMDL RRTLFSNIVL
310 320 330 340 350
SGGSTLFKGF GDRLLSEVKK LAPKDVKIKI SAPQERLYST WIGGSILASL
360 370
DTFKKMWVSK KEYEEDGSRA IHRKTF
Length:376
Mass (Da):42,281
Last modified:June 1, 2002 - v1
Checksum:iC038D186113C1A69
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E0CYB4E0CYB4_MOUSE
Beta-centractin
Actr1b
149Annotation score:
E0CZD4E0CZD4_MOUSE
Beta-centractin
Actr1b
142Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK088839 mRNA Translation: BAC40604.1
BC023020 mRNA Translation: AAH23020.1
CCDSiCCDS14887.1
RefSeqiNP_666219.1, NM_146107.2
UniGeneiMm.28521

Genome annotation databases

EnsembliENSMUST00000043951; ENSMUSP00000047326; ENSMUSG00000037351
GeneIDi226977
KEGGimmu:226977
UCSCiuc007aqx.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK088839 mRNA Translation: BAC40604.1
BC023020 mRNA Translation: AAH23020.1
CCDSiCCDS14887.1
RefSeqiNP_666219.1, NM_146107.2
UniGeneiMm.28521

3D structure databases

ProteinModelPortaliQ8R5C5
SMRiQ8R5C5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230579, 30 interactors
IntActiQ8R5C5, 32 interactors
MINTiQ8R5C5
STRINGi10090.ENSMUSP00000047326

PTM databases

iPTMnetiQ8R5C5
PhosphoSitePlusiQ8R5C5

2D gel databases

UCD-2DPAGEiQ8R5C5

Proteomic databases

EPDiQ8R5C5
MaxQBiQ8R5C5
PaxDbiQ8R5C5
PeptideAtlasiQ8R5C5
PRIDEiQ8R5C5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000043951; ENSMUSP00000047326; ENSMUSG00000037351
GeneIDi226977
KEGGimmu:226977
UCSCiuc007aqx.1 mouse

Organism-specific databases

CTDi10120
MGIiMGI:1917446 Actr1b

Phylogenomic databases

eggNOGiKOG0676 Eukaryota
COG5277 LUCA
GeneTreeiENSGT00760000118957
HOGENOMiHOG000233340
HOVERGENiHBG003771
InParanoidiQ8R5C5
KOiK16575
OMAiISAPNER
OrthoDBiEOG091G08LD
PhylomeDBiQ8R5C5
TreeFamiTF300420

Enzyme and pathway databases

ReactomeiR-MMU-2132295 MHC class II antigen presentation
R-MMU-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRSiActr1b mouse
PROiPR:Q8R5C5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037351 Expressed in 282 organ(s), highest expression level in cerebellum
CleanExiMM_ACTR1B
ExpressionAtlasiQ8R5C5 baseline and differential
GenevisibleiQ8R5C5 MM

Family and domain databases

InterProiView protein in InterPro
IPR004000 Actin
IPR020902 Actin/actin-like_CS
IPR004001 Actin_CS
IPR029909 Arp1
PANTHERiPTHR11937 PTHR11937, 1 hit
PTHR11937:SF195 PTHR11937:SF195, 1 hit
PfamiView protein in Pfam
PF00022 Actin, 1 hit
PRINTSiPR00190 ACTIN
SMARTiView protein in SMART
SM00268 ACTIN, 1 hit
PROSITEiView protein in PROSITE
PS00432 ACTINS_2, 1 hit
PS01132 ACTINS_ACT_LIKE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiACTY_MOUSE
AccessioniPrimary (citable) accession number: Q8R5C5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: June 1, 2002
Last modified: November 7, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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