UniProtKB - Q8R574 (KPRB_MOUSE)
Protein
Phosphoribosyl pyrophosphate synthase-associated protein 2
Gene
Prpsap2
Organism
Mus musculus (Mouse)
Status
Functioni
Seems to play a negative regulatory role in 5-phosphoribose 1-diphosphate synthesis.By similarity
GO - Molecular functioni
- identical protein binding Source: MGI
- magnesium ion binding Source: InterPro
- ribose phosphate diphosphokinase activity Source: GO_Central
GO - Biological processi
- 5-phosphoribose 1-diphosphate biosynthetic process Source: GO_Central
- bone development Source: MGI
- nucleoside metabolic process Source: InterPro
- purine nucleotide biosynthetic process Source: GO_Central
Keywordsi
Biological process | Nucleotide biosynthesis |
Names & Taxonomyi
Protein namesi | Recommended name: Phosphoribosyl pyrophosphate synthase-associated protein 2Short name: PRPP synthase-associated protein 2 Alternative name(s): 41 kDa phosphoribosypyrophosphate synthetase-associated protein Short name: PAP41 |
Gene namesi | Name:Prpsap2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2384838, Prpsap2 |
Subcellular locationi
Other locations
- cytoplasm Source: GO_Central
- protein-containing complex Source: MGI
- ribose phosphate diphosphokinase complex Source: MGI
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000141083 | 1 – 369 | Phosphoribosyl pyrophosphate synthase-associated protein 2Add BLAST | 369 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineBy similarity | 1 | |
Modified residuei | 219 | PhosphoserineBy similarity | 1 | |
Modified residuei | 227 | PhosphoserineCombined sources | 1 | |
Modified residuei | 233 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q8R574 |
jPOSTi | Q8R574 |
MaxQBi | Q8R574 |
PaxDbi | Q8R574 |
PRIDEi | Q8R574 |
ProteomicsDBi | 264794 |
PTM databases
iPTMneti | Q8R574 |
PhosphoSitePlusi | Q8R574 |
SwissPalmi | Q8R574 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000020528, Expressed in secondary oocyte and 67 other tissues |
ExpressionAtlasi | Q8R574, baseline and differential |
Genevisiblei | Q8R574, MM |
Interactioni
Subunit structurei
Binds to PRPS1 and PRPS2.
By similarityGO - Molecular functioni
- identical protein binding Source: MGI
Protein-protein interaction databases
IntActi | Q8R574, 1 interactor |
STRINGi | 10090.ENSMUSP00000004955 |
Miscellaneous databases
RNActi | Q8R574, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the ribose-phosphate pyrophosphokinase family.Curated
Phylogenomic databases
eggNOGi | KOG1503, Eukaryota |
GeneTreei | ENSGT00950000182803 |
HOGENOMi | CLU_033546_0_0_1 |
InParanoidi | Q8R574 |
OMAi | HYAYARS |
OrthoDBi | 1043963at2759 |
PhylomeDBi | Q8R574 |
TreeFami | TF106367 |
Family and domain databases
CDDi | cd06223, PRTases_typeI, 1 hit |
InterProi | View protein in InterPro IPR029099, Pribosyltran_N IPR000836, PRibTrfase_dom IPR029057, PRTase-like IPR005946, Rib-P_diPkinase |
PANTHERi | PTHR10210, PTHR10210, 1 hit |
Pfami | View protein in Pfam PF14572, Pribosyl_synth, 1 hit PF13793, Pribosyltran_N, 1 hit |
SUPFAMi | SSF53271, SSF53271, 2 hits |
TIGRFAMsi | TIGR01251, ribP_PPkin, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8R574-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFCVAPPELE TKMNITKGGL VLFSANSNSS CMELSKKIAE RLGVEMGKVQ
60 70 80 90 100
VYQEPNRETR VQIQESVRGK DVFIIQTISK DVNTTIMELL IMVYACKTSC
110 120 130 140 150
AKSIIGVIPY FPYSKQCKMR KRGSIVSKLL ASMMCKAGLT HLITMDLHQK
160 170 180 190 200
EIQGFFNIPV DNLRASPFLL QYIQEEIPDY RNAVIVAKSP ASAKRAQSFA
210 220 230 240 250
ERLRLGIAVI HGEAQDAESD LVDGRHSPPM VRSVAAIHPS LEIPMLIPKE
260 270 280 290 300
KPPITVVGDV GGRIAIIVDD IIDDVDSFLA AAETLKERGA YKIFVMATHG
310 320 330 340 350
LLSSDAPRLI EESAIDEVVV TNTIPHEIQK LQCPKIKTVD ISMILSEAIR
360
RIHNGESMSY LFRNIGLDD
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK076811 mRNA Translation: BAC36491.1 BC023178 mRNA Translation: AAH23178.1 |
CCDSi | CCDS24819.1 |
RefSeqi | NP_001157714.1, NM_001164242.1 NP_659055.1, NM_144806.2 XP_006532824.1, XM_006532761.3 |
Genome annotation databases
Ensembli | ENSMUST00000004955; ENSMUSP00000004955; ENSMUSG00000020528 ENSMUST00000168115; ENSMUSP00000126274; ENSMUSG00000020528 |
GeneIDi | 212627 |
KEGGi | mmu:212627 |
UCSCi | uc007jie.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK076811 mRNA Translation: BAC36491.1 BC023178 mRNA Translation: AAH23178.1 |
CCDSi | CCDS24819.1 |
RefSeqi | NP_001157714.1, NM_001164242.1 NP_659055.1, NM_144806.2 XP_006532824.1, XM_006532761.3 |
3D structure databases
SMRi | Q8R574 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q8R574, 1 interactor |
STRINGi | 10090.ENSMUSP00000004955 |
PTM databases
iPTMneti | Q8R574 |
PhosphoSitePlusi | Q8R574 |
SwissPalmi | Q8R574 |
Proteomic databases
EPDi | Q8R574 |
jPOSTi | Q8R574 |
MaxQBi | Q8R574 |
PaxDbi | Q8R574 |
PRIDEi | Q8R574 |
ProteomicsDBi | 264794 |
Protocols and materials databases
Antibodypediai | 13570, 143 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000004955; ENSMUSP00000004955; ENSMUSG00000020528 ENSMUST00000168115; ENSMUSP00000126274; ENSMUSG00000020528 |
GeneIDi | 212627 |
KEGGi | mmu:212627 |
UCSCi | uc007jie.2, mouse |
Organism-specific databases
CTDi | 5636 |
MGIi | MGI:2384838, Prpsap2 |
Phylogenomic databases
eggNOGi | KOG1503, Eukaryota |
GeneTreei | ENSGT00950000182803 |
HOGENOMi | CLU_033546_0_0_1 |
InParanoidi | Q8R574 |
OMAi | HYAYARS |
OrthoDBi | 1043963at2759 |
PhylomeDBi | Q8R574 |
TreeFami | TF106367 |
Miscellaneous databases
BioGRID-ORCSi | 212627, 1 hit in 53 CRISPR screens |
ChiTaRSi | Prpsap2, mouse |
PROi | PR:Q8R574 |
RNActi | Q8R574, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000020528, Expressed in secondary oocyte and 67 other tissues |
ExpressionAtlasi | Q8R574, baseline and differential |
Genevisiblei | Q8R574, MM |
Family and domain databases
CDDi | cd06223, PRTases_typeI, 1 hit |
InterProi | View protein in InterPro IPR029099, Pribosyltran_N IPR000836, PRibTrfase_dom IPR029057, PRTase-like IPR005946, Rib-P_diPkinase |
PANTHERi | PTHR10210, PTHR10210, 1 hit |
Pfami | View protein in Pfam PF14572, Pribosyl_synth, 1 hit PF13793, Pribosyltran_N, 1 hit |
SUPFAMi | SSF53271, SSF53271, 2 hits |
TIGRFAMsi | TIGR01251, ribP_PPkin, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KPRB_MOUSE | |
Accessioni | Q8R574Primary (citable) accession number: Q8R574 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 25, 2002 |
Last sequence update: | June 1, 2002 | |
Last modified: | April 7, 2021 | |
This is version 137 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families