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Protein

Ankyrin repeat domain-containing protein 1

Gene

Ankrd1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes.2 Publications

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 1
Alternative name(s):
Cardiac adriamycin-responsive protein
Cardiac ankyrin repeat protein
Gene namesi
Name:Ankrd1
Synonyms:Carp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi61989 Ankrd1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002404831 – 319Ankyrin repeat domain-containing protein 1Add BLAST319

Proteomic databases

PaxDbiQ8R560
PRIDEiQ8R560

Expressioni

Tissue specificityi

Expressed in heart, cardiac muscle.1 Publication

Inductioni

Down-regulated by doxorubicin (adriamycin), in vitro.1 Publication

Gene expression databases

BgeeiENSRNOG00000018598
GenevisibleiQ8R560 RN

Interactioni

Subunit structurei

Interacts with TTN/titin (By similarity). Interacts with YBX1.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PDE4DIPQ5VU43-112EBI-10817505,EBI-10769071From a different organism.

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ8R560, 1 interactor
STRINGi10116.ENSRNOP00000025258

Structurei

3D structure databases

ProteinModelPortaliQ8R560
SMRiQ8R560
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati152 – 181ANK 1Add BLAST30
Repeati185 – 214ANK 2Add BLAST30
Repeati218 – 247ANK 3Add BLAST30
Repeati251 – 280ANK 4Add BLAST30
Repeati284 – 315ANK 5Add BLAST32

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili55 – 89Sequence analysisAdd BLAST35

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00910000144039
HOGENOMiHOG000236321
HOVERGENiHBG071561
InParanoidiQ8R560
KOiK21433
OMAiKGDPNVC
OrthoDBiEOG091G0DCN
PhylomeDBiQ8R560
TreeFamiTF331650

Family and domain databases

CDDicd00204 ANK, 2 hits
Gene3Di1.25.40.20, 2 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 4 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 4 hits

Sequencei

Sequence statusi: Complete.

Q8R560-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMVFRVEELV TGKKNSNGSS GEFLPGEFRN GEYEAAVALE KQEDLKTLPA
60 70 80 90 100
NSVNLGEEQR KSEKVREAEL KKKKLEQRSK LENLEDLEII VQLKKRKKYK
110 120 130 140 150
KTKVPVVKEP EPEIITEPVD VPRFLKAALE NKLPVVEKFL SDKNSPDVCD
160 170 180 190 200
EYKRTALHRA CLEGHLAIVE KLMEAGAQIE FRDMLESTAI HWACRGGNLD
210 220 230 240 250
VLKLLLNKGA KISARDKLLS TALHVAVRTG HYECAEHLIA CEADLNAKDR
260 270 280 290 300
EGDTPLHDAV RLNRYKMIRL LMTFGADLNV KNCAGKTPMD LVLHWQNGTK
310
AIFDSLKENA YKNSRIATF
Length:319
Mass (Da):36,064
Last modified:June 1, 2002 - v1
Checksum:iE760BF7BFD6049E0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti287T → I in AAD10401 (PubMed:9278441).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L81174 mRNA Translation: AAL77519.1
U50736 mRNA Translation: AAD10401.1
BC072699 mRNA Translation: AAH72699.1
RefSeqiNP_037352.1, NM_013220.1
UniGeneiRn.3789

Genome annotation databases

EnsembliENSRNOT00000025258; ENSRNOP00000025258; ENSRNOG00000018598
GeneIDi27064
KEGGirno:27064
UCSCiRGD:61989 rat

Similar proteinsi

Entry informationi

Entry nameiANKR1_RAT
AccessioniPrimary (citable) accession number: Q8R560
Secondary accession number(s): Q9Z1F0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 1, 2002
Last modified: June 20, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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