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Entry version 111 (22 Apr 2020)
Sequence version 2 (19 Feb 2014)
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Protein

Polycystic kidney disease protein 1-like 1

Gene

Pkd1l1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of a ciliary calcium channel that controls calcium concentration within primary cilia without affecting cytoplasmic calcium concentration. Forms a heterodimer with PKD2L1 in primary cilia and forms a calcium-permeant ciliary channel that regulates sonic hedgehog/SHH signaling and GLI2 transcription. Does not constitute the pore-forming subunit. Also involved in left/right axis specification downstream of nodal flow: forms a complex with PKD2 in cilia to facilitate flow detection in left/right patterning.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalcium channel, Ion channel
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Polycystic kidney disease protein 1-like 1
Alternative name(s):
PC1-like 1 protein
Polycystin-1L1
Protein rikishi
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Pkd1l1
Synonyms:Rks
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2156538 Pkd1l1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 1524ExtracellularSequence analysisAdd BLAST1524
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1525 – 1545HelicalSequence analysisAdd BLAST21
Topological domaini1546 – 1732CytoplasmicSequence analysisAdd BLAST187
Transmembranei1733 – 1753HelicalSequence analysisAdd BLAST21
Topological domaini1754 – 1772ExtracellularSequence analysisAdd BLAST19
Transmembranei1773 – 1793HelicalSequence analysisAdd BLAST21
Topological domaini1794 – 1905CytoplasmicSequence analysisAdd BLAST112
Transmembranei1906 – 1926HelicalSequence analysisAdd BLAST21
Topological domaini1927 – 1950ExtracellularSequence analysisAdd BLAST24
Transmembranei1951 – 1971HelicalSequence analysisAdd BLAST21
Topological domaini1972 – 2057CytoplasmicSequence analysisAdd BLAST86
Transmembranei2058 – 2078HelicalSequence analysisAdd BLAST21
Topological domaini2079 – 2288ExtracellularSequence analysisAdd BLAST210
Transmembranei2289 – 2309HelicalSequence analysisAdd BLAST21
Topological domaini2310 – 2332CytoplasmicSequence analysisAdd BLAST23
Transmembranei2333 – 2353HelicalSequence analysisAdd BLAST21
Topological domaini2354 – 2379ExtracellularSequence analysisAdd BLAST26
Transmembranei2380 – 2400HelicalSequence analysisAdd BLAST21
Topological domaini2401 – 2405CytoplasmicSequence analysis5
Transmembranei2406 – 2426HelicalSequence analysisAdd BLAST21
Topological domaini2427 – 2483ExtracellularSequence analysisAdd BLAST57
Transmembranei2484 – 2504HelicalSequence analysisAdd BLAST21
Topological domaini2505 – 2615CytoplasmicSequence analysisAdd BLAST111

Keywords - Cellular componenti

Cell membrane, Cell projection, Cilium, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Situs inversus in approximately one third of the homozygous mutant mice. No other notable phenotype (such as espiratory tract lesions, hydrocephalus, and male infertility) is observed.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi411D → G in rks; mice exhibit gross left-right abnormalities. Embryos do not show defects in kidney development. The nodes appear normal. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001643591 – 2615Polycystic kidney disease protein 1-like 1Add BLAST2615

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi224N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi297N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi306N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi390N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi440N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi534N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi619N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1458N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1510N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8R526

PRoteomics IDEntifications database

More...
PRIDEi
Q8R526

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8R526

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8R526

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

In testis, strong expression in Leydig cells, low level in seminal ducts, myoid cells and tunica vaginalis. Other tissues, including adrenal gland and heart myocardium, also show low expression. In embryo, highly expressed in the node.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer; heterodimerizes with PKD2 proteins to form a calcium channel.

Interacts with PKD2L1; to form ciliary calcium channel.

Interacts with PKD2.

1 Publication

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000120803

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8R526 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini291 – 373PKD 1PROSITE-ProRule annotationAdd BLAST83
Domaini375 – 456PKD 2PROSITE-ProRule annotationAdd BLAST82
Domaini457 – 1349REJPROSITE-ProRule annotationAdd BLAST893
Domaini1465 – 1511GPSAdd BLAST47
Domaini1573 – 1690PLATPROSITE-ProRule annotationAdd BLAST118

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the polycystin family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IQ5F Eukaryota
ENOG410ZBZ7 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8R526

TreeFam database of animal gene trees

More...
TreeFami
TF316484

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013783 Ig-like_fold
IPR022409 PKD/Chitinase_dom
IPR002859 PKD/REJ-like
IPR013122 PKD1_2_channel
IPR000601 PKD_dom
IPR035986 PKD_dom_sf
IPR001024 PLAT/LH2_dom
IPR036392 PLAT/LH2_dom_sf
IPR014010 REJ_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00801 PKD, 1 hit
PF08016 PKD_channel, 1 hit
PF01477 PLAT, 1 hit
PF02010 REJ, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00308 LH2, 1 hit
SM00089 PKD, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49299 SSF49299, 2 hits
SSF49723 SSF49723, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50093 PKD, 1 hit
PS50095 PLAT, 1 hit
PS51111 REJ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8R526-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDVDEDQHAV AVLHHKIQAN PELCVSDEQD SCPSDAPKGT ARDPESQKPS
60 70 80 90 100
SPAPWDKNVL NTGSEERLSF INGEPQAPPN WDEGTNSFSN PPPGISHTCN
110 120 130 140 150
LSASWYHPES SSPLTQHPPR ATLVTQPENV EHFAICCFPE TDAQALPALG
160 170 180 190 200
IRVHVASGTA LCLLLDFGDN CGAQMRLCTL AGATTVTGYH QYRKEGVYEL
210 220 230 240 250
KAVVHDFHRA EELGPYYVDI SHGNVSVFMN SSSIHDSEAL SFADSLPQQR
260 270 280 290 300
GTVVVHCFSS ISSYNVSFIS QTQVASGQAW CGVTVGYKMQ SVSVYTNGTV
310 320 330 340 350
FAANTNITFV AITEETIPLE FAWYFGENPP VMTTSRSIRR RLSVPQWYRV
360 370 380 390 400
KVKATSRIGS VVSEPHLIRV QKRIMANRLV STASALVNAN VSFECRLNFG
410 420 430 440 450
TDVAYLWNFG DDTIELGSSS SSHVYSREGE FTVEVLAFNN VSSTTLRKQL
460 470 480 490 500
FIVREPCQPP PVKNMGPAKV QIWRSQPLRL GVTFEAAILC NISQGLSYTW
510 520 530 540 550
SFVSAEMTTV TLPTAVNTRR QTIMLPSYTL ECGNYTAIAK VQIKGSMVYS
560 570 580 590 600
NYCVGVEVRA RAPVSVISEG THIFISTATS TFIILRGAQS YDPDNPGAAL
610 620 630 640 650
RYHWTCTAAS SPRWPCFDNS TSYQVDTQAP AISFPAKWLS ECCDQFLVTL
660 670 680 690 700
TVSSRGQNSS QALMFLSTRP DLAFRFVHIS WVNFRDISVN WNEEVSLRAV
710 720 730 740 750
CEDCGDVPDL TYSWDLFLVN ATEKSAVEVP FCSTVGLLGA LALGTSLKSS
760 770 780 790 800
KSDLPSNLRA PLTPHSPEPS PTPLGWTALS NLGSISAEST AGGHHVPASG
810 820 830 840 850
AVAGSGEPME EYSSLSSLAE EALMTNSSEG SWPSPSSSTD FDDFEAYYSD
860 870 880 890 900
IQEAVLSLGR QPGTSTNFQE AGPSLSAEES ASYGDNLLGP FLHTGRAKPT
910 920 930 940 950
LMIDWPKALV SQAAFHGYTT SGIMGPAVTI KPFSLSSGKT YVLQASVASK
960 970 980 990 1000
HVLLGKAQLY LTVNQAPQDM SCQVRPHHGM EAYTIFSVFC MSGKPDFHYE
1010 1020 1030 1040 1050
FRYRIGNTSS HTLYRGQDTQ HYFLLPAGDS SDNYKVIVST EITDGHGSKV
1060 1070 1080 1090 1100
QPCTVAVTVL PRYHGNDCCD KELYNSTLES LSTLRLAGSY METRNYITMI
1110 1120 1130 1140 1150
TGILSRLYVE SRNTSSCGQW SQIQDVLISS ACKVPYTDQE GMMDSIHILR
1160 1170 1180 1190 1200
DLISFPNKLS LTSAMCIFKY TKMFLAQGQF SRRLLVDKKL RVEFVLLISG
1210 1220 1230 1240 1250
VWEAAKEDAR DGDYLQEEGM KIISDMLLAC LSDEHQIHVS TGQMEFQTLL
1260 1270 1280 1290 1300
HRSPQSSIQN LGFVQVHFPS DLASLHSTTQ EATQSSCYIS QLMFFMKSPY
1310 1320 1330 1340 1350
LGGQVPGQVG GVMIPRLYSC ESRRPILRGQ LETPVTMEFG EEDYLHKRNP
1360 1370 1380 1390 1400
AMFVLLRDEV NVHRFTGLSE NSQESLQIHI KFSKPVTRPF PIILLVRFSE
1410 1420 1430 1440 1450
KATPSDFLVK RVYFWDEQTV QMYVPAAPWK GANVGYLSLL DADYDRKPPN
1460 1470 1480 1490 1500
KYLAGAVNYT VHFQWIQCVF WDKTEWRSEG PYPQPGSSPE KVNCSYHHLA
1510 1520 1530 1540 1550
PVSVLRRKLN ATLEVSSISE FQSHPHNLLP GIFSAFLLVL YGILVSKSRY
1560 1570 1580 1590 1600
VDCHEKKNPG FIFLEEDTLP GYQLYAVVID TGFRSPVRFT SKVFIVLCGE
1610 1620 1630 1640 1650
NGCSETKELC CPEKPLFGRN SRHTFILSIP NQLGPLQKIR LWHDSSGSSP
1660 1670 1680 1690 1700
CWFISHVMVK ELCSGQAWFF SAQCWLAVSK LGGHVLREFF CLSHGLGFWK
1710 1720 1730 1740 1750
LFYSKFTEYL EDFHIWLSLY SQPPSRSYLH TQRLAVSFCL LCVYSCLTAL
1760 1770 1780 1790 1800
VTVRDHQQRP LDVGPTAITL EPFCMALLCT LLACPVAQLL SLLFRCSKEA
1810 1820 1830 1840 1850
RGDMQASTQW PLRGVKTETP QGHDSSGRPD SRQPSPHPTS DLLPWNDQAW
1860 1870 1880 1890 1900
RIAASSSAVV CSPFPMEACS HKHHDLREKS HYSPPSSQAP GSGFEELGSQ
1910 1920 1930 1940 1950
KSRVCLLWSS SVAWAISGSA SLACGLGTGF LGYWFVPAQC MWWLYLLLLS
1960 1970 1980 1990 2000
LVCCAFITQP LMICLAALVF AWKRKHDSKF FTESLQDATK GLDLELEEHS
2010 2020 2030 2040 2050
RTRVPLSPIS YSPDTAEEAE RVLATRQRER HLRWAQTPSK AKLRVTGERL
2060 2070 2080 2090 2100
RRESIMQAAL RDMTTHSIML LLLLFIAYGR FCPGEISLNH AIRKAFTRKA
2110 2120 2130 2140 2150
NHSLGDLSST EDWWDWTLST LLDELYPERT SARAWGAQPG ALGGQCHLIG
2160 2170 2180 2190 2200
PPVVKLLKIS AGTACTPPRP FSELVEDVLP MHSNDLDLEN QNVSPGGPET
2210 2220 2230 2240 2250
CGVKKESYMH SLGKTRHEAH AALTALRASK WIDHSTRAMS VHFTLYNPPT
2260 2270 2280 2290 2300
QLFTSVILGT ECLPSGGLVP SFLVESFRIF YSDSALKYLL MLSELLFLVL
2310 2320 2330 2340 2350
NVIHLCFQLW GMTTKGILSY WRKPRHWLEL SMVGVAIAYY AASGHLTTLA
2360 2370 2380 2390 2400
VNITDQFHKG LYQRLVDIGL MVSWHQRARC LQGILLFLWM LKYVHLLSSL
2410 2420 2430 2440 2450
STMTPFSAVT CFPLFRVLLV GALLLAAHYH SRWFLLFTGT LSHGTSAEAF
2460 2470 2480 2490 2500
PGLLLQFPGR SKKDSWHNCL KSDHGVMRCY YGTLFLLLAT LGFRMLRATF
2510 2520 2530 2540 2550
LTVFQNRKSS HRKPLVTLKD IAVYTWHKVL TLLGLETTLE ETEVATDHIY
2560 2570 2580 2590 2600
YLDEFSSLLD ELLMKIDGLS DSLELSILEN QWKRALESRA GDSPPVGSSE
2610
YQATGVSGPL AAESE
Length:2,615
Mass (Da):290,844
Last modified:February 19, 2014 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEBA1538C9D3AB74C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MQK4A0A0A0MQK4_MOUSE
Polycystic kidney disease protein 1...
Pkd1l1
2,521Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MQP1A0A0A0MQP1_MOUSE
Polycystic kidney disease protein 1...
Pkd1l1
2,070Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1680 – 1681KL → RQ in BAB85808 (PubMed:11863367).Curated2
Sequence conflicti1699 – 1700WK → LQ in BAB85808 (PubMed:11863367).Curated2
Sequence conflicti1789L → F in BAB85808 (PubMed:11863367).Curated1
Sequence conflicti1833Q → H in BAB85808 (PubMed:11863367).Curated1
Sequence conflicti1846N → T in BAB85808 (PubMed:11863367).Curated1

Sequence databases

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EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AL645571 Genomic DNA No translation available.
AB061684 mRNA Translation: BAB85808.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL645571 Genomic DNA No translation available.
AB061684 mRNA Translation: BAB85808.1

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000120803

PTM databases

iPTMnetiQ8R526
PhosphoSitePlusiQ8R526

Proteomic databases

PaxDbiQ8R526
PRIDEiQ8R526

Organism-specific databases

MGIiMGI:2156538 Pkd1l1

Phylogenomic databases

eggNOGiENOG410IQ5F Eukaryota
ENOG410ZBZ7 LUCA
InParanoidiQ8R526
TreeFamiTF316484

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Pkd1l1 mouse

Protein Ontology

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PROi
PR:Q8R526
RNActiQ8R526 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR022409 PKD/Chitinase_dom
IPR002859 PKD/REJ-like
IPR013122 PKD1_2_channel
IPR000601 PKD_dom
IPR035986 PKD_dom_sf
IPR001024 PLAT/LH2_dom
IPR036392 PLAT/LH2_dom_sf
IPR014010 REJ_dom
PfamiView protein in Pfam
PF00801 PKD, 1 hit
PF08016 PKD_channel, 1 hit
PF01477 PLAT, 1 hit
PF02010 REJ, 1 hit
SMARTiView protein in SMART
SM00308 LH2, 1 hit
SM00089 PKD, 2 hits
SUPFAMiSSF49299 SSF49299, 2 hits
SSF49723 SSF49723, 1 hit
PROSITEiView protein in PROSITE
PS50093 PKD, 1 hit
PS50095 PLAT, 1 hit
PS51111 REJ, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPK1L1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8R526
Secondary accession number(s): F6VYK1, J3QMZ2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: February 19, 2014
Last modified: April 22, 2020
This is version 111 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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