Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 150 (18 Sep 2019)
Sequence version 2 (05 Jul 2005)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

E3 ubiquitin-protein ligase MIB2

Gene

Mib2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC:2.3.2.27

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri85 – 132ZZ-typePROSITE-ProRule annotationAdd BLAST48
Zinc fingeri850 – 885RING-type 1PROSITE-ProRule annotationAdd BLAST36
Zinc fingeri929 – 962RING-type 2PROSITE-ProRule annotationAdd BLAST34

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding, Transferase
Biological processNotch signaling pathway, Ubl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
E3 ubiquitin-protein ligase MIB2 (EC:2.3.2.27)
Alternative name(s):
Dystrophin-like protein
Short name:
Dyslike
Mind bomb homolog 2
Short name:
Mind bomb-2
RING-type E3 ubiquitin transferase MIB2Curated
Skeletrophin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Mib2
Synonyms:Skd
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2679684 Mib2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi874C → S: No effect. 1 Publication1
Mutagenesisi951C → S: Abolishes ubiquitin ligase activity. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000559481 – 973E3 ubiquitin-protein ligase MIB2Add BLAST973

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei251PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated. Possibly via autoubiquitination.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q8R516

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8R516

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8R516

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in brain, heart, liver and kidney.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Highly expressed in neonate and adult, but only slightly in embryos. In 10.5 dpc embryos, it is weakly expressed in the tail bud and limb buds. Expressed in the same pattern than MIB1 in the skin and intestine at postnatal day 1 (P1) and in the hair follicle in the skin in the adult.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000029060 Expressed in 265 organ(s), highest expression level in cerebellum

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8R516 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8R516 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with actin monomer.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
218188, 9 interactors

Protein interaction database and analysis system

More...
IntActi
Q8R516, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000099465

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8R516

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 80MIB/HERC2 1PROSITE-ProRule annotationAdd BLAST80
Domaini149 – 227MIB/HERC2 2PROSITE-ProRule annotationAdd BLAST79
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati480 – 509ANK 1Add BLAST30
Repeati513 – 542ANK 2Add BLAST30
Repeati546 – 575ANK 3Add BLAST30
Repeati579 – 611ANK 4Add BLAST33
Repeati615 – 644ANK 5Add BLAST30
Repeati649 – 679ANK 6Add BLAST31
Repeati683 – 712ANK 7Add BLAST30
Repeati716 – 744ANK 8Add BLAST29
Repeati785 – 814ANK 9Add BLAST30

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri85 – 132ZZ-typePROSITE-ProRule annotationAdd BLAST48
Zinc fingeri850 – 885RING-type 1PROSITE-ProRule annotationAdd BLAST36
Zinc fingeri929 – 962RING-type 2PROSITE-ProRule annotationAdd BLAST34

Keywords - Domaini

ANK repeat, Repeat, Zinc-finger

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158097

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231158

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8R516

KEGG Orthology (KO)

More...
KOi
K10645

Identification of Orthologs from Complete Genome Data

More...
OMAi
ATCGGHY

Database of Orthologous Groups

More...
OrthoDBi
220300at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8R516

TreeFam database of animal gene trees

More...
TreeFami
TF324147

Family and domain databases

Conserved Domains Database

More...
CDDi
cd02339 ZZ_Mind_bomb, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 2 hits
2.30.30.920, 2 hits
3.30.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR042056 MIB1/2_ZZ
IPR010606 Mib_Herc2
IPR037252 Mib_Herc2_sf
IPR040847 SH3_15
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR000433 Znf_ZZ

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796 Ank_2, 2 hits
PF06701 MIB_HERC2, 2 hits
PF18346 SH3_15, 2 hits
PF00569 ZZ, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01415 ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248 ANK, 8 hits
SM00184 RING, 2 hits
SM00291 ZnF_ZZ, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF159034 SSF159034, 2 hits
SSF48403 SSF48403, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 5 hits
PS51416 MIB_HERC2, 2 hits
PS50089 ZF_RING_2, 2 hits
PS01357 ZF_ZZ_1, 1 hit
PS50135 ZF_ZZ_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8R516-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDLDPHAGVQ VGMRVVRGMD WKWGQQDGGE GGVGTVVELG RHGSPSTPDR
60 70 80 90 100
TVVVQWDQGT RTNYRAGYQG AHDLLLYDNA QIGIRHPNII CDCCKKHGLR
110 120 130 140 150
GMRWKCRVCF DYDLCTQCYM HNKHDLTHAF ERYETSHSRP VTLSPRQGLP
160 170 180 190 200
RIPLRGIFQG AKVVRGPDWE WGSQDGGEGK TGRVVDIRGW DVETGRSVAS
210 220 230 240 250
VTWADGTTNV YRVGHKGKVD LRCVGEAAGG FYYKEHLPKL GKPAELQRRV
260 270 280 290 300
SADGQPFQRG DKVKCLLDTD VLRDMQEGHG GWNPRMAEFI GQMGTVHRIT
310 320 330 340 350
DRGDVRVQFN HETRWTFHPG ALTKHNSFWV GDVVRVIGDL DTVKRLQAGH
360 370 380 390 400
GEWTDDMAPA LGRVGKVVKV FGDGNLRVAV GGQRWTFSPS CLVAYRPEED
410 420 430 440 450
ANLDVAERAR ENKSAASVSV AGSLSVALDK LRTQKSDPEH PGRLVVEAAL
460 470 480 490 500
GNVARALDLL RRHPEQASYH PALVVDTKNQ GRTALQVAAY LGQVELVRLL
510 520 530 540 550
LQARASMDLP DDEGNTVLHY TAMGNQPEAT RVLLSAGCAV DARNGTRSTA
560 570 580 590 600
LHVAVQRGFL EVVKILCERG CDVNLPDAHA DTPLHSAISA GAGASSIVEV
610 620 630 640 650
LTEVPGIDVT ATNSQGFTLL HHASLKGHVL AVRKILARAR QLVDAKKEDG
660 670 680 690 700
FTALHLAALN NHREVAQVLI REGRCDVNVR NRKLQSPLHL AVQQAHLGLV
710 720 730 740 750
PLLVDAGCSV NTEDEEGDTA LHVALQRHQL LPLVADRAGG DPGPLQLLSR
760 770 780 790 800
LQASGLPGCT ELTVGAAVAC FLALEGADVS YANHRGRSPL DLATEGRVLK
810 820 830 840 850
ALQGCAQRFR ERQAGGGGGV PPGPRHVLST PNTVTNLHVS GTAGPEAAEC
860 870 880 890 900
LVCSELALLI LFSPCQHRTV CEECARRMKK CIRCQVVISK KLRPDGSEVV
910 920 930 940 950
NAIQVPGPPR QLVEELQSRY RQMEERITCP ICIDSHIRLV FQCGHGACAP
960 970
CGAALNACPI CRQPIRDRIQ IFV
Length:973
Mass (Da):105,961
Last modified:July 5, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3E9406DEB30541D7
GO
Isoform 2 (identifier: Q8R516-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     289-324: Missing.
     415-422: Missing.
     467-474: Missing.

Show »
Length:921
Mass (Da):100,287
Checksum:i5D2B2CBFBFA9EA69
GO
Isoform 3 (identifier: Q8R516-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     289-294: FIGQMG → VSHLFC
     295-973: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.
Show »
Length:294
Mass (Da):32,911
Checksum:i8D99C17F39E05DB0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2A9P8A2A9P8_MOUSE
E3 ubiquitin-protein ligase MIB2
Mib2
375Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB79447 differs from that shown. Reason: Frameshift at positions 151 and 161.Curated
The sequence BAB86856 differs from that shown. Reason: Frameshift at positions 780 and 840.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti89I → T in BAB79447 (Ref. 2) Curated1
Sequence conflicti89I → T in BAB86856 (Ref. 2) Curated1
Sequence conflicti131E → G in BAB79447 (Ref. 2) Curated1
Sequence conflicti131E → G in BAB86856 (Ref. 2) Curated1
Sequence conflicti138S → L in BAB79447 (Ref. 2) Curated1
Sequence conflicti138S → L in BAB86856 (Ref. 2) Curated1
Sequence conflicti393V → S in BAB86856 (Ref. 2) Curated1
Sequence conflicti407E → D in BAB86856 (Ref. 2) Curated1
Sequence conflicti465E → D in BAB86856 (Ref. 2) Curated1
Sequence conflicti487V → L in BAB86856 (Ref. 2) Curated1
Sequence conflicti537G → R in BAB86856 (Ref. 2) Curated1
Sequence conflicti626K → R in BAB86856 (Ref. 2) Curated1
Sequence conflicti745 – 750LQLLSR → CSCCQG in BAC25227 (PubMed:16141072).Curated6
Sequence conflicti904Q → R in BAB86856 (Ref. 2) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_014397289 – 324Missing in isoform 2. 1 PublicationAdd BLAST36
Alternative sequenceiVSP_014398289 – 294FIGQMG → VSHLFC in isoform 3. 1 Publication6
Alternative sequenceiVSP_014399295 – 973Missing in isoform 3. 1 PublicationAdd BLAST679
Alternative sequenceiVSP_014400415 – 422Missing in isoform 2. 1 Publication8
Alternative sequenceiVSP_014401467 – 474Missing in isoform 2. 1 Publication8

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY974090 mRNA Translation: AAX84652.1
AB063290 mRNA Translation: BAB79447.1 Frameshift.
AB072336 mRNA Translation: BAB86856.1 Frameshift.
AL627405 Genomic DNA No translation available.
CH466594 Genomic DNA Translation: EDL15023.1
BC058086 mRNA No translation available.
AK008671 mRNA Translation: BAC25227.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS19035.1 [Q8R516-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001243037.2, NM_001256108.2 [Q8R516-2]
NP_660106.2, NM_145124.3 [Q8R516-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000103176; ENSMUSP00000099465; ENSMUSG00000029060 [Q8R516-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
76580

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:76580

UCSC genome browser

More...
UCSCi
uc008wee.2 mouse [Q8R516-1]
uc008wef.2 mouse [Q8R516-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY974090 mRNA Translation: AAX84652.1
AB063290 mRNA Translation: BAB79447.1 Frameshift.
AB072336 mRNA Translation: BAB86856.1 Frameshift.
AL627405 Genomic DNA No translation available.
CH466594 Genomic DNA Translation: EDL15023.1
BC058086 mRNA No translation available.
AK008671 mRNA Translation: BAC25227.1
CCDSiCCDS19035.1 [Q8R516-2]
RefSeqiNP_001243037.2, NM_001256108.2 [Q8R516-2]
NP_660106.2, NM_145124.3 [Q8R516-2]

3D structure databases

SMRiQ8R516
ModBaseiSearch...

Protein-protein interaction databases

BioGridi218188, 9 interactors
IntActiQ8R516, 1 interactor
STRINGi10090.ENSMUSP00000099465

PTM databases

iPTMnetiQ8R516
PhosphoSitePlusiQ8R516

Proteomic databases

PRIDEiQ8R516

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
76580
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000103176; ENSMUSP00000099465; ENSMUSG00000029060 [Q8R516-2]
GeneIDi76580
KEGGimmu:76580
UCSCiuc008wee.2 mouse [Q8R516-1]
uc008wef.2 mouse [Q8R516-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
142678
MGIiMGI:2679684 Mib2

Phylogenomic databases

GeneTreeiENSGT00940000158097
HOGENOMiHOG000231158
InParanoidiQ8R516
KOiK10645
OMAiATCGGHY
OrthoDBi220300at2759
PhylomeDBiQ8R516
TreeFamiTF324147

Enzyme and pathway databases

UniPathwayiUPA00143
ReactomeiR-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Mib2 mouse

Protein Ontology

More...
PROi
PR:Q8R516

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000029060 Expressed in 265 organ(s), highest expression level in cerebellum
ExpressionAtlasiQ8R516 baseline and differential
GenevisibleiQ8R516 MM

Family and domain databases

CDDicd02339 ZZ_Mind_bomb, 1 hit
Gene3Di1.25.40.20, 2 hits
2.30.30.920, 2 hits
3.30.40.10, 2 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR042056 MIB1/2_ZZ
IPR010606 Mib_Herc2
IPR037252 Mib_Herc2_sf
IPR040847 SH3_15
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR000433 Znf_ZZ
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PF06701 MIB_HERC2, 2 hits
PF18346 SH3_15, 2 hits
PF00569 ZZ, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 8 hits
SM00184 RING, 2 hits
SM00291 ZnF_ZZ, 1 hit
SUPFAMiSSF159034 SSF159034, 2 hits
SSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 5 hits
PS51416 MIB_HERC2, 2 hits
PS50089 ZF_RING_2, 2 hits
PS01357 ZF_ZZ_1, 1 hit
PS50135 ZF_ZZ_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMIB2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8R516
Secondary accession number(s): A2A9P9
, Q52QU8, Q6PEF6, Q8C1N7, Q8VIB4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2005
Last modified: September 18, 2019
This is version 150 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again