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UniProtKB - Q8R508 (FAT3_RAT)

Entry version 111 (02 Dec 2020)
Sequence version 1 (01 Jun 2002)
Previous versions | rss
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Protein

Protocadherin Fat 3

Gene

Fat3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in the interactions between neurites derived from specific subsets of neurons during development.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processCell adhesion
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protocadherin Fat 3
Alternative name(s):
FAT tumor suppressor homolog 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Fat3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Rat genome database

More...RGDi		620657, Fat3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini32 – 4153ExtracellularSequence analysisAdd BLAST4122
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei4154 – 4174HelicalSequence analysisAdd BLAST21
Topological domaini4175 – 4555CytoplasmicSequence analysisAdd BLAST381

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 31Sequence analysisAdd BLAST31
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000032463632 – 4555Protocadherin Fat 3Add BLAST4524

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi48N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi341N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi481N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi562N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi667N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi799N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi879N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi898N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1006N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1367N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1429N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1751N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1944N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1993N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1996N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2208N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2292N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2331N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2467N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2734N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3000N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3201N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3449N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3618N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3741N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi3798 ↔ 3809By similarity
Disulfide bondi3803 ↔ 3821By similarity
Disulfide bondi3823 ↔ 3831By similarity
Glycosylationi3926N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi3984 ↔ 4017By similarity
Disulfide bondi4024 ↔ 4035By similarity
Disulfide bondi4029 ↔ 4045By similarity
Disulfide bondi4047 ↔ 4056By similarity
Disulfide bondi4063 ↔ 4074By similarity
Disulfide bondi4068 ↔ 4083By similarity
Disulfide bondi4085 ↔ 4094By similarity
Disulfide bondi4101 ↔ 4112By similarity
Disulfide bondi4106 ↔ 4121By similarity
Disulfide bondi4123 ↔ 4132By similarity
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei4508Omega-N-methylarginineBy similarity1
Modified residuei4518Omega-N-methylarginineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Methylation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8R508

PRoteomics IDEntifications database

More...PRIDEi		Q8R508

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q8R508, 26 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8R508

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8R508

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Restricted to the nervous system. Abundantly expressed in the fetal brain.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Present in brain and peaks at E15 during embryonic development. Also present in the spinal cord (at protein level).1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		251318, 1 interactor

STRING: functional protein association networks

More...STRINGi		10116.ENSRNOP00000015976

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8R508

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini43 – 157Cadherin 1PROSITE-ProRule annotationAdd BLAST115
Domaini158 – 265Cadherin 2PROSITE-ProRule annotationAdd BLAST108
Domaini263 – 374Cadherin 3PROSITE-ProRule annotationAdd BLAST112
Domaini376 – 471Cadherin 4PROSITE-ProRule annotationAdd BLAST96
Domaini472 – 577Cadherin 5PROSITE-ProRule annotationAdd BLAST106
Domaini578 – 680Cadherin 6PROSITE-ProRule annotationAdd BLAST103
Domaini726 – 830Cadherin 7PROSITE-ProRule annotationAdd BLAST105
Domaini831 – 935Cadherin 8PROSITE-ProRule annotationAdd BLAST105
Domaini936 – 1042Cadherin 9PROSITE-ProRule annotationAdd BLAST107
Domaini1043 – 1147Cadherin 10PROSITE-ProRule annotationAdd BLAST105
Domaini1148 – 1253Cadherin 11PROSITE-ProRule annotationAdd BLAST106
Domaini1254 – 1358Cadherin 12PROSITE-ProRule annotationAdd BLAST105
Domaini1362 – 1459Cadherin 13PROSITE-ProRule annotationAdd BLAST98
Domaini1460 – 1565Cadherin 14PROSITE-ProRule annotationAdd BLAST106
Domaini1566 – 1768Cadherin 15PROSITE-ProRule annotationAdd BLAST203
Domaini1769 – 1882Cadherin 16PROSITE-ProRule annotationAdd BLAST114
Domaini1883 – 1985Cadherin 17PROSITE-ProRule annotationAdd BLAST103
Domaini1982 – 2083Cadherin 18PROSITE-ProRule annotationAdd BLAST102
Domaini2084 – 2185Cadherin 19PROSITE-ProRule annotationAdd BLAST102
Domaini2186 – 2286Cadherin 20PROSITE-ProRule annotationAdd BLAST101
Domaini2287 – 2393Cadherin 21PROSITE-ProRule annotationAdd BLAST107
Domaini2394 – 2495Cadherin 22PROSITE-ProRule annotationAdd BLAST102
Domaini2496 – 2599Cadherin 23PROSITE-ProRule annotationAdd BLAST104
Domaini2600 – 2707Cadherin 24PROSITE-ProRule annotationAdd BLAST108
Domaini2708 – 2813Cadherin 25PROSITE-ProRule annotationAdd BLAST106
Domaini2814 – 2923Cadherin 26PROSITE-ProRule annotationAdd BLAST110
Domaini2924 – 3028Cadherin 27PROSITE-ProRule annotationAdd BLAST105
Domaini3029 – 3130Cadherin 28PROSITE-ProRule annotationAdd BLAST102
Domaini3131 – 3235Cadherin 29PROSITE-ProRule annotationAdd BLAST105
Domaini3236 – 3340Cadherin 30PROSITE-ProRule annotationAdd BLAST105
Domaini3341 – 3445Cadherin 31PROSITE-ProRule annotationAdd BLAST105
Domaini3446 – 3550Cadherin 32PROSITE-ProRule annotationAdd BLAST105
Domaini3551 – 3652Cadherin 33PROSITE-ProRule annotationAdd BLAST102
Domaini3794 – 3832EGF-like 1PROSITE-ProRule annotationAdd BLAST39
Domaini3834 – 4017Laminin G-likePROSITE-ProRule annotationAdd BLAST184
Domaini4020 – 4057EGF-like 2PROSITE-ProRule annotationAdd BLAST38
Domaini4059 – 4095EGF-like 3PROSITE-ProRule annotationAdd BLAST37
Domaini4097 – 4133EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST37

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi4404 – 4475Pro-richAdd BLAST72

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1219, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8R508

Database of Orthologous Groups

More...OrthoDBi		12779at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8R508

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002126, Cadherin-like_dom
IPR015919, Cadherin-like_sf
IPR020894, Cadherin_CS
IPR013320, ConA-like_dom_sf
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR001791, Laminin_G

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00028, Cadherin, 27 hits
PF00008, EGF, 1 hit
PF02210, Laminin_G_2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00205, CADHERIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00112, CA, 32 hits
SM00181, EGF, 4 hits
SM00179, EGF_CA, 3 hits
SM00282, LamG, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49313, SSF49313, 34 hits
SSF49899, SSF49899, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00010, ASX_HYDROXYL, 1 hit
PS00232, CADHERIN_1, 19 hits
PS50268, CADHERIN_2, 32 hits
PS00022, EGF_1, 3 hits
PS01186, EGF_2, 1 hit
PS50026, EGF_3, 4 hits
PS01187, EGF_CA, 1 hit
PS50025, LAM_G_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8R508-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGVTMRHCID TRPPSCLIFL LLKLCATVSQ GLPGTGPLGF HFTHALYNAT 
        60         70         80         90        100
VYENSAARTY VNSQSRMGIT LIDLSWDIKY RIVSGDEEGF FKAEEVIIAD 
       110        120        130        140        150
FCFLRIRTKG GNSAILNREI QDNYLLIIKG SVRGEDLEAW TKVNIQVLDM 
       160        170        180        190        200
NDLRPLFSPT TYSVTIAEST PLRTSVAQVT ATDADIGSNG EFYYYFKNKV 
       210        220        230        240        250
DLFSVHPTSG VISLSGRLNY DEKNRYDLEI LAVDRGMKLY GNNGVSSTAK 
       260        270        280        290        300
LYVHIERINE HAPIIHVVTH TPFSLDKEPT YAVVTVDDLD EGANGEIESV 
       310        320        330        340        350
SIVDGDPLEQ FFLAKEGKWM NEYKVKERRQ VDWESFSYGY NLTIQAKDKG 
       360        370        380        390        400
SPQKFSELKT VHIANPRRDS TPIKFEKDVY DISISEFSPP GVMVAIVKVN 
       410        420        430        440        450
PEPLDVEYKL LPGKDAEYFK INPRSGLIVT AQPLNTVKKE VYKLEVSDKE 
       460        470        480        490        500
GDAKAQVTIG IEDANDHTPE FQETLYETFV NESVPVGTNV LTVSASDKDK 
       510        520        530        540        550
GENGYITYSI ASLNLLPFAI NQFTGVISTT EELDFESSPE TYRFIVRASD 
       560        570        580        590        600
WGSPYRHESE VNVTIRVGNV NDNSPLFEKV ACQGVISYDF PVGGHITAIS 
       610        620        630        640        650
AIDIDELELV KYKIISGNEL GFFYLNPDSG VLQLKKSLMN SGIKNGNFAL 
       660        670        680        690        700
RITATDGENF ADPMAINISV LHGKVSSKSF SCRETRVAQK LAEKLLIKAK 
       710        720        730        740        750
ANGKLNQEDG FLDFYSINRQ GPHFDKSFPS DVAVKENMPV GTNILKIKAY 
       760        770        780        790        800
DADSGFNGKV LFTISDGNTD SCFNIDMETG QLKVLMPMDR EHTDLYVLNI 
       810        820        830        840        850
TIYDLGKPQK SSWRLLTVNV EDANDNSPVF LQDSYSVSIL ESSSIGTEII 
       860        870        880        890        900
QVEARDKDLG SNGEVTYSVL TDTHQFVINS STGIVYIADQ LDRESKANYS 
       910        920        930        940        950
LKIEARDKAE SGQQLFSVVT LKIFLDDVND CSPAFIPSSY SVKVLEDLPV 
       960        970        980        990       1000
GTVIAWLETQ DPDLGLGGQV RYSLVNDYNG RFEIDKASGA IRLSKELDYE 
      1010       1020       1030       1040       1050
KQQFYNLTVR AKDKGRPVSL SSISFVEVEV VDVNENLHTP YFPDFAVVGS 
      1060       1070       1080       1090       1100
VKENSRIGTS VLQVTAHDED SGRDGEIQYS IRDGSGLGRF NIDDESGVIT 
      1110       1120       1130       1140       1150
AADILDRETT ASYWLTVYAT DRGVVPLYST IEVYIEVEDV NDNAPLTSEP 
      1160       1170       1180       1190       1200
IYYPVVMENS PKDVSVIQIQ AEDPDSGSNE KLTYRITSGN PQNFFAINIK 
      1210       1220       1230       1240       1250
TGLITTTSRK LDREQQAEHF LEVTVTDGGS SPKQSTIWVV VQVLDENDNK 
      1260       1270       1280       1290       1300
PQFPEKVYQI KLPERDRKKR GEPIYRAFAF DRDEGPNAEI SYSIVDGNDD 
      1310       1320       1330       1340       1350
GKFFIDPKTG MVSSRKQFTA GSYDILTIKA VDNGRPQKSS TARLHIEWIK 
      1360       1370       1380       1390       1400
KPPPSPIPLT FDEPFYNFTI MESDKVTEIV GVVSVQPANT PLWFDIIGGN 
      1410       1420       1430       1440       1450
FDSSFDAEKG VGTIVIAKPL DAEQRSVYNM SVEVTDGTNV AVTQVFITVL 
      1460       1470       1480       1490       1500
DNNDNGPEFS QPHYDVTISE DVPPDTEILQ IEATDRDEKH KLSYTIHSSI 
      1510       1520       1530       1540       1550
DAISMRKFRI DPSTGVLYTA ERLDHEAQDK HILNIMVRDQ EFPYRRNLAR 
      1560       1570       1580       1590       1600
VIVNVEDAND HSPYFTNPLY EASVFESAAL GSVVLQVTAL DKDKGENAEL 
      1610       1620       1630       1640       1650
IYSIEAGNTG NTFKIEPVLG IITISKEPDM TAMGQFVLSV KVTDQGSPPM 
      1660       1670       1680       1690       1700
SATAIVRISI SMSDNSHPKF THKDYQAEVN ENVDIGTSVI LISAISQSTL 
      1710       1720       1730       1740       1750
IYEVKDGNIN GVFTINPYSG VITTRRALDY EHTSSYQLII QATNMAGMAS 
      1760       1770       1780       1790       1800
NATVSVQVVD ENDNPPVFLF SQYSGSLSEA APINSLVRSL DNSPLVIRAT 
      1810       1820       1830       1840       1850
DADSNQNALL VYQIVESTAK KFFTVDSSTG AIRTIANLDH EVIAHFHFHV 
      1860       1870       1880       1890       1900
HVRDSGNPQL TAESPVEVNI EVTDVNDNPP VFTQAVFETV LLLPTYVGVE 
      1910       1920       1930       1940       1950
VLKVSATDPD SEVPPELTYS LMEGSVDHFL MDPNTGVLTI KNNNLSKDHY 
      1960       1970       1980       1990       2000
MLIVRVSDGK FYSTAMVTIM VKEAMDSGLH FTQSFYSTSI SENSTNITKV 
      2010       2020       2030       2040       2050
AIVNAVGNRL NEPLKYSILN PGNKFKIKST SGVIQTTGVP FDREEQELYE 
      2060       2070       2080       2090       2100
LVVEASRELD HLRVARVVVR VNIEDVNDNS PVFVGLPYYA AVQVDAEPGT 
      2110       2120       2130       2140       2150
LIYRVTAIDK DKGANGEVTY VLQDDYGHFE INPNSGNVIL KEAFNSDLSN 
      2160       2170       2180       2190       2200
IDYGVTILAK DGGTPSLSTF VELPITIVNK AMPVFDKPFY TASINEDISI 
      2210       2220       2230       2240       2250
NTPILSINAT SPEGQGIIYL IIDGDPFQQF NIDFDTGVLK VISPLDYEVM 
      2260       2270       2280       2290       2300
SVYKLTVRAS DALTGARAEV TVDLLVDDVN DNPPVFDQPT YNTTLSESSL 
      2310       2320       2330       2340       2350
IGTPVLQLVS TDADSGNNNL VHYQIVQDTY NSTDYFHIDS SSGLILTARM 
      2360       2370       2380       2390       2400
LDHELVQHCT LKVTATDNGF PSLSSEVLVQ IYISDVNDNP PVFNQLIYES 
      2410       2420       2430       2440       2450
YVSELAPRGH FVTCVQASDA DSSDFDRLEY SILSGNDRTS FLMDSKSGVL 
      2460       2470       2480       2490       2500
TLSSHRKQRM EPLYSLNVSV SDGLFTSTAQ VHIRVLGANL YSPAFSQSTY 
      2510       2520       2530       2540       2550
VAEVRENAAS GTKVIHVRAT DGDPGTYGQV SYSIINDFAK DRFLIDSNGQ 
      2560       2570       2580       2590       2600
IITTERLDRE NPLEGDISIY LRALDGGGRT TFCTVRVIVV DENDNAPQFM 
      2610       2620       2630       2640       2650
TLEYRASVRA DVGRGHLVTQ VQALDPDDGA NSRITYSLYS EASVSVADLL 
      2660       2670       2680       2690       2700
EIDPDNGWMV TKGNFNQLRN TVLSFFVKAV DGGIPVRHSL IPVYIHVLPP 
      2710       2720       2730       2740       2750
ETFLPSFTQS QYSFTIAEDT SIGSTIDTLR ILPNQSVRFS TVNGERPENN 
      2760       2770       2780       2790       2800
KENVFIIEQE TGAIKLDKRL DHEVSPAFHF KVAATIPLDK VDIVFTVDVD 
      2810       2820       2830       2840       2850
VKVLDLNDNK PVFETSSYET IIMEGMPVGT KLAQVRAIDT DWGANGQVTY 
      2860       2870       2880       2890       2900
SLHSDSHLEK VMEAFNIDSN TGWISTLKDL DHETDPTFSF FVVASDLGEA 
      2910       2920       2930       2940       2950
FSLSSMALVS VKVTDINDNA PVFAHEVYRG NVKESDPPGE VVAVLSTLDK 
      2960       2970       2980       2990       3000
DTSNINRQVS YHITGGNPRG RFALGMVQSE WKVYVKRPLD REEQDIYFLN 
      3010       3020       3030       3040       3050
ITASDGLFVT QAMVEVTVSD VNDNSPVCDQ VAYSASLPED IPSNKIILKV 
      3060       3070       3080       3090       3100
SAKDADIGSN GDIRYSLYGS GNSDFFLDPE SGELKTLALL DRERVPVYNL 
      3110       3120       3130       3140       3150
IARATDGGGR FCSSTVLLLL EDVNDNPPVF SSNHYTACVY ENTATKALLT 
      3160       3170       3180       3190       3200
RVQAVDPDVG INRKVVYSLE DSASGVFSID SSSGVIVLEQ PLDREQQSSY 
      3210       3220       3230       3240       3250
NISVRATDQS PGQSLSSLTS VTITVLDIND NPPVFERRDY LVTVPEDTSL 
      3260       3270       3280       3290       3300
GTQVLSVFAT SKDIGTNAEI TYLIRSGNEQ GKFRINPKTG GISVLEALDY 
      3310       3320       3330       3340       3350
EMCKRFYLVV EAKDGGTPAL STAATVSIDL TDVNDNPPRF SQDVYSAVIS 
      3360       3370       3380       3390       3400
EDALEGDSVI LLIAEDVDSK PNGQIRFSIV GGDRDNEFAV DPILGLVKVK 
      3410       3420       3430       3440       3450
KKLDRERVSG YSLLIQAVDS GIPAMSSTTT VNIDISDVND NSPVFTPANY 
      3460       3470       3480       3490       3500
TAVIQENKPV GTSILQLVVT DRDSFHNGPP FSFSILSGNE DEEFMLDSHG 
      3510       3520       3530       3540       3550
ILRSAVVFRH MESPEYLLCI QAKDSGKPQQ VSHTYIRVRV IEESTHKPTA 
      3560       3570       3580       3590       3600
IPLEIFIVTM EDDFPGGVIG KIHATDQDMY DVLTFALKSE QKSLFKVNSH 
      3610       3620       3630       3640       3650
DGKIIALGGL DSGKYVLNVS VSDGRFQVPI DVVVHVEQLV HEMLQNTVTI 
      3660       3670       3680       3690       3700
RFENVSPEDF VGLHMHGFRR ILRNAVLTQK QDSLRIISIQ PVVGTNQLDM 
      3710       3720       3730       3740       3750
LFAVEMHSSE FYKPAYLIQK LSNARRHLEN VMHIAAILEK NCSGLDCQEQ 
      3760       3770       3780       3790       3800
HCEQGLSLDS HALMTYSTAR ISFVCPRFYR NVRCTCNGGV CPGSNDPCVE 
      3810       3820       3830       3840       3850
KPCPEDMQCV GYEASRRPFL CQCPPGKLGE CSGHTSLSFA GNSYIKYRLS 
      3860       3870       3880       3890       3900
ENSREEDFKL ALRLRTLQSN GIIMYTRANP CMILKIVEGK LWFQLDCGSG 
      3910       3920       3930       3940       3950
PGILGISSRA VNDGSWHSVF LELNRNFTSL SLDDSYVERR RAPLYFQTLS 
      3960       3970       3980       3990       4000
TDSAIFFGAL VQADNIRSLT DTRVTQVLGG FQGCLDSVVL NHNELPLQNK 
      4010       4020       4030       4040       4050
RSSFAEVVGL TELKLGCVLY PDACQRSPCL HGGSCSGLPS GGYQCSCLSQ 
      4060       4070       4080       4090       4100
FTGTNCESEI TACFPNPCRN GGSCDPIGNT FICSCKAGLT GVTCEDDVDE 
      4110       4120       4130       4140       4150
CEREECENGG SCVNLFGSFF CNCTPGYVGQ YCGLRPVVVP NIQAGHSYVG 
      4160       4170       4180       4190       4200
KEELIGIAVV LFVIFTLIVL FIVFRKKVFR KNYSRNNITL VQDPATAALL 
      4210       4220       4230       4240       4250
HKSNGIPFRS LRAGDGRNVY QEVGPPQVPV RPMAYTPCFQ SDSRSNLDKG 
      4260       4270       4280       4290       4300
LDALGGEPQE LSTFHPESPR ILTARRGVVV CSVAPNLPAV SPCRSDCDSI 
      4310       4320       4330       4340       4350
RKNGWDTGSE NKGAEDTGEV TCFANSNKGS NSEVQSLNSF QSDSGDDNAY 
      4360       4370       4380       4390       4400
HWDTSDWMPG ARLSDIEEMP NYESQDGGAV HQGSTRELES DYYLGGYDID 
      4410       4420       4430       4440       4450
SEYPPPHEEE FLSQDQLPPP LPEDFPEQYE ALPPSQPTSL TGTMSPDCRR 
      4460       4470       4480       4490       4500
RPRFHPSQYL PPHPLPGETD LGGPPSSCDF STFAVSMNQG TEVMAPTDSV 
      4510       4520       4530       4540       4550
SLSLHNSRGT SSSDMSARCG FDDSEVAMSD YESAGELSLT NLHIPFVETQ 

HQTQV
Length:4,555
Mass (Da):502,088
Last modified:June 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB47CBC10638EA73B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1LMF4F1LMF4_RAT
Protocadherin Fat 3
Fat3
4,555Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB076401 mRNA Translation: BAB86869.1

NCBI Reference Sequences

More...RefSeqi		NP_612553.1, NM_138544.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		191571

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		rno:191571

UCSC genome browser

More...UCSCi		RGD:620657, rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB076401 mRNA Translation: BAB86869.1
RefSeqiNP_612553.1, NM_138544.1

3D structure databases

SMRiQ8R508
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi251318, 1 interactor
STRINGi10116.ENSRNOP00000015976

PTM databases

GlyGeniQ8R508, 26 sites
iPTMnetiQ8R508
PhosphoSitePlusiQ8R508

Proteomic databases

PaxDbiQ8R508
PRIDEiQ8R508

Genome annotation databases

GeneIDi191571
KEGGirno:191571
UCSCiRGD:620657, rat

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		120114
RGDi620657, Fat3

Phylogenomic databases

eggNOGiKOG1219, Eukaryota
InParanoidiQ8R508
OrthoDBi12779at2759
PhylomeDBiQ8R508

Miscellaneous databases

Protein Ontology

More...PROi		PR:Q8R508

Family and domain databases

InterProiView protein in InterPro
IPR002126, Cadherin-like_dom
IPR015919, Cadherin-like_sf
IPR020894, Cadherin_CS
IPR013320, ConA-like_dom_sf
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR001791, Laminin_G
PfamiView protein in Pfam
PF00028, Cadherin, 27 hits
PF00008, EGF, 1 hit
PF02210, Laminin_G_2, 1 hit
PRINTSiPR00205, CADHERIN
SMARTiView protein in SMART
SM00112, CA, 32 hits
SM00181, EGF, 4 hits
SM00179, EGF_CA, 3 hits
SM00282, LamG, 1 hit
SUPFAMiSSF49313, SSF49313, 34 hits
SSF49899, SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS00010, ASX_HYDROXYL, 1 hit
PS00232, CADHERIN_1, 19 hits
PS50268, CADHERIN_2, 32 hits
PS00022, EGF_1, 3 hits
PS01186, EGF_2, 1 hit
PS50026, EGF_3, 4 hits
PS01187, EGF_CA, 1 hit
PS50025, LAM_G_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFAT3_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8R508
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: June 1, 2002
Last modified: December 2, 2020
This is version 111 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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