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Entry version 111 (02 Dec 2020)
Sequence version 1 (01 Jun 2002)
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Protein

Protocadherin Fat 3

Gene

Fat3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in the interactions between neurites derived from specific subsets of neurons during development.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processCell adhesion
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protocadherin Fat 3
Alternative name(s):
FAT tumor suppressor homolog 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Fat3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Rat genome database

More...
RGDi
620657, Fat3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini32 – 4153ExtracellularSequence analysisAdd BLAST4122
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei4154 – 4174HelicalSequence analysisAdd BLAST21
Topological domaini4175 – 4555CytoplasmicSequence analysisAdd BLAST381

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 31Sequence analysisAdd BLAST31
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000032463632 – 4555Protocadherin Fat 3Add BLAST4524

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi48N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi341N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi481N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi562N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi667N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi799N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi879N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi898N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1006N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1367N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1429N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1751N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1944N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1993N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1996N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2208N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2292N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2331N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2467N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2734N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3000N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3201N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3449N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3618N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3741N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi3798 ↔ 3809By similarity
Disulfide bondi3803 ↔ 3821By similarity
Disulfide bondi3823 ↔ 3831By similarity
Glycosylationi3926N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi3984 ↔ 4017By similarity
Disulfide bondi4024 ↔ 4035By similarity
Disulfide bondi4029 ↔ 4045By similarity
Disulfide bondi4047 ↔ 4056By similarity
Disulfide bondi4063 ↔ 4074By similarity
Disulfide bondi4068 ↔ 4083By similarity
Disulfide bondi4085 ↔ 4094By similarity
Disulfide bondi4101 ↔ 4112By similarity
Disulfide bondi4106 ↔ 4121By similarity
Disulfide bondi4123 ↔ 4132By similarity
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei4508Omega-N-methylarginineBy similarity1
Modified residuei4518Omega-N-methylarginineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Methylation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8R508

PRoteomics IDEntifications database

More...
PRIDEi
Q8R508

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q8R508, 26 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8R508

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8R508

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Restricted to the nervous system. Abundantly expressed in the fetal brain.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Present in brain and peaks at E15 during embryonic development. Also present in the spinal cord (at protein level).1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
251318, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000015976

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8R508

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini43 – 157Cadherin 1PROSITE-ProRule annotationAdd BLAST115
Domaini158 – 265Cadherin 2PROSITE-ProRule annotationAdd BLAST108
Domaini263 – 374Cadherin 3PROSITE-ProRule annotationAdd BLAST112
Domaini376 – 471Cadherin 4PROSITE-ProRule annotationAdd BLAST96
Domaini472 – 577Cadherin 5PROSITE-ProRule annotationAdd BLAST106
Domaini578 – 680Cadherin 6PROSITE-ProRule annotationAdd BLAST103
Domaini726 – 830Cadherin 7PROSITE-ProRule annotationAdd BLAST105
Domaini831 – 935Cadherin 8PROSITE-ProRule annotationAdd BLAST105
Domaini936 – 1042Cadherin 9PROSITE-ProRule annotationAdd BLAST107
Domaini1043 – 1147Cadherin 10PROSITE-ProRule annotationAdd BLAST105
Domaini1148 – 1253Cadherin 11PROSITE-ProRule annotationAdd BLAST106
Domaini1254 – 1358Cadherin 12PROSITE-ProRule annotationAdd BLAST105
Domaini1362 – 1459Cadherin 13PROSITE-ProRule annotationAdd BLAST98
Domaini1460 – 1565Cadherin 14PROSITE-ProRule annotationAdd BLAST106
Domaini1566 – 1768Cadherin 15PROSITE-ProRule annotationAdd BLAST203
Domaini1769 – 1882Cadherin 16PROSITE-ProRule annotationAdd BLAST114
Domaini1883 – 1985Cadherin 17PROSITE-ProRule annotationAdd BLAST103
Domaini1982 – 2083Cadherin 18PROSITE-ProRule annotationAdd BLAST102
Domaini2084 – 2185Cadherin 19PROSITE-ProRule annotationAdd BLAST102
Domaini2186 – 2286Cadherin 20PROSITE-ProRule annotationAdd BLAST101
Domaini2287 – 2393Cadherin 21PROSITE-ProRule annotationAdd BLAST107
Domaini2394 – 2495Cadherin 22PROSITE-ProRule annotationAdd BLAST102
Domaini2496 – 2599Cadherin 23PROSITE-ProRule annotationAdd BLAST104
Domaini2600 – 2707Cadherin 24PROSITE-ProRule annotationAdd BLAST108
Domaini2708 – 2813Cadherin 25PROSITE-ProRule annotationAdd BLAST106
Domaini2814 – 2923Cadherin 26PROSITE-ProRule annotationAdd BLAST110
Domaini2924 – 3028Cadherin 27PROSITE-ProRule annotationAdd BLAST105
Domaini3029 – 3130Cadherin 28PROSITE-ProRule annotationAdd BLAST102
Domaini3131 – 3235Cadherin 29PROSITE-ProRule annotationAdd BLAST105
Domaini3236 – 3340Cadherin 30PROSITE-ProRule annotationAdd BLAST105
Domaini3341 – 3445Cadherin 31PROSITE-ProRule annotationAdd BLAST105
Domaini3446 – 3550Cadherin 32PROSITE-ProRule annotationAdd BLAST105
Domaini3551 – 3652Cadherin 33PROSITE-ProRule annotationAdd BLAST102
Domaini3794 – 3832EGF-like 1PROSITE-ProRule annotationAdd BLAST39
Domaini3834 – 4017Laminin G-likePROSITE-ProRule annotationAdd BLAST184
Domaini4020 – 4057EGF-like 2PROSITE-ProRule annotationAdd BLAST38
Domaini4059 – 4095EGF-like 3PROSITE-ProRule annotationAdd BLAST37
Domaini4097 – 4133EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST37

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi4404 – 4475Pro-richAdd BLAST72

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1219, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8R508

Database of Orthologous Groups

More...
OrthoDBi
12779at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8R508

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002126, Cadherin-like_dom
IPR015919, Cadherin-like_sf
IPR020894, Cadherin_CS
IPR013320, ConA-like_dom_sf
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR001791, Laminin_G

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00028, Cadherin, 27 hits
PF00008, EGF, 1 hit
PF02210, Laminin_G_2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00205, CADHERIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00112, CA, 32 hits
SM00181, EGF, 4 hits
SM00179, EGF_CA, 3 hits
SM00282, LamG, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49313, SSF49313, 34 hits
SSF49899, SSF49899, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010, ASX_HYDROXYL, 1 hit
PS00232, CADHERIN_1, 19 hits
PS50268, CADHERIN_2, 32 hits
PS00022, EGF_1, 3 hits
PS01186, EGF_2, 1 hit
PS50026, EGF_3, 4 hits
PS01187, EGF_CA, 1 hit
PS50025, LAM_G_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8R508-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGVTMRHCID TRPPSCLIFL LLKLCATVSQ GLPGTGPLGF HFTHALYNAT
60 70 80 90 100
VYENSAARTY VNSQSRMGIT LIDLSWDIKY RIVSGDEEGF FKAEEVIIAD
110 120 130 140 150
FCFLRIRTKG GNSAILNREI QDNYLLIIKG SVRGEDLEAW TKVNIQVLDM
160 170 180 190 200
NDLRPLFSPT TYSVTIAEST PLRTSVAQVT ATDADIGSNG EFYYYFKNKV
210 220 230 240 250
DLFSVHPTSG VISLSGRLNY DEKNRYDLEI LAVDRGMKLY GNNGVSSTAK
260 270 280 290 300
LYVHIERINE HAPIIHVVTH TPFSLDKEPT YAVVTVDDLD EGANGEIESV
310 320 330 340 350
SIVDGDPLEQ FFLAKEGKWM NEYKVKERRQ VDWESFSYGY NLTIQAKDKG
360 370 380 390 400
SPQKFSELKT VHIANPRRDS TPIKFEKDVY DISISEFSPP GVMVAIVKVN
410 420 430 440 450
PEPLDVEYKL LPGKDAEYFK INPRSGLIVT AQPLNTVKKE VYKLEVSDKE
460 470 480 490 500
GDAKAQVTIG IEDANDHTPE FQETLYETFV NESVPVGTNV LTVSASDKDK
510 520 530 540 550
GENGYITYSI ASLNLLPFAI NQFTGVISTT EELDFESSPE TYRFIVRASD
560 570 580 590 600
WGSPYRHESE VNVTIRVGNV NDNSPLFEKV ACQGVISYDF PVGGHITAIS
610 620 630 640 650
AIDIDELELV KYKIISGNEL GFFYLNPDSG VLQLKKSLMN SGIKNGNFAL
660 670 680 690 700
RITATDGENF ADPMAINISV LHGKVSSKSF SCRETRVAQK LAEKLLIKAK
710 720 730 740 750
ANGKLNQEDG FLDFYSINRQ GPHFDKSFPS DVAVKENMPV GTNILKIKAY
760 770 780 790 800
DADSGFNGKV LFTISDGNTD SCFNIDMETG QLKVLMPMDR EHTDLYVLNI
810 820 830 840 850
TIYDLGKPQK SSWRLLTVNV EDANDNSPVF LQDSYSVSIL ESSSIGTEII
860 870 880 890 900
QVEARDKDLG SNGEVTYSVL TDTHQFVINS STGIVYIADQ LDRESKANYS
910 920 930 940 950
LKIEARDKAE SGQQLFSVVT LKIFLDDVND CSPAFIPSSY SVKVLEDLPV
960 970 980 990 1000
GTVIAWLETQ DPDLGLGGQV RYSLVNDYNG RFEIDKASGA IRLSKELDYE
1010 1020 1030 1040 1050
KQQFYNLTVR AKDKGRPVSL SSISFVEVEV VDVNENLHTP YFPDFAVVGS
1060 1070 1080 1090 1100
VKENSRIGTS VLQVTAHDED SGRDGEIQYS IRDGSGLGRF NIDDESGVIT
1110 1120 1130 1140 1150
AADILDRETT ASYWLTVYAT DRGVVPLYST IEVYIEVEDV NDNAPLTSEP
1160 1170 1180 1190 1200
IYYPVVMENS PKDVSVIQIQ AEDPDSGSNE KLTYRITSGN PQNFFAINIK
1210 1220 1230 1240 1250
TGLITTTSRK LDREQQAEHF LEVTVTDGGS SPKQSTIWVV VQVLDENDNK
1260 1270 1280 1290 1300
PQFPEKVYQI KLPERDRKKR GEPIYRAFAF DRDEGPNAEI SYSIVDGNDD
1310 1320 1330 1340 1350
GKFFIDPKTG MVSSRKQFTA GSYDILTIKA VDNGRPQKSS TARLHIEWIK
1360 1370 1380 1390 1400
KPPPSPIPLT FDEPFYNFTI MESDKVTEIV GVVSVQPANT PLWFDIIGGN
1410 1420 1430 1440 1450
FDSSFDAEKG VGTIVIAKPL DAEQRSVYNM SVEVTDGTNV AVTQVFITVL
1460 1470 1480 1490 1500
DNNDNGPEFS QPHYDVTISE DVPPDTEILQ IEATDRDEKH KLSYTIHSSI
1510 1520 1530 1540 1550
DAISMRKFRI DPSTGVLYTA ERLDHEAQDK HILNIMVRDQ EFPYRRNLAR
1560 1570 1580 1590 1600
VIVNVEDAND HSPYFTNPLY EASVFESAAL GSVVLQVTAL DKDKGENAEL
1610 1620 1630 1640 1650
IYSIEAGNTG NTFKIEPVLG IITISKEPDM TAMGQFVLSV KVTDQGSPPM
1660 1670 1680 1690 1700
SATAIVRISI SMSDNSHPKF THKDYQAEVN ENVDIGTSVI LISAISQSTL
1710 1720 1730 1740 1750
IYEVKDGNIN GVFTINPYSG VITTRRALDY EHTSSYQLII QATNMAGMAS
1760 1770 1780 1790 1800
NATVSVQVVD ENDNPPVFLF SQYSGSLSEA APINSLVRSL DNSPLVIRAT
1810 1820 1830 1840 1850
DADSNQNALL VYQIVESTAK KFFTVDSSTG AIRTIANLDH EVIAHFHFHV
1860 1870 1880 1890 1900
HVRDSGNPQL TAESPVEVNI EVTDVNDNPP VFTQAVFETV LLLPTYVGVE
1910 1920 1930 1940 1950
VLKVSATDPD SEVPPELTYS LMEGSVDHFL MDPNTGVLTI KNNNLSKDHY
1960 1970 1980 1990 2000
MLIVRVSDGK FYSTAMVTIM VKEAMDSGLH FTQSFYSTSI SENSTNITKV
2010 2020 2030 2040 2050
AIVNAVGNRL NEPLKYSILN PGNKFKIKST SGVIQTTGVP FDREEQELYE
2060 2070 2080 2090 2100
LVVEASRELD HLRVARVVVR VNIEDVNDNS PVFVGLPYYA AVQVDAEPGT
2110 2120 2130 2140 2150
LIYRVTAIDK DKGANGEVTY VLQDDYGHFE INPNSGNVIL KEAFNSDLSN
2160 2170 2180 2190 2200
IDYGVTILAK DGGTPSLSTF VELPITIVNK AMPVFDKPFY TASINEDISI
2210 2220 2230 2240 2250
NTPILSINAT SPEGQGIIYL IIDGDPFQQF NIDFDTGVLK VISPLDYEVM
2260 2270 2280 2290 2300
SVYKLTVRAS DALTGARAEV TVDLLVDDVN DNPPVFDQPT YNTTLSESSL
2310 2320 2330 2340 2350
IGTPVLQLVS TDADSGNNNL VHYQIVQDTY NSTDYFHIDS SSGLILTARM
2360 2370 2380 2390 2400
LDHELVQHCT LKVTATDNGF PSLSSEVLVQ IYISDVNDNP PVFNQLIYES
2410 2420 2430 2440 2450
YVSELAPRGH FVTCVQASDA DSSDFDRLEY SILSGNDRTS FLMDSKSGVL
2460 2470 2480 2490 2500
TLSSHRKQRM EPLYSLNVSV SDGLFTSTAQ VHIRVLGANL YSPAFSQSTY
2510 2520 2530 2540 2550
VAEVRENAAS GTKVIHVRAT DGDPGTYGQV SYSIINDFAK DRFLIDSNGQ
2560 2570 2580 2590 2600
IITTERLDRE NPLEGDISIY LRALDGGGRT TFCTVRVIVV DENDNAPQFM
2610 2620 2630 2640 2650
TLEYRASVRA DVGRGHLVTQ VQALDPDDGA NSRITYSLYS EASVSVADLL
2660 2670 2680 2690 2700
EIDPDNGWMV TKGNFNQLRN TVLSFFVKAV DGGIPVRHSL IPVYIHVLPP
2710 2720 2730 2740 2750
ETFLPSFTQS QYSFTIAEDT SIGSTIDTLR ILPNQSVRFS TVNGERPENN
2760 2770 2780 2790 2800
KENVFIIEQE TGAIKLDKRL DHEVSPAFHF KVAATIPLDK VDIVFTVDVD
2810 2820 2830 2840 2850
VKVLDLNDNK PVFETSSYET IIMEGMPVGT KLAQVRAIDT DWGANGQVTY
2860 2870 2880 2890 2900
SLHSDSHLEK VMEAFNIDSN TGWISTLKDL DHETDPTFSF FVVASDLGEA
2910 2920 2930 2940 2950
FSLSSMALVS VKVTDINDNA PVFAHEVYRG NVKESDPPGE VVAVLSTLDK
2960 2970 2980 2990 3000
DTSNINRQVS YHITGGNPRG RFALGMVQSE WKVYVKRPLD REEQDIYFLN
3010 3020 3030 3040 3050
ITASDGLFVT QAMVEVTVSD VNDNSPVCDQ VAYSASLPED IPSNKIILKV
3060 3070 3080 3090 3100
SAKDADIGSN GDIRYSLYGS GNSDFFLDPE SGELKTLALL DRERVPVYNL
3110 3120 3130 3140 3150
IARATDGGGR FCSSTVLLLL EDVNDNPPVF SSNHYTACVY ENTATKALLT
3160 3170 3180 3190 3200
RVQAVDPDVG INRKVVYSLE DSASGVFSID SSSGVIVLEQ PLDREQQSSY
3210 3220 3230 3240 3250
NISVRATDQS PGQSLSSLTS VTITVLDIND NPPVFERRDY LVTVPEDTSL
3260 3270 3280 3290 3300
GTQVLSVFAT SKDIGTNAEI TYLIRSGNEQ GKFRINPKTG GISVLEALDY
3310 3320 3330 3340 3350
EMCKRFYLVV EAKDGGTPAL STAATVSIDL TDVNDNPPRF SQDVYSAVIS
3360 3370 3380 3390 3400
EDALEGDSVI LLIAEDVDSK PNGQIRFSIV GGDRDNEFAV DPILGLVKVK
3410 3420 3430 3440 3450
KKLDRERVSG YSLLIQAVDS GIPAMSSTTT VNIDISDVND NSPVFTPANY
3460 3470 3480 3490 3500
TAVIQENKPV GTSILQLVVT DRDSFHNGPP FSFSILSGNE DEEFMLDSHG
3510 3520 3530 3540 3550
ILRSAVVFRH MESPEYLLCI QAKDSGKPQQ VSHTYIRVRV IEESTHKPTA
3560 3570 3580 3590 3600
IPLEIFIVTM EDDFPGGVIG KIHATDQDMY DVLTFALKSE QKSLFKVNSH
3610 3620 3630 3640 3650
DGKIIALGGL DSGKYVLNVS VSDGRFQVPI DVVVHVEQLV HEMLQNTVTI
3660 3670 3680 3690 3700
RFENVSPEDF VGLHMHGFRR ILRNAVLTQK QDSLRIISIQ PVVGTNQLDM
3710 3720 3730 3740 3750
LFAVEMHSSE FYKPAYLIQK LSNARRHLEN VMHIAAILEK NCSGLDCQEQ
3760 3770 3780 3790 3800
HCEQGLSLDS HALMTYSTAR ISFVCPRFYR NVRCTCNGGV CPGSNDPCVE
3810 3820 3830 3840 3850
KPCPEDMQCV GYEASRRPFL CQCPPGKLGE CSGHTSLSFA GNSYIKYRLS
3860 3870 3880 3890 3900
ENSREEDFKL ALRLRTLQSN GIIMYTRANP CMILKIVEGK LWFQLDCGSG
3910 3920 3930 3940 3950
PGILGISSRA VNDGSWHSVF LELNRNFTSL SLDDSYVERR RAPLYFQTLS
3960 3970 3980 3990 4000
TDSAIFFGAL VQADNIRSLT DTRVTQVLGG FQGCLDSVVL NHNELPLQNK
4010 4020 4030 4040 4050
RSSFAEVVGL TELKLGCVLY PDACQRSPCL HGGSCSGLPS GGYQCSCLSQ
4060 4070 4080 4090 4100
FTGTNCESEI TACFPNPCRN GGSCDPIGNT FICSCKAGLT GVTCEDDVDE
4110 4120 4130 4140 4150
CEREECENGG SCVNLFGSFF CNCTPGYVGQ YCGLRPVVVP NIQAGHSYVG
4160 4170 4180 4190 4200
KEELIGIAVV LFVIFTLIVL FIVFRKKVFR KNYSRNNITL VQDPATAALL
4210 4220 4230 4240 4250
HKSNGIPFRS LRAGDGRNVY QEVGPPQVPV RPMAYTPCFQ SDSRSNLDKG
4260 4270 4280 4290 4300
LDALGGEPQE LSTFHPESPR ILTARRGVVV CSVAPNLPAV SPCRSDCDSI
4310 4320 4330 4340 4350
RKNGWDTGSE NKGAEDTGEV TCFANSNKGS NSEVQSLNSF QSDSGDDNAY
4360 4370 4380 4390 4400
HWDTSDWMPG ARLSDIEEMP NYESQDGGAV HQGSTRELES DYYLGGYDID
4410 4420 4430 4440 4450
SEYPPPHEEE FLSQDQLPPP LPEDFPEQYE ALPPSQPTSL TGTMSPDCRR
4460 4470 4480 4490 4500
RPRFHPSQYL PPHPLPGETD LGGPPSSCDF STFAVSMNQG TEVMAPTDSV
4510 4520 4530 4540 4550
SLSLHNSRGT SSSDMSARCG FDDSEVAMSD YESAGELSLT NLHIPFVETQ

HQTQV
Length:4,555
Mass (Da):502,088
Last modified:June 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB47CBC10638EA73B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1LMF4F1LMF4_RAT
Protocadherin Fat 3
Fat3
4,555Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB076401 mRNA Translation: BAB86869.1

NCBI Reference Sequences

More...
RefSeqi
NP_612553.1, NM_138544.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
191571

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:191571

UCSC genome browser

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UCSCi
RGD:620657, rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB076401 mRNA Translation: BAB86869.1
RefSeqiNP_612553.1, NM_138544.1

3D structure databases

SMRiQ8R508
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi251318, 1 interactor
STRINGi10116.ENSRNOP00000015976

PTM databases

GlyGeniQ8R508, 26 sites
iPTMnetiQ8R508
PhosphoSitePlusiQ8R508

Proteomic databases

PaxDbiQ8R508
PRIDEiQ8R508

Genome annotation databases

GeneIDi191571
KEGGirno:191571
UCSCiRGD:620657, rat

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
120114
RGDi620657, Fat3

Phylogenomic databases

eggNOGiKOG1219, Eukaryota
InParanoidiQ8R508
OrthoDBi12779at2759
PhylomeDBiQ8R508

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q8R508

Family and domain databases

InterProiView protein in InterPro
IPR002126, Cadherin-like_dom
IPR015919, Cadherin-like_sf
IPR020894, Cadherin_CS
IPR013320, ConA-like_dom_sf
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR001791, Laminin_G
PfamiView protein in Pfam
PF00028, Cadherin, 27 hits
PF00008, EGF, 1 hit
PF02210, Laminin_G_2, 1 hit
PRINTSiPR00205, CADHERIN
SMARTiView protein in SMART
SM00112, CA, 32 hits
SM00181, EGF, 4 hits
SM00179, EGF_CA, 3 hits
SM00282, LamG, 1 hit
SUPFAMiSSF49313, SSF49313, 34 hits
SSF49899, SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS00010, ASX_HYDROXYL, 1 hit
PS00232, CADHERIN_1, 19 hits
PS50268, CADHERIN_2, 32 hits
PS00022, EGF_1, 3 hits
PS01186, EGF_2, 1 hit
PS50026, EGF_3, 4 hits
PS01187, EGF_CA, 1 hit
PS50025, LAM_G_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFAT3_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8R508
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: June 1, 2002
Last modified: December 2, 2020
This is version 111 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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