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Protein

Fc receptor-like protein 1

Gene

Fcrl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May function as an activating coreceptor in B-cells. May function in B-cells activation and differentiation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor

Names & Taxonomyi

Protein namesi
Recommended name:
Fc receptor-like protein 1
Short name:
FcR-like protein 1
Short name:
FcRL1
Alternative name(s):
BXMAS1-like protein 1
Short name:
mBXMH1
Fc receptor homolog 1
Short name:
FcRH1
Short name:
moFcRH1
IFGP family protein 1
Short name:
mIFGP1
CD_antigen: CD307a
Gene namesi
Name:Fcrl1
Synonyms:Fcrh1, Ifgp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2442862 Fcrl1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini17 – 219ExtracellularSequence analysisAdd BLAST203
Transmembranei220 – 240HelicalSequence analysisAdd BLAST21
Topological domaini241 – 343CytoplasmicSequence analysisAdd BLAST103

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000033163917 – 343Fc receptor-like protein 1Add BLAST327

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi51N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi138 ↔ 185PROSITE-ProRule annotation
Glycosylationi202N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Phosphorylated on tyrosines upon activation.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiQ8R4Y0

PTM databases

iPTMnetiQ8R4Y0
PhosphoSitePlusiQ8R4Y0

Expressioni

Tissue specificityi

Widely expressed. Expressed in B-cells at the various stages of differentiation.2 Publications

Gene expression databases

CleanExiMM_FCRL1

Structurei

3D structure databases

ProteinModelPortaliQ8R4Y0
SMRiQ8R4Y0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 109Ig-like C2-type 1Add BLAST93
Domaini117 – 200Ig-like C2-type 2Add BLAST84

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi266 – 271ITIM motif 16
Motifi279 – 284ITIM motif 26
Motifi291 – 296ITIM motif 36
Motifi325 – 330ITIM motif 46
Motifi337 – 342ITIM motif 56

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000036945
HOVERGENiHBG074073
InParanoidiQ8R4Y0
KOiK06727
PhylomeDBiQ8R4Y0

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
PfamiView protein in Pfam
PF13895 Ig_2, 1 hit
SMARTiView protein in SMART
SM00409 IG, 2 hits
SUPFAMiSSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits

Sequences (4+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8R4Y0-1) [UniParc]FASTAAdd to basket
Also known as: a, long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLPWLLLLIC ALPCEPAGIS DVSLKTRPPG GWVMEGDKLV LICSVDRVTG
60 70 80 90 100
NITYFWYRGA LGFQLETKTQ PSLTAEFEIS DMKQSDADQY YCAANDGHDP
110 120 130 140 150
IASELVSIHV RVPVSRPVLT FGDSGTQAVL GDLVELHCKA LRGSPPIFYQ
160 170 180 190 200
FYHESIILGN SSAPSGGGAS FNFSLTAEHS GNFSCEASNG QGAQRSEVVA
210 220 230 240 250
LNLTGLSLVP TENGISHLSL GLTGWLLGCL SPITMALIFC YWLKRKIGRQ
260 270 280 290 300
SEDPVRSPPQ TVLQGSTYPK SPDSRQPEPL YENVNVVSGN EVYSLVYHTP
310 320 330 340
QVLEPAAAQH VRTHGVSESF QVSSGLYSKP RINIAHMDYE DAM
Length:343
Mass (Da):37,277
Last modified:June 1, 2002 - v1
Checksum:iF4F235954A907B6C
GO
Isoform 2 (identifier: Q8R4Y0-2) [UniParc]FASTAAdd to basket
Also known as: short

The sequence of this isoform differs from the canonical sequence as follows:
     205-247: Missing.

Show »
Length:300
Mass (Da):32,579
Checksum:iA48E7D10C57AE5FB
GO
Isoform 3 (identifier: Q8R4Y0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     319-343: SFQVSSGLYSKPRINIAHMDYEDAM → VQGGIA

Note: No experimental confirmation available.
Show »
Length:324
Mass (Da):34,961
Checksum:iF73E6FBEE47A3A95
GO
Isoform 4 (identifier: Q8R4Y0-4) [UniParc]FASTAAdd to basket
Also known as: b

The sequence of this isoform differs from the canonical sequence as follows:
     206-208: LSL → KPT
     209-343: Missing.

Note: No experimental confirmation available.
Show »
Length:208
Mass (Da):22,326
Checksum:i72C1F3BD5044DC28
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J0W8A0A0R4J0W8_MOUSE
Fc receptor-like protein 1
Fcrl1
343Annotation score:
A0A0A6YY56A0A0A6YY56_MOUSE
Fc receptor-like protein 1
Fcrl1
324Annotation score:
E9Q958E9Q958_MOUSE
Fc receptor-like protein 1
Fcrl1
363Annotation score:
E9Q5S9E9Q5S9_MOUSE
Fc receptor-like protein 1
Fcrl1
300Annotation score:
A0A0A6YXB2A0A0A6YXB2_MOUSE
Fc receptor-like protein 1
Fcrl1
208Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti102A → P in BAC30017 (PubMed:16141072).Curated1
Sequence conflicti232P → L in BAC30017 (PubMed:16141072).Curated1
Sequence conflicti271S → P in BAC30017 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_033296205 – 247Missing in isoform 2. 2 PublicationsAdd BLAST43
Alternative sequenceiVSP_033297206 – 208LSL → KPT in isoform 4. 1 Publication3
Alternative sequenceiVSP_033298209 – 343Missing in isoform 4. 1 PublicationAdd BLAST135
Alternative sequenceiVSP_033299319 – 343SFQVS…YEDAM → VQGGIA in isoform 3. 1 PublicationAdd BLAST25

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF329485 mRNA Translation: AAM11542.1
AY506554 mRNA Translation: AAS91574.1
AY506555 mRNA Translation: AAS91575.1
AY158088 mRNA Translation: AAO20871.1
AY158089 mRNA Translation: AAO20872.1
AK038494 mRNA Translation: BAC30017.1
AK156985 mRNA Translation: BAE33923.1
BC055830 mRNA Translation: AAH55830.1
CCDSiCCDS17452.1 [Q8R4Y0-1]
CCDS50942.1 [Q8R4Y0-2]
CCDS79937.1 [Q8R4Y0-3]
RefSeqiNP_001129708.1, NM_001136236.1
NP_001297474.1, NM_001310545.1
NP_694730.2, NM_153090.2
NP_835459.1, NM_178165.4
UniGeneiMm.255203

Genome annotation databases

GeneIDi229499
KEGGimmu:229499

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF329485 mRNA Translation: AAM11542.1
AY506554 mRNA Translation: AAS91574.1
AY506555 mRNA Translation: AAS91575.1
AY158088 mRNA Translation: AAO20871.1
AY158089 mRNA Translation: AAO20872.1
AK038494 mRNA Translation: BAC30017.1
AK156985 mRNA Translation: BAE33923.1
BC055830 mRNA Translation: AAH55830.1
CCDSiCCDS17452.1 [Q8R4Y0-1]
CCDS50942.1 [Q8R4Y0-2]
CCDS79937.1 [Q8R4Y0-3]
RefSeqiNP_001129708.1, NM_001136236.1
NP_001297474.1, NM_001310545.1
NP_694730.2, NM_153090.2
NP_835459.1, NM_178165.4
UniGeneiMm.255203

3D structure databases

ProteinModelPortaliQ8R4Y0
SMRiQ8R4Y0
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ8R4Y0
PhosphoSitePlusiQ8R4Y0

Proteomic databases

PRIDEiQ8R4Y0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi229499
KEGGimmu:229499

Organism-specific databases

CTDi115350
MGIiMGI:2442862 Fcrl1

Phylogenomic databases

HOGENOMiHOG000036945
HOVERGENiHBG074073
InParanoidiQ8R4Y0
KOiK06727
PhylomeDBiQ8R4Y0

Miscellaneous databases

PROiPR:Q8R4Y0
SOURCEiSearch...

Gene expression databases

CleanExiMM_FCRL1

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
PfamiView protein in Pfam
PF13895 Ig_2, 1 hit
SMARTiView protein in SMART
SM00409 IG, 2 hits
SUPFAMiSSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiFCRL1_MOUSE
AccessioniPrimary (citable) accession number: Q8R4Y0
Secondary accession number(s): Q68SP0
, Q7TMH2, Q80WN3, Q8BYS4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: June 1, 2002
Last modified: October 10, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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