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Protein

Procollagen C-endopeptidase enhancer 2

Gene

Pcolce2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds to the C-terminal propeptide of types I and II procollagens and may enhance the cleavage of that propeptide by BMP1.By similarity

GO - Molecular functioni

GO - Biological processi

  • cellular response to leukemia inhibitory factor Source: MGI

Keywordsi

Molecular functionHeparin-binding

Enzyme and pathway databases

ReactomeiR-MMU-1650814 Collagen biosynthesis and modifying enzymes

Names & Taxonomyi

Protein namesi
Recommended name:
Procollagen C-endopeptidase enhancer 2
Alternative name(s):
Procollagen COOH-terminal proteinase enhancer 2
Short name:
PCPE-2
Short name:
Procollagen C-proteinase enhancer 2
Gene namesi
Name:Pcolce2
Synonyms:Pcpe2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1923727 Pcolce2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000002202123 – 414Procollagen C-endopeptidase enhancer 2Add BLAST392

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi32 ↔ 58PROSITE-ProRule annotation
Disulfide bondi85 ↔ 106PROSITE-ProRule annotation
Disulfide bondi153 ↔ 180PROSITE-ProRule annotation
Disulfide bondi207 ↔ 230PROSITE-ProRule annotation
Disulfide bondi296 ↔ 363By similarity
Disulfide bondi300 ↔ 366By similarity
Disulfide bondi311 ↔ 414By similarity
Glycosylationi354N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

O-glycosylated; contains sialic acid.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ8R4W6
PaxDbiQ8R4W6
PeptideAtlasiQ8R4W6
PRIDEiQ8R4W6

PTM databases

PhosphoSitePlusiQ8R4W6

Expressioni

Developmental stagei

Expressed at all stages of development, with expression level decreasing from 7 to 11 dpc and more abundant levels of expression at 15 and 17 dpc. First detectable at relatively low level at 10.5 dpc in the area of the third and fourth branchial arches. At 13.5 dpc easily discernible expression seems primarily confined to the cartilage primordia of future bones. At 15.5 dpc expressed at the highest levels in skeletal elements in the interior non-ossified regions of cartilaginous structures and excluded from regions of ossification.1 Publication

Gene expression databases

BgeeiENSMUSG00000015354 Expressed in 207 organ(s), highest expression level in lung
CleanExiMM_PCOLCE2
GenevisibleiQ8R4W6 MM

Interactioni

Subunit structurei

Interacts with heparin with high affinity, and type I or II collagen.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000015498

Structurei

3D structure databases

ProteinModelPortaliQ8R4W6
SMRiQ8R4W6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 143CUB 1PROSITE-ProRule annotationAdd BLAST112
Domaini153 – 267CUB 2PROSITE-ProRule annotationAdd BLAST115
Domaini296 – 414NTRPROSITE-ProRule annotationAdd BLAST119

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi273 – 277Poly-Thr5

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IEMJ Eukaryota
ENOG410Y9AW LUCA
GeneTreeiENSGT00760000119018
HOGENOMiHOG000059592
HOVERGENiHBG053528
InParanoidiQ8R4W6
OMAiSIINVYK
OrthoDBiEOG091G06JY
PhylomeDBiQ8R4W6
TreeFamiTF316506

Family and domain databases

CDDicd00041 CUB, 2 hits
cd03576 NTR_PCOLCE, 1 hit
Gene3Di2.60.120.290, 2 hits
InterProiView protein in InterPro
IPR000859 CUB_dom
IPR001134 Netrin_domain
IPR018933 Netrin_module_non-TIMP
IPR035814 NTR_PCOLCE
IPR035914 Sperma_CUB_dom_sf
IPR008993 TIMP-like_OB-fold
PfamiView protein in Pfam
PF00431 CUB, 2 hits
PF01759 NTR, 1 hit
SMARTiView protein in SMART
SM00643 C345C, 1 hit
SM00042 CUB, 2 hits
SUPFAMiSSF49854 SSF49854, 2 hits
SSF50242 SSF50242, 1 hit
PROSITEiView protein in PROSITE
PS01180 CUB, 2 hits
PS50189 NTR, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8R4W6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGGASACIPL CLLLATARMA RPQTPERPVF TCGGILTGES GFIGSEGFPG
60 70 80 90 100
MYPPNSKCTW KITVPEGKVV VLNFRFIDLE NDNLCRYDFV DVYNGHANGQ
110 120 130 140 150
RIGRFCGTFR PGSLVASGNK MTVQMISDAN TAGSGFMATY SAAAPDGKGD
160 170 180 190 200
RYCGGRLEKP SGTFKTPNWP DRDYPVGVTC VWHIIAPKNQ LIELKFEKFD
210 220 230 240 250
VERDNYCRYD YVAVFNGGEV NDAKRIGKYC GDSPPVPIVS ERNELLIQFL
260 270 280 290 300
SDLSLTADGF IGHYKFRPKK FPTTTTTPVT TTLPVTTGLK PTVALCQQKC
310 320 330 340 350
RRMGTLESNY CSSNFVLAGT VITTVTRGGS LHATVSIISI YREGNLAIQQ
360 370 380 390 400
AGKNMSVKLT VVCRQCPLLR RGLNYIIMGQ VGEDGRGKIM PNSFVKMFKN
410
KNQKPMNALK NKQC
Length:414
Mass (Da):45,408
Last modified:May 10, 2005 - v2
Checksum:iE51A29A352A2CF1D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti167P → S in AAL83947 (PubMed:12393877).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF352788 mRNA Translation: AAL83947.1
AK010249 mRNA Translation: BAB26794.1
AK132395 mRNA Translation: BAE21144.1
BC051174 mRNA Translation: AAH51174.1
CCDSiCCDS23410.1
RefSeqiNP_083896.1, NM_029620.2
UniGeneiMm.46016

Genome annotation databases

EnsembliENSMUST00000015498; ENSMUSP00000015498; ENSMUSG00000015354
GeneIDi76477
KEGGimmu:76477
UCSCiuc009rbg.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF352788 mRNA Translation: AAL83947.1
AK010249 mRNA Translation: BAB26794.1
AK132395 mRNA Translation: BAE21144.1
BC051174 mRNA Translation: AAH51174.1
CCDSiCCDS23410.1
RefSeqiNP_083896.1, NM_029620.2
UniGeneiMm.46016

3D structure databases

ProteinModelPortaliQ8R4W6
SMRiQ8R4W6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000015498

PTM databases

PhosphoSitePlusiQ8R4W6

Proteomic databases

MaxQBiQ8R4W6
PaxDbiQ8R4W6
PeptideAtlasiQ8R4W6
PRIDEiQ8R4W6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000015498; ENSMUSP00000015498; ENSMUSG00000015354
GeneIDi76477
KEGGimmu:76477
UCSCiuc009rbg.1 mouse

Organism-specific databases

CTDi26577
MGIiMGI:1923727 Pcolce2

Phylogenomic databases

eggNOGiENOG410IEMJ Eukaryota
ENOG410Y9AW LUCA
GeneTreeiENSGT00760000119018
HOGENOMiHOG000059592
HOVERGENiHBG053528
InParanoidiQ8R4W6
OMAiSIINVYK
OrthoDBiEOG091G06JY
PhylomeDBiQ8R4W6
TreeFamiTF316506

Enzyme and pathway databases

ReactomeiR-MMU-1650814 Collagen biosynthesis and modifying enzymes

Miscellaneous databases

PROiPR:Q8R4W6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000015354 Expressed in 207 organ(s), highest expression level in lung
CleanExiMM_PCOLCE2
GenevisibleiQ8R4W6 MM

Family and domain databases

CDDicd00041 CUB, 2 hits
cd03576 NTR_PCOLCE, 1 hit
Gene3Di2.60.120.290, 2 hits
InterProiView protein in InterPro
IPR000859 CUB_dom
IPR001134 Netrin_domain
IPR018933 Netrin_module_non-TIMP
IPR035814 NTR_PCOLCE
IPR035914 Sperma_CUB_dom_sf
IPR008993 TIMP-like_OB-fold
PfamiView protein in Pfam
PF00431 CUB, 2 hits
PF01759 NTR, 1 hit
SMARTiView protein in SMART
SM00643 C345C, 1 hit
SM00042 CUB, 2 hits
SUPFAMiSSF49854 SSF49854, 2 hits
SSF50242 SSF50242, 1 hit
PROSITEiView protein in PROSITE
PS01180 CUB, 2 hits
PS50189 NTR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPCOC2_MOUSE
AccessioniPrimary (citable) accession number: Q8R4W6
Secondary accession number(s): Q3V1K6, Q9CX06
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: May 10, 2005
Last modified: November 7, 2018
This is version 112 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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