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UniProtKB - Q8R4U0 (STAB2_MOUSE)

Entry version 155 (29 Sep 2021)
Sequence version 1 (01 Jun 2002)
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Protein

Stabilin-2

Gene

Stab2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Hyaluronan receptor that binds to and mediates endocytosis of hyaluronic acid (HA). Acts also, in different species, as a primary systemic scavenger receptor for heparin (Hep), chondroitin sulfate (CS), dermatan sulfate (DS), nonglycosaminoglycan (GAG), acetylated low-density lipoprotein (AcLDL), pro-collagen propeptides and advanced glycation end products (AGE). May serve to maintain tissue integrity by supporting extracellular matrix turnover or it may contribute to maintaining fluidity of bodily liquids by resorption of hyaluronan. Counter receptor which plays an important role in lymphocyte recruitment in the hepatic vasculature. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. The proteolytically processed short form also functions as an endocytosis receptor for heparin internalization as well as HA and CS.

2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processEndocytosis
LigandHyaluronic acid

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-2160916, Hyaluronan uptake and degradation
R-MMU-3000497, Scavenging by Class H Receptors

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Stabilin-2
Alternative name(s):
Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 2
Short name:
FEEL-2
Cleaved into the following chain:
Short form stabilin-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Stab2Imported
Synonyms:Feel2, Hare
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:2178743, Stab2

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSMUSG00000035459

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini29 – 2464ExtracellularSequence analysisAdd BLAST2436
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2465 – 2485HelicalSequence analysisAdd BLAST21
Topological domaini2486 – 2559CytoplasmicSequence analysisAdd BLAST74

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 28Sequence analysisAdd BLAST28
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000771429 – 2559Stabilin-2Add BLAST2531
ChainiPRO_00000077151136 – 2551Short form stabilin-2By similarityAdd BLAST1416

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi71N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi120 ↔ 134By similarity
Disulfide bondi128 ↔ 144By similarity
Disulfide bondi146 ↔ 155By similarity
Glycosylationi167N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi168 ↔ 179By similarity
Disulfide bondi172 ↔ 189By similarity
Disulfide bondi191 ↔ 200By similarity
Disulfide bondi207 ↔ 218By similarity
Disulfide bondi212 ↔ 230By similarity
Disulfide bondi232 ↔ 243By similarity
Disulfide bondi249 ↔ 260By similarity
Disulfide bondi254 ↔ 270By similarity
Disulfide bondi272 ↔ 283By similarity
Disulfide bondi334 ↔ 346By similarity
Disulfide bondi340 ↔ 356By similarity
Glycosylationi345N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi358 ↔ 369By similarity
Glycosylationi572N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi626N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi673N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi691N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi747 ↔ 761By similarity
Disulfide bondi755 ↔ 771By similarity
Glycosylationi768N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi773 ↔ 782By similarity
Glycosylationi796N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi837 ↔ 850By similarity
Disulfide bondi844 ↔ 859By similarity
Glycosylationi854N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi861 ↔ 872By similarity
Disulfide bondi878 ↔ 893By similarity
Disulfide bondi887 ↔ 903By similarity
Disulfide bondi905 ↔ 916By similarity
Disulfide bondi922 ↔ 936By similarity
Disulfide bondi930 ↔ 946By similarity
Glycosylationi933N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi948 ↔ 959By similarity
Disulfide bondi965 ↔ 978By similarity
Disulfide bondi972 ↔ 988By similarity
Disulfide bondi990 ↔ 1001By similarity
Glycosylationi1024N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1036N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1108N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1255N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1283N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1355 ↔ 1369By similarity
Disulfide bondi1363 ↔ 1379By similarity
Glycosylationi1374N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1381 ↔ 1390By similarity
Glycosylationi1386N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1402 ↔ 1413By similarity
Disulfide bondi1406 ↔ 1423By similarity
Disulfide bondi1425 ↔ 1434By similarity
Disulfide bondi1443 ↔ 1453By similarity
Glycosylationi1444N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1447 ↔ 1463By similarity
Disulfide bondi1465 ↔ 1476By similarity
Glycosylationi1472N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1482 ↔ 1495By similarity
Disulfide bondi1489 ↔ 1505By similarity
Disulfide bondi1507 ↔ 1518By similarity
Disulfide bondi1524 ↔ 1537By similarity
Disulfide bondi1531 ↔ 1547By similarity
Disulfide bondi1549 ↔ 1560By similarity
Disulfide bondi1566 ↔ 1579By similarity
Disulfide bondi1573 ↔ 1589By similarity
Glycosylationi1580N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1591 ↔ 1602By similarity
Glycosylationi1750N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1970 ↔ 1984By similarity
Disulfide bondi1978 ↔ 1994By similarity
Disulfide bondi1996 ↔ 2005By similarity
Glycosylationi2001N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2017 ↔ 2028By similarity
Disulfide bondi2022 ↔ 2038By similarity
Disulfide bondi2040 ↔ 2049By similarity
Disulfide bondi2059 ↔ 2069By similarity
Disulfide bondi2063 ↔ 2075By similarity
Glycosylationi2072N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2077 ↔ 2088By similarity
Disulfide bondi2094 ↔ 2107By similarity
Disulfide bondi2101 ↔ 2116By similarity
Disulfide bondi2118 ↔ 2129By similarity
Disulfide bondi2135 ↔ 2149By similarity
Disulfide bondi2143 ↔ 2159By similarity
Disulfide bondi2161 ↔ 2172By similarity
Disulfide bondi2228 ↔ 2296By similarity
Disulfide bondi2252 ↔ 2273By similarity
Glycosylationi2287N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2303N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2375N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2391N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2400N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2503PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Glycosylated.By similarity
Proteolytically processed to yield a smaller protein.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

The CPTAC Assay portal

More...CPTACi		non-CPTAC-3499

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8R4U0

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8R4U0

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8R4U0

PRoteomics IDEntifications database

More...PRIDEi		Q8R4U0

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		257446

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q8R4U0, 29 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8R4U0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8R4U0

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q8R4U0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in endothelial sinuses of liver, lymph nodes, bone marrow, spleen and in specialised structures of eye, heart, brain and kidney. Expression is detected in corneal and lens epithelium, in mesenchymal cells of the heart valves, in the ependymal cells lining the ventricles in the brain, and in the prismatic epithelial cells covering the renal papillae.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000035459, Expressed in liver and 145 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8R4U0, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with heparin, alpha-M/beta-2 integrin (ITGAM and ITGB2), and thymosin beta 4 (TMSB4X) (By similarity).

Interacts with GULP1. Associates with clathrin and adapter protein AP-2; in liver sinusoidal endothelial cells (LSECs).

By similarity2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		228666, 1 interactor

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000048309

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8R4U0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8R4U0

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini116 – 156EGF-like 1PROSITE-ProRule annotationAdd BLAST41
Domaini164 – 201EGF-like 2PROSITE-ProRule annotationAdd BLAST38
Domaini203 – 244EGF-like 3PROSITE-ProRule annotationAdd BLAST42
Domaini245 – 284EGF-like 4PROSITE-ProRule annotationAdd BLAST40
Domaini330 – 370EGF-like 5PROSITE-ProRule annotationAdd BLAST41
Domaini379 – 512FAS1 1PROSITE-ProRule annotationAdd BLAST134
Domaini522 – 659FAS1 2PROSITE-ProRule annotationAdd BLAST138
Domaini743 – 783EGF-like 6PROSITE-ProRule annotationAdd BLAST41
Domaini833 – 873EGF-like 7PROSITE-ProRule annotationAdd BLAST41
Domaini874 – 917EGF-like 8PROSITE-ProRule annotationAdd BLAST44
Domaini918 – 960EGF-like 9PROSITE-ProRule annotationAdd BLAST43
Domaini961 – 1002EGF-like 10PROSITE-ProRule annotationAdd BLAST42
Domaini1002 – 1135FAS1 3PROSITE-ProRule annotationAdd BLAST134
Domaini1145 – 1273FAS1 4PROSITE-ProRule annotationAdd BLAST129
Domaini1350 – 1415Laminin EGF-like 1Sequence analysisAdd BLAST66
Domaini1439 – 1477EGF-like 11PROSITE-ProRule annotationAdd BLAST39
Domaini1478 – 1519EGF-like 12PROSITE-ProRule annotationAdd BLAST42
Domaini1520 – 1561EGF-like 13PROSITE-ProRule annotationAdd BLAST42
Domaini1562 – 1603EGF-like 14PROSITE-ProRule annotationAdd BLAST42
Domaini1603 – 1731FAS1 5PROSITE-ProRule annotationAdd BLAST129
Domaini1747 – 1888FAS1 6PROSITE-ProRule annotationAdd BLAST142
Domaini1965 – 2030Laminin EGF-like 2Sequence analysisAdd BLAST66
Domaini2055 – 2089EGF-like 15PROSITE-ProRule annotationAdd BLAST35
Domaini2090 – 2130EGF-like 16PROSITE-ProRule annotationAdd BLAST41
Domaini2131 – 2173EGF-like 17PROSITE-ProRule annotationAdd BLAST43
Domaini2206 – 2298LinkPROSITE-ProRule annotationAdd BLAST93
Domaini2318 – 2452FAS1 7PROSITE-ProRule annotationAdd BLAST135

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2510 – 2520Interaction with TMSB4XBy similarityAdd BLAST11
Regioni2514 – 2559DisorderedSequence analysisAdd BLAST46

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi2515 – 2529Polar residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Recognizes phosphatidyl serine via its epidermal growth factor-like domains.

Keywords - Domaini

EGF-like domain, Laminin EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1218, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156566

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_001035_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8R4U0

Identification of Orthologs from Complete Genome Data

More...OMAi		PQCQACP

Database of Orthologous Groups

More...OrthoDBi		6428at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8R4U0

TreeFam database of animal gene trees

More...TreeFami		TF331489

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.30.180.10, 7 hits
3.10.100.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR016186, C-type_lectin-like/link_sf
IPR016187, CTDL_fold
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR024731, EGF_dom
IPR036378, FAS1_dom_sf
IPR000782, FAS1_domain
IPR002049, Laminin_EGF
IPR000538, Link_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12947, EGF_3, 7 hits
PF02469, Fasciclin, 6 hits
PF00193, Xlink, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00181, EGF, 21 hits
SM00179, EGF_CA, 7 hits
SM00180, EGF_Lam, 5 hits
SM00554, FAS1, 7 hits
SM00445, LINK, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF56436, SSF56436, 1 hit
SSF82153, SSF82153, 7 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00022, EGF_1, 7 hits
PS01186, EGF_2, 16 hits
PS50026, EGF_3, 21 hits
PS01248, EGF_LAM_1, 2 hits
PS50213, FAS1, 7 hits
PS01241, LINK_1, 1 hit
PS50963, LINK_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8R4U0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARSKLLLGK LLPLILIFLG LLVQNACSPT EAPELTKRCD KKSTLTIKTE 
        60         70         80         90        100
CQSCSVNIAV KCPDGYIKIT NGTVGVRDCR YSLKIQSYVL DIPGCRHICR 
       110        120        130        140        150
KDYLQPQCCP GHWGPDCMEC PGGARAPCGG RGVCDEGMEG TGSCSCRAGF 
       160        170        180        190        200
RGTACENCAA EDVFGPNCSA VCSCVHGVCN SGISGDGTCE CLSAYRGPRC 
       210        220        230        240        250
DKPIPECAAL LCPENSRCSP SSKDETKLQC KCLPSYKGDG QTCKPINPCL 
       260        270        280        290        300
KNVCHPHASC SYLGPNRHSC VCQKGYQGDG QVCLPVDPCQ TSYGNCPTKS 
       310        320        330        340        350
TVCRYDGPGQ SHCECKEHYR NFVPGVGCSM TDICESKNPC HKNANCSTVS 
       360        370        380        390        400
PGQTQCTCQK GYVGDGLNCY GNIMQRLREL NTEPRGMWQG QLTSFISILD 
       410        420        430        440        450
RTYAWPLSNL GPFTVLLPSD KGLKGVDVKE LLMDKEAARY FVKLHIIAGQ 
       460        470        480        490        500
MSTEQMYNLD TFYTLTGKSG EIINKDKDNQ LKLKLYGSKI VQIIQGNIVA 
       510        520        530        540        550
SNGLVHILDR AMDKIEPTLE SNPQQTIMTM LQPRYGKFRS LLEKTNVGQA 
       560        570        580        590        600
LEKGGIDEPY TIFVPSNEAL SNMTAGVLDY LLSPEGSRKL LELVRYHIVA 
       610        620        630        640        650
FTQLEVATLV STLHIRSMAN QIITFNISSK GQILANNVAV DETEVAAKNG 
       660        670        680        690        700
RIYTLTGVLI PPSILPILPH RCNETKREMK LGTCVRCFMK NWSKCPTNSE 
       710        720        730        740        750
PTAIFTNKCF YGSRAWNLKI GCARYCDVTV EIPRCCKGFF GPDCNPCPGG 
       760        770        780        790        800
FMNPCSGNGQ CIDGLGGNGT CICEDGFQGS RCQFCSKPNR YGPQCNRTCQ 
       810        820        830        840        850
CVHGICDNRL DSDGSCLPGT CREGTAGRFC DKQTSACGPY MQFCHIHATC 
       860        870        880        890        900
EYSNETASCV CNDGYEGDGT LCSKKDPCLG STSRGGCSPN AECIQASTGT 
       910        920        930        940        950
YSCVCQRGWT GNGRDCVEIN SCLLPSSGGC HDNATCLYVG PGQNECECKK 
       960        970        980        990       1000
GFRGNGIDCE PIISCLEQIE KCHPLATCQY TLSGVWSCVC QEGYEGNGVL 
      1010       1020       1030       1040       1050
CYGNVLMELS FLSEAAVFYQ WINNASLQSM LSATSNLTVL VPSLQAIKDM 
      1060       1070       1080       1090       1100
DQNEKSFWLS RNNIPALIKY HTLLGTYRVA DLQTLPSSHM LATSLQGSFL 
      1110       1120       1130       1140       1150
RLDKADGNIT IEGASFVDGD NAATNGVVHI INKVLIPQRG LTGSLPSLLT 
      1160       1170       1180       1190       1200
RLEQMPDYSI FRGYIIHYNL ASAIEAADAY TVFVPNNEAI ESYIREKKAT 
      1210       1220       1230       1240       1250
SLKEDILQYH VVLGEKLLRN DLHNGMHRET MLGFSYLLAF FLHNDQLYVN 
      1260       1270       1280       1290       1300
EAPINYTNVA TDKGVIHGLE KVLEIKKNRC DNNDTIIVRG KCGKCSQQTL 
      1310       1320       1330       1340       1350
CPLETKPLSE TRKCIYSVYF MGKRSIFIGC QLQCVRTIIT SACCAGFFGP 
      1360       1370       1380       1390       1400
QCQACPGKGQ NVCSGNGFCL DGVNGTGTCE CEQGFNGTAC ETCTEGKYGI 
      1410       1420       1430       1440       1450
HCDQACSCVH GRCNQGPSGD GSCDCDVGWR GVKCDSEITT DNCNGTCHTS 
      1460       1470       1480       1490       1500
ANCLLDPDGK ASCKCAAGFQ GNGTVCTAIN ACEISNGGCS AKADCKRTIP 
      1510       1520       1530       1540       1550
GSRVCVCKAG YTGDGIVCLE INPCLENHGG CDRHAECTQT GPNQAVCNCL 
      1560       1570       1580       1590       1600
PKYTGDGKVC TLINVCLTNN GGCSPFAFCN HTEQDQRTCT CKPDYTGDGI 
      1610       1620       1630       1640       1650
VCRGSIHSEL PKNPSTSQYF FQLQEHAVQE LAGPGPFTVF VPSSDSFNSE 
      1660       1670       1680       1690       1700
SKLKVWDKQG LMSQILRYHV VACQQLLLEN LKVITSATTL QGEPISISVS 
      1710       1720       1730       1740       1750
QDTVLINKKA KVLSSDIIST NGVIHVIDTL LSPQNLLITP KGASGRVLLN 
      1760       1770       1780       1790       1800
LTTVAANHGY TKFSKLIQDS GLLKVITDPM HTPVTLFWPT DKALQALPQE 
      1810       1820       1830       1840       1850
QQDFLFNEDN KDKLKAYLKF HVIRDTMALA SDLPRSASWK TLQGSELSVR 
      1860       1870       1880       1890       1900
CGTGSDVGEL FLNGQMCRII QRRLLFDGGV AYGIDCLLMD PTEGGRCDTF 
      1910       1920       1930       1940       1950
TTFNIPGECG SCFSTPRCPL QSKPKGVRKK CIYNPLPFRR DVEGCQNLCT 
      1960       1970       1980       1990       2000
LVVHVPRCCS GYFMPDCQAC PGGPDTPCNN RGMCYDQYKP TGQCQCHTGF 
      2010       2020       2030       2040       2050
NGTACELCLP GRFGPDCQPC GCSEHGQCDE GITGSGQCLC EAGWTGRFCD 
      2060       2070       2080       2090       2100
APTVVIPVCI PACSMHATCM ENNTCVCNLN YEGDGITCTV VDFCKQNNGG 
      2110       2120       2130       2140       2150
CAKVAKCSQK GTQVSCSCQK GYKGDGHSCT EIDPCANGVN GGCHEHATCR 
      2160       2170       2180       2190       2200
MTGPGKQKCE CKSHYVGDGR DCEPEQLPLD RCLQDNGQCH PDANCVDLHF 
      2210       2220       2230       2240       2250
QDTTVGVFHL RSPLGQYKLT FDKAKEACAK EAASIATYNQ LSYAQKAKYH 
      2260       2270       2280       2290       2300
LCSAGWLESG RVAYPTIYAS KKCANIVGIV DYGTRTNKSE MWDVFCYRMK 
      2310       2320       2330       2340       2350
DVNCTCKAGY VGDGFSCNGN LLQVLMSFPS LTNFLTEVLV FSRSSAQGRA 
      2360       2370       2380       2390       2400
FLKHLTDLSI SGTLFVPQNS GLPKNKSLSG RDIEHHLTNV NVSFYDDLVN 
      2410       2420       2430       2440       2450
GTVLKTRLGS QLLITSSQDQ LHQEARFVDG RAILQWDIIA SNGVLHIISE 
      2460       2470       2480       2490       2500
PLKAPPTAAT AAHSGLGTGI FCAVVLVTGA IALAAYSYFR LNQRTTGFRR 
      2510       2520       2530       2540       2550
FESEDDIDAL AFGKQQPESI TNPLYETSTP AAPEPSCDPF TDSGERELEN 

SDPLGALRS
Length:2,559
Mass (Da):277,532
Last modified:June 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1C9855AD61EFF015
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1W2P6Y4A0A1W2P6Y4_MOUSE
Stabilin-2
Stab2
870Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1666L → G in BAC28741 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF364951 mRNA Translation: AAL91684.2
AK034522 mRNA Translation: BAC28741.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS36021.1

NCBI Reference Sequences

More...RefSeqi		NP_619614.1, NM_138673.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000035288; ENSMUSP00000048309; ENSMUSG00000035459

Database of genes from NCBI RefSeq genomes

More...GeneIDi		192188

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:192188

UCSC genome browser

More...UCSCi		uc007gqo.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF364951 mRNA Translation: AAL91684.2
AK034522 mRNA Translation: BAC28741.1
CCDSiCCDS36021.1
RefSeqiNP_619614.1, NM_138673.2

3D structure databases

SMRiQ8R4U0
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi228666, 1 interactor
STRINGi10090.ENSMUSP00000048309

PTM databases

GlyGeniQ8R4U0, 29 sites
iPTMnetiQ8R4U0
PhosphoSitePlusiQ8R4U0
SwissPalmiQ8R4U0

Proteomic databases

CPTACinon-CPTAC-3499
jPOSTiQ8R4U0
MaxQBiQ8R4U0
PaxDbiQ8R4U0
PRIDEiQ8R4U0
ProteomicsDBi257446

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		18052, 147 antibodies

The DNASU plasmid repository

More...DNASUi		192188

Genome annotation databases

EnsembliENSMUST00000035288; ENSMUSP00000048309; ENSMUSG00000035459
GeneIDi192188
KEGGimmu:192188
UCSCiuc007gqo.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		55576
MGIiMGI:2178743, Stab2
VEuPathDBiHostDB:ENSMUSG00000035459

Phylogenomic databases

eggNOGiKOG1218, Eukaryota
GeneTreeiENSGT00940000156566
HOGENOMiCLU_001035_0_0_1
InParanoidiQ8R4U0
OMAiPQCQACP
OrthoDBi6428at2759
PhylomeDBiQ8R4U0
TreeFamiTF331489

Enzyme and pathway databases

ReactomeiR-MMU-2160916, Hyaluronan uptake and degradation
R-MMU-3000497, Scavenging by Class H Receptors

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		192188, 0 hits in 61 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Stab2, mouse

Protein Ontology

More...PROi		PR:Q8R4U0
RNActiQ8R4U0, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000035459, Expressed in liver and 145 other tissues
GenevisibleiQ8R4U0, MM

Family and domain databases

Gene3Di2.30.180.10, 7 hits
3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR016186, C-type_lectin-like/link_sf
IPR016187, CTDL_fold
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR024731, EGF_dom
IPR036378, FAS1_dom_sf
IPR000782, FAS1_domain
IPR002049, Laminin_EGF
IPR000538, Link_dom
PfamiView protein in Pfam
PF12947, EGF_3, 7 hits
PF02469, Fasciclin, 6 hits
PF00193, Xlink, 1 hit
SMARTiView protein in SMART
SM00181, EGF, 21 hits
SM00179, EGF_CA, 7 hits
SM00180, EGF_Lam, 5 hits
SM00554, FAS1, 7 hits
SM00445, LINK, 1 hit
SUPFAMiSSF56436, SSF56436, 1 hit
SSF82153, SSF82153, 7 hits
PROSITEiView protein in PROSITE
PS00022, EGF_1, 7 hits
PS01186, EGF_2, 16 hits
PS50026, EGF_3, 21 hits
PS01248, EGF_LAM_1, 2 hits
PS50213, FAS1, 7 hits
PS01241, LINK_1, 1 hit
PS50963, LINK_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSTAB2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8R4U0
Secondary accession number(s): Q8BM87
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: June 1, 2002
Last modified: September 29, 2021
This is version 155 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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