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Entry version 145 (16 Oct 2019)
Sequence version 1 (01 Jun 2002)
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Protein

Stabilin-2

Gene

Stab2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Hyaluronan receptor that binds to and mediates endocytosis of hyaluronic acid (HA). Acts also, in different species, as a primary systemic scavenger receptor for heparin (Hep), chondroitin sulfate (CS), dermatan sulfate (DS), nonglycosaminoglycan (GAG), acetylated low-density lipoprotein (AcLDL), pro-collagen propeptides and advanced glycation end products (AGE). May serve to maintain tissue integrity by supporting extracellular matrix turnover or it may contribute to maintaining fluidity of bodily liquids by resorption of hyaluronan. Counter receptor which plays an important role in lymphocyte recruitment in the hepatic vasculature. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. The proteolytically processed short form also functions as an endocytosis receptor for heparin internalisation as well as HA and CS.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processEndocytosis
LigandHyaluronic acid

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-2160916 Hyaluronan uptake and degradation
R-MMU-3000497 Scavenging by Class H Receptors

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Stabilin-2
Alternative name(s):
Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 2
Short name:
FEEL-2
Cleaved into the following chain:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Stab2Imported
Synonyms:Feel2, Hare
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2178743 Stab2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini29 – 2464ExtracellularSequence analysisAdd BLAST2436
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2465 – 2485HelicalSequence analysisAdd BLAST21
Topological domaini2486 – 2559CytoplasmicSequence analysisAdd BLAST74

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 28Sequence analysisAdd BLAST28
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000771429 – 2559Stabilin-2Add BLAST2531
ChainiPRO_00000077151136 – 2551Short form stabilin-2By similarityAdd BLAST1416

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi71N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi120 ↔ 134By similarity
Disulfide bondi128 ↔ 144By similarity
Disulfide bondi146 ↔ 155By similarity
Glycosylationi167N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi168 ↔ 179By similarity
Disulfide bondi172 ↔ 189By similarity
Disulfide bondi191 ↔ 200By similarity
Disulfide bondi207 ↔ 218By similarity
Disulfide bondi212 ↔ 230By similarity
Disulfide bondi232 ↔ 243By similarity
Disulfide bondi249 ↔ 260By similarity
Disulfide bondi254 ↔ 270By similarity
Disulfide bondi272 ↔ 283By similarity
Disulfide bondi334 ↔ 346By similarity
Disulfide bondi340 ↔ 356By similarity
Glycosylationi345N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi358 ↔ 369By similarity
Glycosylationi572N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi626N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi673N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi691N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi747 ↔ 761By similarity
Disulfide bondi755 ↔ 771By similarity
Glycosylationi768N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi773 ↔ 782By similarity
Glycosylationi796N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi837 ↔ 850By similarity
Disulfide bondi844 ↔ 859By similarity
Glycosylationi854N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi861 ↔ 872By similarity
Disulfide bondi878 ↔ 893By similarity
Disulfide bondi887 ↔ 903By similarity
Disulfide bondi905 ↔ 916By similarity
Disulfide bondi922 ↔ 936By similarity
Disulfide bondi930 ↔ 946By similarity
Glycosylationi933N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi948 ↔ 959By similarity
Disulfide bondi965 ↔ 978By similarity
Disulfide bondi972 ↔ 988By similarity
Disulfide bondi990 ↔ 1001By similarity
Glycosylationi1024N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1036N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1108N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1255N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1283N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1355 ↔ 1369By similarity
Disulfide bondi1363 ↔ 1379By similarity
Glycosylationi1374N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1381 ↔ 1390By similarity
Glycosylationi1386N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1402 ↔ 1413By similarity
Disulfide bondi1406 ↔ 1423By similarity
Disulfide bondi1425 ↔ 1434By similarity
Disulfide bondi1443 ↔ 1453By similarity
Glycosylationi1444N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1447 ↔ 1463By similarity
Disulfide bondi1465 ↔ 1476By similarity
Glycosylationi1472N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1482 ↔ 1495By similarity
Disulfide bondi1489 ↔ 1505By similarity
Disulfide bondi1507 ↔ 1518By similarity
Disulfide bondi1524 ↔ 1537By similarity
Disulfide bondi1531 ↔ 1547By similarity
Disulfide bondi1549 ↔ 1560By similarity
Disulfide bondi1566 ↔ 1579By similarity
Disulfide bondi1573 ↔ 1589By similarity
Glycosylationi1580N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1591 ↔ 1602By similarity
Glycosylationi1750N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1970 ↔ 1984By similarity
Disulfide bondi1978 ↔ 1994By similarity
Disulfide bondi1996 ↔ 2005By similarity
Glycosylationi2001N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2017 ↔ 2028By similarity
Disulfide bondi2022 ↔ 2038By similarity
Disulfide bondi2040 ↔ 2049By similarity
Disulfide bondi2059 ↔ 2069By similarity
Disulfide bondi2063 ↔ 2075By similarity
Glycosylationi2072N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2077 ↔ 2088By similarity
Disulfide bondi2094 ↔ 2107By similarity
Disulfide bondi2101 ↔ 2116By similarity
Disulfide bondi2118 ↔ 2129By similarity
Disulfide bondi2135 ↔ 2149By similarity
Disulfide bondi2143 ↔ 2159By similarity
Disulfide bondi2161 ↔ 2172By similarity
Disulfide bondi2228 ↔ 2296By similarity
Disulfide bondi2252 ↔ 2273By similarity
Glycosylationi2287N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2303N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2375N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2391N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2400N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2503PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Glycosylated.By similarity
Proteolytically processed to yield a smaller protein.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

The CPTAC Assay portal

More...
CPTACi
non-CPTAC-3499

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q8R4U0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8R4U0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8R4U0

PRoteomics IDEntifications database

More...
PRIDEi
Q8R4U0

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8R4U0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8R4U0

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8R4U0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in endothelial sinuses of liver, lymph nodes, bone marrow, spleen and in specialised structures of eye, heart, brain and kidney. Expression is detected in corneal and lens epithelium, in mesenchymal cells of the heart valves, in the ependymal cells lining the ventricles in the brain, and in the prismatic epithelial cells covering the renal papillae.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000035459 Expressed in 111 organ(s), highest expression level in liver

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q8R4U0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8R4U0 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with heparin, alpha-M/beta-2 integrin (ITGAM and ITGB2), and thymosin beta 4 (TMSB4X) (By similarity).

Interacts with GULP1. Associates with clathrin and adapter protein AP-2; in liver sinusoidal endothelial cells (LSECs).

By similarity2 Publications

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000048309

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8R4U0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini116 – 156EGF-like 1PROSITE-ProRule annotationAdd BLAST41
Domaini164 – 201EGF-like 2PROSITE-ProRule annotationAdd BLAST38
Domaini203 – 244EGF-like 3PROSITE-ProRule annotationAdd BLAST42
Domaini245 – 284EGF-like 4PROSITE-ProRule annotationAdd BLAST40
Domaini330 – 370EGF-like 5PROSITE-ProRule annotationAdd BLAST41
Domaini379 – 512FAS1 1PROSITE-ProRule annotationAdd BLAST134
Domaini522 – 659FAS1 2PROSITE-ProRule annotationAdd BLAST138
Domaini743 – 783EGF-like 6PROSITE-ProRule annotationAdd BLAST41
Domaini833 – 873EGF-like 7PROSITE-ProRule annotationAdd BLAST41
Domaini874 – 917EGF-like 8PROSITE-ProRule annotationAdd BLAST44
Domaini918 – 960EGF-like 9PROSITE-ProRule annotationAdd BLAST43
Domaini961 – 1002EGF-like 10PROSITE-ProRule annotationAdd BLAST42
Domaini1002 – 1135FAS1 3PROSITE-ProRule annotationAdd BLAST134
Domaini1145 – 1273FAS1 4PROSITE-ProRule annotationAdd BLAST129
Domaini1350 – 1415Laminin EGF-like 1Sequence analysisAdd BLAST66
Domaini1439 – 1477EGF-like 11PROSITE-ProRule annotationAdd BLAST39
Domaini1478 – 1519EGF-like 12PROSITE-ProRule annotationAdd BLAST42
Domaini1520 – 1561EGF-like 13PROSITE-ProRule annotationAdd BLAST42
Domaini1562 – 1603EGF-like 14PROSITE-ProRule annotationAdd BLAST42
Domaini1603 – 1731FAS1 5PROSITE-ProRule annotationAdd BLAST129
Domaini1747 – 1888FAS1 6PROSITE-ProRule annotationAdd BLAST142
Domaini1965 – 2030Laminin EGF-like 2Sequence analysisAdd BLAST66
Domaini2055 – 2089EGF-like 15PROSITE-ProRule annotationAdd BLAST35
Domaini2090 – 2130EGF-like 16PROSITE-ProRule annotationAdd BLAST41
Domaini2131 – 2173EGF-like 17PROSITE-ProRule annotationAdd BLAST43
Domaini2206 – 2298LinkPROSITE-ProRule annotationAdd BLAST93
Domaini2318 – 2452FAS1 7PROSITE-ProRule annotationAdd BLAST135

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2510 – 2520Interaction with TMSB4XBy similarityAdd BLAST11

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Recognizes phosphatidyl serine via its epidermal growth factor-like domains.

Keywords - Domaini

EGF-like domain, Laminin EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IRWM Eukaryota
ENOG4110T5S LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156566

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000154436

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8R4U0

KEGG Orthology (KO)

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KOi
K19013

Identification of Orthologs from Complete Genome Data

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OMAi
AHATCKE

Database of Orthologous Groups

More...
OrthoDBi
6428at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8R4U0

TreeFam database of animal gene trees

More...
TreeFami
TF331489

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.180.10, 6 hits
3.10.100.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR024731 EGF_dom
IPR036378 FAS1_dom_sf
IPR000782 FAS1_domain
IPR002049 Laminin_EGF
IPR000538 Link_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12947 EGF_3, 5 hits
PF02469 Fasciclin, 6 hits
PF00193 Xlink, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181 EGF, 21 hits
SM00179 EGF_CA, 7 hits
SM00180 EGF_Lam, 5 hits
SM00554 FAS1, 7 hits
SM00445 LINK, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56436 SSF56436, 1 hit
SSF82153 SSF82153, 7 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00022 EGF_1, 7 hits
PS01186 EGF_2, 16 hits
PS50026 EGF_3, 21 hits
PS01248 EGF_LAM_1, 2 hits
PS50213 FAS1, 7 hits
PS01241 LINK_1, 1 hit
PS50963 LINK_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8R4U0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARSKLLLGK LLPLILIFLG LLVQNACSPT EAPELTKRCD KKSTLTIKTE
60 70 80 90 100
CQSCSVNIAV KCPDGYIKIT NGTVGVRDCR YSLKIQSYVL DIPGCRHICR
110 120 130 140 150
KDYLQPQCCP GHWGPDCMEC PGGARAPCGG RGVCDEGMEG TGSCSCRAGF
160 170 180 190 200
RGTACENCAA EDVFGPNCSA VCSCVHGVCN SGISGDGTCE CLSAYRGPRC
210 220 230 240 250
DKPIPECAAL LCPENSRCSP SSKDETKLQC KCLPSYKGDG QTCKPINPCL
260 270 280 290 300
KNVCHPHASC SYLGPNRHSC VCQKGYQGDG QVCLPVDPCQ TSYGNCPTKS
310 320 330 340 350
TVCRYDGPGQ SHCECKEHYR NFVPGVGCSM TDICESKNPC HKNANCSTVS
360 370 380 390 400
PGQTQCTCQK GYVGDGLNCY GNIMQRLREL NTEPRGMWQG QLTSFISILD
410 420 430 440 450
RTYAWPLSNL GPFTVLLPSD KGLKGVDVKE LLMDKEAARY FVKLHIIAGQ
460 470 480 490 500
MSTEQMYNLD TFYTLTGKSG EIINKDKDNQ LKLKLYGSKI VQIIQGNIVA
510 520 530 540 550
SNGLVHILDR AMDKIEPTLE SNPQQTIMTM LQPRYGKFRS LLEKTNVGQA
560 570 580 590 600
LEKGGIDEPY TIFVPSNEAL SNMTAGVLDY LLSPEGSRKL LELVRYHIVA
610 620 630 640 650
FTQLEVATLV STLHIRSMAN QIITFNISSK GQILANNVAV DETEVAAKNG
660 670 680 690 700
RIYTLTGVLI PPSILPILPH RCNETKREMK LGTCVRCFMK NWSKCPTNSE
710 720 730 740 750
PTAIFTNKCF YGSRAWNLKI GCARYCDVTV EIPRCCKGFF GPDCNPCPGG
760 770 780 790 800
FMNPCSGNGQ CIDGLGGNGT CICEDGFQGS RCQFCSKPNR YGPQCNRTCQ
810 820 830 840 850
CVHGICDNRL DSDGSCLPGT CREGTAGRFC DKQTSACGPY MQFCHIHATC
860 870 880 890 900
EYSNETASCV CNDGYEGDGT LCSKKDPCLG STSRGGCSPN AECIQASTGT
910 920 930 940 950
YSCVCQRGWT GNGRDCVEIN SCLLPSSGGC HDNATCLYVG PGQNECECKK
960 970 980 990 1000
GFRGNGIDCE PIISCLEQIE KCHPLATCQY TLSGVWSCVC QEGYEGNGVL
1010 1020 1030 1040 1050
CYGNVLMELS FLSEAAVFYQ WINNASLQSM LSATSNLTVL VPSLQAIKDM
1060 1070 1080 1090 1100
DQNEKSFWLS RNNIPALIKY HTLLGTYRVA DLQTLPSSHM LATSLQGSFL
1110 1120 1130 1140 1150
RLDKADGNIT IEGASFVDGD NAATNGVVHI INKVLIPQRG LTGSLPSLLT
1160 1170 1180 1190 1200
RLEQMPDYSI FRGYIIHYNL ASAIEAADAY TVFVPNNEAI ESYIREKKAT
1210 1220 1230 1240 1250
SLKEDILQYH VVLGEKLLRN DLHNGMHRET MLGFSYLLAF FLHNDQLYVN
1260 1270 1280 1290 1300
EAPINYTNVA TDKGVIHGLE KVLEIKKNRC DNNDTIIVRG KCGKCSQQTL
1310 1320 1330 1340 1350
CPLETKPLSE TRKCIYSVYF MGKRSIFIGC QLQCVRTIIT SACCAGFFGP
1360 1370 1380 1390 1400
QCQACPGKGQ NVCSGNGFCL DGVNGTGTCE CEQGFNGTAC ETCTEGKYGI
1410 1420 1430 1440 1450
HCDQACSCVH GRCNQGPSGD GSCDCDVGWR GVKCDSEITT DNCNGTCHTS
1460 1470 1480 1490 1500
ANCLLDPDGK ASCKCAAGFQ GNGTVCTAIN ACEISNGGCS AKADCKRTIP
1510 1520 1530 1540 1550
GSRVCVCKAG YTGDGIVCLE INPCLENHGG CDRHAECTQT GPNQAVCNCL
1560 1570 1580 1590 1600
PKYTGDGKVC TLINVCLTNN GGCSPFAFCN HTEQDQRTCT CKPDYTGDGI
1610 1620 1630 1640 1650
VCRGSIHSEL PKNPSTSQYF FQLQEHAVQE LAGPGPFTVF VPSSDSFNSE
1660 1670 1680 1690 1700
SKLKVWDKQG LMSQILRYHV VACQQLLLEN LKVITSATTL QGEPISISVS
1710 1720 1730 1740 1750
QDTVLINKKA KVLSSDIIST NGVIHVIDTL LSPQNLLITP KGASGRVLLN
1760 1770 1780 1790 1800
LTTVAANHGY TKFSKLIQDS GLLKVITDPM HTPVTLFWPT DKALQALPQE
1810 1820 1830 1840 1850
QQDFLFNEDN KDKLKAYLKF HVIRDTMALA SDLPRSASWK TLQGSELSVR
1860 1870 1880 1890 1900
CGTGSDVGEL FLNGQMCRII QRRLLFDGGV AYGIDCLLMD PTEGGRCDTF
1910 1920 1930 1940 1950
TTFNIPGECG SCFSTPRCPL QSKPKGVRKK CIYNPLPFRR DVEGCQNLCT
1960 1970 1980 1990 2000
LVVHVPRCCS GYFMPDCQAC PGGPDTPCNN RGMCYDQYKP TGQCQCHTGF
2010 2020 2030 2040 2050
NGTACELCLP GRFGPDCQPC GCSEHGQCDE GITGSGQCLC EAGWTGRFCD
2060 2070 2080 2090 2100
APTVVIPVCI PACSMHATCM ENNTCVCNLN YEGDGITCTV VDFCKQNNGG
2110 2120 2130 2140 2150
CAKVAKCSQK GTQVSCSCQK GYKGDGHSCT EIDPCANGVN GGCHEHATCR
2160 2170 2180 2190 2200
MTGPGKQKCE CKSHYVGDGR DCEPEQLPLD RCLQDNGQCH PDANCVDLHF
2210 2220 2230 2240 2250
QDTTVGVFHL RSPLGQYKLT FDKAKEACAK EAASIATYNQ LSYAQKAKYH
2260 2270 2280 2290 2300
LCSAGWLESG RVAYPTIYAS KKCANIVGIV DYGTRTNKSE MWDVFCYRMK
2310 2320 2330 2340 2350
DVNCTCKAGY VGDGFSCNGN LLQVLMSFPS LTNFLTEVLV FSRSSAQGRA
2360 2370 2380 2390 2400
FLKHLTDLSI SGTLFVPQNS GLPKNKSLSG RDIEHHLTNV NVSFYDDLVN
2410 2420 2430 2440 2450
GTVLKTRLGS QLLITSSQDQ LHQEARFVDG RAILQWDIIA SNGVLHIISE
2460 2470 2480 2490 2500
PLKAPPTAAT AAHSGLGTGI FCAVVLVTGA IALAAYSYFR LNQRTTGFRR
2510 2520 2530 2540 2550
FESEDDIDAL AFGKQQPESI TNPLYETSTP AAPEPSCDPF TDSGERELEN

SDPLGALRS
Length:2,559
Mass (Da):277,532
Last modified:June 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1C9855AD61EFF015
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1W2P6Y4A0A1W2P6Y4_MOUSE
Stabilin-2
Stab2
870Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1666L → G in BAC28741 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF364951 mRNA Translation: AAL91684.2
AK034522 mRNA Translation: BAC28741.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS36021.1

NCBI Reference Sequences

More...
RefSeqi
NP_619614.1, NM_138673.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000035288; ENSMUSP00000048309; ENSMUSG00000035459

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
192188

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:192188

UCSC genome browser

More...
UCSCi
uc007gqo.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF364951 mRNA Translation: AAL91684.2
AK034522 mRNA Translation: BAC28741.1
CCDSiCCDS36021.1
RefSeqiNP_619614.1, NM_138673.2

3D structure databases

SMRiQ8R4U0
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000048309

PTM databases

iPTMnetiQ8R4U0
PhosphoSitePlusiQ8R4U0
SwissPalmiQ8R4U0

Proteomic databases

CPTACinon-CPTAC-3499
jPOSTiQ8R4U0
MaxQBiQ8R4U0
PaxDbiQ8R4U0
PRIDEiQ8R4U0

Genome annotation databases

EnsembliENSMUST00000035288; ENSMUSP00000048309; ENSMUSG00000035459
GeneIDi192188
KEGGimmu:192188
UCSCiuc007gqo.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55576
MGIiMGI:2178743 Stab2

Phylogenomic databases

eggNOGiENOG410IRWM Eukaryota
ENOG4110T5S LUCA
GeneTreeiENSGT00940000156566
HOGENOMiHOG000154436
InParanoidiQ8R4U0
KOiK19013
OMAiAHATCKE
OrthoDBi6428at2759
PhylomeDBiQ8R4U0
TreeFamiTF331489

Enzyme and pathway databases

ReactomeiR-MMU-2160916 Hyaluronan uptake and degradation
R-MMU-3000497 Scavenging by Class H Receptors

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Stab2 mouse

Protein Ontology

More...
PROi
PR:Q8R4U0

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000035459 Expressed in 111 organ(s), highest expression level in liver
ExpressionAtlasiQ8R4U0 baseline and differential
GenevisibleiQ8R4U0 MM

Family and domain databases

Gene3Di2.30.180.10, 6 hits
3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR024731 EGF_dom
IPR036378 FAS1_dom_sf
IPR000782 FAS1_domain
IPR002049 Laminin_EGF
IPR000538 Link_dom
PfamiView protein in Pfam
PF12947 EGF_3, 5 hits
PF02469 Fasciclin, 6 hits
PF00193 Xlink, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 21 hits
SM00179 EGF_CA, 7 hits
SM00180 EGF_Lam, 5 hits
SM00554 FAS1, 7 hits
SM00445 LINK, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
SSF82153 SSF82153, 7 hits
PROSITEiView protein in PROSITE
PS00022 EGF_1, 7 hits
PS01186 EGF_2, 16 hits
PS50026 EGF_3, 21 hits
PS01248 EGF_LAM_1, 2 hits
PS50213 FAS1, 7 hits
PS01241 LINK_1, 1 hit
PS50963 LINK_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSTAB2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8R4U0
Secondary accession number(s): Q8BM87
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: June 1, 2002
Last modified: October 16, 2019
This is version 145 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
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