Stab2

Functionⁱ

Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Hyaluronan receptor that binds to and mediates endocytosis of hyaluronic acid (HA). Acts also, in different species, as a primary systemic scavenger receptor for heparin (Hep), chondroitin sulfate (CS), dermatan sulfate (DS), nonglycosaminoglycan (GAG), acetylated low-density lipoprotein (AcLDL), pro-collagen propeptides and advanced glycation end products (AGE). May serve to maintain tissue integrity by supporting extracellular matrix turnover or it may contribute to maintaining fluidity of bodily liquids by resorption of hyaluronan. Counter receptor which plays an important role in lymphocyte recruitment in the hepatic vasculature. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. The proteolytically processed short form also functions as an endocytosis receptor for heparin internalisation as well as HA and CS.2 Publications

GO - Molecular functionⁱ

calcium ion binding Source: InterPro
hyaluronic acid binding Source: UniProtKB
low-density lipoprotein particle binding Source: MGI
low-density lipoprotein particle receptor activity Source: MGI
scavenger receptor activity Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell adhesion Source: InterPro
defense response to bacterium Source: MGI
defense response to Gram-positive bacterium Source: UniProtKB
endocytosis Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Receptor
Biological process	Endocytosis
Ligand	Hyaluronic acid

Enzyme and pathway databases

Reactomeⁱ	R-MMU-2160916 Hyaluronan uptake and degradation R-MMU-3000497 Scavenging by Class H Receptors

Reactomeⁱ

R-MMU-2160916 Hyaluronan uptake and degradation
R-MMU-3000497 Scavenging by Class H Receptors

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Stabilin-2 Alternative name(s): Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 2 Short name: FEEL-2 Cleaved into the following chain: Short form stabilin-2
Gene namesⁱ	Name:Stab2Imported Synonyms:Feel2, Hare
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 10

Organism-specific databases

MGIⁱ	MGI:2178743 Stab2

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	29 – 2464	ExtracellularSequence analysisAdd BLAST	2436
Transmembraneⁱ	2465 – 2485	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	2486 – 2559	CytoplasmicSequence analysisAdd BLAST	74

Keywords - Cellular componentⁱ

Cell membrane, Cytoplasm, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 28	Sequence analysisAdd BLAST	28
ChainⁱPRO_0000007714	29 – 2559	Stabilin-2Add BLAST	2531
ChainⁱPRO_0000007715	1136 – 2551	Short form stabilin-2By similarityAdd BLAST	1416

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	71	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	120 ↔ 134	By similarity
Disulfide bondⁱ	128 ↔ 144	By similarity
Disulfide bondⁱ	146 ↔ 155	By similarity
Glycosylationⁱ	167	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	168 ↔ 179	By similarity
Disulfide bondⁱ	172 ↔ 189	By similarity
Disulfide bondⁱ	191 ↔ 200	By similarity
Disulfide bondⁱ	207 ↔ 218	By similarity
Disulfide bondⁱ	212 ↔ 230	By similarity
Disulfide bondⁱ	232 ↔ 243	By similarity
Disulfide bondⁱ	249 ↔ 260	By similarity
Disulfide bondⁱ	254 ↔ 270	By similarity
Disulfide bondⁱ	272 ↔ 283	By similarity
Disulfide bondⁱ	334 ↔ 346	By similarity
Disulfide bondⁱ	340 ↔ 356	By similarity
Glycosylationⁱ	345	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	358 ↔ 369	By similarity
Glycosylationⁱ	572	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	626	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	673	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	691	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	747 ↔ 761	By similarity
Disulfide bondⁱ	755 ↔ 771	By similarity
Glycosylationⁱ	768	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	773 ↔ 782	By similarity
Glycosylationⁱ	796	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	837 ↔ 850	By similarity
Disulfide bondⁱ	844 ↔ 859	By similarity
Glycosylationⁱ	854	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	861 ↔ 872	By similarity
Disulfide bondⁱ	878 ↔ 893	By similarity
Disulfide bondⁱ	887 ↔ 903	By similarity
Disulfide bondⁱ	905 ↔ 916	By similarity
Disulfide bondⁱ	922 ↔ 936	By similarity
Disulfide bondⁱ	930 ↔ 946	By similarity
Glycosylationⁱ	933	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	948 ↔ 959	By similarity
Disulfide bondⁱ	965 ↔ 978	By similarity
Disulfide bondⁱ	972 ↔ 988	By similarity
Disulfide bondⁱ	990 ↔ 1001	By similarity
Glycosylationⁱ	1024	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	1036	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	1108	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	1255	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	1283	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	1355 ↔ 1369	By similarity
Disulfide bondⁱ	1363 ↔ 1379	By similarity
Glycosylationⁱ	1374	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	1381 ↔ 1390	By similarity
Glycosylationⁱ	1386	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	1402 ↔ 1413	By similarity
Disulfide bondⁱ	1406 ↔ 1423	By similarity
Disulfide bondⁱ	1425 ↔ 1434	By similarity
Disulfide bondⁱ	1443 ↔ 1453	By similarity
Glycosylationⁱ	1444	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	1447 ↔ 1463	By similarity
Disulfide bondⁱ	1465 ↔ 1476	By similarity
Glycosylationⁱ	1472	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	1482 ↔ 1495	By similarity
Disulfide bondⁱ	1489 ↔ 1505	By similarity
Disulfide bondⁱ	1507 ↔ 1518	By similarity
Disulfide bondⁱ	1524 ↔ 1537	By similarity
Disulfide bondⁱ	1531 ↔ 1547	By similarity
Disulfide bondⁱ	1549 ↔ 1560	By similarity
Disulfide bondⁱ	1566 ↔ 1579	By similarity
Disulfide bondⁱ	1573 ↔ 1589	By similarity
Glycosylationⁱ	1580	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	1591 ↔ 1602	By similarity
Glycosylationⁱ	1750	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	1970 ↔ 1984	By similarity
Disulfide bondⁱ	1978 ↔ 1994	By similarity
Disulfide bondⁱ	1996 ↔ 2005	By similarity
Glycosylationⁱ	2001	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	2017 ↔ 2028	By similarity
Disulfide bondⁱ	2022 ↔ 2038	By similarity
Disulfide bondⁱ	2040 ↔ 2049	By similarity
Disulfide bondⁱ	2059 ↔ 2069	By similarity
Disulfide bondⁱ	2063 ↔ 2075	By similarity
Glycosylationⁱ	2072	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	2077 ↔ 2088	By similarity
Disulfide bondⁱ	2094 ↔ 2107	By similarity
Disulfide bondⁱ	2101 ↔ 2116	By similarity
Disulfide bondⁱ	2118 ↔ 2129	By similarity
Disulfide bondⁱ	2135 ↔ 2149	By similarity
Disulfide bondⁱ	2143 ↔ 2159	By similarity
Disulfide bondⁱ	2161 ↔ 2172	By similarity
Disulfide bondⁱ	2228 ↔ 2296	By similarity
Disulfide bondⁱ	2252 ↔ 2273	By similarity
Glycosylationⁱ	2287	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	2303	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	2375	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	2391	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	2400	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	2503	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Glycosylated.By similarity

Proteolytically processed to yield a smaller protein.

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8R4U0
PaxDbⁱ	Q8R4U0
PRIDEⁱ	Q8R4U0

PTM databases

iPTMnetⁱ	Q8R4U0
PhosphoSitePlusⁱ	Q8R4U0
SwissPalmⁱ	Q8R4U0

Expressionⁱ

Tissue specificityⁱ

Expressed in endothelial sinuses of liver, lymph nodes, bone marrow, spleen and in specialised structures of eye, heart, brain and kidney. Expression is detected in corneal and lens epithelium, in mesenchymal cells of the heart valves, in the ependymal cells lining the ventricles in the brain, and in the prismatic epithelial cells covering the renal papillae.2 Publications

Gene expression databases

Bgeeⁱ	ENSMUSG00000035459 Expressed in 111 organ(s), highest expression level in liver
CleanExⁱ	MM_STAB2
ExpressionAtlasⁱ	Q8R4U0 baseline and differential
Genevisibleⁱ	Q8R4U0 MM

Interactionⁱ

Subunit structureⁱ

Interacts with heparin, alpha-M/beta-2 integrin (ITGAM and ITGB2), and thymosin beta 4 (TMSB4X) (By similarity). Interacts with GULP1. Associates with clathrin and adapter protein AP-2; in liver sinusoidal endothelial cells (LSECs).By similarity2 Publications

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000048309

STRINGⁱ

10090.ENSMUSP00000048309

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8R4U0
SMRⁱ	Q8R4U0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	116 – 156	EGF-like 1PROSITE-ProRule annotationAdd BLAST	41
Domainⁱ	164 – 201	EGF-like 2PROSITE-ProRule annotationAdd BLAST	38
Domainⁱ	203 – 244	EGF-like 3PROSITE-ProRule annotationAdd BLAST	42
Domainⁱ	245 – 284	EGF-like 4PROSITE-ProRule annotationAdd BLAST	40
Domainⁱ	330 – 370	EGF-like 5PROSITE-ProRule annotationAdd BLAST	41
Domainⁱ	379 – 512	FAS1 1PROSITE-ProRule annotationAdd BLAST	134
Domainⁱ	522 – 659	FAS1 2PROSITE-ProRule annotationAdd BLAST	138
Domainⁱ	743 – 783	EGF-like 6PROSITE-ProRule annotationAdd BLAST	41
Domainⁱ	833 – 873	EGF-like 7PROSITE-ProRule annotationAdd BLAST	41
Domainⁱ	874 – 917	EGF-like 8PROSITE-ProRule annotationAdd BLAST	44
Domainⁱ	918 – 960	EGF-like 9PROSITE-ProRule annotationAdd BLAST	43
Domainⁱ	961 – 1002	EGF-like 10PROSITE-ProRule annotationAdd BLAST	42
Domainⁱ	1002 – 1135	FAS1 3PROSITE-ProRule annotationAdd BLAST	134
Domainⁱ	1145 – 1273	FAS1 4PROSITE-ProRule annotationAdd BLAST	129
Domainⁱ	1350 – 1415	Laminin EGF-like 1Sequence analysisAdd BLAST	66
Domainⁱ	1439 – 1477	EGF-like 11PROSITE-ProRule annotationAdd BLAST	39
Domainⁱ	1478 – 1519	EGF-like 12PROSITE-ProRule annotationAdd BLAST	42
Domainⁱ	1520 – 1561	EGF-like 13PROSITE-ProRule annotationAdd BLAST	42
Domainⁱ	1562 – 1603	EGF-like 14PROSITE-ProRule annotationAdd BLAST	42
Domainⁱ	1603 – 1731	FAS1 5PROSITE-ProRule annotationAdd BLAST	129
Domainⁱ	1747 – 1888	FAS1 6PROSITE-ProRule annotationAdd BLAST	142
Domainⁱ	1965 – 2030	Laminin EGF-like 2Sequence analysisAdd BLAST	66
Domainⁱ	2055 – 2089	EGF-like 15PROSITE-ProRule annotationAdd BLAST	35
Domainⁱ	2090 – 2130	EGF-like 16PROSITE-ProRule annotationAdd BLAST	41
Domainⁱ	2131 – 2173	EGF-like 17PROSITE-ProRule annotationAdd BLAST	43
Domainⁱ	2206 – 2298	LinkPROSITE-ProRule annotationAdd BLAST	93
Domainⁱ	2318 – 2452	FAS1 7PROSITE-ProRule annotationAdd BLAST	135

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	2510 – 2520	Interaction with TMSB4XBy similarityAdd BLAST		11

Domainⁱ

Recognizes phosphatidyl serine via its epidermal growth factor-like domains.

Keywords - Domainⁱ

EGF-like domain, Laminin EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IRWM Eukaryota ENOG4110T5S LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119025
HOGENOMⁱ	HOG000154436
HOVERGENⁱ	HBG079218
InParanoidⁱ	Q8R4U0
KEGG Orthology (KO) More...KOⁱ	K19013
OMAⁱ	KCCKGFY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G002T
PhylomeDBⁱ	Q8R4U0
TreeFamⁱ	TF331489

Family and domain databases

Gene3Dⁱ	2.30.180.10, 6 hits 3.10.100.10, 1 hit
InterProⁱ	View protein in InterPro IPR016186 C-type_lectin-like/link_sf IPR016187 CTDL_fold IPR001881 EGF-like_Ca-bd_dom IPR013032 EGF-like_CS IPR000742 EGF-like_dom IPR024731 EGF_dom IPR036378 FAS1_dom_sf IPR000782 FAS1_domain IPR002049 Laminin_EGF IPR000538 Link_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12947 EGF_3, 5 hits PF02469 Fasciclin, 7 hits PF00193 Xlink, 1 hit
SMARTⁱ	View protein in SMART SM00181 EGF, 21 hits SM00179 EGF_CA, 7 hits SM00180 EGF_Lam, 5 hits SM00554 FAS1, 7 hits SM00445 LINK, 1 hit
SUPFAMⁱ	SSF56436 SSF56436, 1 hit SSF82153 SSF82153, 7 hits
PROSITEⁱ	View protein in PROSITE PS00022 EGF_1, 7 hits PS01186 EGF_2, 16 hits PS50026 EGF_3, 21 hits PS01248 EGF_LAM_1, 2 hits PS50213 FAS1, 7 hits PS01241 LINK_1, 1 hit PS50963 LINK_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q8R4U0-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MARSKLLLGK LLPLILIFLG LLVQNACSPT EAPELTKRCD KKSTLTIKTE 
        60         70         80         90        100
CQSCSVNIAV KCPDGYIKIT NGTVGVRDCR YSLKIQSYVL DIPGCRHICR 
       110        120        130        140        150
KDYLQPQCCP GHWGPDCMEC PGGARAPCGG RGVCDEGMEG TGSCSCRAGF 
       160        170        180        190        200
RGTACENCAA EDVFGPNCSA VCSCVHGVCN SGISGDGTCE CLSAYRGPRC 
       210        220        230        240        250
DKPIPECAAL LCPENSRCSP SSKDETKLQC KCLPSYKGDG QTCKPINPCL 
       260        270        280        290        300
KNVCHPHASC SYLGPNRHSC VCQKGYQGDG QVCLPVDPCQ TSYGNCPTKS 
       310        320        330        340        350
TVCRYDGPGQ SHCECKEHYR NFVPGVGCSM TDICESKNPC HKNANCSTVS 
       360        370        380        390        400
PGQTQCTCQK GYVGDGLNCY GNIMQRLREL NTEPRGMWQG QLTSFISILD 
       410        420        430        440        450
RTYAWPLSNL GPFTVLLPSD KGLKGVDVKE LLMDKEAARY FVKLHIIAGQ 
       460        470        480        490        500
MSTEQMYNLD TFYTLTGKSG EIINKDKDNQ LKLKLYGSKI VQIIQGNIVA 
       510        520        530        540        550
SNGLVHILDR AMDKIEPTLE SNPQQTIMTM LQPRYGKFRS LLEKTNVGQA 
       560        570        580        590        600
LEKGGIDEPY TIFVPSNEAL SNMTAGVLDY LLSPEGSRKL LELVRYHIVA 
       610        620        630        640        650
FTQLEVATLV STLHIRSMAN QIITFNISSK GQILANNVAV DETEVAAKNG 
       660        670        680        690        700
RIYTLTGVLI PPSILPILPH RCNETKREMK LGTCVRCFMK NWSKCPTNSE 
       710        720        730        740        750
PTAIFTNKCF YGSRAWNLKI GCARYCDVTV EIPRCCKGFF GPDCNPCPGG 
       760        770        780        790        800
FMNPCSGNGQ CIDGLGGNGT CICEDGFQGS RCQFCSKPNR YGPQCNRTCQ 
       810        820        830        840        850
CVHGICDNRL DSDGSCLPGT CREGTAGRFC DKQTSACGPY MQFCHIHATC 
       860        870        880        890        900
EYSNETASCV CNDGYEGDGT LCSKKDPCLG STSRGGCSPN AECIQASTGT 
       910        920        930        940        950
YSCVCQRGWT GNGRDCVEIN SCLLPSSGGC HDNATCLYVG PGQNECECKK 
       960        970        980        990       1000
GFRGNGIDCE PIISCLEQIE KCHPLATCQY TLSGVWSCVC QEGYEGNGVL 
      1010       1020       1030       1040       1050
CYGNVLMELS FLSEAAVFYQ WINNASLQSM LSATSNLTVL VPSLQAIKDM 
      1060       1070       1080       1090       1100
DQNEKSFWLS RNNIPALIKY HTLLGTYRVA DLQTLPSSHM LATSLQGSFL 
      1110       1120       1130       1140       1150
RLDKADGNIT IEGASFVDGD NAATNGVVHI INKVLIPQRG LTGSLPSLLT 
      1160       1170       1180       1190       1200
RLEQMPDYSI FRGYIIHYNL ASAIEAADAY TVFVPNNEAI ESYIREKKAT 
      1210       1220       1230       1240       1250
SLKEDILQYH VVLGEKLLRN DLHNGMHRET MLGFSYLLAF FLHNDQLYVN 
      1260       1270       1280       1290       1300
EAPINYTNVA TDKGVIHGLE KVLEIKKNRC DNNDTIIVRG KCGKCSQQTL 
      1310       1320       1330       1340       1350
CPLETKPLSE TRKCIYSVYF MGKRSIFIGC QLQCVRTIIT SACCAGFFGP 
      1360       1370       1380       1390       1400
QCQACPGKGQ NVCSGNGFCL DGVNGTGTCE CEQGFNGTAC ETCTEGKYGI 
      1410       1420       1430       1440       1450
HCDQACSCVH GRCNQGPSGD GSCDCDVGWR GVKCDSEITT DNCNGTCHTS 
      1460       1470       1480       1490       1500
ANCLLDPDGK ASCKCAAGFQ GNGTVCTAIN ACEISNGGCS AKADCKRTIP 
      1510       1520       1530       1540       1550
GSRVCVCKAG YTGDGIVCLE INPCLENHGG CDRHAECTQT GPNQAVCNCL 
      1560       1570       1580       1590       1600
PKYTGDGKVC TLINVCLTNN GGCSPFAFCN HTEQDQRTCT CKPDYTGDGI 
      1610       1620       1630       1640       1650
VCRGSIHSEL PKNPSTSQYF FQLQEHAVQE LAGPGPFTVF VPSSDSFNSE 
      1660       1670       1680       1690       1700
SKLKVWDKQG LMSQILRYHV VACQQLLLEN LKVITSATTL QGEPISISVS 
      1710       1720       1730       1740       1750
QDTVLINKKA KVLSSDIIST NGVIHVIDTL LSPQNLLITP KGASGRVLLN 
      1760       1770       1780       1790       1800
LTTVAANHGY TKFSKLIQDS GLLKVITDPM HTPVTLFWPT DKALQALPQE 
      1810       1820       1830       1840       1850
QQDFLFNEDN KDKLKAYLKF HVIRDTMALA SDLPRSASWK TLQGSELSVR 
      1860       1870       1880       1890       1900
CGTGSDVGEL FLNGQMCRII QRRLLFDGGV AYGIDCLLMD PTEGGRCDTF 
      1910       1920       1930       1940       1950
TTFNIPGECG SCFSTPRCPL QSKPKGVRKK CIYNPLPFRR DVEGCQNLCT 
      1960       1970       1980       1990       2000
LVVHVPRCCS GYFMPDCQAC PGGPDTPCNN RGMCYDQYKP TGQCQCHTGF 
      2010       2020       2030       2040       2050
NGTACELCLP GRFGPDCQPC GCSEHGQCDE GITGSGQCLC EAGWTGRFCD 
      2060       2070       2080       2090       2100
APTVVIPVCI PACSMHATCM ENNTCVCNLN YEGDGITCTV VDFCKQNNGG 
      2110       2120       2130       2140       2150
CAKVAKCSQK GTQVSCSCQK GYKGDGHSCT EIDPCANGVN GGCHEHATCR 
      2160       2170       2180       2190       2200
MTGPGKQKCE CKSHYVGDGR DCEPEQLPLD RCLQDNGQCH PDANCVDLHF 
      2210       2220       2230       2240       2250
QDTTVGVFHL RSPLGQYKLT FDKAKEACAK EAASIATYNQ LSYAQKAKYH 
      2260       2270       2280       2290       2300
LCSAGWLESG RVAYPTIYAS KKCANIVGIV DYGTRTNKSE MWDVFCYRMK 
      2310       2320       2330       2340       2350
DVNCTCKAGY VGDGFSCNGN LLQVLMSFPS LTNFLTEVLV FSRSSAQGRA 
      2360       2370       2380       2390       2400
FLKHLTDLSI SGTLFVPQNS GLPKNKSLSG RDIEHHLTNV NVSFYDDLVN 
      2410       2420       2430       2440       2450
GTVLKTRLGS QLLITSSQDQ LHQEARFVDG RAILQWDIIA SNGVLHIISE 
      2460       2470       2480       2490       2500
PLKAPPTAAT AAHSGLGTGI FCAVVLVTGA IALAAYSYFR LNQRTTGFRR 
      2510       2520       2530       2540       2550
FESEDDIDAL AFGKQQPESI TNPLYETSTP AAPEPSCDPF TDSGERELEN 

SDPLGALRS

Length:2,559

Mass (Da):277,532

Last modified:June 1, 2002 - v1

Checksum:ⁱ1C9855AD61EFF015

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A1W2P6Y4	A0A1W2P6Y4_MOUSE		Stabilin-2 Stabilin-2	Stab2	870	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	1666	L → G in BAC28741 (PubMed:16141072).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF364951 mRNA Translation: AAL91684.2 AK034522 mRNA Translation: BAC28741.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS36021.1
NCBI Reference Sequences More...RefSeqⁱ	NP_619614.1, NM_138673.2
UniGeneⁱ	Mm.279611

Genome annotation databases

Ensemblⁱ	ENSMUST00000035288; ENSMUSP00000048309; ENSMUSG00000035459
GeneIDⁱ	192188
KEGGⁱ	mmu:192188
UCSC genome browser More...UCSCⁱ	uc007gqo.1 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8R4U0	Scavenger receptor FEEL-2a		MOUSE		2559	UniRef100_Q8R4U0
Scavenger receptor FEEL-2e		MOUSE		1652

Protein	Similar proteins		Species	Score	Length	Source
Q8R4U0	Scavenger receptor FEEL-2a		MOUSE		2559	UniRef90_Q8R4U0
UPI000A305247		MUSPA		2560
UPI000A31A6D8		MUSCR		2555
Scavenger receptor FEEL-2e		MOUSE		1652
FEX2		MOUSE		2559
+1

Protein	Similar proteins		Species	Score	Length	Source
Q8R4U0	Stabilin-2	)	HUMAN		2551	UniRef50_Q8WWQ8
Uncharacterized protein		RHIBE		2560
Stabilin 2		CHLSB		2559
Uncharacterized protein		MACFA		2554
Stabilin 2		PANTR		2551
+308

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF364951 mRNA Translation: AAL91684.2 AK034522 mRNA Translation: BAC28741.1
CCDSⁱ	CCDS36021.1
RefSeqⁱ	NP_619614.1, NM_138673.2
UniGeneⁱ	Mm.279611

3D structure databases

ProteinModelPortalⁱ	Q8R4U0
SMRⁱ	Q8R4U0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000048309

STRINGⁱ

10090.ENSMUSP00000048309

PTM databases

iPTMnetⁱ	Q8R4U0
PhosphoSitePlusⁱ	Q8R4U0
SwissPalmⁱ	Q8R4U0

Proteomic databases

MaxQBⁱ	Q8R4U0
PaxDbⁱ	Q8R4U0
PRIDEⁱ	Q8R4U0

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000035288; ENSMUSP00000048309; ENSMUSG00000035459
GeneIDⁱ	192188
KEGGⁱ	mmu:192188
UCSCⁱ	uc007gqo.1 mouse

Organism-specific databases

CTDⁱ	55576
MGIⁱ	MGI:2178743 Stab2

Phylogenomic databases

eggNOGⁱ	ENOG410IRWM Eukaryota ENOG4110T5S LUCA
GeneTreeⁱ	ENSGT00760000119025
HOGENOMⁱ	HOG000154436
HOVERGENⁱ	HBG079218
InParanoidⁱ	Q8R4U0
KOⁱ	K19013
OMAⁱ	KCCKGFY
OrthoDBⁱ	EOG091G002T
PhylomeDBⁱ	Q8R4U0
TreeFamⁱ	TF331489

Enzyme and pathway databases

Reactomeⁱ	R-MMU-2160916 Hyaluronan uptake and degradation R-MMU-3000497 Scavenging by Class H Receptors

Reactomeⁱ

R-MMU-2160916 Hyaluronan uptake and degradation
R-MMU-3000497 Scavenging by Class H Receptors

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q8R4U0
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000035459 Expressed in 111 organ(s), highest expression level in liver
CleanExⁱ	MM_STAB2
ExpressionAtlasⁱ	Q8R4U0 baseline and differential
Genevisibleⁱ	Q8R4U0 MM

Family and domain databases

Gene3Dⁱ	2.30.180.10, 6 hits 3.10.100.10, 1 hit
InterProⁱ	View protein in InterPro IPR016186 C-type_lectin-like/link_sf IPR016187 CTDL_fold IPR001881 EGF-like_Ca-bd_dom IPR013032 EGF-like_CS IPR000742 EGF-like_dom IPR024731 EGF_dom IPR036378 FAS1_dom_sf IPR000782 FAS1_domain IPR002049 Laminin_EGF IPR000538 Link_dom
Pfamⁱ	View protein in Pfam PF12947 EGF_3, 5 hits PF02469 Fasciclin, 7 hits PF00193 Xlink, 1 hit
SMARTⁱ	View protein in SMART SM00181 EGF, 21 hits SM00179 EGF_CA, 7 hits SM00180 EGF_Lam, 5 hits SM00554 FAS1, 7 hits SM00445 LINK, 1 hit
SUPFAMⁱ	SSF56436 SSF56436, 1 hit SSF82153 SSF82153, 7 hits
PROSITEⁱ	View protein in PROSITE PS00022 EGF_1, 7 hits PS01186 EGF_2, 16 hits PS50026 EGF_3, 21 hits PS01248 EGF_LAM_1, 2 hits PS50213 FAS1, 7 hits PS01241 LINK_1, 1 hit PS50963 LINK_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	STAB2_MOUSE
Accessionⁱ	Q8R4U0Primary (citable) accession number: Q8R4U0 Secondary accession number(s): Q8BM87
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
	Last sequence update:	June 1, 2002
	Last modified:	November 7, 2018
	This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - Q8R4U0 (STAB2_MOUSE)

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Stabilin-2

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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GO - Biological processi

Enzyme and pathway databases

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Organism-specific databases

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Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

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3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

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Keywords - Domaini

Phylogenomic databases

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Experimental Info

Sequence databases

Genome annotation databases

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Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

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Enzyme and pathway databases

Miscellaneous databases

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<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ