UniProtKB - Q8R4U0 (STAB2_MOUSE)
Protein
Stabilin-2
Gene
Stab2
Organism
Mus musculus (Mouse)
Status
Functioni
Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Hyaluronan receptor that binds to and mediates endocytosis of hyaluronic acid (HA). Acts also, in different species, as a primary systemic scavenger receptor for heparin (Hep), chondroitin sulfate (CS), dermatan sulfate (DS), nonglycosaminoglycan (GAG), acetylated low-density lipoprotein (AcLDL), pro-collagen propeptides and advanced glycation end products (AGE). May serve to maintain tissue integrity by supporting extracellular matrix turnover or it may contribute to maintaining fluidity of bodily liquids by resorption of hyaluronan. Counter receptor which plays an important role in lymphocyte recruitment in the hepatic vasculature. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. The proteolytically processed short form also functions as an endocytosis receptor for heparin internalisation as well as HA and CS.2 Publications
GO - Molecular functioni
- calcium ion binding Source: InterPro
- hyaluronic acid binding Source: UniProtKB
- low-density lipoprotein particle binding Source: MGI
- low-density lipoprotein particle receptor activity Source: MGI
- scavenger receptor activity Source: MGI
GO - Biological processi
- cell adhesion Source: InterPro
- defense response to bacterium Source: MGI
- defense response to Gram-positive bacterium Source: UniProtKB
- endocytosis Source: UniProtKB
Keywordsi
Molecular function | Receptor |
Biological process | Endocytosis |
Ligand | Hyaluronic acid |
Enzyme and pathway databases
Reactomei | R-MMU-2160916 Hyaluronan uptake and degradation R-MMU-3000497 Scavenging by Class H Receptors |
Names & Taxonomyi
Protein namesi | Recommended name: Stabilin-2Alternative name(s): Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 2 Short name: FEEL-2 Cleaved into the following chain: |
Gene namesi | |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2178743 Stab2 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication
Other locations
- Cytoplasm By similarity
Cytosol
- cytosol Source: MGI
Plasma Membrane
- external side of plasma membrane Source: UniProtKB
- integral component of plasma membrane Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 29 – 2464 | ExtracellularSequence analysisAdd BLAST | 2436 | |
Transmembranei | 2465 – 2485 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 2486 – 2559 | CytoplasmicSequence analysisAdd BLAST | 74 |
Keywords - Cellular componenti
Cell membrane, Cytoplasm, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 28 | Sequence analysisAdd BLAST | 28 | |
ChainiPRO_0000007714 | 29 – 2559 | Stabilin-2Add BLAST | 2531 | |
ChainiPRO_0000007715 | 1136 – 2551 | Short form stabilin-2By similarityAdd BLAST | 1416 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 71 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 120 ↔ 134 | By similarity | ||
Disulfide bondi | 128 ↔ 144 | By similarity | ||
Disulfide bondi | 146 ↔ 155 | By similarity | ||
Glycosylationi | 167 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 168 ↔ 179 | By similarity | ||
Disulfide bondi | 172 ↔ 189 | By similarity | ||
Disulfide bondi | 191 ↔ 200 | By similarity | ||
Disulfide bondi | 207 ↔ 218 | By similarity | ||
Disulfide bondi | 212 ↔ 230 | By similarity | ||
Disulfide bondi | 232 ↔ 243 | By similarity | ||
Disulfide bondi | 249 ↔ 260 | By similarity | ||
Disulfide bondi | 254 ↔ 270 | By similarity | ||
Disulfide bondi | 272 ↔ 283 | By similarity | ||
Disulfide bondi | 334 ↔ 346 | By similarity | ||
Disulfide bondi | 340 ↔ 356 | By similarity | ||
Glycosylationi | 345 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 358 ↔ 369 | By similarity | ||
Glycosylationi | 572 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 626 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 673 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 691 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 747 ↔ 761 | By similarity | ||
Disulfide bondi | 755 ↔ 771 | By similarity | ||
Glycosylationi | 768 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 773 ↔ 782 | By similarity | ||
Glycosylationi | 796 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 837 ↔ 850 | By similarity | ||
Disulfide bondi | 844 ↔ 859 | By similarity | ||
Glycosylationi | 854 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 861 ↔ 872 | By similarity | ||
Disulfide bondi | 878 ↔ 893 | By similarity | ||
Disulfide bondi | 887 ↔ 903 | By similarity | ||
Disulfide bondi | 905 ↔ 916 | By similarity | ||
Disulfide bondi | 922 ↔ 936 | By similarity | ||
Disulfide bondi | 930 ↔ 946 | By similarity | ||
Glycosylationi | 933 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 948 ↔ 959 | By similarity | ||
Disulfide bondi | 965 ↔ 978 | By similarity | ||
Disulfide bondi | 972 ↔ 988 | By similarity | ||
Disulfide bondi | 990 ↔ 1001 | By similarity | ||
Glycosylationi | 1024 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1036 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1108 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1255 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1283 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 1355 ↔ 1369 | By similarity | ||
Disulfide bondi | 1363 ↔ 1379 | By similarity | ||
Glycosylationi | 1374 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 1381 ↔ 1390 | By similarity | ||
Glycosylationi | 1386 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 1402 ↔ 1413 | By similarity | ||
Disulfide bondi | 1406 ↔ 1423 | By similarity | ||
Disulfide bondi | 1425 ↔ 1434 | By similarity | ||
Disulfide bondi | 1443 ↔ 1453 | By similarity | ||
Glycosylationi | 1444 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 1447 ↔ 1463 | By similarity | ||
Disulfide bondi | 1465 ↔ 1476 | By similarity | ||
Glycosylationi | 1472 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 1482 ↔ 1495 | By similarity | ||
Disulfide bondi | 1489 ↔ 1505 | By similarity | ||
Disulfide bondi | 1507 ↔ 1518 | By similarity | ||
Disulfide bondi | 1524 ↔ 1537 | By similarity | ||
Disulfide bondi | 1531 ↔ 1547 | By similarity | ||
Disulfide bondi | 1549 ↔ 1560 | By similarity | ||
Disulfide bondi | 1566 ↔ 1579 | By similarity | ||
Disulfide bondi | 1573 ↔ 1589 | By similarity | ||
Glycosylationi | 1580 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 1591 ↔ 1602 | By similarity | ||
Glycosylationi | 1750 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 1970 ↔ 1984 | By similarity | ||
Disulfide bondi | 1978 ↔ 1994 | By similarity | ||
Disulfide bondi | 1996 ↔ 2005 | By similarity | ||
Glycosylationi | 2001 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 2017 ↔ 2028 | By similarity | ||
Disulfide bondi | 2022 ↔ 2038 | By similarity | ||
Disulfide bondi | 2040 ↔ 2049 | By similarity | ||
Disulfide bondi | 2059 ↔ 2069 | By similarity | ||
Disulfide bondi | 2063 ↔ 2075 | By similarity | ||
Glycosylationi | 2072 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 2077 ↔ 2088 | By similarity | ||
Disulfide bondi | 2094 ↔ 2107 | By similarity | ||
Disulfide bondi | 2101 ↔ 2116 | By similarity | ||
Disulfide bondi | 2118 ↔ 2129 | By similarity | ||
Disulfide bondi | 2135 ↔ 2149 | By similarity | ||
Disulfide bondi | 2143 ↔ 2159 | By similarity | ||
Disulfide bondi | 2161 ↔ 2172 | By similarity | ||
Disulfide bondi | 2228 ↔ 2296 | By similarity | ||
Disulfide bondi | 2252 ↔ 2273 | By similarity | ||
Glycosylationi | 2287 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 2303 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 2375 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 2391 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 2400 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 2503 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Glycosylated.By similarity
Proteolytically processed to yield a smaller protein.
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
CPTACi | non-CPTAC-3499 |
jPOSTi | Q8R4U0 |
MaxQBi | Q8R4U0 |
PaxDbi | Q8R4U0 |
PRIDEi | Q8R4U0 |
PTM databases
iPTMneti | Q8R4U0 |
PhosphoSitePlusi | Q8R4U0 |
SwissPalmi | Q8R4U0 |
Expressioni
Tissue specificityi
Expressed in endothelial sinuses of liver, lymph nodes, bone marrow, spleen and in specialised structures of eye, heart, brain and kidney. Expression is detected in corneal and lens epithelium, in mesenchymal cells of the heart valves, in the ependymal cells lining the ventricles in the brain, and in the prismatic epithelial cells covering the renal papillae.2 Publications
Gene expression databases
Bgeei | ENSMUSG00000035459 Expressed in 111 organ(s), highest expression level in liver |
ExpressionAtlasi | Q8R4U0 baseline and differential |
Genevisiblei | Q8R4U0 MM |
Interactioni
Subunit structurei
Interacts with heparin, alpha-M/beta-2 integrin (ITGAM and ITGB2), and thymosin beta 4 (TMSB4X) (By similarity).
Interacts with GULP1. Associates with clathrin and adapter protein AP-2; in liver sinusoidal endothelial cells (LSECs).
By similarity2 PublicationsProtein-protein interaction databases
STRINGi | 10090.ENSMUSP00000048309 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 116 – 156 | EGF-like 1PROSITE-ProRule annotationAdd BLAST | 41 | |
Domaini | 164 – 201 | EGF-like 2PROSITE-ProRule annotationAdd BLAST | 38 | |
Domaini | 203 – 244 | EGF-like 3PROSITE-ProRule annotationAdd BLAST | 42 | |
Domaini | 245 – 284 | EGF-like 4PROSITE-ProRule annotationAdd BLAST | 40 | |
Domaini | 330 – 370 | EGF-like 5PROSITE-ProRule annotationAdd BLAST | 41 | |
Domaini | 379 – 512 | FAS1 1PROSITE-ProRule annotationAdd BLAST | 134 | |
Domaini | 522 – 659 | FAS1 2PROSITE-ProRule annotationAdd BLAST | 138 | |
Domaini | 743 – 783 | EGF-like 6PROSITE-ProRule annotationAdd BLAST | 41 | |
Domaini | 833 – 873 | EGF-like 7PROSITE-ProRule annotationAdd BLAST | 41 | |
Domaini | 874 – 917 | EGF-like 8PROSITE-ProRule annotationAdd BLAST | 44 | |
Domaini | 918 – 960 | EGF-like 9PROSITE-ProRule annotationAdd BLAST | 43 | |
Domaini | 961 – 1002 | EGF-like 10PROSITE-ProRule annotationAdd BLAST | 42 | |
Domaini | 1002 – 1135 | FAS1 3PROSITE-ProRule annotationAdd BLAST | 134 | |
Domaini | 1145 – 1273 | FAS1 4PROSITE-ProRule annotationAdd BLAST | 129 | |
Domaini | 1350 – 1415 | Laminin EGF-like 1Sequence analysisAdd BLAST | 66 | |
Domaini | 1439 – 1477 | EGF-like 11PROSITE-ProRule annotationAdd BLAST | 39 | |
Domaini | 1478 – 1519 | EGF-like 12PROSITE-ProRule annotationAdd BLAST | 42 | |
Domaini | 1520 – 1561 | EGF-like 13PROSITE-ProRule annotationAdd BLAST | 42 | |
Domaini | 1562 – 1603 | EGF-like 14PROSITE-ProRule annotationAdd BLAST | 42 | |
Domaini | 1603 – 1731 | FAS1 5PROSITE-ProRule annotationAdd BLAST | 129 | |
Domaini | 1747 – 1888 | FAS1 6PROSITE-ProRule annotationAdd BLAST | 142 | |
Domaini | 1965 – 2030 | Laminin EGF-like 2Sequence analysisAdd BLAST | 66 | |
Domaini | 2055 – 2089 | EGF-like 15PROSITE-ProRule annotationAdd BLAST | 35 | |
Domaini | 2090 – 2130 | EGF-like 16PROSITE-ProRule annotationAdd BLAST | 41 | |
Domaini | 2131 – 2173 | EGF-like 17PROSITE-ProRule annotationAdd BLAST | 43 | |
Domaini | 2206 – 2298 | LinkPROSITE-ProRule annotationAdd BLAST | 93 | |
Domaini | 2318 – 2452 | FAS1 7PROSITE-ProRule annotationAdd BLAST | 135 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 2510 – 2520 | Interaction with TMSB4XBy similarityAdd BLAST | 11 |
Domaini
Recognizes phosphatidyl serine via its epidermal growth factor-like domains.
Keywords - Domaini
EGF-like domain, Laminin EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG410IRWM Eukaryota ENOG4110T5S LUCA |
GeneTreei | ENSGT00940000156566 |
HOGENOMi | HOG000154436 |
InParanoidi | Q8R4U0 |
KOi | K19013 |
OMAi | AHATCKE |
OrthoDBi | 6428at2759 |
PhylomeDBi | Q8R4U0 |
TreeFami | TF331489 |
Family and domain databases
Gene3Di | 2.30.180.10, 6 hits 3.10.100.10, 1 hit |
InterProi | View protein in InterPro IPR016186 C-type_lectin-like/link_sf IPR016187 CTDL_fold IPR001881 EGF-like_Ca-bd_dom IPR013032 EGF-like_CS IPR000742 EGF-like_dom IPR024731 EGF_dom IPR036378 FAS1_dom_sf IPR000782 FAS1_domain IPR002049 Laminin_EGF IPR000538 Link_dom |
Pfami | View protein in Pfam PF12947 EGF_3, 5 hits PF02469 Fasciclin, 6 hits PF00193 Xlink, 1 hit |
SMARTi | View protein in SMART SM00181 EGF, 21 hits SM00179 EGF_CA, 7 hits SM00180 EGF_Lam, 5 hits SM00554 FAS1, 7 hits SM00445 LINK, 1 hit |
SUPFAMi | SSF56436 SSF56436, 1 hit SSF82153 SSF82153, 7 hits |
PROSITEi | View protein in PROSITE PS00022 EGF_1, 7 hits PS01186 EGF_2, 16 hits PS50026 EGF_3, 21 hits PS01248 EGF_LAM_1, 2 hits PS50213 FAS1, 7 hits PS01241 LINK_1, 1 hit PS50963 LINK_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q8R4U0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MARSKLLLGK LLPLILIFLG LLVQNACSPT EAPELTKRCD KKSTLTIKTE
60 70 80 90 100
CQSCSVNIAV KCPDGYIKIT NGTVGVRDCR YSLKIQSYVL DIPGCRHICR
110 120 130 140 150
KDYLQPQCCP GHWGPDCMEC PGGARAPCGG RGVCDEGMEG TGSCSCRAGF
160 170 180 190 200
RGTACENCAA EDVFGPNCSA VCSCVHGVCN SGISGDGTCE CLSAYRGPRC
210 220 230 240 250
DKPIPECAAL LCPENSRCSP SSKDETKLQC KCLPSYKGDG QTCKPINPCL
260 270 280 290 300
KNVCHPHASC SYLGPNRHSC VCQKGYQGDG QVCLPVDPCQ TSYGNCPTKS
310 320 330 340 350
TVCRYDGPGQ SHCECKEHYR NFVPGVGCSM TDICESKNPC HKNANCSTVS
360 370 380 390 400
PGQTQCTCQK GYVGDGLNCY GNIMQRLREL NTEPRGMWQG QLTSFISILD
410 420 430 440 450
RTYAWPLSNL GPFTVLLPSD KGLKGVDVKE LLMDKEAARY FVKLHIIAGQ
460 470 480 490 500
MSTEQMYNLD TFYTLTGKSG EIINKDKDNQ LKLKLYGSKI VQIIQGNIVA
510 520 530 540 550
SNGLVHILDR AMDKIEPTLE SNPQQTIMTM LQPRYGKFRS LLEKTNVGQA
560 570 580 590 600
LEKGGIDEPY TIFVPSNEAL SNMTAGVLDY LLSPEGSRKL LELVRYHIVA
610 620 630 640 650
FTQLEVATLV STLHIRSMAN QIITFNISSK GQILANNVAV DETEVAAKNG
660 670 680 690 700
RIYTLTGVLI PPSILPILPH RCNETKREMK LGTCVRCFMK NWSKCPTNSE
710 720 730 740 750
PTAIFTNKCF YGSRAWNLKI GCARYCDVTV EIPRCCKGFF GPDCNPCPGG
760 770 780 790 800
FMNPCSGNGQ CIDGLGGNGT CICEDGFQGS RCQFCSKPNR YGPQCNRTCQ
810 820 830 840 850
CVHGICDNRL DSDGSCLPGT CREGTAGRFC DKQTSACGPY MQFCHIHATC
860 870 880 890 900
EYSNETASCV CNDGYEGDGT LCSKKDPCLG STSRGGCSPN AECIQASTGT
910 920 930 940 950
YSCVCQRGWT GNGRDCVEIN SCLLPSSGGC HDNATCLYVG PGQNECECKK
960 970 980 990 1000
GFRGNGIDCE PIISCLEQIE KCHPLATCQY TLSGVWSCVC QEGYEGNGVL
1010 1020 1030 1040 1050
CYGNVLMELS FLSEAAVFYQ WINNASLQSM LSATSNLTVL VPSLQAIKDM
1060 1070 1080 1090 1100
DQNEKSFWLS RNNIPALIKY HTLLGTYRVA DLQTLPSSHM LATSLQGSFL
1110 1120 1130 1140 1150
RLDKADGNIT IEGASFVDGD NAATNGVVHI INKVLIPQRG LTGSLPSLLT
1160 1170 1180 1190 1200
RLEQMPDYSI FRGYIIHYNL ASAIEAADAY TVFVPNNEAI ESYIREKKAT
1210 1220 1230 1240 1250
SLKEDILQYH VVLGEKLLRN DLHNGMHRET MLGFSYLLAF FLHNDQLYVN
1260 1270 1280 1290 1300
EAPINYTNVA TDKGVIHGLE KVLEIKKNRC DNNDTIIVRG KCGKCSQQTL
1310 1320 1330 1340 1350
CPLETKPLSE TRKCIYSVYF MGKRSIFIGC QLQCVRTIIT SACCAGFFGP
1360 1370 1380 1390 1400
QCQACPGKGQ NVCSGNGFCL DGVNGTGTCE CEQGFNGTAC ETCTEGKYGI
1410 1420 1430 1440 1450
HCDQACSCVH GRCNQGPSGD GSCDCDVGWR GVKCDSEITT DNCNGTCHTS
1460 1470 1480 1490 1500
ANCLLDPDGK ASCKCAAGFQ GNGTVCTAIN ACEISNGGCS AKADCKRTIP
1510 1520 1530 1540 1550
GSRVCVCKAG YTGDGIVCLE INPCLENHGG CDRHAECTQT GPNQAVCNCL
1560 1570 1580 1590 1600
PKYTGDGKVC TLINVCLTNN GGCSPFAFCN HTEQDQRTCT CKPDYTGDGI
1610 1620 1630 1640 1650
VCRGSIHSEL PKNPSTSQYF FQLQEHAVQE LAGPGPFTVF VPSSDSFNSE
1660 1670 1680 1690 1700
SKLKVWDKQG LMSQILRYHV VACQQLLLEN LKVITSATTL QGEPISISVS
1710 1720 1730 1740 1750
QDTVLINKKA KVLSSDIIST NGVIHVIDTL LSPQNLLITP KGASGRVLLN
1760 1770 1780 1790 1800
LTTVAANHGY TKFSKLIQDS GLLKVITDPM HTPVTLFWPT DKALQALPQE
1810 1820 1830 1840 1850
QQDFLFNEDN KDKLKAYLKF HVIRDTMALA SDLPRSASWK TLQGSELSVR
1860 1870 1880 1890 1900
CGTGSDVGEL FLNGQMCRII QRRLLFDGGV AYGIDCLLMD PTEGGRCDTF
1910 1920 1930 1940 1950
TTFNIPGECG SCFSTPRCPL QSKPKGVRKK CIYNPLPFRR DVEGCQNLCT
1960 1970 1980 1990 2000
LVVHVPRCCS GYFMPDCQAC PGGPDTPCNN RGMCYDQYKP TGQCQCHTGF
2010 2020 2030 2040 2050
NGTACELCLP GRFGPDCQPC GCSEHGQCDE GITGSGQCLC EAGWTGRFCD
2060 2070 2080 2090 2100
APTVVIPVCI PACSMHATCM ENNTCVCNLN YEGDGITCTV VDFCKQNNGG
2110 2120 2130 2140 2150
CAKVAKCSQK GTQVSCSCQK GYKGDGHSCT EIDPCANGVN GGCHEHATCR
2160 2170 2180 2190 2200
MTGPGKQKCE CKSHYVGDGR DCEPEQLPLD RCLQDNGQCH PDANCVDLHF
2210 2220 2230 2240 2250
QDTTVGVFHL RSPLGQYKLT FDKAKEACAK EAASIATYNQ LSYAQKAKYH
2260 2270 2280 2290 2300
LCSAGWLESG RVAYPTIYAS KKCANIVGIV DYGTRTNKSE MWDVFCYRMK
2310 2320 2330 2340 2350
DVNCTCKAGY VGDGFSCNGN LLQVLMSFPS LTNFLTEVLV FSRSSAQGRA
2360 2370 2380 2390 2400
FLKHLTDLSI SGTLFVPQNS GLPKNKSLSG RDIEHHLTNV NVSFYDDLVN
2410 2420 2430 2440 2450
GTVLKTRLGS QLLITSSQDQ LHQEARFVDG RAILQWDIIA SNGVLHIISE
2460 2470 2480 2490 2500
PLKAPPTAAT AAHSGLGTGI FCAVVLVTGA IALAAYSYFR LNQRTTGFRR
2510 2520 2530 2540 2550
FESEDDIDAL AFGKQQPESI TNPLYETSTP AAPEPSCDPF TDSGERELEN
SDPLGALRS
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A1W2P6Y4 | A0A1W2P6Y4_MOUSE | Stabilin-2 | Stab2 | 870 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 1666 | L → G in BAC28741 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF364951 mRNA Translation: AAL91684.2 AK034522 mRNA Translation: BAC28741.1 |
CCDSi | CCDS36021.1 |
RefSeqi | NP_619614.1, NM_138673.2 |
Genome annotation databases
Ensembli | ENSMUST00000035288; ENSMUSP00000048309; ENSMUSG00000035459 |
GeneIDi | 192188 |
KEGGi | mmu:192188 |
UCSCi | uc007gqo.1 mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF364951 mRNA Translation: AAL91684.2 AK034522 mRNA Translation: BAC28741.1 |
CCDSi | CCDS36021.1 |
RefSeqi | NP_619614.1, NM_138673.2 |
3D structure databases
SMRi | Q8R4U0 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000048309 |
PTM databases
iPTMneti | Q8R4U0 |
PhosphoSitePlusi | Q8R4U0 |
SwissPalmi | Q8R4U0 |
Proteomic databases
CPTACi | non-CPTAC-3499 |
jPOSTi | Q8R4U0 |
MaxQBi | Q8R4U0 |
PaxDbi | Q8R4U0 |
PRIDEi | Q8R4U0 |
Genome annotation databases
Ensembli | ENSMUST00000035288; ENSMUSP00000048309; ENSMUSG00000035459 |
GeneIDi | 192188 |
KEGGi | mmu:192188 |
UCSCi | uc007gqo.1 mouse |
Organism-specific databases
CTDi | 55576 |
MGIi | MGI:2178743 Stab2 |
Phylogenomic databases
eggNOGi | ENOG410IRWM Eukaryota ENOG4110T5S LUCA |
GeneTreei | ENSGT00940000156566 |
HOGENOMi | HOG000154436 |
InParanoidi | Q8R4U0 |
KOi | K19013 |
OMAi | AHATCKE |
OrthoDBi | 6428at2759 |
PhylomeDBi | Q8R4U0 |
TreeFami | TF331489 |
Enzyme and pathway databases
Reactomei | R-MMU-2160916 Hyaluronan uptake and degradation R-MMU-3000497 Scavenging by Class H Receptors |
Miscellaneous databases
ChiTaRSi | Stab2 mouse |
PROi | PR:Q8R4U0 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000035459 Expressed in 111 organ(s), highest expression level in liver |
ExpressionAtlasi | Q8R4U0 baseline and differential |
Genevisiblei | Q8R4U0 MM |
Family and domain databases
Gene3Di | 2.30.180.10, 6 hits 3.10.100.10, 1 hit |
InterProi | View protein in InterPro IPR016186 C-type_lectin-like/link_sf IPR016187 CTDL_fold IPR001881 EGF-like_Ca-bd_dom IPR013032 EGF-like_CS IPR000742 EGF-like_dom IPR024731 EGF_dom IPR036378 FAS1_dom_sf IPR000782 FAS1_domain IPR002049 Laminin_EGF IPR000538 Link_dom |
Pfami | View protein in Pfam PF12947 EGF_3, 5 hits PF02469 Fasciclin, 6 hits PF00193 Xlink, 1 hit |
SMARTi | View protein in SMART SM00181 EGF, 21 hits SM00179 EGF_CA, 7 hits SM00180 EGF_Lam, 5 hits SM00554 FAS1, 7 hits SM00445 LINK, 1 hit |
SUPFAMi | SSF56436 SSF56436, 1 hit SSF82153 SSF82153, 7 hits |
PROSITEi | View protein in PROSITE PS00022 EGF_1, 7 hits PS01186 EGF_2, 16 hits PS50026 EGF_3, 21 hits PS01248 EGF_LAM_1, 2 hits PS50213 FAS1, 7 hits PS01241 LINK_1, 1 hit PS50963 LINK_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | STAB2_MOUSE | |
Accessioni | Q8R4U0Primary (citable) accession number: Q8R4U0 Secondary accession number(s): Q8BM87 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2004 |
Last sequence update: | June 1, 2002 | |
Last modified: | October 16, 2019 | |
This is version 145 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot