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Protein

Stabilin-2

Gene

Stab2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Hyaluronan receptor that binds to and mediates endocytosis of hyaluronic acid (HA). Acts also, in different species, as a primary systemic scavenger receptor for heparin (Hep), chondroitin sulfate (CS), dermatan sulfate (DS), nonglycosaminoglycan (GAG), acetylated low-density lipoprotein (AcLDL), pro-collagen propeptides and advanced glycation end products (AGE). May serve to maintain tissue integrity by supporting extracellular matrix turnover or it may contribute to maintaining fluidity of bodily liquids by resorption of hyaluronan. Counter receptor which plays an important role in lymphocyte recruitment in the hepatic vasculature. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. The proteolytically processed short form also functions as an endocytosis receptor for heparin internalisation as well as HA and CS.2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processEndocytosis
LigandHyaluronic acid

Enzyme and pathway databases

ReactomeiR-MMU-2160916 Hyaluronan uptake and degradation
R-MMU-3000497 Scavenging by Class H Receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Stabilin-2
Alternative name(s):
Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 2
Short name:
FEEL-2
Cleaved into the following chain:
Gene namesi
Name:Stab2Imported
Synonyms:Feel2, Hare
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:2178743 Stab2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini29 – 2464ExtracellularSequence analysisAdd BLAST2436
Transmembranei2465 – 2485HelicalSequence analysisAdd BLAST21
Topological domaini2486 – 2559CytoplasmicSequence analysisAdd BLAST74

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000000771429 – 2559Stabilin-2Add BLAST2531
ChainiPRO_00000077151136 – 2551Short form stabilin-2By similarityAdd BLAST1416

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi71N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi120 ↔ 134By similarity
Disulfide bondi128 ↔ 144By similarity
Disulfide bondi146 ↔ 155By similarity
Glycosylationi167N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi168 ↔ 179By similarity
Disulfide bondi172 ↔ 189By similarity
Disulfide bondi191 ↔ 200By similarity
Disulfide bondi207 ↔ 218By similarity
Disulfide bondi212 ↔ 230By similarity
Disulfide bondi232 ↔ 243By similarity
Disulfide bondi249 ↔ 260By similarity
Disulfide bondi254 ↔ 270By similarity
Disulfide bondi272 ↔ 283By similarity
Disulfide bondi334 ↔ 346By similarity
Disulfide bondi340 ↔ 356By similarity
Glycosylationi345N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi358 ↔ 369By similarity
Glycosylationi572N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi626N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi673N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi691N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi747 ↔ 761By similarity
Disulfide bondi755 ↔ 771By similarity
Glycosylationi768N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi773 ↔ 782By similarity
Glycosylationi796N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi837 ↔ 850By similarity
Disulfide bondi844 ↔ 859By similarity
Glycosylationi854N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi861 ↔ 872By similarity
Disulfide bondi878 ↔ 893By similarity
Disulfide bondi887 ↔ 903By similarity
Disulfide bondi905 ↔ 916By similarity
Disulfide bondi922 ↔ 936By similarity
Disulfide bondi930 ↔ 946By similarity
Glycosylationi933N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi948 ↔ 959By similarity
Disulfide bondi965 ↔ 978By similarity
Disulfide bondi972 ↔ 988By similarity
Disulfide bondi990 ↔ 1001By similarity
Glycosylationi1024N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1036N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1108N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1255N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1283N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1355 ↔ 1369By similarity
Disulfide bondi1363 ↔ 1379By similarity
Glycosylationi1374N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1381 ↔ 1390By similarity
Glycosylationi1386N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1402 ↔ 1413By similarity
Disulfide bondi1406 ↔ 1423By similarity
Disulfide bondi1425 ↔ 1434By similarity
Disulfide bondi1443 ↔ 1453By similarity
Glycosylationi1444N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1447 ↔ 1463By similarity
Disulfide bondi1465 ↔ 1476By similarity
Glycosylationi1472N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1482 ↔ 1495By similarity
Disulfide bondi1489 ↔ 1505By similarity
Disulfide bondi1507 ↔ 1518By similarity
Disulfide bondi1524 ↔ 1537By similarity
Disulfide bondi1531 ↔ 1547By similarity
Disulfide bondi1549 ↔ 1560By similarity
Disulfide bondi1566 ↔ 1579By similarity
Disulfide bondi1573 ↔ 1589By similarity
Glycosylationi1580N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1591 ↔ 1602By similarity
Glycosylationi1750N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1970 ↔ 1984By similarity
Disulfide bondi1978 ↔ 1994By similarity
Disulfide bondi1996 ↔ 2005By similarity
Glycosylationi2001N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2017 ↔ 2028By similarity
Disulfide bondi2022 ↔ 2038By similarity
Disulfide bondi2040 ↔ 2049By similarity
Disulfide bondi2059 ↔ 2069By similarity
Disulfide bondi2063 ↔ 2075By similarity
Glycosylationi2072N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2077 ↔ 2088By similarity
Disulfide bondi2094 ↔ 2107By similarity
Disulfide bondi2101 ↔ 2116By similarity
Disulfide bondi2118 ↔ 2129By similarity
Disulfide bondi2135 ↔ 2149By similarity
Disulfide bondi2143 ↔ 2159By similarity
Disulfide bondi2161 ↔ 2172By similarity
Disulfide bondi2228 ↔ 2296By similarity
Disulfide bondi2252 ↔ 2273By similarity
Glycosylationi2287N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2303N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2375N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2391N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2400N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei2503PhosphoserineCombined sources1

Post-translational modificationi

Glycosylated.By similarity
Proteolytically processed to yield a smaller protein.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ8R4U0
PaxDbiQ8R4U0
PRIDEiQ8R4U0

PTM databases

iPTMnetiQ8R4U0
PhosphoSitePlusiQ8R4U0
SwissPalmiQ8R4U0

Expressioni

Tissue specificityi

Expressed in endothelial sinuses of liver, lymph nodes, bone marrow, spleen and in specialised structures of eye, heart, brain and kidney. Expression is detected in corneal and lens epithelium, in mesenchymal cells of the heart valves, in the ependymal cells lining the ventricles in the brain, and in the prismatic epithelial cells covering the renal papillae.2 Publications

Gene expression databases

BgeeiENSMUSG00000035459 Expressed in 111 organ(s), highest expression level in liver
CleanExiMM_STAB2
ExpressionAtlasiQ8R4U0 baseline and differential
GenevisibleiQ8R4U0 MM

Interactioni

Subunit structurei

Interacts with heparin, alpha-M/beta-2 integrin (ITGAM and ITGB2), and thymosin beta 4 (TMSB4X) (By similarity). Interacts with GULP1. Associates with clathrin and adapter protein AP-2; in liver sinusoidal endothelial cells (LSECs).By similarity2 Publications

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000048309

Structurei

3D structure databases

ProteinModelPortaliQ8R4U0
SMRiQ8R4U0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini116 – 156EGF-like 1PROSITE-ProRule annotationAdd BLAST41
Domaini164 – 201EGF-like 2PROSITE-ProRule annotationAdd BLAST38
Domaini203 – 244EGF-like 3PROSITE-ProRule annotationAdd BLAST42
Domaini245 – 284EGF-like 4PROSITE-ProRule annotationAdd BLAST40
Domaini330 – 370EGF-like 5PROSITE-ProRule annotationAdd BLAST41
Domaini379 – 512FAS1 1PROSITE-ProRule annotationAdd BLAST134
Domaini522 – 659FAS1 2PROSITE-ProRule annotationAdd BLAST138
Domaini743 – 783EGF-like 6PROSITE-ProRule annotationAdd BLAST41
Domaini833 – 873EGF-like 7PROSITE-ProRule annotationAdd BLAST41
Domaini874 – 917EGF-like 8PROSITE-ProRule annotationAdd BLAST44
Domaini918 – 960EGF-like 9PROSITE-ProRule annotationAdd BLAST43
Domaini961 – 1002EGF-like 10PROSITE-ProRule annotationAdd BLAST42
Domaini1002 – 1135FAS1 3PROSITE-ProRule annotationAdd BLAST134
Domaini1145 – 1273FAS1 4PROSITE-ProRule annotationAdd BLAST129
Domaini1350 – 1415Laminin EGF-like 1Sequence analysisAdd BLAST66
Domaini1439 – 1477EGF-like 11PROSITE-ProRule annotationAdd BLAST39
Domaini1478 – 1519EGF-like 12PROSITE-ProRule annotationAdd BLAST42
Domaini1520 – 1561EGF-like 13PROSITE-ProRule annotationAdd BLAST42
Domaini1562 – 1603EGF-like 14PROSITE-ProRule annotationAdd BLAST42
Domaini1603 – 1731FAS1 5PROSITE-ProRule annotationAdd BLAST129
Domaini1747 – 1888FAS1 6PROSITE-ProRule annotationAdd BLAST142
Domaini1965 – 2030Laminin EGF-like 2Sequence analysisAdd BLAST66
Domaini2055 – 2089EGF-like 15PROSITE-ProRule annotationAdd BLAST35
Domaini2090 – 2130EGF-like 16PROSITE-ProRule annotationAdd BLAST41
Domaini2131 – 2173EGF-like 17PROSITE-ProRule annotationAdd BLAST43
Domaini2206 – 2298LinkPROSITE-ProRule annotationAdd BLAST93
Domaini2318 – 2452FAS1 7PROSITE-ProRule annotationAdd BLAST135

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2510 – 2520Interaction with TMSB4XBy similarityAdd BLAST11

Domaini

Recognizes phosphatidyl serine via its epidermal growth factor-like domains.

Keywords - Domaini

EGF-like domain, Laminin EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IRWM Eukaryota
ENOG4110T5S LUCA
GeneTreeiENSGT00760000119025
HOGENOMiHOG000154436
HOVERGENiHBG079218
InParanoidiQ8R4U0
KOiK19013
OMAiKCCKGFY
OrthoDBiEOG091G002T
PhylomeDBiQ8R4U0
TreeFamiTF331489

Family and domain databases

Gene3Di2.30.180.10, 6 hits
3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR024731 EGF_dom
IPR036378 FAS1_dom_sf
IPR000782 FAS1_domain
IPR002049 Laminin_EGF
IPR000538 Link_dom
PfamiView protein in Pfam
PF12947 EGF_3, 5 hits
PF02469 Fasciclin, 7 hits
PF00193 Xlink, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 21 hits
SM00179 EGF_CA, 7 hits
SM00180 EGF_Lam, 5 hits
SM00554 FAS1, 7 hits
SM00445 LINK, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
SSF82153 SSF82153, 7 hits
PROSITEiView protein in PROSITE
PS00022 EGF_1, 7 hits
PS01186 EGF_2, 16 hits
PS50026 EGF_3, 21 hits
PS01248 EGF_LAM_1, 2 hits
PS50213 FAS1, 7 hits
PS01241 LINK_1, 1 hit
PS50963 LINK_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8R4U0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARSKLLLGK LLPLILIFLG LLVQNACSPT EAPELTKRCD KKSTLTIKTE
60 70 80 90 100
CQSCSVNIAV KCPDGYIKIT NGTVGVRDCR YSLKIQSYVL DIPGCRHICR
110 120 130 140 150
KDYLQPQCCP GHWGPDCMEC PGGARAPCGG RGVCDEGMEG TGSCSCRAGF
160 170 180 190 200
RGTACENCAA EDVFGPNCSA VCSCVHGVCN SGISGDGTCE CLSAYRGPRC
210 220 230 240 250
DKPIPECAAL LCPENSRCSP SSKDETKLQC KCLPSYKGDG QTCKPINPCL
260 270 280 290 300
KNVCHPHASC SYLGPNRHSC VCQKGYQGDG QVCLPVDPCQ TSYGNCPTKS
310 320 330 340 350
TVCRYDGPGQ SHCECKEHYR NFVPGVGCSM TDICESKNPC HKNANCSTVS
360 370 380 390 400
PGQTQCTCQK GYVGDGLNCY GNIMQRLREL NTEPRGMWQG QLTSFISILD
410 420 430 440 450
RTYAWPLSNL GPFTVLLPSD KGLKGVDVKE LLMDKEAARY FVKLHIIAGQ
460 470 480 490 500
MSTEQMYNLD TFYTLTGKSG EIINKDKDNQ LKLKLYGSKI VQIIQGNIVA
510 520 530 540 550
SNGLVHILDR AMDKIEPTLE SNPQQTIMTM LQPRYGKFRS LLEKTNVGQA
560 570 580 590 600
LEKGGIDEPY TIFVPSNEAL SNMTAGVLDY LLSPEGSRKL LELVRYHIVA
610 620 630 640 650
FTQLEVATLV STLHIRSMAN QIITFNISSK GQILANNVAV DETEVAAKNG
660 670 680 690 700
RIYTLTGVLI PPSILPILPH RCNETKREMK LGTCVRCFMK NWSKCPTNSE
710 720 730 740 750
PTAIFTNKCF YGSRAWNLKI GCARYCDVTV EIPRCCKGFF GPDCNPCPGG
760 770 780 790 800
FMNPCSGNGQ CIDGLGGNGT CICEDGFQGS RCQFCSKPNR YGPQCNRTCQ
810 820 830 840 850
CVHGICDNRL DSDGSCLPGT CREGTAGRFC DKQTSACGPY MQFCHIHATC
860 870 880 890 900
EYSNETASCV CNDGYEGDGT LCSKKDPCLG STSRGGCSPN AECIQASTGT
910 920 930 940 950
YSCVCQRGWT GNGRDCVEIN SCLLPSSGGC HDNATCLYVG PGQNECECKK
960 970 980 990 1000
GFRGNGIDCE PIISCLEQIE KCHPLATCQY TLSGVWSCVC QEGYEGNGVL
1010 1020 1030 1040 1050
CYGNVLMELS FLSEAAVFYQ WINNASLQSM LSATSNLTVL VPSLQAIKDM
1060 1070 1080 1090 1100
DQNEKSFWLS RNNIPALIKY HTLLGTYRVA DLQTLPSSHM LATSLQGSFL
1110 1120 1130 1140 1150
RLDKADGNIT IEGASFVDGD NAATNGVVHI INKVLIPQRG LTGSLPSLLT
1160 1170 1180 1190 1200
RLEQMPDYSI FRGYIIHYNL ASAIEAADAY TVFVPNNEAI ESYIREKKAT
1210 1220 1230 1240 1250
SLKEDILQYH VVLGEKLLRN DLHNGMHRET MLGFSYLLAF FLHNDQLYVN
1260 1270 1280 1290 1300
EAPINYTNVA TDKGVIHGLE KVLEIKKNRC DNNDTIIVRG KCGKCSQQTL
1310 1320 1330 1340 1350
CPLETKPLSE TRKCIYSVYF MGKRSIFIGC QLQCVRTIIT SACCAGFFGP
1360 1370 1380 1390 1400
QCQACPGKGQ NVCSGNGFCL DGVNGTGTCE CEQGFNGTAC ETCTEGKYGI
1410 1420 1430 1440 1450
HCDQACSCVH GRCNQGPSGD GSCDCDVGWR GVKCDSEITT DNCNGTCHTS
1460 1470 1480 1490 1500
ANCLLDPDGK ASCKCAAGFQ GNGTVCTAIN ACEISNGGCS AKADCKRTIP
1510 1520 1530 1540 1550
GSRVCVCKAG YTGDGIVCLE INPCLENHGG CDRHAECTQT GPNQAVCNCL
1560 1570 1580 1590 1600
PKYTGDGKVC TLINVCLTNN GGCSPFAFCN HTEQDQRTCT CKPDYTGDGI
1610 1620 1630 1640 1650
VCRGSIHSEL PKNPSTSQYF FQLQEHAVQE LAGPGPFTVF VPSSDSFNSE
1660 1670 1680 1690 1700
SKLKVWDKQG LMSQILRYHV VACQQLLLEN LKVITSATTL QGEPISISVS
1710 1720 1730 1740 1750
QDTVLINKKA KVLSSDIIST NGVIHVIDTL LSPQNLLITP KGASGRVLLN
1760 1770 1780 1790 1800
LTTVAANHGY TKFSKLIQDS GLLKVITDPM HTPVTLFWPT DKALQALPQE
1810 1820 1830 1840 1850
QQDFLFNEDN KDKLKAYLKF HVIRDTMALA SDLPRSASWK TLQGSELSVR
1860 1870 1880 1890 1900
CGTGSDVGEL FLNGQMCRII QRRLLFDGGV AYGIDCLLMD PTEGGRCDTF
1910 1920 1930 1940 1950
TTFNIPGECG SCFSTPRCPL QSKPKGVRKK CIYNPLPFRR DVEGCQNLCT
1960 1970 1980 1990 2000
LVVHVPRCCS GYFMPDCQAC PGGPDTPCNN RGMCYDQYKP TGQCQCHTGF
2010 2020 2030 2040 2050
NGTACELCLP GRFGPDCQPC GCSEHGQCDE GITGSGQCLC EAGWTGRFCD
2060 2070 2080 2090 2100
APTVVIPVCI PACSMHATCM ENNTCVCNLN YEGDGITCTV VDFCKQNNGG
2110 2120 2130 2140 2150
CAKVAKCSQK GTQVSCSCQK GYKGDGHSCT EIDPCANGVN GGCHEHATCR
2160 2170 2180 2190 2200
MTGPGKQKCE CKSHYVGDGR DCEPEQLPLD RCLQDNGQCH PDANCVDLHF
2210 2220 2230 2240 2250
QDTTVGVFHL RSPLGQYKLT FDKAKEACAK EAASIATYNQ LSYAQKAKYH
2260 2270 2280 2290 2300
LCSAGWLESG RVAYPTIYAS KKCANIVGIV DYGTRTNKSE MWDVFCYRMK
2310 2320 2330 2340 2350
DVNCTCKAGY VGDGFSCNGN LLQVLMSFPS LTNFLTEVLV FSRSSAQGRA
2360 2370 2380 2390 2400
FLKHLTDLSI SGTLFVPQNS GLPKNKSLSG RDIEHHLTNV NVSFYDDLVN
2410 2420 2430 2440 2450
GTVLKTRLGS QLLITSSQDQ LHQEARFVDG RAILQWDIIA SNGVLHIISE
2460 2470 2480 2490 2500
PLKAPPTAAT AAHSGLGTGI FCAVVLVTGA IALAAYSYFR LNQRTTGFRR
2510 2520 2530 2540 2550
FESEDDIDAL AFGKQQPESI TNPLYETSTP AAPEPSCDPF TDSGERELEN

SDPLGALRS
Length:2,559
Mass (Da):277,532
Last modified:June 1, 2002 - v1
Checksum:i1C9855AD61EFF015
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1W2P6Y4A0A1W2P6Y4_MOUSE
Stabilin-2
Stab2
870Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1666L → G in BAC28741 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF364951 mRNA Translation: AAL91684.2
AK034522 mRNA Translation: BAC28741.1
CCDSiCCDS36021.1
RefSeqiNP_619614.1, NM_138673.2
UniGeneiMm.279611

Genome annotation databases

EnsembliENSMUST00000035288; ENSMUSP00000048309; ENSMUSG00000035459
GeneIDi192188
KEGGimmu:192188
UCSCiuc007gqo.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF364951 mRNA Translation: AAL91684.2
AK034522 mRNA Translation: BAC28741.1
CCDSiCCDS36021.1
RefSeqiNP_619614.1, NM_138673.2
UniGeneiMm.279611

3D structure databases

ProteinModelPortaliQ8R4U0
SMRiQ8R4U0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000048309

PTM databases

iPTMnetiQ8R4U0
PhosphoSitePlusiQ8R4U0
SwissPalmiQ8R4U0

Proteomic databases

MaxQBiQ8R4U0
PaxDbiQ8R4U0
PRIDEiQ8R4U0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035288; ENSMUSP00000048309; ENSMUSG00000035459
GeneIDi192188
KEGGimmu:192188
UCSCiuc007gqo.1 mouse

Organism-specific databases

CTDi55576
MGIiMGI:2178743 Stab2

Phylogenomic databases

eggNOGiENOG410IRWM Eukaryota
ENOG4110T5S LUCA
GeneTreeiENSGT00760000119025
HOGENOMiHOG000154436
HOVERGENiHBG079218
InParanoidiQ8R4U0
KOiK19013
OMAiKCCKGFY
OrthoDBiEOG091G002T
PhylomeDBiQ8R4U0
TreeFamiTF331489

Enzyme and pathway databases

ReactomeiR-MMU-2160916 Hyaluronan uptake and degradation
R-MMU-3000497 Scavenging by Class H Receptors

Miscellaneous databases

PROiPR:Q8R4U0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035459 Expressed in 111 organ(s), highest expression level in liver
CleanExiMM_STAB2
ExpressionAtlasiQ8R4U0 baseline and differential
GenevisibleiQ8R4U0 MM

Family and domain databases

Gene3Di2.30.180.10, 6 hits
3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR024731 EGF_dom
IPR036378 FAS1_dom_sf
IPR000782 FAS1_domain
IPR002049 Laminin_EGF
IPR000538 Link_dom
PfamiView protein in Pfam
PF12947 EGF_3, 5 hits
PF02469 Fasciclin, 7 hits
PF00193 Xlink, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 21 hits
SM00179 EGF_CA, 7 hits
SM00180 EGF_Lam, 5 hits
SM00554 FAS1, 7 hits
SM00445 LINK, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
SSF82153 SSF82153, 7 hits
PROSITEiView protein in PROSITE
PS00022 EGF_1, 7 hits
PS01186 EGF_2, 16 hits
PS50026 EGF_3, 21 hits
PS01248 EGF_LAM_1, 2 hits
PS50213 FAS1, 7 hits
PS01241 LINK_1, 1 hit
PS50963 LINK_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSTAB2_MOUSE
AccessioniPrimary (citable) accession number: Q8R4U0
Secondary accession number(s): Q8BM87
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: June 1, 2002
Last modified: November 7, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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