Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 132 (18 Sep 2019)
Sequence version 1 (01 Jun 2002)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Multidrug resistance-associated protein 7

Gene

Abcc10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

ATP-dependent transporter probably involved in cellular detoxification through lipophilic anion extrusion.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi634 – 641ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1289 – 1296ATP 2PROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-382556 ABC-family proteins mediated transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Multidrug resistance-associated protein 7
Alternative name(s):
ATP-binding cassette sub-family C member 10
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Abcc10
Synonyms:Mrp7
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2386976 Abcc10

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei32 – 52HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei70 – 90HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei102 – 122HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei133 – 153HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei172 – 192HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei294 – 314HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei321 – 341HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei392 – 412HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei415 – 435HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei508 – 528HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei539 – 559HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei877 – 897HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei969 – 989HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei1033 – 1053HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei1056 – 1076HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei1158 – 1178HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei1187 – 1207HelicalPROSITE-ProRule annotationAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002535771 – 1501Multidrug resistance-associated protein 7Add BLAST1501

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei464PhosphothreonineBy similarity1
Modified residuei468PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8R4P9

PRoteomics IDEntifications database

More...
PRIDEi
Q8R4P9

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8R4P9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8R4P9

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8R4P9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in all tissues tested including liver, brain, heart, skeletal muscle, kidney and spleen.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in embryo.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000032842 Expressed in 153 organ(s), highest expression level in substantia nigra

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8R4P9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8R4P9 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000131843

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8R4P9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini286 – 564ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST279
Domaini599 – 825ABC transporter 1PROSITE-ProRule annotationAdd BLAST227
Domaini887 – 1215ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST329
Domaini1255 – 1488ABC transporter 2PROSITE-ProRule annotationAdd BLAST234

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0054 Eukaryota
COG1132 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161082

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8R4P9

KEGG Orthology (KO)

More...
KOi
K05674

Identification of Orthologs from Complete Genome Data

More...
OMAi
CFGWEFY

Database of Orthologous Groups

More...
OrthoDBi
138195at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8R4P9

TreeFam database of animal gene trees

More...
TreeFami
TF105203

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1560.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR027417 P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8R4P9-1) [UniParc]FASTAAdd to basket
Also known as: Mrp7B

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEGLLAQLCG TDAARPLPLW EGDTTGHCFT QLVLSALPHA LLAVLSACHL
60 70 80 90 100
GTPRTTNHSP ALNPGWRLRL AASFLLSIFP LLDLLPVVLP PGSRPGPLWL
110 120 130 140 150
EVLAGCVTAV AWFTHSLALW ALVHSPHGRS RGPLALALAA FLPTPALVLT
160 170 180 190 200
LLWHCQRGTF LPPLLPGPLG RVCLLILQLA AVLAYGLGWA APGGPQEPWT
210 220 230 240 250
HDPFLSSESQ ETEVAEDGES WLSRFSYAWL APLLARGVRG ELQQPRDTCR
260 270 280 290 300
LPRRLHPAFL ARVFQAHWKE GAQLWRALYR AFGCCYLALG LLKMVGTMLG
310 320 330 340 350
FSGPLLLSLL VGFLEEGQEP LSHGLLYVLG LAGGTVISAV LQNQYGYEVR
360 370 380 390 400
KVTLQARVAV LSTLYRKALK LGPSRPPTGE VLNLLGTDSE RLLNFAGSFH
410 420 430 440 450
EAWGLPLQLA ITLYLLYQQV GMAFLAGLVL ALLLVPVNKV IATRIMASNQ
460 470 480 490 500
EMLRHKDARV KLMTELLSGI RVIKFFRWEQ ALGDRVKACR TKELGRLRVI
510 520 530 540 550
KYLDAACVYL WAALPVVICI TIFITYVLMG HQLTATKVFT ALALVRMLIL
560 570 580 590 600
PLNNFPWVIN GLLESKVSLD RIQRFLDLPS YSPEAYYSPD PPAEPSTALE
610 620 630 640 650
LHEALFSWDP IGASQKTFIS HLQVKKGMLV GIVGKVGCGK SSLLAAITGE
660 670 680 690 700
LHRLCGWVAV SELSKGFGLA TQEPWIQCAT IRDNILFGKT FDAQLYREVL
710 720 730 740 750
EACALNDDLS ILPAGDQTEV GEKGVTLSGG QRARIALARA VYQEKALYLL
760 770 780 790 800
DDPLAAVDAD VANHLLHRCI LGVLSHTTRL LCTHRTEYLE RADVVLLMEA
810 820 830 840 850
GQLVRTGPPS EILPLVQAVP TAWAEKEQVA TSGQSPSVCD LERTTEEELE
860 870 880 890 900
VEQSTCGCLV QEESKSEGAV ALHVYRAYWR AMGSGLAAAI LVSLLLMQAT
910 920 930 940 950
RNGADWWLAH WLSQLKAGRN GSREDPASCS PGSTALFSPR LLLFSPGNLY
960 970 980 990 1000
TPLLSTPLHK AASNGTADVH FYLIVYATIA GVNSLCTLLR AVLFAAGALQ
1010 1020 1030 1040 1050
AAASLHHRLL HRLLMAPVTF YDSTPSGRVL NRFSSDVACV DDSLPFLLNI
1060 1070 1080 1090 1100
LLANSVGLLG LLAVLGSGLP WLLLLLPPLS FVYYSVQGYY RASFRELRRL
1110 1120 1130 1140 1150
GSLTWSPLYS HLADTLAGLP VLRAAGATYR FEEENQRLLE LNQRCQFASY
1160 1170 1180 1190 1200
ATMQWLDIRL QLMGAAVVSA IAGIALVQHQ QGLANPGLVG LVLSYALSLT
1210 1220 1230 1240 1250
GLLSGLVSSF TQTEAMMVSV ERLEEYSCDV PQEPHSQPLQ SPHQQRISWL
1260 1270 1280 1290 1300
TQGSVEFQDV VLVYRPGLPN ALDGVTFRVE PGEKLGIVGR TGSGKSSLFL
1310 1320 1330 1340 1350
VLFRLLEPNA GRVLLDNVDT SQLELAELRS QLAVIPQEPF LFSGTIRENL
1360 1370 1380 1390 1400
DPQGLHEDRA LWQALEQCHL SEVAVAMGGL DGELGERGQN LSLGQRQLLC
1410 1420 1430 1440 1450
LARALLTDAK ILCIDEATAS VDQKTDQLLQ QTICKRFANK TVLTIAHRLN
1460 1470 1480 1490 1500
TILNSDRVLV LQAGRVVELD SPSALRNQPH SLFQQLLQSS QQGAHSGPSG

C
Length:1,501
Mass (Da):163,735
Last modified:June 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i573D5CFA52DDF3BA
GO
Isoform 2 (identifier: Q8R4P9-2) [UniParc]FASTAAdd to basket
Also known as: Mrp7A

The sequence of this isoform differs from the canonical sequence as follows:
     1-41: Missing.
     42-53: LAVLSACHLGTP → MICGLLFFSFFP

Show »
Length:1,460
Mass (Da):159,646
Checksum:i3C1471FEE43339E1
GO
Isoform 3 (identifier: Q8R4P9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1377-1377: M → MGESQACQRSQREAKNGHWQCSALLT

Note: No experimental confirmation available.
Show »
Length:1,526
Mass (Da):166,506
Checksum:iCD55D65669560B95
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PY11E9PY11_MOUSE
Multidrug resistance-associated pro...
Abcc10
245Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PZG1E9PZG1_MOUSE
Multidrug resistance-associated pro...
Abcc10
487Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0210811 – 41Missing in isoform 2. 1 PublicationAdd BLAST41
Alternative sequenceiVSP_02108242 – 53LAVLS…HLGTP → MICGLLFFSFFP in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_0210831377M → MGESQACQRSQREAKNGHWQ CSALLT in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF406642 mRNA Translation: AAM18535.1
AF417121 mRNA Translation: AAM18536.1
AK133240 mRNA Translation: BAE21573.1
AK170600 mRNA Translation: BAE41905.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS28825.1 [Q8R4P9-2]
CCDS50124.1 [Q8R4P9-1]
CCDS84315.1 [Q8R4P9-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001334325.1, NM_001347396.1 [Q8R4P9-3]
NP_660122.1, NM_145140.2 [Q8R4P9-2]
NP_733780.1, NM_170680.2 [Q8R4P9-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000047970; ENSMUSP00000038041; ENSMUSG00000032842 [Q8R4P9-3]
ENSMUST00000095261; ENSMUSP00000092895; ENSMUSG00000032842 [Q8R4P9-2]
ENSMUST00000167360; ENSMUSP00000131843; ENSMUSG00000032842 [Q8R4P9-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
224814

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:224814

UCSC genome browser

More...
UCSCi
uc008csn.1 mouse [Q8R4P9-2]
uc008cso.1 mouse [Q8R4P9-1]
uc012auq.1 mouse [Q8R4P9-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF406642 mRNA Translation: AAM18535.1
AF417121 mRNA Translation: AAM18536.1
AK133240 mRNA Translation: BAE21573.1
AK170600 mRNA Translation: BAE41905.1
CCDSiCCDS28825.1 [Q8R4P9-2]
CCDS50124.1 [Q8R4P9-1]
CCDS84315.1 [Q8R4P9-3]
RefSeqiNP_001334325.1, NM_001347396.1 [Q8R4P9-3]
NP_660122.1, NM_145140.2 [Q8R4P9-2]
NP_733780.1, NM_170680.2 [Q8R4P9-1]

3D structure databases

SMRiQ8R4P9
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000131843

PTM databases

iPTMnetiQ8R4P9
PhosphoSitePlusiQ8R4P9
SwissPalmiQ8R4P9

Proteomic databases

PaxDbiQ8R4P9
PRIDEiQ8R4P9

Genome annotation databases

EnsembliENSMUST00000047970; ENSMUSP00000038041; ENSMUSG00000032842 [Q8R4P9-3]
ENSMUST00000095261; ENSMUSP00000092895; ENSMUSG00000032842 [Q8R4P9-2]
ENSMUST00000167360; ENSMUSP00000131843; ENSMUSG00000032842 [Q8R4P9-1]
GeneIDi224814
KEGGimmu:224814
UCSCiuc008csn.1 mouse [Q8R4P9-2]
uc008cso.1 mouse [Q8R4P9-1]
uc012auq.1 mouse [Q8R4P9-3]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
89845
MGIiMGI:2386976 Abcc10

Phylogenomic databases

eggNOGiKOG0054 Eukaryota
COG1132 LUCA
GeneTreeiENSGT00940000161082
InParanoidiQ8R4P9
KOiK05674
OMAiCFGWEFY
OrthoDBi138195at2759
PhylomeDBiQ8R4P9
TreeFamiTF105203

Enzyme and pathway databases

ReactomeiR-MMU-382556 ABC-family proteins mediated transport

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Abcc10 mouse

Protein Ontology

More...
PROi
PR:Q8R4P9

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000032842 Expressed in 153 organ(s), highest expression level in substantia nigra
ExpressionAtlasiQ8R4P9 baseline and differential
GenevisibleiQ8R4P9 MM

Family and domain databases

Gene3Di1.20.1560.10, 2 hits
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMRP7_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8R4P9
Secondary accession number(s): Q3TCQ0, Q3V0D1, Q8R4S1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: June 1, 2002
Last modified: September 18, 2019
This is version 132 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again