Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transmembrane channel-like protein 2

Gene

Tmc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable ion channel required for the normal function of cochlear hair cells (By similarity). Component of the hair cell's mechanotransduction (MET) machinery. Involved in mechanosensitive responses of the hair cells (By similarity).By similarity

GO - Molecular functioni

  • ion channel activity Source: GO_Central
  • mechanosensitive ion channel activity Source: MGI
  • voltage-gated calcium channel activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionIon channel
Biological processIon transport, Transport

Protein family/group databases

TCDBi1.A.17.4.1 the calcium-dependent chloride channel (ca-clc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane channel-like protein 2
Alternative name(s):
Transmembrane cochlear-expressed protein 2
Gene namesi
Name:Tmc2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2151017 Tmc2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 245CytoplasmicSequence analysisAdd BLAST245
Transmembranei246 – 266HelicalSequence analysisAdd BLAST21
Topological domaini267 – 318ExtracellularSequence analysisAdd BLAST52
Transmembranei319 – 339HelicalSequence analysisAdd BLAST21
Topological domaini340 – 412CytoplasmicSequence analysisAdd BLAST73
Transmembranei413 – 433HelicalSequence analysisAdd BLAST21
Topological domaini434 – 490ExtracellularSequence analysisAdd BLAST57
Transmembranei491 – 511HelicalSequence analysisAdd BLAST21
Topological domaini512 – 675CytoplasmicSequence analysisAdd BLAST164
Transmembranei676 – 696HelicalSequence analysisAdd BLAST21
Topological domaini697 – 732ExtracellularSequence analysisAdd BLAST36
Transmembranei733 – 753HelicalSequence analysisAdd BLAST21
Topological domaini754 – 888CytoplasmicSequence analysisAdd BLAST135

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001853831 – 888Transmembrane channel-like protein 2Add BLAST888

Proteomic databases

PaxDbiQ8R4P4
PRIDEiQ8R4P4

PTM databases

iPTMnetiQ8R4P4
PhosphoSitePlusiQ8R4P4

Expressioni

Tissue specificityi

Inner ear and testis.2 Publications

Developmental stagei

Expressed at low, constant levels in temporal bone from embryonic day 14 to day 1 after birth. Increases by 8 to 16-fold at day 5, 10 and 20.1 Publication

Gene expression databases

BgeeiENSMUSG00000060332 Expressed in 11 organ(s), highest expression level in fibroblast
CleanExiMM_TMC2
GenevisibleiQ8R4P4 MM

Interactioni

Subunit structurei

Interacts with TOMT. The interaction of TMC1 and TMC2 with TOMT is required for the transportation of TMC1/2 into the stereocilia of hair cells (PubMed:28504928). Interacts (via N-terminus) with both isoforms CD1 and CD3 of PCDH15 (PubMed:25114259).2 Publications

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000077139

Structurei

3D structure databases

ProteinModelPortaliQ8R4P4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi6 – 224Arg/Asp/Glu/Lys-rich (highly charged)Add BLAST219

Sequence similaritiesi

Belongs to the TMC family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF2J Eukaryota
ENOG410XTGF LUCA
GeneTreeiENSGT00760000119171
HOGENOMiHOG000231742
HOVERGENiHBG036209
InParanoidiQ8R4P4
KOiK21988
OMAiTMRSKPW
OrthoDBiEOG091G00X0
PhylomeDBiQ8R4P4
TreeFamiTF313462

Family and domain databases

InterProiView protein in InterPro
IPR038900 TMC
IPR012496 TMC_dom
PANTHERiPTHR23302 PTHR23302, 1 hit
PfamiView protein in Pfam
PF07810 TMC, 1 hit

Sequencei

Sequence statusi: Complete.

Q8R4P4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSPQLKSLDE EGDKSARRPT RKQTSRAACP QDGHRAQSSR KDPAKGSPRP
60 70 80 90 100
GSSRKKQMEH GSYHKGLQGQ KPRKVERSLQ GRKKDRRTSL KEQRASPKKE
110 120 130 140 150
REALRKEAGK QLRKPRSTSL GSSVSTGDSL SEEELAQILE QVEEKKKLIT
160 170 180 190 200
TVRNKPWPMA KKLRELREAQ AFVEKYEGAL GKGKGKHLYA YRMMMAKKWV
210 220 230 240 250
KFKRDFDNFK TQCIPWEMKI KDIESHFGSS VASYFIFLRW MYGVNLVLFG
260 270 280 290 300
LIFGLVIIPE VLMGMPYGSI PRKTVPRAEE ERAMDFSVLW DFEGYIKYSA
310 320 330 340 350
LFYGYYNNQR TIGWLRYRLP MAYFMVGVSV FGYSLMIVIR SMASNTQGST
360 370 380 390 400
SEGDSDSFTF SFKMFTSWDY LIGNSETADN KYVSITTSFK ESIVDEQESN
410 420 430 440 450
KEGNIHLTRF LRVLANFLIL CCLCGSGYLI YFVVKRSQEF SKMQNVSWYE
460 470 480 490 500
RNEVEIVMSL LGMFCPPLFE TIAALENYHP RTGLKWQLGR IFALFLGNLY
510 520 530 540 550
TFLLALMDDV HLKLSNEEKI KNITHWTLFN YYNSSGGNES VPRPPPHPAD
560 570 580 590 600
VPRGSCWETA VGIEFMRLTV SDMLVTYLTI LVGDFLRACF VRFMNHCWCW
610 620 630 640 650
DLEAGFPSYA EFDISGNVLG LIFNQGMIWM GSFYAPGLVG INVLRLLTSM
660 670 680 690 700
YFQCWAVMSS NVPHERVFKA SRSNNFYMGL LLLVLFLSLL PVAYTVMSLP
710 720 730 740 750
PSFDCGPFSG KNRMYDVLHE TIENDFPKFL GKIFAFLANP GLIIPAILLM
760 770 780 790 800
FLAIYYLNSV SKSLSRANAQ LRKKIQALRE VEKNHKSIKG KAIVTYSEDT
810 820 830 840 850
IKNSSKNATQ IHLTKEEPTS HSSSQIQTLD KKAQGPHTSS TEGGASPSTS
860 870 880
WHHVGSQPPR GRRDSGQPQS QTYTGRSPSG KRTQRPHN
Length:888
Mass (Da):101,134
Last modified:June 1, 2002 - v1
Checksum:i6D834D7987768FA7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF417581 mRNA Translation: AAL86402.1
AY263156 mRNA Translation: AAP35264.1
CCDSiCCDS16736.1
RefSeqiNP_619596.1, NM_138655.1
UniGeneiMm.219546

Genome annotation databases

EnsembliENSMUST00000077988; ENSMUSP00000077139; ENSMUSG00000060332
ENSMUST00000166774; ENSMUSP00000125843; ENSMUSG00000060332
GeneIDi192140
KEGGimmu:192140
UCSCiuc008mik.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF417581 mRNA Translation: AAL86402.1
AY263156 mRNA Translation: AAP35264.1
CCDSiCCDS16736.1
RefSeqiNP_619596.1, NM_138655.1
UniGeneiMm.219546

3D structure databases

ProteinModelPortaliQ8R4P4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000077139

Protein family/group databases

TCDBi1.A.17.4.1 the calcium-dependent chloride channel (ca-clc) family

PTM databases

iPTMnetiQ8R4P4
PhosphoSitePlusiQ8R4P4

Proteomic databases

PaxDbiQ8R4P4
PRIDEiQ8R4P4

Protocols and materials databases

DNASUi192140
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000077988; ENSMUSP00000077139; ENSMUSG00000060332
ENSMUST00000166774; ENSMUSP00000125843; ENSMUSG00000060332
GeneIDi192140
KEGGimmu:192140
UCSCiuc008mik.1 mouse

Organism-specific databases

CTDi117532
MGIiMGI:2151017 Tmc2

Phylogenomic databases

eggNOGiENOG410IF2J Eukaryota
ENOG410XTGF LUCA
GeneTreeiENSGT00760000119171
HOGENOMiHOG000231742
HOVERGENiHBG036209
InParanoidiQ8R4P4
KOiK21988
OMAiTMRSKPW
OrthoDBiEOG091G00X0
PhylomeDBiQ8R4P4
TreeFamiTF313462

Miscellaneous databases

PROiPR:Q8R4P4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000060332 Expressed in 11 organ(s), highest expression level in fibroblast
CleanExiMM_TMC2
GenevisibleiQ8R4P4 MM

Family and domain databases

InterProiView protein in InterPro
IPR038900 TMC
IPR012496 TMC_dom
PANTHERiPTHR23302 PTHR23302, 1 hit
PfamiView protein in Pfam
PF07810 TMC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTMC2_MOUSE
AccessioniPrimary (citable) accession number: Q8R4P4
Secondary accession number(s): Q7TQB1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: June 1, 2002
Last modified: November 7, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again