Neto1

Functionⁱ

Involved in the development and/or maintenance of neuronal circuitry. Accessory subunit of the neuronal N-methyl-D-aspartate receptor (NMDAR) critical for maintaining the abundance of GRIN2A-containing NMDARs in the postsynaptic density. Regulates long-term NMDA receptor-dependent synaptic plasticity and cognition, at least in the context of spatial learning and memory.2 Publications

GO - Molecular functionⁱ

ionotropic glutamate receptor binding
Source: MGI
Inferred from physical interactionⁱ
- 21734292

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

memory
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19243221
positive regulation of excitatory postsynaptic potential
Source: MGI
Inferred from mutant phenotypeⁱ
- 21734292
receptor localization to synapse
Source: MGI
Inferred from mutant phenotypeⁱ
- 21734292
regulation of kainate selective glutamate receptor activity Source: MGI
regulation of long-term neuronal synaptic plasticity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19243221
visual learning
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19243221

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Receptor

Molecular function

Receptor

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Neuropilin and tolloid-like protein 1 Alternative name(s): Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 1
Gene namesⁱ	Name:Neto1 Synonyms:Btcl1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 18

Organism-specific databases

MGIⁱ	MGI:2180216 Neto1

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	23 – 344	ExtracellularSequence analysisAdd BLAST	322
Transmembraneⁱ	345 – 365	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	366 – 533	CytoplasmicSequence analysisAdd BLAST	168

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechⁱ

Disruption phenotypeⁱ

Depressed long-term potentiation (LTP) at Schaffer collateral-CA1 synapses, NMDAR-dependent spatial learning and memory. Rescued by the ampakine CX546 at physiological doses.1 Publication

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 22	Sequence analysisAdd BLAST		22
ChainⁱPRO_0000021800	23 – 533	Neuropilin and tolloid-like protein 1Add BLAST		511

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	41 ↔ 68	By similarity
Disulfide bondⁱ	96 ↔ 118	By similarity
Disulfide bondⁱ	172 ↔ 202	By similarity
Disulfide bondⁱ	229 ↔ 251	By similarity
Disulfide bondⁱ	292 ↔ 304	By similarity
Disulfide bondⁱ	299 ↔ 317	By similarity
Glycosylationⁱ	306	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	311 ↔ 326	By similarity
Glycosylationⁱ	340	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	417	PhosphotyrosineCombined sources	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbⁱ	Q8R4I7
PeptideAtlas More...PeptideAtlasⁱ	Q8R4I7
PRIDEⁱ	Q8R4I7

PTM databases

iPTMnetⁱ	Q8R4I7
PhosphoSitePlusⁱ	Q8R4I7

Expressionⁱ

Tissue specificityⁱ

Expressed only in brain. Present throughout the central nervous system. Highly expressed in the hippocampal CA3 region, olfactory bulb and tubercle, caudate putamen, and neocortex in the adult brain.3 Publications

Developmental stageⁱ

Observed restrictively in brain throughout embryonic and postnatal stages. Expression pattern in brain slightly changes from E13 to postnatal day 21 (P21). Expressed in both cerebrum and cerebellum throughout P0 to P35. In the cerebrum expression reached a plateau at P14 while expression in the cerebellum remains constant throughout all postnatal stages.2 Publications

Gene expression databases

Bgeeⁱ	ENSMUSG00000050321 Expressed in 108 organ(s), highest expression level in striatum
CleanExⁱ	MM_NETO1
Genevisibleⁱ	Q8R4I7 MM

Interactionⁱ

Subunit structureⁱ

Interacts with PLZ domains of DLG2, DLG3 and DLG4 via its C-terminal TRV domain. Interacts with GRIN2A and GRIN2B via its CUB domains.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
DLG4	P78352	2	EBI-2314926,EBI-80389	From Homo sapiens.
Dlg4	Q62108	7	EBI-2314926,EBI-300895
Grin2a	Q00959	4	EBI-2314926,EBI-630970	From Rattus norvegicus.
Grin2b	Q00960	2	EBI-2314926,EBI-396905	From Rattus norvegicus.

GO - Molecular functionⁱ

ionotropic glutamate receptor binding
Source: MGI
Inferred from physical interactionⁱ
- 21734292

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	232925, 1 interactor
Database of interacting proteins More...DIPⁱ	DIP-48395N
IntActⁱ	Q8R4I7, 10 interactors
STRINGⁱ	10090.ENSMUSP00000057340

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8R4I7
SMRⁱ	Q8R4I7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	41 – 155	CUB 1PROSITE-ProRule annotationAdd BLAST	115
Domainⁱ	172 – 287	CUB 2PROSITE-ProRule annotationAdd BLAST	116
Domainⁱ	291 – 327	LDL-receptor class APROSITE-ProRule annotationAdd BLAST	37

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	531 – 533	PDZ-binding		3

Keywords - Domainⁱ

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IJXA Eukaryota ENOG410ZS19 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119018
HOGENOMⁱ	HOG000060303
HOVERGENⁱ	HBG052600
InParanoidⁱ	Q8R4I7
OMAⁱ	TEAVDCK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G060O
PhylomeDBⁱ	Q8R4I7

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00041 CUB, 2 hits cd00112 LDLa, 1 hit
Gene3Dⁱ	2.60.120.290, 2 hits
InterProⁱ	View protein in InterPro IPR000859 CUB_dom IPR036055 LDL_receptor-like_sf IPR023415 LDLR_class-A_CS IPR002172 LDrepeatLR_classA_rpt IPR028867 NETO1 IPR035914 Sperma_CUB_dom_sf
PANTHERⁱ	PTHR44143:SF1 PTHR44143:SF1, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00431 CUB, 2 hits PF00057 Ldl_recept_a, 1 hit
SMARTⁱ	View protein in SMART SM00042 CUB, 2 hits SM00192 LDLa, 1 hit
SUPFAMⁱ	SSF49854 SSF49854, 2 hits SSF57424 SSF57424, 1 hit
PROSITEⁱ	View protein in PROSITE PS01180 CUB, 2 hits PS01209 LDLRA_1, 1 hit PS50068 LDLRA_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q8R4I7-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MIYGRSLFHI IASLIILHSS GATKKGTEKQ ITPETQKSVQ CGTWTKHAEG 
        60         70         80         90        100
GVFTSPNYPS KYPPDRECVY IIEAAPRQCI ELYFDEKYSI EPSWECKFDH 
       110        120        130        140        150
IEVRDGPFGF SPIIGRFCGQ QNPPVIKSSG RFLWIKFFAD GELESMGFSA 
       160        170        180        190        200
RYNFTPDPDF KDLGVLKPLP ACEFEMGGPE GIVESIQILK EGKASASEAV 
       210        220        230        240        250
DCKWYIRAPP RSKIYLRFLD YEMQNSNECK RNFVAVYDGS SSVEDLKAKF 
       260        270        280        290        300
CSTVANDVML RTGLGVIRMW ADEGSRNSRF QMLFTSFQEP PCEGNTFFCH 
       310        320        330        340        350
SNMCINNTLV CNGLQNCVYP WDENHCKEKR KTSLLDQLTN TSGTVIGVTS 
       360        370        380        390        400
CIVIILIIVS VIVQIKQPRK KYVQRKSDFD QTVFQEVFEP PHYELCTLRG 
       410        420        430        440        450
TGATADFADV AEDFENYHKL RRSSSKCIHD HHCGSQLSSA KGSRSNLSTR 
       460        470        480        490        500
DASILAEIPT QPVKPLIPPV NRRNILVMKH NYSQDAADAC DIDEIEEVPT 
       510        520        530 
TSHRLSRHEK SVQRFCLIGS LSKHESEYNT TRV

Length:533

Mass (Da):60,242

Last modified:February 15, 2005 - v2

Checksum:ⁱ6375B395421D558F

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	80	I → F in BAC38196 (PubMed:16141072).Curated	1
Sequence conflictⁱ	514	R → Q in AAM18028 (PubMed:11943477).Curated	1
Sequence conflictⁱ	514	R → Q in BAC38196 (PubMed:16141072).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF448840 mRNA Translation: AAM18028.1 AY138990 mRNA Translation: AAN38318.1 AK032510 mRNA Translation: BAC27902.1 AK081325 mRNA Translation: BAC38196.1 BC051145 mRNA Translation: AAH51145.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS29387.1
NCBI Reference Sequences More...RefSeqⁱ	NP_659195.3, NM_144946.4 XP_006526543.1, XM_006526480.3 XP_006526544.1, XM_006526481.3 XP_006526545.1, XM_006526482.3 XP_017173396.1, XM_017317907.1 XP_017173397.1, XM_017317908.1
UniGeneⁱ	Mm.329578

Genome annotation databases

Ensemblⁱ	ENSMUST00000058829; ENSMUSP00000057340; ENSMUSG00000050321
GeneIDⁱ	246317
KEGGⁱ	mmu:246317
UCSC genome browser More...UCSCⁱ	uc008fuz.2 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8R4I7	Neuropilin and tolloid-like protein 1		HUMAN		533	UniRef90_Q8R4I7
Uncharacterized protein		ICTTR		540
Uncharacterized protein		ANAPL		536
Neuropilin and tolloid like 1		MELGA		535
neuropilin and tolloid-like protein 1		ERIEU		534
+226

Protein	Similar proteins		Species	Score	Length	Source
Q8R4I7	Neuropilin and tolloid-like protein 1		HUMAN		533	UniRef50_Q8R4I7
Uncharacterized protein		ICTTR		540
Uncharacterized protein		ANAPL		536
Neuropilin and tolloid like 1		MELGA		535
Neuropilin and tolloid like 1		LOXAF		534
+408

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF448840 mRNA Translation: AAM18028.1 AY138990 mRNA Translation: AAN38318.1 AK032510 mRNA Translation: BAC27902.1 AK081325 mRNA Translation: BAC38196.1 BC051145 mRNA Translation: AAH51145.1
CCDSⁱ	CCDS29387.1
RefSeqⁱ	NP_659195.3, NM_144946.4 XP_006526543.1, XM_006526480.3 XP_006526544.1, XM_006526481.3 XP_006526545.1, XM_006526482.3 XP_017173396.1, XM_017317907.1 XP_017173397.1, XM_017317908.1
UniGeneⁱ	Mm.329578

3D structure databases

ProteinModelPortalⁱ	Q8R4I7
SMRⁱ	Q8R4I7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	232925, 1 interactor
DIPⁱ	DIP-48395N
IntActⁱ	Q8R4I7, 10 interactors
STRINGⁱ	10090.ENSMUSP00000057340

PTM databases

iPTMnetⁱ	Q8R4I7
PhosphoSitePlusⁱ	Q8R4I7

Proteomic databases

PaxDbⁱ	Q8R4I7
PeptideAtlasⁱ	Q8R4I7
PRIDEⁱ	Q8R4I7

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000058829; ENSMUSP00000057340; ENSMUSG00000050321
GeneIDⁱ	246317
KEGGⁱ	mmu:246317
UCSCⁱ	uc008fuz.2 mouse

Organism-specific databases

CTDⁱ	81832
MGIⁱ	MGI:2180216 Neto1

Phylogenomic databases

eggNOGⁱ	ENOG410IJXA Eukaryota ENOG410ZS19 LUCA
GeneTreeⁱ	ENSGT00760000119018
HOGENOMⁱ	HOG000060303
HOVERGENⁱ	HBG052600
InParanoidⁱ	Q8R4I7
OMAⁱ	TEAVDCK
OrthoDBⁱ	EOG091G060O
PhylomeDBⁱ	Q8R4I7

Miscellaneous databases

ChiTaRSⁱ	Neto1 mouse
Protein Ontology More...PROⁱ	PR:Q8R4I7
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000050321 Expressed in 108 organ(s), highest expression level in striatum
CleanExⁱ	MM_NETO1
Genevisibleⁱ	Q8R4I7 MM

Family and domain databases

CDDⁱ	cd00041 CUB, 2 hits cd00112 LDLa, 1 hit
Gene3Dⁱ	2.60.120.290, 2 hits
InterProⁱ	View protein in InterPro IPR000859 CUB_dom IPR036055 LDL_receptor-like_sf IPR023415 LDLR_class-A_CS IPR002172 LDrepeatLR_classA_rpt IPR028867 NETO1 IPR035914 Sperma_CUB_dom_sf
PANTHERⁱ	PTHR44143:SF1 PTHR44143:SF1, 1 hit
Pfamⁱ	View protein in Pfam PF00431 CUB, 2 hits PF00057 Ldl_recept_a, 1 hit
SMARTⁱ	View protein in SMART SM00042 CUB, 2 hits SM00192 LDLa, 1 hit
SUPFAMⁱ	SSF49854 SSF49854, 2 hits SSF57424 SSF57424, 1 hit
PROSITEⁱ	View protein in PROSITE PS01180 CUB, 2 hits PS01209 LDLRA_1, 1 hit PS50068 LDLRA_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NETO1_MOUSE
Accessionⁱ	Q8R4I7Primary (citable) accession number: Q8R4I7 Secondary accession number(s): Q80X39, Q8C4S3, Q8CCM2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 15, 2005
	Last sequence update:	February 15, 2005
	Last modified:	November 7, 2018
	This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8R4I7 (NETO1_MOUSE)

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Neuropilin and tolloid-like protein 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Other locations

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Motif

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ