Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
We will be switching to the new UniProt website soon. Please explore and share your feedback. Take me to the new website.

UniProtKB - Q8R4E9 (CDT1_MOUSE)

Entry version 144 (23 Feb 2022)
Sequence version 1 (01 Jun 2002)
Previous versions | rss
Add a publicationFeedback
Protein

DNA replication factor Cdt1

Gene

Cdt1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for both DNA replication and mitosis. DNA replication licensing factor, required for pre-replication complex assembly. Cooperates with CDC6 and the origin recognition complex (ORC) during G1 phase of the cell cycle to promote the loading of the mini-chromosome maintenance (MCM) complex onto DNA to generate pre-replication complexes (pre-RC). Required also for mitosis by promoting stable kinetochore-microtubule attachments (By similarity).

Potential oncogene (PubMed:11850834).

By similarity3 Publications

Caution

Was originally thought to have DNA binding activity (PubMed:12192004). However, more recent studies show that CDT1 binds DNA indirectly via ORC.Curated1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • chromatin binding Source: MGI
  • DNA binding Source: UniProtKB
  • DNA polymerase binding Source: GO_Central
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processCell cycle, DNA replication

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-68827, CDT1 association with the CDC6:ORC:origin complex
R-MMU-68867, Assembly of the pre-replicative complex
R-MMU-68949, Orc1 removal from chromatin
R-MMU-68962, Activation of the pre-replicative complex

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA replication factor Cdt1
Alternative name(s):
Double parked homolog
Short name:
DUP
Retroviral insertion site 2 protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Cdt11 Publication
Synonyms:Ris2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1914427, Cdt1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSMUSG00000006585

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001916201 – 557DNA replication factor Cdt1Add BLAST557

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei28Phosphothreonine; by MAPK8By similarity1
Modified residuei30PhosphoserineBy similarity1
Modified residuei107Phosphoserine; by MAPK8By similarity1
Modified residuei392PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Two independent E3 ubiquitin ligase complexes, SCF(SKP2) and the DCX(DTL) complex, mediated CDT1 degradation in S phase. Ubiquitinated by the DCX(DTL) complex, in response to DNA damage, leading to its degradation. Ubiquitination by the DCX(DTL) complex is necessary to ensure proper cell cycle regulation and is PCNA-dependent: interacts with PCNA via its PIP-box, while the presence of the containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to its degradation. Phosphorylation at Thr-28 by CDK2 targets CDT1 for ubiquitynation by SCF(SKP2) E3 ubiquitin ligase and subsequent degradation. The interaction with GMNN protects it against ubiquitination. Deubiquitinated by USP37.By similarity
Phosphorylation by cyclin A-dependent kinases at Thr-28 targets CDT1 for ubiquitynation by SCF(SKP2) E3 ubiquitin ligase and subsequent degradation. Phosphorylated at Thr-28 by MAPK8/JNK1, which blocks replication licensing in response to stress. Binding to GMNN is not affected by phosphorylation (PubMed:14993212).By similarity1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8R4E9

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8R4E9

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8R4E9

PeptideAtlas

More...PeptideAtlasi		Q8R4E9

PRoteomics IDEntifications database

More...PRIDEi		Q8R4E9

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		281303

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8R4E9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8R4E9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Present during G1 and early S phase of the cell cycle. Degraded during the late S, G2, and M phases.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000006585, Expressed in fetal liver hematopoietic progenitor cell and 262 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8R4E9, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with GMNN; inhibits binding of the MCM complex to origins of replication (PubMed:12192004).

Interacts with CDC6; are mutually dependent on one another for loading MCM complexes onto chromatin (By similarity).

Interacts with PCNA (By similarity).

Interacts with LRWD1 during G1 phase and during mitosis (By similarity).

Interacts with NDC80 subunit of the NDC80 complex; leading to kinetochore localization (By similarity).

Interacts with KAT7 (By similarity).

Interacts with ubiquitin-binding protein FAF1; the interaction is likely to promote CDT1 degradation (By similarity).

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		211995, 5 interactors

Protein interaction database and analysis system

More...IntActi		Q8R4E9, 5 interactors

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000006760

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8R4E9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1557
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8R4E9

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q8R4E9

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni20 – 113DisorderedSequence analysisAdd BLAST94
Regioni163 – 203Interaction with GMNNBy similarityAdd BLAST41
Regioni397 – 427DisorderedSequence analysisAdd BLAST31
Regioni463 – 557Interaction with LRWD1By similarityAdd BLAST95

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1 – 25PIP-box K+4 motifBy similarityAdd BLAST25
Motifi65 – 67Cyclin-binding motifBy similarity3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi81 – 104Pro residuesSequence analysisAdd BLAST24
Compositional biasi405 – 422Pro residuesSequence analysisAdd BLAST18

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PIP-box K+4 motif mediates both the interaction with PCNA and the recruitment of the DCX(DTL) complex: while the PIP-box interacts with PCNA, the presence of the K+4 submotif, recruits the DCX(DTL) complex, leading to its ubiquitination.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Cdt1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4762, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000012337

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_023373_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8R4E9

Identification of Orthologs from Complete Genome Data

More...OMAi		DRVKEHH

Database of Orthologous Groups

More...OrthoDBi		648388at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8R4E9

TreeFam database of animal gene trees

More...TreeFami		TF101159

Family and domain databases

Conserved Domains Database

More...CDDi		cd08767, Cdt1_c, 1 hit
cd08674, Cdt1_m, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.10.1420, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR045173, Cdt1
IPR032054, Cdt1_C
IPR038090, Cdt1_C_WH_dom_sf
IPR014939, CDT1_Gemini-bd-like
IPR036390, WH_DNA-bd_sf

The PANTHER Classification System

More...PANTHERi		PTHR28637, PTHR28637, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF08839, CDT1, 1 hit
PF16679, CDT1_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01075, CDT1, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF46785, SSF46785, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8R4E9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQSRVTDFY ACRRPGLTTP RAKSICLTPS PGGLVAPAFT RSSSRKRARP 
        60         70         80         90        100
PAEPGSDQPA PLARRRLRLP GLDSCPSSLP EPSSPAEPSP PADPSPPADP 
       110        120        130        140        150
GSPVCPSPVK RTKSTTVYVG QQPGKIPSED SVSELQSCLR RARKLGAQAR 
       160        170        180        190        200
ALRARVQENA VEPSTPDAKV PTEQPCVEKA PAYQRFHALA QPGLPGLVLP 
       210        220        230        240        250
YKYQVLVEMF RSMDTIVSML HNRSETVTFA KVKQGVQEMM RKRFEERNVG 
       260        270        280        290        300
QIKTVYPTSY RFRQECNVPT FKDSIKRSDY QLTIEPLLGQ EAGGATQLTA 
       310        320        330        340        350
TCLLQRRQVF RQNLVERVKE QHKVFLASLN PPMAVPDDQL TRWHPRFNVD 
       360        370        380        390        400
EVPDIEPAEL PQPPVTEKLT TAQEVLARAR SLMTPKMEKA LSNLALRSAE 
       410        420        430        440        450
PGSPGTSTPP LPATPPATPP AASPSALKGV SQALLERIRA KEVQKQLARM 
       460        470        480        490        500
TRCPEQELRL QRLERLPELA RVLRNVFVSE RKPALTMEVV CARMVDSCQT 
       510        520        530        540        550
ALSPGEMEKH LVLLAELLPD WLSLHRIRTD TYVKLDKAVD LAGLTARLAH 

HVHAEGL
Length:557
Mass (Da):61,510
Last modified:June 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBFBA4E6DB5ABC1E6
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC38731 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti4S → G in BAC33579 (PubMed:16141072).Curated1
Sequence conflicti211R → H in AAL88446 (PubMed:11850834).Curated1
Sequence conflicti258T → M in AAL88446 (PubMed:11850834).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF477481 mRNA Translation: AAL82630.1
AF477990 Genomic DNA Translation: AAL88446.1
AB086655 mRNA Translation: BAC22085.1
AK028287 mRNA Translation: BAC25859.1
AK049163 mRNA Translation: BAC33579.1
AK083015 mRNA Translation: BAC38731.1 Frameshift.
BC024485 mRNA Translation: AAH24485.1
BC048076 mRNA Translation: AAH48076.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS22741.1

NCBI Reference Sequences

More...RefSeqi		NP_080290.3, NM_026014.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000006760; ENSMUSP00000006760; ENSMUSG00000006585

Database of genes from NCBI RefSeq genomes

More...GeneIDi		67177

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:67177

UCSC genome browser

More...UCSCi		uc009ntd.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF477481 mRNA Translation: AAL82630.1
AF477990 Genomic DNA Translation: AAL88446.1
AB086655 mRNA Translation: BAC22085.1
AK028287 mRNA Translation: BAC25859.1
AK049163 mRNA Translation: BAC33579.1
AK083015 mRNA Translation: BAC38731.1 Frameshift.
BC024485 mRNA Translation: AAH24485.1
BC048076 mRNA Translation: AAH48076.1
CCDSiCCDS22741.1
RefSeqiNP_080290.3, NM_026014.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KLONMR-A420-557[»]
2RQQNMR-A450-557[»]
2ZXXX-ray2.80C/F172-368[»]
3A4CX-ray1.89A452-557[»]
SMRiQ8R4E9
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi211995, 5 interactors
IntActiQ8R4E9, 5 interactors
STRINGi10090.ENSMUSP00000006760

PTM databases

iPTMnetiQ8R4E9
PhosphoSitePlusiQ8R4E9

Proteomic databases

EPDiQ8R4E9
MaxQBiQ8R4E9
PaxDbiQ8R4E9
PeptideAtlasiQ8R4E9
PRIDEiQ8R4E9
ProteomicsDBi281303

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1905, 216 antibodies from 36 providers

The DNASU plasmid repository

More...DNASUi		67177

Genome annotation databases

EnsembliENSMUST00000006760; ENSMUSP00000006760; ENSMUSG00000006585
GeneIDi67177
KEGGimmu:67177
UCSCiuc009ntd.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		81620
MGIiMGI:1914427, Cdt1
VEuPathDBiHostDB:ENSMUSG00000006585

Phylogenomic databases

eggNOGiKOG4762, Eukaryota
GeneTreeiENSGT00390000012337
HOGENOMiCLU_023373_1_0_1
InParanoidiQ8R4E9
OMAiDRVKEHH
OrthoDBi648388at2759
PhylomeDBiQ8R4E9
TreeFamiTF101159

Enzyme and pathway databases

ReactomeiR-MMU-68827, CDT1 association with the CDC6:ORC:origin complex
R-MMU-68867, Assembly of the pre-replicative complex
R-MMU-68949, Orc1 removal from chromatin
R-MMU-68962, Activation of the pre-replicative complex

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		67177, 16 hits in 67 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Cdt1, mouse
EvolutionaryTraceiQ8R4E9

Protein Ontology

More...PROi		PR:Q8R4E9
RNActiQ8R4E9, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000006585, Expressed in fetal liver hematopoietic progenitor cell and 262 other tissues
GenevisibleiQ8R4E9, MM

Family and domain databases

CDDicd08767, Cdt1_c, 1 hit
cd08674, Cdt1_m, 1 hit
Gene3Di1.10.10.1420, 1 hit
InterProiView protein in InterPro
IPR045173, Cdt1
IPR032054, Cdt1_C
IPR038090, Cdt1_C_WH_dom_sf
IPR014939, CDT1_Gemini-bd-like
IPR036390, WH_DNA-bd_sf
PANTHERiPTHR28637, PTHR28637, 1 hit
PfamiView protein in Pfam
PF08839, CDT1, 1 hit
PF16679, CDT1_C, 1 hit
SMARTiView protein in SMART
SM01075, CDT1, 1 hit
SUPFAMiSSF46785, SSF46785, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCDT1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8R4E9
Secondary accession number(s): Q8BUQ1
, Q8BX29, Q8R3V0, Q8R4E8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: June 1, 2002
Last modified: February 23, 2022
This is version 144 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again