Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Myozenin-3

Gene

Myoz3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Myozenins may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis.

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Myozenin-3
Alternative name(s):
Calsarcin-3
FATZ-related protein 3
Gene namesi
Name:Myoz3Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2179296 Myoz3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001111031 – 245Myozenin-3Add BLAST245

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei31PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8R4E4
PaxDbiQ8R4E4
PRIDEiQ8R4E4

PTM databases

iPTMnetiQ8R4E4
PhosphoSitePlusiQ8R4E4

Expressioni

Tissue specificityi

Expressed specifically in skeletal muscle and is enriched in fast-twitch muscle fibers. Not detected in heart.1 Publication

Gene expression databases

CleanExiMM_MYOZ3

Interactioni

Subunit structurei

Interacts with ACTN2, LDB3, FLNC, PPP3CA and TCAP.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000063108

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni50 – 67Binding to ACTN2, PPP3CA and TCAPBy similarityAdd BLAST18
Regioni67 – 108Binding to FLNCBy similarityAdd BLAST42
Regioni180 – 201Binding to ACTN2By similarityAdd BLAST22

Sequence similaritiesi

Belongs to the myozenin family.Curated

Phylogenomic databases

eggNOGiENOG410IWTE Eukaryota
ENOG410YKQB LUCA
HOGENOMiHOG000030910
HOVERGENiHBG071289
InParanoidiQ8R4E4
PhylomeDBiQ8R4E4

Family and domain databases

InterProiView protein in InterPro
IPR008438 MYOZ
PANTHERiPTHR15941 PTHR15941, 1 hit
PfamiView protein in Pfam
PF05556 Calsarcin, 1 hit

Sequencei

Sequence statusi: Complete.

Q8R4E4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIPKEQKEPV MAVPGDLAEP VPSLDLGKKL SVPQDLMIEE LSLRNNRGSL
60 70 80 90 100
LFQKRQRRVQ KFTFELSESL QAILASSARG KVAGRAAQAT VPNGLEEQNH
110 120 130 140 150
HSETHVFQGS PGDPGITHLG AAGTGSVRSP SALAPGYAEP LKGVPPEKFN
160 170 180 190 200
HTAIPKGYRC PWQEFTSYQD YSSGSRSHTP IPRDYRNFNK TPVPFGGPHV
210 220 230 240
REAIFHAGTP FVPESFSGLE LLRLRPNFNR VAQGWVRKLP ESEEL
Length:245
Mass (Da):26,982
Last modified:June 1, 2002 - v1
Checksum:iCF3FB6C4114FF03E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF480442 mRNA Translation: AAL79335.1
BC104046 mRNA Translation: AAI04047.1
BC104047 mRNA Translation: AAI04048.1
CCDSiCCDS29273.1
RefSeqiNP_579941.2, NM_133363.3
UniGeneiMm.159257

Genome annotation databases

GeneIDi170947
KEGGimmu:170947

Similar proteinsi

Entry informationi

Entry nameiMYOZ3_MOUSE
AccessioniPrimary (citable) accession number: Q8R4E4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: June 1, 2002
Last modified: May 10, 2017
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health