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UniProtKB - Q8R4D5 (TRPM8_MOUSE)

Entry version 126 (02 Jun 2021)
Sequence version 3 (06 Feb 2013)
Previous versions | rss
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Protein

Transient receptor potential cation channel subfamily M member 8

Gene

Trpm8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing.

2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel
Biological processIon transport, Sensory transduction, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-3295583, TRP channels

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transient receptor potential cation channel subfamily M member 8
Alternative name(s):
Long transient receptor potential channel 6
Short name:
LTrpC-6
Short name:
LTrpC6
Transient receptor potential p8
Short name:
Trp-p8
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Trpm8
Synonyms:Ltrpc6, Trpp8
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:2181435, Trpm8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 691CytoplasmicSequence analysisAdd BLAST691
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei692 – 712Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini713 – 734ExtracellularSequence analysisAdd BLAST22
Transmembranei735 – 755Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini756 – 759CytoplasmicSequence analysis4
Transmembranei760 – 780Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini781 – 794ExtracellularSequence analysisAdd BLAST14
Transmembranei795 – 815Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini816 – 829CytoplasmicSequence analysisAdd BLAST14
Transmembranei830 – 850Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini851 – 958ExtracellularSequence analysisAdd BLAST108
Transmembranei959 – 979Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini980 – 1104CytoplasmicSequence analysisAdd BLAST125

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi821N → Q: No effect on glycosylation or ability to form functional channels. 1 Publication1
Mutagenesisi929C → A: Abolishes ion channel activity. No effect on cell surface expression. Reduced glycosylation. 1 Publication1
Mutagenesisi934N → D: Slighty reduced ion channel sensitivity to cold stimuli. No significant effect on ion channel sensitivity to menthol plus cold stimuli. 3 Publications1
Mutagenesisi934N → K: Reduced ion channel sensitivity to cold stimuli or menthol plus cold stimuli. 3 Publications1
Mutagenesisi934N → Q: Abolishes glycosylation. Shifts threshold of temperature activation from 26.5 to 24 degrees Celsius. Reduced cell surface expression, association with lipid rafts and response to cold. 3 Publications1
Mutagenesisi940C → A: Abolishes ion channel activity. No effect on cell surface expression. Reduced glycosylation. 1 Publication1

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3108632

DrugCentral

More...DrugCentrali		Q8R4D5

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		500

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002153341 – 1104Transient receptor potential cation channel subfamily M member 8Add BLAST1104

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi934N-linked (GlcNAc...) (complex) asparagine2 Publications1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylation is not essential for but facilitates cell surface expression, multimerization, association with lipid rafts and ion channel activity.2 Publications

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8R4D5

PRoteomics IDEntifications database

More...PRIDEi		Q8R4D5

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		300027

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q8R4D5, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8R4D5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8R4D5

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q8R4D5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in dorsal root and trigeminal ganglia. Specifically expressed in a subset of pain- and temperature-sensing neurons. Not expressed in heavily myelinated neurons. Not expressed in neurons expressing TRPA1 or TRPV1.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000036251, Expressed in dorsal root ganglion and 52 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8R4D5, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via N-terminus and C-terminus domains) with TCAF1; the interaction stimulates TRPM8 channel activity.

Interacts (via N-terminus and C-terminus domains) with TCAF2; the interaction inhibits TRPM8 channel activity (By similarity). Homotetramer.

By similarity1 Publication

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		228590, 1 interactor

Database of interacting proteins

More...DIPi		DIP-61852N

Protein interaction database and analysis system

More...IntActi		Q8R4D5, 1 interactor

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000036991

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q8R4D5

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8R4D5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8R4D5

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 22DisorderedSequence analysisAdd BLAST22

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1069 – 1104Sequence analysisAdd BLAST36

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The coiled coil region is required for multimerization.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM8 sub-subfamily. [View classification]Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3614, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160270

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_001390_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8R4D5

Identification of Orthologs from Complete Genome Data

More...OMAi		CCKEKNT

Database of Orthologous Groups

More...OrthoDBi		738147at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8R4D5

TreeFam database of animal gene trees

More...TreeFami		TF314204

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR029603, TRPM8
IPR041491, TRPM_SLOG

The PANTHER Classification System

More...PANTHERi		PTHR13800:SF9, PTHR13800:SF9, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF18139, LSDAT_euk, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8R4D5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSFEGARLSM RSRRNGTMGS TRTLYSSVSR STDVSYSDSD LVNFIQANFK 
        60         70         80         90        100
KRECVFFTRD SKAMENICKC GYAQSQHIEG TQINQNEKWN YKKHTKEFPT 
       110        120        130        140        150
DAFGDIQFET LGKKGKYLRL SCDTDSETLY ELLTQHWHLK TPNLVISVTG 
       160        170        180        190        200
GAKNFALKPR MRKIFSRLIY IAQSKGAWIL TGGTHYGLMK YIGEVVRDNT 
       210        220        230        240        250
ISRNSEENIV AIGIAAWGMV SNRDTLIRSC DDEGHFSAQY IMDDFTRDPL 
       260        270        280        290        300
YILDNNHTHL LLVDNGCHGH PTVEAKLRNQ LEKYISERTS QDSNYGGKIP 
       310        320        330        340        350
IVCFAQGGGR ETLKAINTSV KSKIPCVVVE GSGQIADVIA SLVEVEDVLT 
       360        370        380        390        400
SSMVKEKLVR FLPRTVSRLP EEEIESWIKW LKEILESSHL LTVIKMEEAG 
       410        420        430        440        450
DEIVSNAISY ALYKAFSTNE QDKDNWNGQL KLLLEWNQLD LASDEIFTND 
       460        470        480        490        500
RRWESADLQE VMFTALIKDR PKFVRLFLEN GLNLQKFLTN EVLTELFSTH 
       510        520        530        540        550
FSTLVYRNLQ IAKNSYNDAL LTFVWKLVAN FRRSFWKEDR SSREDLDVEL 
       560        570        580        590        600
HDASLTTRHP LQALFIWAIL QNKKELSKVI WEQTKGCTLA ALGASKLLKT 
       610        620        630        640        650
LAKVKNDINA AGESEELANE YETRAVELFT ECYSNDEDLA EQLLVYSCEA 
       660        670        680        690        700
WGGSNCLELA VEATDQHFIA QPGVQNFLSK QWYGEISRDT KNWKIILCLF 
       710        720        730        740        750
IIPLVGCGLV SFRKKPIDKH KKLLWYYVAF FTSPFVVFSW NVVFYIAFLL 
       760        770        780        790        800
LFAYVLLMDF HSVPHTPELI LYALVFVLFC DEVRQWYMNG VNYFTDLWNV 
       810        820        830        840        850
MDTLGLFYFI AGIVFRLHSS NKSSLYSGRV IFCLDYIIFT LRLIHIFTVS 
       860        870        880        890        900
RNLGPKIIML QRMLIDVFFF LFLFAVWMVA FGVARQGILR QNEQRWRWIF 
       910        920        930        940        950
RSVIYEPYLA MFGQVPSDVD STTYDFSHCT FSGNESKPLC VELDEHNLPR 
       960        970        980        990       1000
FPEWITIPLV CIYMLSTNIL LVNLLVAMFG YTVGIVQENN DQVWKFQRYF 
      1010       1020       1030       1040       1050
LVQEYCNRLN IPFPFVVFAY FYMVVKKCFK CCCKEKNMES NACCFRNEDN 
      1060       1070       1080       1090       1100
ETLAWEGVMK ENYLVKINTK ANDNSEEMRH RFRQLDSKLN DLKSLLKEIA 

NNIK
Length:1,104
Mass (Da):127,710
Last modified:February 6, 2013 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i16B5D6FBED2BE96D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF481480 mRNA Translation: AAL79553.1
AY095352 mRNA Translation: AAM23261.1
AC087780 Genomic DNA No translation available.
AC102505 Genomic DNA No translation available.
CH466520 Genomic DNA Translation: EDL40112.1
BC117934 mRNA Translation: AAI17935.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS48316.1

NCBI Reference Sequences

More...RefSeqi		NP_599013.1, NM_134252.3
XP_006529288.1, XM_006529225.1
XP_006529289.1, XM_006529226.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000040210; ENSMUSP00000036991; ENSMUSG00000036251
ENSMUST00000113114; ENSMUSP00000108739; ENSMUSG00000036251
ENSMUST00000171176; ENSMUSP00000131209; ENSMUSG00000036251

Database of genes from NCBI RefSeq genomes

More...GeneIDi		171382

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:171382

UCSC genome browser

More...UCSCi		uc029qrk.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF481480 mRNA Translation: AAL79553.1
AY095352 mRNA Translation: AAM23261.1
AC087780 Genomic DNA No translation available.
AC102505 Genomic DNA No translation available.
CH466520 Genomic DNA Translation: EDL40112.1
BC117934 mRNA Translation: AAI17935.1
CCDSiCCDS48316.1
RefSeqiNP_599013.1, NM_134252.3
XP_006529288.1, XM_006529225.1
XP_006529289.1, XM_006529226.1

3D structure databases

SMRiQ8R4D5
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi228590, 1 interactor
DIPiDIP-61852N
IntActiQ8R4D5, 1 interactor
STRINGi10090.ENSMUSP00000036991

Chemistry databases

BindingDBiQ8R4D5
ChEMBLiCHEMBL3108632
DrugCentraliQ8R4D5
GuidetoPHARMACOLOGYi500

PTM databases

GlyGeniQ8R4D5, 1 site
iPTMnetiQ8R4D5
PhosphoSitePlusiQ8R4D5
SwissPalmiQ8R4D5

Proteomic databases

PaxDbiQ8R4D5
PRIDEiQ8R4D5
ProteomicsDBi300027

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		20244, 489 antibodies

The DNASU plasmid repository

More...DNASUi		171382

Genome annotation databases

EnsembliENSMUST00000040210; ENSMUSP00000036991; ENSMUSG00000036251
ENSMUST00000113114; ENSMUSP00000108739; ENSMUSG00000036251
ENSMUST00000171176; ENSMUSP00000131209; ENSMUSG00000036251
GeneIDi171382
KEGGimmu:171382
UCSCiuc029qrk.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		79054
MGIiMGI:2181435, Trpm8

Phylogenomic databases

eggNOGiKOG3614, Eukaryota
GeneTreeiENSGT00940000160270
HOGENOMiCLU_001390_0_0_1
InParanoidiQ8R4D5
OMAiCCKEKNT
OrthoDBi738147at2759
PhylomeDBiQ8R4D5
TreeFamiTF314204

Enzyme and pathway databases

ReactomeiR-MMU-3295583, TRP channels

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		171382, 0 hits in 52 CRISPR screens

Protein Ontology

More...PROi		PR:Q8R4D5
RNActiQ8R4D5, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000036251, Expressed in dorsal root ganglion and 52 other tissues
GenevisibleiQ8R4D5, MM

Family and domain databases

InterProiView protein in InterPro
IPR029603, TRPM8
IPR041491, TRPM_SLOG
PANTHERiPTHR13800:SF9, PTHR13800:SF9, 1 hit
PfamiView protein in Pfam
PF18139, LSDAT_euk, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRPM8_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8R4D5
Secondary accession number(s): E9Q165, Q148W9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: February 6, 2013
Last modified: June 2, 2021
This is version 126 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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