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Protein

Calpain-5

Gene

Capn5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Calcium-regulated non-lysosomal thiol-protease.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei81By similarity1
Active sitei252By similarity1
Active sitei284By similarity1

GO - Molecular functioni

GO - Biological processi

  • granulosa cell differentiation Source: RGD
  • luteinization Source: RGD
  • ovarian follicle development Source: RGD
  • proteolysis Source: GO_Central

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease

Enzyme and pathway databases

BRENDAi3.4.22.B25 5301

Protein family/group databases

MEROPSiC02.011

Names & Taxonomyi

Protein namesi
Recommended name:
Calpain-5 (EC:3.4.22.-)
Gene namesi
Name:Capn5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620084 Capn5

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002077151 – 640Calpain-5Add BLAST640

Proteomic databases

PaxDbiQ8R4C0
PRIDEiQ8R4C0

PTM databases

PhosphoSitePlusiQ8R4C0
SwissPalmiQ8R4C0

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019370

Structurei

3D structure databases

ProteinModelPortaliQ8R4C0
SMRiQ8R4C0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 343Calpain catalyticPROSITE-ProRule annotationAdd BLAST318
Domaini518 – 619C2Add BLAST102

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni344 – 496Domain IIIAdd BLAST153

Sequence similaritiesi

Belongs to the peptidase C2 family.Curated

Phylogenomic databases

eggNOGiKOG0045 Eukaryota
ENOG410XP0B LUCA
HOGENOMiHOG000232036
HOVERGENiHBG001095
InParanoidiQ8R4C0
PhylomeDBiQ8R4C0

Family and domain databases

CDDicd04046 C2_Calpain, 1 hit
cd00214 Calpain_III, 1 hit
cd00044 CysPc, 1 hit
Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR033884 C2_Calpain
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR033883 C2_III
IPR022684 Calpain_cysteine_protease
IPR022682 Calpain_domain_III
IPR022683 Calpain_III
IPR036213 Calpain_III_sf
IPR038765 Papain_like_cys_pep_sf
IPR000169 Pept_cys_AS
IPR001300 Peptidase_C2_calpain_cat
PfamiView protein in Pfam
PF01067 Calpain_III, 1 hit
PF00648 Peptidase_C2, 1 hit
PRINTSiPR00704 CALPAIN
SMARTiView protein in SMART
SM00239 C2, 1 hit
SM00720 calpain_III, 1 hit
SM00230 CysPc, 1 hit
SUPFAMiSSF49758 SSF49758, 1 hit
SSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS50203 CALPAIN_CAT, 1 hit
PS00139 THIOL_PROTEASE_CYS, 1 hit

Sequencei

Sequence statusi: Complete.

Q8R4C0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSCTKAYEY QNYSALKRAC LRRKVLFEDP HFPASDDSLY YKGTPGPTVR
60 70 80 90 100
WKRPFDICDD PRLFVDGISS HDLHQGQVGN CWFVAACSSL ASRESLWQKV
110 120 130 140 150
IPDWKEQEWN PEKPDSYAGI FHFNFWRFGE WVDVVVDDRL PTVNNQLIYC
160 170 180 190 200
HSNSKNEFWC APVEKAYAKL AGCYQALDGG NTADALVDFT GGVSEPIDLT
210 220 230 240 250
EGDLATDEAK RSQLFERVLK VHSRGGLISA SIKAMTAADM ETRLACGLVK
260 270 280 290 300
GHAYAVTDVR KVRLGHGLLA FFKSEKLDMI RLRNPWGERV WTGPWSDTSE
310 320 330 340 350
EWQKVSKSER EKMGVTVQDD GEFWMTYEDM CRYFTDIIKC RLINTSYLSI
360 370 380 390 400
HKTWEEARLR GAWTRHEDPQ QNRSGGCINH KDTFFQNPQY IFEVKKPEDE
410 420 430 440 450
VLICIQQRPK RSTRREGKGE NLAIGFDIYK VEENRQYRMH SLQHKAASSI
460 470 480 490 500
YINSRSVFLR TELPEGRYVI IPTTFEPGHT GELLLRVFTD VPSNCRELRL
510 520 530 540 550
DEPPRTCWSS LCGYPQQVTQ VHVLGAAGLK DSSTGANSYV IIKCEGEKVR
560 570 580 590 600
SAVQRGTSTP EYNVKGIFYR KKLSQPITVQ VWNNRVLKDE FLGQVHLKTA
610 620 630 640
PDDLQDLHSL HLQDRSGRQP SDLPGIVAVR VLCSASLTAV
Length:640
Mass (Da):73,065
Last modified:June 1, 2002 - v1
Checksum:i098A6CDA7799BC61
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF484958 mRNA Translation: AAL92024.1
UniGeneiRn.15526

Similar proteinsi

Entry informationi

Entry nameiCAN5_RAT
AccessioniPrimary (citable) accession number: Q8R4C0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: June 1, 2002
Last modified: June 20, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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