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Protein

Interleukin-36 gamma

Gene

Il36g

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Functions as an agonist of NF-kappa B activation through the orphan IL-1-receptor-related protein 2/IL1RL2. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP (By similarity). Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. May play a role in proinflammatory responses during particular neutrophilic airway inflammation. May be involved in the innate immune response to fungal pathogens. Induces the production of proinflammatory cytokines in bone marrow-derived dendritic cells (BMDCs), including IL-12, Il-1 beta, IL-6, TNF-alpha and IL-23. Involved in dendritic cell maturation by stimulating the surface expression of CD80, CD86 and MHC class II. Induces the production of IFN-gamma, IL-4 and IL-17 by cultured CD4+ T-cells and splenocytes.By similarity2 Publications

GO - Molecular functioni

  • cytokine activity Source: MGI
  • interleukin-1 receptor binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processImmunity, Inflammatory response, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-36 gamma
Alternative name(s):
Interleukin-1 family member 9
Short name:
IL-1F9
Gene namesi
Name:Il36g
Synonyms:Il1f9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2449929 Il1f9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00004305501 – 121 PublicationAdd BLAST12
ChainiPRO_000015364913 – 164Interleukin-36 gammaAdd BLAST152

Post-translational modificationi

N-terminal truncation leads to a dramatic enhancement of its activity (>1000-fold).1 Publication

Proteomic databases

MaxQBiQ8R460
PaxDbiQ8R460
PRIDEiQ8R460

Expressioni

Gene expression databases

CleanExiMM_IL1F9

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ8R460
SMRiQ8R460
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-1 family.Curated

Phylogenomic databases

eggNOGiENOG410J1V3 Eukaryota
ENOG4111C31 LUCA
HOVERGENiHBG052100
InParanoidiQ8R460

Family and domain databases

InterProiView protein in InterPro
IPR000975 IL-1_fam
IPR008996 IL1/FGF
PfamiView protein in Pfam
PF00340 IL1, 1 hit
SUPFAMiSSF50353 SSF50353, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8R460-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFSKHPFSTH ISGRETPDFG EVFDLDQQVW IFRNQALVTV PRSHRVTPVS
60 70 80 90 100
VTILPCKYPE SLEQDKGIAI YLGIQNPDKC LFCKEVNGHP TLLLKEEKIL
110 120 130 140 150
DLYHHPEPMK PFLFYHTRTG GTSTFESVAF PGHYIASSKT GNPIFLTSKK
160
GEYYNINFNL DIKS
Length:164
Mass (Da):18,733
Last modified:June 1, 2002 - v1
Checksum:iA7338D475DFEADBE
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3U0P4Q3U0P4_MOUSE
Interleukin 1 family, member 9
Il1f9 mCG_1029993
193Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY071843 mRNA Translation: AAL67153.1
BC116227 mRNA Translation: AAI16228.1
BC116228 mRNA Translation: AAI16229.1
UniGeneiMm.249379

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY071843 mRNA Translation: AAL67153.1
BC116227 mRNA Translation: AAI16228.1
BC116228 mRNA Translation: AAI16229.1
UniGeneiMm.249379

3D structure databases

ProteinModelPortaliQ8R460
SMRiQ8R460
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiQ8R460
PaxDbiQ8R460
PRIDEiQ8R460

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:2449929 Il1f9

Phylogenomic databases

eggNOGiENOG410J1V3 Eukaryota
ENOG4111C31 LUCA
HOVERGENiHBG052100
InParanoidiQ8R460

Miscellaneous databases

PROiPR:Q8R460
SOURCEiSearch...

Gene expression databases

CleanExiMM_IL1F9

Family and domain databases

InterProiView protein in InterPro
IPR000975 IL-1_fam
IPR008996 IL1/FGF
PfamiView protein in Pfam
PF00340 IL1, 1 hit
SUPFAMiSSF50353 SSF50353, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIL36G_MOUSE
AccessioniPrimary (citable) accession number: Q8R460
Secondary accession number(s): Q14BB6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: June 1, 2002
Last modified: November 7, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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