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Protein

Interleukin-1 family member 10

Gene

Il1f10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cytokine with immunomodulatory activity. Alone, does not induce cytokine production, but reduces IL22 and IL17A production by T-cells in response to heat-killed Candida albicans. Reduces IL36G-induced production of IL8 by peripheral blood mononuclear cells. Increases IL6 production by dendritic cells stimulated by bacterial lipopolysaccharides (LPS). Ligand for IL-36R/IL1RL2 (By similarity).By similarity

GO - Molecular functioni

  • cytokine activity Source: GO_Central
  • interleukin-1 receptor binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionCytokine

Enzyme and pathway databases

ReactomeiR-MMU-9007892 Interleukin-38 signaling
R-MMU-9014826 Interleukin-36 pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-1 family member 10
Short name:
IL-1F10
Gene namesi
Name:Il1f10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2652548 Il1f10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001536511 – 152Interleukin-1 family member 10Add BLAST152

Proteomic databases

PaxDbiQ8R459
PRIDEiQ8R459

PTM databases

PhosphoSitePlusiQ8R459

Expressioni

Gene expression databases

BgeeiENSMUSG00000046845 Expressed in 19 organ(s), highest expression level in skin of back
CleanExiMM_IL1F10
ExpressionAtlasiQ8R459 baseline and differential
GenevisibleiQ8R459 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000063004

Structurei

3D structure databases

ProteinModelPortaliQ8R459
SMRiQ8R459
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-1 family.Curated

Phylogenomic databases

eggNOGiENOG410IWY5 Eukaryota
ENOG41118N6 LUCA
GeneTreeiENSGT00900000141028
HOGENOMiHOG000231506
HOVERGENiHBG052099
InParanoidiQ8R459
KOiK05488
OMAiAAWPGWF
OrthoDBiEOG091G0PWA
PhylomeDBiQ8R459
TreeFamiTF300203

Family and domain databases

InterProiView protein in InterPro
IPR027164 IL-1_F10
IPR000975 IL-1_fam
IPR003297 IL-1RA/IL-36
IPR008996 IL1/FGF
PANTHERiPTHR45416 PTHR45416, 1 hit
PfamiView protein in Pfam
PF00340 IL1, 1 hit
PRINTSiPR00264 INTERLEUKIN1
PR01360 INTRLEUKIN1X
SUPFAMiSSF50353 SSF50353, 1 hit

Sequencei

Sequence statusi: Complete.

Q8R459-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCSLPMARYY IIKDAHQKAL YTRNGQLLLG DPDSDNYSPE KVCILPNRGL
60 70 80 90 100
DRSKVPIFLG MQGGSCCLAC VKTREGPLLQ LEDVNIEDLY KGGEQTTRFT
110 120 130 140 150
FFQRSLGSAF RLEAAACPGW FLCGPAEPQQ PVQLTKESEP STHTEFYFEM

SR
Length:152
Mass (Da):17,078
Last modified:June 1, 2002 - v1
Checksum:i9AD03EB0C3C61D8A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY071844 mRNA Translation: AAL67155.1
CCDSiCCDS15735.1
RefSeqiNP_694717.1, NM_153077.2
UniGeneiMm.218750

Genome annotation databases

EnsembliENSMUST00000058056; ENSMUSP00000063004; ENSMUSG00000046845
GeneIDi215274
KEGGimmu:215274
UCSCiuc008iou.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY071844 mRNA Translation: AAL67155.1
CCDSiCCDS15735.1
RefSeqiNP_694717.1, NM_153077.2
UniGeneiMm.218750

3D structure databases

ProteinModelPortaliQ8R459
SMRiQ8R459
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000063004

PTM databases

PhosphoSitePlusiQ8R459

Proteomic databases

PaxDbiQ8R459
PRIDEiQ8R459

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000058056; ENSMUSP00000063004; ENSMUSG00000046845
GeneIDi215274
KEGGimmu:215274
UCSCiuc008iou.1 mouse

Organism-specific databases

CTDi84639
MGIiMGI:2652548 Il1f10

Phylogenomic databases

eggNOGiENOG410IWY5 Eukaryota
ENOG41118N6 LUCA
GeneTreeiENSGT00900000141028
HOGENOMiHOG000231506
HOVERGENiHBG052099
InParanoidiQ8R459
KOiK05488
OMAiAAWPGWF
OrthoDBiEOG091G0PWA
PhylomeDBiQ8R459
TreeFamiTF300203

Enzyme and pathway databases

ReactomeiR-MMU-9007892 Interleukin-38 signaling
R-MMU-9014826 Interleukin-36 pathway

Miscellaneous databases

PROiPR:Q8R459
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000046845 Expressed in 19 organ(s), highest expression level in skin of back
CleanExiMM_IL1F10
ExpressionAtlasiQ8R459 baseline and differential
GenevisibleiQ8R459 MM

Family and domain databases

InterProiView protein in InterPro
IPR027164 IL-1_F10
IPR000975 IL-1_fam
IPR003297 IL-1RA/IL-36
IPR008996 IL1/FGF
PANTHERiPTHR45416 PTHR45416, 1 hit
PfamiView protein in Pfam
PF00340 IL1, 1 hit
PRINTSiPR00264 INTERLEUKIN1
PR01360 INTRLEUKIN1X
SUPFAMiSSF50353 SSF50353, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIL1FA_MOUSE
AccessioniPrimary (citable) accession number: Q8R459
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: June 1, 2002
Last modified: November 7, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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