UniProtKB - Q8R456 (OPN4_RAT)
Protein
Melanopsin
Gene
Opn4
Organism
Rattus norvegicus (Rat)
Status
Functioni
Photoreceptor that binds cis-retinaldehydes (By similarity). Contributes to pupillar reflex, photoentrainment and other non-image forming responses to light (By similarity). May be involved in the optokinetic visual tracking response (By similarity). May be involved in the regulation of retinal hyaloid vessel growth and regression (By similarity).By similarity
GO - Molecular functioni
- 11-cis retinal binding Source: UniProtKB
- G protein-coupled photoreceptor activity Source: RGD
GO - Biological processi
- cellular response to light stimulus Source: GO_Central
- detection of temperature stimulus involved in thermoception Source: RGD
- entrainment of circadian clock by photoperiod Source: RGD
- G protein-coupled receptor signaling pathway Source: GO_Central
- hyaloid vascular plexus regression Source: UniProtKB
- optokinetic behavior Source: UniProtKB
- phototransduction Source: RGD
- positive regulation of circadian sleep/wake cycle, sleep Source: RGD
- protein-chromophore linkage Source: UniProtKB-KW
- regulation of circadian rhythm Source: UniProtKB
- rhodopsin mediated signaling pathway Source: RGD
- rhythmic process Source: UniProtKB-KW
- thermotaxis Source: RGD
- visual perception Source: InterPro
Keywordsi
Molecular function | G-protein coupled receptor, Photoreceptor protein, Receptor, Retinal protein, Transducer |
Biological process | Biological rhythms |
Ligand | Chromophore |
Enzyme and pathway databases
Reactomei | R-RNO-416476, G alpha (q) signalling events R-RNO-419771, Opsins |
Names & Taxonomyi
Protein namesi | Recommended name: MelanopsinAlternative name(s): Opsin-4 |
Gene namesi | Name:Opn4Imported |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 621701, Opn4 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Multi-pass membrane protein Sequence analysis
Other locations
- axon By similarity
- dendrite By similarity
- Perikaryon By similarity
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: RGD
- sperm head plasma membrane Source: RGD
Other locations
- axon Source: UniProtKB-SubCell
- dendrite Source: UniProtKB-SubCell
- integral component of membrane Source: UniProtKB
- perikaryon Source: UniProtKB-SubCell
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 72 | ExtracellularSequence analysisAdd BLAST | 72 | |
Transmembranei | 73 – 93 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 94 – 107 | CytoplasmicSequence analysisAdd BLAST | 14 | |
Transmembranei | 108 – 128 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 129 – 144 | ExtracellularSequence analysisAdd BLAST | 16 | |
Transmembranei | 145 – 165 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 166 – 188 | CytoplasmicSequence analysisAdd BLAST | 23 | |
Transmembranei | 189 – 209 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 210 – 238 | ExtracellularSequence analysisAdd BLAST | 29 | |
Transmembranei | 239 – 259 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 260 – 293 | CytoplasmicSequence analysisAdd BLAST | 34 | |
Transmembranei | 294 – 314 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 315 – 355 | ExtracellularSequence analysisAdd BLAST | 41 | |
Transmembranei | 356 – 372 | Helical; Name=7Sequence analysisAdd BLAST | 17 | |
Topological domaini | 373 – 474 | CytoplasmicSequence analysisAdd BLAST | 102 |
Keywords - Cellular componenti
Cell membrane, Cell projection, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000233062 | 1 – 474 | MelanopsinAdd BLAST | 474 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 31 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 35 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 143 ↔ 221 | PROSITE-ProRule annotation | ||
Modified residuei | 337 | N6-(retinylidene)lysineBy similarity | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q8R456 |
PRIDEi | Q8R456 |
PTM databases
GlyGeni | Q8R456, 2 sites |
iPTMneti | Q8R456 |
PhosphoSitePlusi | Q8R456 |
Expressioni
Tissue specificityi
Eye; expressed in a photosensitive subset of retinal ganglion cells (at protein level).1 Publication
Gene expression databases
Bgeei | ENSRNOG00000053893, Expressed in brain and 10 other tissues |
Genevisiblei | Q8R456, RN |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01010000222330 |
HOGENOMi | CLU_009579_3_12_1 |
InParanoidi | Q8R456 |
OMAi | WVYSMGW |
OrthoDBi | 911005at2759 |
PhylomeDBi | Q8R456 |
TreeFami | TF324998 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR001760, Opsin IPR027430, Retinal_BS |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00238, OPSIN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit PS00238, OPSIN, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8R456-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNSPSESRVP SSLTQDPSFT ASPALLQGIW NSTQNISVRV QLLSVSPTTP
60 70 80 90 100
GLQAAAWVPF PTVDVPDHAH YTLGTVILLV GLTGMLGNLT VIYTFCRNRG
110 120 130 140 150
LRTPANMLII NLAVSDFLMS FTQAPVFFAS SLYKKWLFGE TGCKFYAFCG
160 170 180 190 200
AVFGIVSMIT LTAIAMDRYL VITRPLATIG MRSKRRTALV LLGVWLYALA
210 220 230 240 250
WSLPPFFGWS AYVPEGLLTS CSWDYVTFTP LVRAYTMLLF CFVFFLPLLI
260 270 280 290 300
IIFCYIFIFR AIRETGRACE GCGESPLRRR QWQRLQSEWK MAKVALIVIL
310 320 330 340 350
LFVLSWAPYS TVALVGFAGY SHILTPYMSS VPAVIAKASA IHNPIIYAIT
360 370 380 390 400
HPKYRAAIAQ HLPCLGVLLG VSGQRSHPSL SYRSTHRSTL SSQSSDLSWI
410 420 430 440 450
SGQKRQESLG SESEVGWTDT ETTAAWGAAQ QASGQSFCSH DLEDGEVKAP
460 470
SSPQEQKSKT PKTKRHLPSL DRRM
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY072689 mRNA Translation: AAL61854.1 |
RefSeqi | NP_620215.1, NM_138860.1 XP_017455477.1, XM_017599988.1 XP_017455478.1, XM_017599989.1 |
Genome annotation databases
Ensembli | ENSRNOT00000091315; ENSRNOP00000069548; ENSRNOG00000053893 |
GeneIDi | 192223 |
KEGGi | rno:192223 |
UCSCi | RGD:621701, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY072689 mRNA Translation: AAL61854.1 |
RefSeqi | NP_620215.1, NM_138860.1 XP_017455477.1, XM_017599988.1 XP_017455478.1, XM_017599989.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000015642 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | Q8R456, 2 sites |
iPTMneti | Q8R456 |
PhosphoSitePlusi | Q8R456 |
Proteomic databases
PaxDbi | Q8R456 |
PRIDEi | Q8R456 |
Genome annotation databases
Ensembli | ENSRNOT00000091315; ENSRNOP00000069548; ENSRNOG00000053893 |
GeneIDi | 192223 |
KEGGi | rno:192223 |
UCSCi | RGD:621701, rat |
Organism-specific databases
CTDi | 94233 |
RGDi | 621701, Opn4 |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01010000222330 |
HOGENOMi | CLU_009579_3_12_1 |
InParanoidi | Q8R456 |
OMAi | WVYSMGW |
OrthoDBi | 911005at2759 |
PhylomeDBi | Q8R456 |
TreeFami | TF324998 |
Enzyme and pathway databases
Reactomei | R-RNO-416476, G alpha (q) signalling events R-RNO-419771, Opsins |
Miscellaneous databases
PROi | PR:Q8R456 |
Gene expression databases
Bgeei | ENSRNOG00000053893, Expressed in brain and 10 other tissues |
Genevisiblei | Q8R456, RN |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR001760, Opsin IPR027430, Retinal_BS |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00238, OPSIN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit PS00238, OPSIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | OPN4_RAT | |
Accessioni | Q8R456Primary (citable) accession number: Q8R456 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 18, 2006 |
Last sequence update: | June 1, 2002 | |
Last modified: | December 2, 2020 | |
This is version 117 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries