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Protein

Melanopsin

Gene

Opn4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Photoreceptor required for regulation of circadian rhythm. Contributes to pupillar reflex and other non-image forming responses to light. May be able to isomerize covalently bound all-trans retinal back to 11-cis retinal.1 Publication

GO - Molecular functioni

  • 11-cis retinal binding Source: UniProtKB
  • G-protein coupled photoreceptor activity Source: RGD

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Photoreceptor protein, Receptor, Retinal protein, Transducer
Biological processBiological rhythms
LigandChromophore

Enzyme and pathway databases

ReactomeiR-RNO-416476 G alpha (q) signalling events
R-RNO-419771 Opsins

Names & Taxonomyi

Protein namesi
Recommended name:
Melanopsin
Alternative name(s):
Opsin-4
Gene namesi
Name:Opn4Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 16

Organism-specific databases

RGDi621701 Opn4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 72ExtracellularSequence analysisAdd BLAST72
Transmembranei73 – 93Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini94 – 107CytoplasmicSequence analysisAdd BLAST14
Transmembranei108 – 128Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini129 – 144ExtracellularSequence analysisAdd BLAST16
Transmembranei145 – 165Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini166 – 188CytoplasmicSequence analysisAdd BLAST23
Transmembranei189 – 209Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini210 – 238ExtracellularSequence analysisAdd BLAST29
Transmembranei239 – 259Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini260 – 293CytoplasmicSequence analysisAdd BLAST34
Transmembranei294 – 314Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini315 – 355ExtracellularSequence analysisAdd BLAST41
Transmembranei356 – 372Helical; Name=7Sequence analysisAdd BLAST17
Topological domaini373 – 474CytoplasmicSequence analysisAdd BLAST102

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002330621 – 474MelanopsinAdd BLAST474

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi31N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi35N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi143 ↔ 221PROSITE-ProRule annotation
Modified residuei337N6-(retinylidene)lysineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8R456
PRIDEiQ8R456

PTM databases

iPTMnetiQ8R456
PhosphoSitePlusiQ8R456

Expressioni

Tissue specificityi

Eye; expressed in a photosensitive subset of retinal ganglion cells.1 Publication

Gene expression databases

BgeeiENSRNOG00000053893
GenevisibleiQ8R456 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015642

Structurei

3D structure databases

ProteinModelPortaliQ8R456
SMRiQ8R456
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000118977
HOGENOMiHOG000264261
HOVERGENiHBG007871
InParanoidiQ8R456
KOiK04255
OMAiHPKYRMA
OrthoDBiEOG091G0ALC
PhylomeDBiQ8R456
TreeFamiTF324998

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR001760 Opsin
IPR027430 Retinal_BS
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00238 OPSIN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
PS00238 OPSIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q8R456-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSPSESRVP SSLTQDPSFT ASPALLQGIW NSTQNISVRV QLLSVSPTTP
60 70 80 90 100
GLQAAAWVPF PTVDVPDHAH YTLGTVILLV GLTGMLGNLT VIYTFCRNRG
110 120 130 140 150
LRTPANMLII NLAVSDFLMS FTQAPVFFAS SLYKKWLFGE TGCKFYAFCG
160 170 180 190 200
AVFGIVSMIT LTAIAMDRYL VITRPLATIG MRSKRRTALV LLGVWLYALA
210 220 230 240 250
WSLPPFFGWS AYVPEGLLTS CSWDYVTFTP LVRAYTMLLF CFVFFLPLLI
260 270 280 290 300
IIFCYIFIFR AIRETGRACE GCGESPLRRR QWQRLQSEWK MAKVALIVIL
310 320 330 340 350
LFVLSWAPYS TVALVGFAGY SHILTPYMSS VPAVIAKASA IHNPIIYAIT
360 370 380 390 400
HPKYRAAIAQ HLPCLGVLLG VSGQRSHPSL SYRSTHRSTL SSQSSDLSWI
410 420 430 440 450
SGQKRQESLG SESEVGWTDT ETTAAWGAAQ QASGQSFCSH DLEDGEVKAP
460 470
SSPQEQKSKT PKTKRHLPSL DRRM
Length:474
Mass (Da):52,407
Last modified:June 1, 2002 - v1
Checksum:i33C302113D41E5EC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY072689 mRNA Translation: AAL61854.1
RefSeqiNP_620215.1, NM_138860.1
XP_017455477.1, XM_017599988.1
XP_017455478.1, XM_017599989.1
UniGeneiRn.54303

Genome annotation databases

EnsembliENSRNOT00000091315; ENSRNOP00000069548; ENSRNOG00000053893
GeneIDi192223
KEGGirno:192223
UCSCiRGD:621701 rat

Similar proteinsi

Entry informationi

Entry nameiOPN4_RAT
AccessioniPrimary (citable) accession number: Q8R456
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: June 1, 2002
Last modified: June 20, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

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