Opn4

Functionⁱ

Photoreceptor required for regulation of circadian rhythm. Contributes to pupillar reflex and other non-image forming responses to light. May be able to isomerize covalently bound all-trans retinal back to 11-cis retinal.1 Publication

GO - Molecular functionⁱ

11-cis retinal binding Source: UniProtKB
G-protein coupled photoreceptor activity
Source: RGD
Inferred from direct assayⁱ
- 11834834

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

entrainment of circadian clock by photoperiod Source: Ensembl
phototransduction
Source: RGD
Inferred from direct assayⁱ
- 11834834
positive regulation of circadian sleep/wake cycle, sleep Source: Ensembl
protein-chromophore linkage Source: UniProtKB-KW
regulation of circadian rhythm Source: UniProtKB
rhodopsin mediated signaling pathway Source: Ensembl
rhythmic process Source: UniProtKB-KW
visual perception Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Photoreceptor protein, Receptor, Retinal protein, Transducer
Biological process	Biological rhythms
Ligand	Chromophore

Enzyme and pathway databases

Reactomeⁱ	R-RNO-416476 G alpha (q) signalling events R-RNO-419771 Opsins

Reactomeⁱ

R-RNO-416476 G alpha (q) signalling events
R-RNO-419771 Opsins

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Melanopsin Alternative name(s): Opsin-4
Gene namesⁱ	Name:Opn4Imported
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 16

Organism-specific databases

Rat genome database More...RGDⁱ	621701 Opn4

RGDⁱ

621701 Opn4

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 72	ExtracellularSequence analysisAdd BLAST	72
Transmembraneⁱ	73 – 93	Helical; Name=1Sequence analysisAdd BLAST	21
Topological domainⁱ	94 – 107	CytoplasmicSequence analysisAdd BLAST	14
Transmembraneⁱ	108 – 128	Helical; Name=2Sequence analysisAdd BLAST	21
Topological domainⁱ	129 – 144	ExtracellularSequence analysisAdd BLAST	16
Transmembraneⁱ	145 – 165	Helical; Name=3Sequence analysisAdd BLAST	21
Topological domainⁱ	166 – 188	CytoplasmicSequence analysisAdd BLAST	23
Transmembraneⁱ	189 – 209	Helical; Name=4Sequence analysisAdd BLAST	21
Topological domainⁱ	210 – 238	ExtracellularSequence analysisAdd BLAST	29
Transmembraneⁱ	239 – 259	Helical; Name=5Sequence analysisAdd BLAST	21
Topological domainⁱ	260 – 293	CytoplasmicSequence analysisAdd BLAST	34
Transmembraneⁱ	294 – 314	Helical; Name=6Sequence analysisAdd BLAST	21
Topological domainⁱ	315 – 355	ExtracellularSequence analysisAdd BLAST	41
Transmembraneⁱ	356 – 372	Helical; Name=7Sequence analysisAdd BLAST	17
Topological domainⁱ	373 – 474	CytoplasmicSequence analysisAdd BLAST	102

Keywords - Cellular componentⁱ

Cell membrane, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000233062	1 – 474	MelanopsinAdd BLAST		474

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	31	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	35	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	143 ↔ 221	PROSITE-ProRule annotation
Modified residueⁱ	337	N6-(retinylidene)lysineBy similarity	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	Q8R456
PRIDEⁱ	Q8R456

PTM databases

iPTMnetⁱ	Q8R456
PhosphoSitePlusⁱ	Q8R456

Expressionⁱ

Tissue specificityⁱ

Eye; expressed in a photosensitive subset of retinal ganglion cells.1 Publication

Gene expression databases

Bgeeⁱ	ENSRNOG00000053893
Genevisibleⁱ	Q8R456 RN

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000015642

STRINGⁱ

10116.ENSRNOP00000015642

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8R456
SMRⁱ	Q8R456
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118977
HOGENOMⁱ	HOG000264261
HOVERGENⁱ	HBG007871
InParanoidⁱ	Q8R456
KEGG Orthology (KO) More...KOⁱ	K04255
OMAⁱ	HPKYRMA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0ALC
PhylomeDBⁱ	Q8R456
TreeFamⁱ	TF324998

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR001760 Opsin IPR027430 Retinal_BS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00237 GPCRRHODOPSN PR00238 OPSIN
SMARTⁱ	View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit PS00238 OPSIN, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q8R456-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MNSPSESRVP SSLTQDPSFT ASPALLQGIW NSTQNISVRV QLLSVSPTTP 
        60         70         80         90        100
GLQAAAWVPF PTVDVPDHAH YTLGTVILLV GLTGMLGNLT VIYTFCRNRG 
       110        120        130        140        150
LRTPANMLII NLAVSDFLMS FTQAPVFFAS SLYKKWLFGE TGCKFYAFCG 
       160        170        180        190        200
AVFGIVSMIT LTAIAMDRYL VITRPLATIG MRSKRRTALV LLGVWLYALA 
       210        220        230        240        250
WSLPPFFGWS AYVPEGLLTS CSWDYVTFTP LVRAYTMLLF CFVFFLPLLI 
       260        270        280        290        300
IIFCYIFIFR AIRETGRACE GCGESPLRRR QWQRLQSEWK MAKVALIVIL 
       310        320        330        340        350
LFVLSWAPYS TVALVGFAGY SHILTPYMSS VPAVIAKASA IHNPIIYAIT 
       360        370        380        390        400
HPKYRAAIAQ HLPCLGVLLG VSGQRSHPSL SYRSTHRSTL SSQSSDLSWI 
       410        420        430        440        450
SGQKRQESLG SESEVGWTDT ETTAAWGAAQ QASGQSFCSH DLEDGEVKAP 
       460        470 
SSPQEQKSKT PKTKRHLPSL DRRM

Length:474

Mass (Da):52,407

Last modified:June 1, 2002 - v1

Checksum:ⁱ33C302113D41E5EC

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY072689 mRNA Translation: AAL61854.1
NCBI Reference Sequences More...RefSeqⁱ	NP_620215.1, NM_138860.1 XP_017455477.1, XM_017599988.1 XP_017455478.1, XM_017599989.1
UniGeneⁱ	Rn.54303

Genome annotation databases

Ensemblⁱ	ENSRNOT00000091315; ENSRNOP00000069548; ENSRNOG00000053893
GeneIDⁱ	192223
KEGGⁱ	rno:192223
UCSC genome browser More...UCSCⁱ	RGD:621701 rat

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q8R456	UPI00081021FC		RAT		556
UPI000A316778		MUSCR		466
UPI000A30CDC8		MUSPA		465
Q9QXZ9-2				466
UPI0008102017		RAT		521

Protein	Similar proteins		Species	Score	Length
Q8R456	UPI00081021FC		RAT		556
UPI000A316778		MUSCR		466
UPI000A30CDC8		MUSPA		465
Opsin 4		XENTR		494
UPI00084E07B1		XENLA		582
+348

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY072689 mRNA Translation: AAL61854.1
NCBI Reference Sequences More...RefSeqⁱ	NP_620215.1, NM_138860.1 XP_017455477.1, XM_017599988.1 XP_017455478.1, XM_017599989.1
UniGeneⁱ	Rn.54303

3D structure databases

ProteinModelPortalⁱ	Q8R456
SMRⁱ	Q8R456
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000015642

STRINGⁱ

10116.ENSRNOP00000015642

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

PTM databases

iPTMnetⁱ	Q8R456
PhosphoSitePlusⁱ	Q8R456

Proteomic databases

PaxDbⁱ	Q8R456
PRIDEⁱ	Q8R456

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000091315; ENSRNOP00000069548; ENSRNOG00000053893
GeneIDⁱ	192223
KEGGⁱ	rno:192223
UCSC genome browser More...UCSCⁱ	RGD:621701 rat

Organism-specific databases

CTDⁱ	94233
Rat genome database More...RGDⁱ	621701 Opn4

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118977
HOGENOMⁱ	HOG000264261
HOVERGENⁱ	HBG007871
InParanoidⁱ	Q8R456
KEGG Orthology (KO) More...KOⁱ	K04255
OMAⁱ	HPKYRMA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0ALC
PhylomeDBⁱ	Q8R456
TreeFamⁱ	TF324998

Enzyme and pathway databases

Reactomeⁱ	R-RNO-416476 G alpha (q) signalling events R-RNO-419771 Opsins

Reactomeⁱ

R-RNO-416476 G alpha (q) signalling events
R-RNO-419771 Opsins

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q8R456

PROⁱ

PR:Q8R456

Gene expression databases

Bgeeⁱ	ENSRNOG00000053893
Genevisibleⁱ	Q8R456 RN

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR001760 Opsin IPR027430 Retinal_BS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00237 GPCRRHODOPSN PR00238 OPSIN
SMARTⁱ	View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit PS00238 OPSIN, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	OPN4_RAT
Accessionⁱ	Q8R456Primary (citable) accession number: Q8R456
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 18, 2006
	Last sequence update:	June 1, 2002
	Last modified:	June 20, 2018
	This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8R456 (OPN4_RAT)

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Melanopsin

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ