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Protein
Submitted name:

Inwardly-rectifying K+ channel protein

Gene
N/A
Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei162Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Voltage-gated channelUniRule annotationSAAS annotation
Biological processIon transport, Potassium transportUniRule annotationSAAS annotation, Transport
LigandPotassium

Names & Taxonomyi

Protein namesi
Submitted name:
Inwardly-rectifying K+ channel proteinImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei56 – 82HelicalSequence analysisAdd BLAST27
Transmembranei146 – 171HelicalSequence analysisAdd BLAST26

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

GenevisibleiQ8R434 MM

Structurei

3D structure databases

ProteinModelPortaliQ8R434
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili368 – 391Sequence analysisAdd BLAST24

Sequence similaritiesi

Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. [View classification]UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3827 Eukaryota
ENOG410XQ62 LUCA
HOVERGENiHBG006178
OMAiWRCVTEE

Family and domain databases

Gene3Di2.60.40.1400, 1 hit
InterProiView protein in InterPro
IPR014756 Ig_E-set
IPR016449 K_chnl_inward-rec_Kir
IPR003273 K_chnl_inward-rec_Kir2.3
IPR013518 K_chnl_inward-rec_Kir_cyto
PANTHERiPTHR11767 PTHR11767, 1 hit
PTHR11767:SF53 PTHR11767:SF53, 1 hit
PfamiView protein in Pfam
PF01007 IRK, 1 hit
PIRSFiPIRSF005465 GIRK_kir, 1 hit
PRINTSiPR01326 KIR23CHANNEL
PR01320 KIRCHANNEL
SUPFAMiSSF81296 SSF81296, 1 hit

Sequencei

Sequence statusi: Fragment.

Q8R434-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
HGHNRNGQAH VPRRKRRNRF VKKNGQCNVY FANLSNKSQR YMADIFTTCV
60 70 80 90 100
DTRWRYMLMI FSAAFLVSWL FFGLLFWCIA FFHGDLEASP SVPAAGGPGG
110 120 130 140 150
NGGASPNAPK PCIMHVNGFL GAFLFSVETQ TTIGYGFRCV TEECPLAVIA
160 170 180 190 200
VVVQSIVGCV IDSFMIGTIM AKMARPKKRA QTLLFSHHAV ISVRDGKLCL
210 220 230 240 250
MWRVGNLRKS HIVEAHVRAQ LIKPYMTQEG EYLPLDQRDL NVGYDIGLDR
260 270 280 290 300
IFLVSPIIIV HEIDEDSPLY GMGKEELESE DFEIVVILEG MVEATAMTTQ
310 320 330 340 350
ARSSYLASEI LWGHRFEPVV FEEKSHYKVD YSRFHKTYEV AGTPCCSARE
360 370 380 390 400
LQESKITVLP APPPPPSAFC YENELALMSQ EEEEMEEEAA AAAAVAAGLG
410 420 430 440
LEAGSKEEAG IIRMLEFGSH LDLERMQAAT LPLDNISYRR ESAI
Length:444
Mass (Da):49,514
Last modified:June 1, 2002 - v1
Checksum:i88B9B415C16F809C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY079448 Genomic DNA Translation: AAL87536.1
UniGeneiMm.140760
Mm.39759

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY079448 Genomic DNA Translation: AAL87536.1
UniGeneiMm.140760
Mm.39759

3D structure databases

ProteinModelPortaliQ8R434
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG3827 Eukaryota
ENOG410XQ62 LUCA
HOVERGENiHBG006178
OMAiWRCVTEE

Gene expression databases

GenevisibleiQ8R434 MM

Family and domain databases

Gene3Di2.60.40.1400, 1 hit
InterProiView protein in InterPro
IPR014756 Ig_E-set
IPR016449 K_chnl_inward-rec_Kir
IPR003273 K_chnl_inward-rec_Kir2.3
IPR013518 K_chnl_inward-rec_Kir_cyto
PANTHERiPTHR11767 PTHR11767, 1 hit
PTHR11767:SF53 PTHR11767:SF53, 1 hit
PfamiView protein in Pfam
PF01007 IRK, 1 hit
PIRSFiPIRSF005465 GIRK_kir, 1 hit
PRINTSiPR01326 KIR23CHANNEL
PR01320 KIRCHANNEL
SUPFAMiSSF81296 SSF81296, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ8R434_MOUSE
AccessioniPrimary (citable) accession number: Q8R434
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2002
Last sequence update: June 1, 2002
Last modified: November 7, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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