UniProtKB - Q8R426 (KCIP1_RAT)
Kv channel-interacting protein 1
Kcnip1
Functioni
Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels (PubMed:14980206).
Regulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner (PubMed:14980206).
Modulates KCND2/Kv4.2 currents (PubMed:14980206).
In vitro, modulates KCND1/Kv4.1 currents (By similarity).
Increases the presence of KCND2 at the cell surface (PubMed:14980206).
By similarity2 PublicationsSites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 146 | Calcium 1PROSITE-ProRule annotation1 Publication | 1 | |
Metal bindingi | 148 | Calcium 1PROSITE-ProRule annotation1 Publication | 1 | |
Metal bindingi | 150 | Calcium 1PROSITE-ProRule annotation1 Publication | 1 | |
Metal bindingi | 152 | Calcium 1PROSITE-ProRule annotation1 Publication | 1 | |
Metal bindingi | 157 | Calcium 1PROSITE-ProRule annotation1 Publication | 1 | |
Metal bindingi | 194 | Calcium 2PROSITE-ProRule annotation1 Publication | 1 | |
Metal bindingi | 196 | Calcium 2PROSITE-ProRule annotation1 Publication | 1 | |
Metal bindingi | 198 | Calcium 2PROSITE-ProRule annotation1 Publication | 1 | |
Metal bindingi | 205 | Calcium 2PROSITE-ProRule annotation1 Publication | 1 |
GO - Molecular functioni
- calcium ion binding Source: RGD
- potassium channel activity Source: UniProtKB-KW
- potassium channel regulator activity Source: RGD
- protein-containing complex binding Source: RGD
- protein N-terminus binding Source: RGD
- transmembrane transporter binding Source: RGD
- voltage-gated ion channel activity Source: UniProtKB-KW
GO - Biological processi
- positive regulation of action potential Source: RGD
- regulation of potassium ion transmembrane transport Source: UniProtKB
Keywordsi
Molecular function | Ion channel, Potassium channel, Voltage-gated channel |
Biological process | Ion transport, Potassium transport, Transport |
Ligand | Calcium, Metal-binding, Potassium |
Enzyme and pathway databases
Reactomei | R-RNO-5576894, Phase 1 - inactivation of fast Na+ channels |
Names & Taxonomyi
Protein namesi | Recommended name: Kv channel-interacting protein 1Short name: KChIP1 Alternative name(s): A-type potassium channel modulatory protein 1 Potassium channel-interacting protein 1 |
Gene namesi | Name:Kcnip1 Synonyms:Kchip1 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 70886, Kcnip1 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 2 Publications
Plasma membrane
- Cell membrane 2 Publications; Peripheral membrane protein 1 Publication
Other locations
- dendrite 1 Publication
Plasma Membrane
- extrinsic component of cytoplasmic side of plasma membrane Source: UniProtKB
- plasma membrane Source: RGD
- voltage-gated potassium channel complex Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- dendrite Source: RGD
- neuronal cell body Source: RGD
- potassium channel complex Source: RGD
Keywords - Cellular componenti
Cell membrane, Cell projection, Cytoplasm, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 214 – 227 | Missing : Abolishes interaction with KCND2. 1 PublicationAdd BLAST | 14 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000073820 | 1 – 227 | Kv channel-interacting protein 1Add BLAST | 227 |
Proteomic databases
PaxDbi | Q8R426 |
Expressioni
Tissue specificityi
Gene expression databases
Genevisiblei | Q8R426, RN |
Interactioni
Subunit structurei
Component of heteromultimeric potassium channels (PubMed:15356203, PubMed:14980206). Identified in potassium channel complexes containing KCND1, KCND2, KCND3, KCNIP1, KCNIP2, KCNIP3, KCNIP4, DPP6 and DPP10 (By similarity).
Part of a heterooctamer composed of the tetrameric channel and four KCNIP1 chains (By similarity).
Interacts with KCND3 and the N-terminal domain of KCND2. Probably part of a complex consisting of KCNIP1, KCNIP2 isoform 3 and KCND2 (PubMed:14980206). Self-associates to form homodimers and homotetramers.
Interacts with KCNIP2 isoform 3 in a calcium-dependent manner.
By similarity4 PublicationsGO - Molecular functioni
- protein N-terminus binding Source: RGD
- transmembrane transporter binding Source: RGD
Protein-protein interaction databases
BioGRIDi | 249216, 1 interactor |
CORUMi | Q8R426 |
IntActi | Q8R426, 1 interactor |
STRINGi | 10116.ENSRNOP00000007187 |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | Q8R426 |
SMRi | Q8R426 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q8R426 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 38 – 94 | EF-hand 1; degenerateCuratedAdd BLAST | 57 | |
Domaini | 97 – 132 | EF-hand 2PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 133 – 168 | EF-hand 3PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 181 – 216 | EF-hand 4PROSITE-ProRule annotationAdd BLAST | 36 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 214 – 227 | Interaction with KCND21 PublicationAdd BLAST | 14 |
Sequence similaritiesi
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0044, Eukaryota |
InParanoidi | Q8R426 |
OrthoDBi | 1271942at2759 |
PhylomeDBi | Q8R426 |
TreeFami | TF318560 |
Family and domain databases
CDDi | cd00051, EFh, 2 hits |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR028846, Recoverin |
PANTHERi | PTHR23055, PTHR23055, 1 hit |
Pfami | View protein in Pfam PF13499, EF-hand_7, 1 hit PF13833, EF-hand_8, 1 hit |
SMARTi | View protein in SMART SM00054, EFh, 3 hits |
SUPFAMi | SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 2 hits PS50222, EF_HAND_2, 3 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGAVMGTFSS LQTKQRRPSK DIAWWYYQYQ RDKIEDDLEM TMVCHRPEGL
60 70 80 90 100
EQLEAQTNFT KRELQVLYRG FKNECPSGVV NEETFKQIYA QFFPHGDAST
110 120 130 140 150
YAHYLFNAFD TTQTGSVKFE DFVTALSILL RGTVHEKLRW TFNLYDINKD
160 170 180 190 200
GYINKEEMMD IVKAIYDMMG KYTYPVLKED TPRQHVDVFF QKMDKNKDGI
210 220
VTLDEFLESC QEDDNIMRSL QLFQNVM
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0H2UHE0 | A0A0H2UHE0_RAT | Kv channel-interacting protein 1 | Kcnip1 | 236 | Annotation score: | ||
A0A0G2K701 | A0A0G2K701_RAT | Kv channel-interacting protein 1 | Kcnip1 | 203 | Annotation score: | ||
A0A0G2K0U3 | A0A0G2K0U3_RAT | Kv channel-interacting protein 1 | Kcnip1 | 232 | Annotation score: | ||
A0A8I6ALG6 | A0A8I6ALG6_RAT | Kv channel-interacting protein 1 | Kcnip1 | 225 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 10 | S → P in AAN34942 (PubMed:12646414).Curated | 1 | |
Sequence conflicti | 37 | D → E in BAB03308 (PubMed:11263977).Curated | 1 | |
Sequence conflicti | 107 | N → D in AAL92564 (Ref. 2) Curated | 1 | |
Sequence conflicti | 107 | N → D in AAL92565 (Ref. 2) Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_015048 | 21 – 31 | Missing in isoform 2. 2 PublicationsAdd BLAST | 11 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB046443 mRNA Translation: BAB03308.1 AY082657 mRNA Translation: AAL92564.1 AY082658 mRNA Translation: AAL92565.1 AY142709 mRNA Translation: AAN34942.1 |
RefSeqi | NP_001248318.1, NM_001261389.1 [Q8R426-1] NP_075218.2, NM_022929.2 [Q8R426-2] |
Genome annotation databases
Ensembli | ENSRNOT00000007187; ENSRNOP00000007187; ENSRNOG00000005365 [Q8R426-1] ENSRNOT00000083090; ENSRNOP00000074006; ENSRNOG00000005365 [Q8R426-2] |
GeneIDi | 65023 |
KEGGi | rno:65023 |
UCSCi | RGD:70886, rat [Q8R426-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB046443 mRNA Translation: BAB03308.1 AY082657 mRNA Translation: AAL92564.1 AY082658 mRNA Translation: AAL92565.1 AY142709 mRNA Translation: AAN34942.1 |
RefSeqi | NP_001248318.1, NM_001261389.1 [Q8R426-1] NP_075218.2, NM_022929.2 [Q8R426-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1S6C | X-ray | 2.00 | A | 45-227 | [»] | |
AlphaFoldDBi | Q8R426 | |||||
SMRi | Q8R426 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 249216, 1 interactor |
CORUMi | Q8R426 |
IntActi | Q8R426, 1 interactor |
STRINGi | 10116.ENSRNOP00000007187 |
Proteomic databases
PaxDbi | Q8R426 |
Protocols and materials databases
ABCDi | Q8R426, 1 sequenced antibody |
Genome annotation databases
Ensembli | ENSRNOT00000007187; ENSRNOP00000007187; ENSRNOG00000005365 [Q8R426-1] ENSRNOT00000083090; ENSRNOP00000074006; ENSRNOG00000005365 [Q8R426-2] |
GeneIDi | 65023 |
KEGGi | rno:65023 |
UCSCi | RGD:70886, rat [Q8R426-1] |
Organism-specific databases
CTDi | 30820 |
RGDi | 70886, Kcnip1 |
Phylogenomic databases
eggNOGi | KOG0044, Eukaryota |
InParanoidi | Q8R426 |
OrthoDBi | 1271942at2759 |
PhylomeDBi | Q8R426 |
TreeFami | TF318560 |
Enzyme and pathway databases
Reactomei | R-RNO-5576894, Phase 1 - inactivation of fast Na+ channels |
Miscellaneous databases
ChiTaRSi | Kcnip1, rat |
EvolutionaryTracei | Q8R426 |
PROi | PR:Q8R426 |
Gene expression databases
Genevisiblei | Q8R426, RN |
Family and domain databases
CDDi | cd00051, EFh, 2 hits |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR028846, Recoverin |
PANTHERi | PTHR23055, PTHR23055, 1 hit |
Pfami | View protein in Pfam PF13499, EF-hand_7, 1 hit PF13833, EF-hand_8, 1 hit |
SMARTi | View protein in SMART SM00054, EFh, 3 hits |
SUPFAMi | SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 2 hits PS50222, EF_HAND_2, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | KCIP1_RAT | |
Accessioni | Q8R426Primary (citable) accession number: Q8R426 Secondary accession number(s): Q793P9, Q8CIR1, Q8R425 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 16, 2005 |
Last sequence update: | August 16, 2005 | |
Last modified: | May 25, 2022 | |
This is version 137 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families