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Entry version 125 (02 Dec 2020)
Sequence version 1 (01 Jun 2002)
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Protein

CD109 antigen

Gene

Cd109

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Modulates negatively TGFB1 signaling in keratinocytes.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-114608, Platelet degranulation
R-MMU-163125, Post-translational modification: synthesis of GPI-anchored proteins

Protein family/group databases

MEROPS protease database

More...
MEROPSi
I39.006

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
CD109 antigen
Alternative name(s):
GPI-anchored alpha-2 macroglobulin-related protein
CD_antigen: CD109
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Cd109
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2445221, Cd109

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21By similarityAdd BLAST21
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000025594722 – 1419CD109 antigenAdd BLAST1398
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_00002559481420 – 1442Removed in mature formSequence analysisAdd BLAST23

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi67N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi117N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi246N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi278N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi370N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi421N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki923 ↔ 926Isoglutamyl cysteine thioester (Cys-Gln)By similarity
Glycosylationi1088N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi1419GPI-anchor amidated alanineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.By similarity
2 forms of 150 (p150) and 120 kDa (p120) exist due to proteolytic degradation from a 180 kDa form.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein, Thioester bond

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8R422

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8R422

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8R422

PRoteomics IDEntifications database

More...
PRIDEi
Q8R422

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q8R422, 7 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8R422

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8R422

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8R422

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000046186, Expressed in ear and 174 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8R422, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8R422, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer; disulfide-linked.

Interacts with TGFB1 and TGFBR1.

Forms a heteromeric complex with TGFBR1, TGFBR2 and TGFBR3 in a ligand-independent manner (By similarity).

By similarity

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q8R422, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000091330

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8R422, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8R422

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni595 – 704Bait region (approximate)By similarityAdd BLAST110

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Bait region, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1366, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155926

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001634_5_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8R422

Identification of Orthologs from Complete Genome Data

More...
OMAi
EIKLFWS

Database of Orthologous Groups

More...
OrthoDBi
354230at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8R422

TreeFam database of animal gene trees

More...
TreeFami
TF313285

Family and domain databases

Conserved Domains Database

More...
CDDi
cd02897, A2M_2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 1 hit
2.60.40.690, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009048, A-macroglobulin_rcpt-bd
IPR036595, A-macroglobulin_rcpt-bd_sf
IPR011625, A2M_N_BRD
IPR041813, A2M_TED
IPR011626, Alpha-macroglobulin_TED
IPR013783, Ig-like_fold
IPR014756, Ig_E-set
IPR001599, Macroglobln_a2
IPR019742, MacrogloblnA2_CS
IPR002890, MG2
IPR041555, MG3
IPR008930, Terpenoid_cyclase/PrenylTrfase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00207, A2M, 1 hit
PF07703, A2M_BRD, 1 hit
PF07677, A2M_recep, 1 hit
PF01835, MG2, 1 hit
PF17791, MG3, 1 hit
PF07678, TED_complement, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01360, A2M, 1 hit
SM01359, A2M_N_2, 1 hit
SM01361, A2M_recep, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48239, SSF48239, 1 hit
SSF49410, SSF49410, 1 hit
SSF81296, SSF81296, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00477, ALPHA_2_MACROGLOBULIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q8R422-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRSRRLLSAA HLLCLCAVAL AAPGSRFLVT APGIIRPGAN VTIGVDLLEN
60 70 80 90 100
SPPQVLVKAQ VFKIASNKSR SILEAEGVFH RGHFKTLVLP ALPLSSADKI
110 120 130 140 150
YELHINGQSE NEIVFSNRTR LTFESKSISV LIQTDKAFYK PKQEVKFRVL
160 170 180 190 200
TLCSDLKPYR TSVDIFIKDP KSNVIQQWFS QKGDLGVVSK TFQLSSNPIF
210 220 230 240 250
GDWSIQVQVN DQQYYQSFQV LEYVLPKFEV TVQTPLYCSL KSKQLNGSVI
260 270 280 290 300
AKYTYGKPVK GSLSLTFLPL SFWGKKKNIT KSFEINGFAN FSFDNYEMKK
310 320 330 340 350
VMNLKPLTDV SEGSYENVDP SFPGPAEIIA TVTESLTGIS RMASTNVFFK
360 370 380 390 400
QHDYIIEIFD YTTVLKPSLN FTATVKVSRS DGNQLTPEEI ENDLVTVVTQ
410 420 430 440 450
RKNNHPESQR DQEMDYIQTV NYTIPQNGII KIEFPVMSIS GELQLKAYFL
460 470 480 490 500
DGTSSVTVHS MFTSPSKTYI QLKTRDEYIK VGSPFDLMVS GNRQFKDLSY
510 520 530 540 550
MVISKGQLVA AGKQSSRTFS LTPEASWAPK ACIIAYYIAE DGEIINDILK
560 570 580 590 600
IPVQLVFENK VKLFWSKPTV KPSDKVSLRI SATQSDSLVG IVAVDKSVTL
610 620 630 640 650
MENSNSITME TMVHELELYN TEYYLGMFMN SFAVFQECGL WVLTDATLIR
660 670 680 690 700
DSIDEVYDTE EYSERFAEEN EANLVDFEDA SSVNNVHVRK NFPETWIWLD
710 720 730 740 750
AYMGSKIYEE FEVTVPDSIT SWVASAFVIS EDLGFGLTTV PAELQAFQPF
760 770 780 790 800
FLFLNLPYSV IRGEEFALEV SIVNYLKDTI KVVILIEESD SFDILMTSND
810 820 830 840 850
TNGTIYRKTV QVPRDNGVTL VFPIKPTHLG EIPITVTAAS PTASDAVTQT
860 870 880 890 900
IVVKPEGIEK SYSKSVLLDL TDSNVESKQQ SMRFSFPPDT VIGSERVQIT
910 920 930 940 950
AIGDILGSSI NGLSSLIRMP YGCGEQNMIY FAPNIYILDY LTKQKQLTVN
960 970 980 990 1000
LKEKALSYMR QGYQRELLYQ REDGSFSAFG DIDSSGSTWL SAFVLRCFLE
1010 1020 1030 1040 1050
ADYYIDIDQD VLHRTYTWLN AHKKFNGEFW EPGRVIHSEL QGGTKSPVTL
1060 1070 1080 1090 1100
TAYIVTSVLG YKKYQPNIDV QDSIKFLEFE FSRGISDNYT LAIISYALST
1110 1120 1130 1140 1150
VGSPKAEEAL NLLMQRSEKE GDTQFWLSSG PALSGSWQPR SVDIEIAAYA
1160 1170 1180 1190 1200
LLAHTLHHVS EGIPVMRWLI QQRNSLGGFV STQDTVVALK ALSEFSALVH
1210 1220 1230 1240 1250
KENTDIQLTV TGPGIPRSIH FRIDSQNLFL LHQEELHALD PITVNVSAHG
1260 1270 1280 1290 1300
SGFAICQLNV DYNVKGSGSS KRRRSTENQE VFDLDVIVNN EDDISHLNLN
1310 1320 1330 1340 1350
VCTSHLGSER TGMVLMEVNL LSGFSASSDS IPLSETLKKV EYDNGKLNLY
1360 1370 1380 1390 1400
LDSVNESQFC VNIPTVRDYK VSNIRDGSVS VMDYYEPRRQ AVRSYNTQVK
1410 1420 1430 1440
LSSCYLSPDT NCKSHTDGAT DSLRRSSSLL VFCSVLLYFV QH
Length:1,442
Mass (Da):161,659
Last modified:June 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE2B9671B8EA5BAA7
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC31190 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY083458 mRNA Translation: AAM00021.1
BC052443 mRNA Translation: AAH52443.1
AK042169 mRNA Translation: BAC31190.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS23365.1

NCBI Reference Sequences

More...
RefSeqi
NP_694738.1, NM_153098.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000093812; ENSMUSP00000091330; ENSMUSG00000046186

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
235505

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:235505

UCSC genome browser

More...
UCSCi
uc009qur.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY083458 mRNA Translation: AAM00021.1
BC052443 mRNA Translation: AAH52443.1
AK042169 mRNA Translation: BAC31190.1 Different initiation.
CCDSiCCDS23365.1
RefSeqiNP_694738.1, NM_153098.3

3D structure databases

SMRiQ8R422
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ8R422, 1 interactor
STRINGi10090.ENSMUSP00000091330

Protein family/group databases

MEROPSiI39.006

PTM databases

GlyGeniQ8R422, 7 sites
iPTMnetiQ8R422
PhosphoSitePlusiQ8R422
SwissPalmiQ8R422

Proteomic databases

jPOSTiQ8R422
MaxQBiQ8R422
PaxDbiQ8R422
PRIDEiQ8R422

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
2141, 371 antibodies

Genome annotation databases

EnsembliENSMUST00000093812; ENSMUSP00000091330; ENSMUSG00000046186
GeneIDi235505
KEGGimmu:235505
UCSCiuc009qur.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
135228
MGIiMGI:2445221, Cd109

Phylogenomic databases

eggNOGiKOG1366, Eukaryota
GeneTreeiENSGT00940000155926
HOGENOMiCLU_001634_5_2_1
InParanoidiQ8R422
OMAiEIKLFWS
OrthoDBi354230at2759
PhylomeDBiQ8R422
TreeFamiTF313285

Enzyme and pathway databases

ReactomeiR-MMU-114608, Platelet degranulation
R-MMU-163125, Post-translational modification: synthesis of GPI-anchored proteins

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
235505, 0 hits in 18 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Cd109, mouse

Protein Ontology

More...
PROi
PR:Q8R422
RNActiQ8R422, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000046186, Expressed in ear and 174 other tissues
ExpressionAtlasiQ8R422, baseline and differential
GenevisibleiQ8R422, MM

Family and domain databases

CDDicd02897, A2M_2, 1 hit
Gene3Di2.60.40.10, 1 hit
2.60.40.690, 1 hit
InterProiView protein in InterPro
IPR009048, A-macroglobulin_rcpt-bd
IPR036595, A-macroglobulin_rcpt-bd_sf
IPR011625, A2M_N_BRD
IPR041813, A2M_TED
IPR011626, Alpha-macroglobulin_TED
IPR013783, Ig-like_fold
IPR014756, Ig_E-set
IPR001599, Macroglobln_a2
IPR019742, MacrogloblnA2_CS
IPR002890, MG2
IPR041555, MG3
IPR008930, Terpenoid_cyclase/PrenylTrfase
PfamiView protein in Pfam
PF00207, A2M, 1 hit
PF07703, A2M_BRD, 1 hit
PF07677, A2M_recep, 1 hit
PF01835, MG2, 1 hit
PF17791, MG3, 1 hit
PF07678, TED_complement, 1 hit
SMARTiView protein in SMART
SM01360, A2M, 1 hit
SM01359, A2M_N_2, 1 hit
SM01361, A2M_recep, 1 hit
SUPFAMiSSF48239, SSF48239, 1 hit
SSF49410, SSF49410, 1 hit
SSF81296, SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS00477, ALPHA_2_MACROGLOBULIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCD109_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8R422
Secondary accession number(s): Q8BLT6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: June 1, 2002
Last modified: December 2, 2020
This is version 125 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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