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Protein

Prokineticin receptor 1

Gene

Prokr1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for prokineticin 1. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase. May play a role during early pregnancy (By similarity).By similarity

GO - Molecular functioni

  • G-protein coupled receptor activity Source: RGD
  • pancreatic polypeptide receptor activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-375276 Peptide ligand-binding receptors
R-RNO-416476 G alpha (q) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Prokineticin receptor 1
Short name:
PK-R1
Alternative name(s):
G-protein coupled receptor 73
G-protein coupled receptor ZAQ
Gene namesi
Name:Prokr1
Synonyms:Gpr73, Pkr1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi708443 Prokr1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 62ExtracellularSequence analysisAdd BLAST62
Transmembranei63 – 83Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini84 – 98CytoplasmicSequence analysisAdd BLAST15
Transmembranei99 – 119Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini120 – 145ExtracellularSequence analysisAdd BLAST26
Transmembranei146 – 166Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini167 – 179CytoplasmicSequence analysisAdd BLAST13
Transmembranei180 – 200Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini201 – 232ExtracellularSequence analysisAdd BLAST32
Transmembranei233 – 253Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini254 – 282CytoplasmicSequence analysisAdd BLAST29
Transmembranei283 – 303Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini304 – 322ExtracellularSequence analysisAdd BLAST19
Transmembranei323 – 343Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini344 – 393CytoplasmicSequence analysisAdd BLAST50

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000700811 – 393Prokineticin receptor 1Add BLAST393

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi11N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi137 ↔ 217PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8R416
PRIDEiQ8R416

PTM databases

PhosphoSitePlusiQ8R416

Expressioni

Tissue specificityi

Widely expressed in peripheral tissues with the highest level in the spleen and moderate levels in the adipose tissues, thymus, lung, kidney, testis, uterus and small intestine.

Gene expression databases

BgeeiENSRNOG00000009556
GenevisibleiQ8R416 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012913

Structurei

3D structure databases

ProteinModelPortaliQ8R416
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00920000148949
HOGENOMiHOG000231664
HOVERGENiHBG039631
InParanoidiQ8R416
KOiK08379
OMAiNFIFITA
OrthoDBiEOG091G086Y
PhylomeDBiQ8R416
TreeFamiTF315303

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000611 NPY_rcpt
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01012 NRPEPTIDEYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8R416-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METTVGTLGE NTTNTFTDFF SARDGSGAET SPLPFTFSYG DYDMPSDEEE
60 70 80 90 100
DVTNSRTFFA AKIVIGMALV GIMLVCGIGN FIFITALARY KKLRNLTNLL
110 120 130 140 150
IANLAISDFL VAIVCCPFEM DYYVVRQLSW EHGHVLCASV NYLRTVSLYV
160 170 180 190 200
STNALLAIAI DRYLAIVHPL RPRMKCQTAA GLIFLVWSVS ILIAIPAAYF
210 220 230 240 250
TTETVLVIVE SQEKIFCGQI WPVDQQFYYR SYFLLVFGLE FVGPVIAMTL
260 270 280 290 300
CYARVSRELW FKAVPGFQTE QIRRRLRCRR RTVLGLVCVL SAYVLCWAPF
310 320 330 340 350
YGFTIVRDFF PSVFVKEKHY LTAFYVVECI AMSNSMINTL CFVTVRNNTS
360 370 380 390
KYLKRILRLQ WRASPSGSKA SADLDLRTTG IPATEEVDCI RLK
Length:393
Mass (Da):44,507
Last modified:June 1, 2002 - v1
Checksum:iC75EC72B97E503A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY089974 mRNA Translation: AAM11890.1
AB158419 mRNA Translation: BAE16991.1
AB158420 mRNA Translation: BAE16992.1
RefSeqiNP_620433.1, NM_138977.1
XP_006236883.1, XM_006236821.3
UniGeneiRn.82759

Genome annotation databases

EnsembliENSRNOT00000012913; ENSRNOP00000012913; ENSRNOG00000009556
GeneIDi192648
KEGGirno:192648
UCSCiRGD:708443 rat

Similar proteinsi

Entry informationi

Entry nameiPKR1_RAT
AccessioniPrimary (citable) accession number: Q8R416
Secondary accession number(s): Q4AEG4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: June 1, 2002
Last modified: June 20, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

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