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Protein

Anterior gradient protein 3

Gene

Agr3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Required for calcium-mediated regulation of ciliary beat frequency and mucociliary clearance in the airway. Might be involved in the regulation of intracellular calcium in tracheal epithelial cells.1 Publication

GO - Molecular functioni

GO - Biological processi

  • negative regulation of cell death Source: GO_Central

Names & Taxonomyi

Protein namesi
Recommended name:
Anterior gradient protein 3Imported
Gene namesi
Name:Agr3Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:2685734 Agr3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum

Pathology & Biotechi

Disruption phenotypei

Knockout mice develop ciliated cells with normal-appearing cilia and histology. However, ciliary beat frequency was lower in airways from knockout mice compared with control mice in presence of calcium (20% lower in the absence of stimulation, 35% lower after ATP stimulation). Knockout mice show reduced mucociliary clearance. Knockout mice do not seem to show endoplasmic reticulum stress response.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000000104121 – 165Anterior gradient protein 3Add BLAST145

Proteomic databases

MaxQBiQ8R3W7
PaxDbiQ8R3W7
PeptideAtlasiQ8R3W7
PRIDEiQ8R3W7

PTM databases

iPTMnetiQ8R3W7
PhosphoSitePlusiQ8R3W7

Expressioni

Tissue specificityi

Expressed in the ciliated cells of the airway epithelium. Not detected in the mucous cells.1 Publication

Gene expression databases

BgeeiENSMUSG00000036231 Expressed in 41 organ(s), highest expression level in saccule of membranous labyrinth
CleanExiMM_AGR3
ExpressionAtlasiQ8R3W7 baseline and differential
GenevisibleiQ8R3W7 MM

Interactioni

Subunit structurei

Interacts with LYPD3 and DAG1 (alphaDAG1).By similarity

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ8R3W7
SMRiQ8R3W7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi162 – 165Prevents secretion from ERCurated4

Sequence similaritiesi

Belongs to the AGR family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWAH Eukaryota
ENOG4111K70 LUCA
GeneTreeiENSGT00530000063273
HOGENOMiHOG000231100
HOVERGENiHBG006516
InParanoidiQ8R3W7
KOiK20357
OMAiAQNNFIM
OrthoDBiEOG091G0RHV
PhylomeDBiQ8R3W7
TreeFamiTF321449

Family and domain databases

InterProiView protein in InterPro
IPR036249 Thioredoxin-like_sf
SUPFAMiSSF52833 SSF52833, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8R3W7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLHSALALCL LLITVSSNLA IAIKKEKRPP QTLSRGWGDD ITWVQTYEEG
60 70 80 90 100
LFHARKSNKP LMVIHHLEDC QYCQALKKEF AKNEEIQEMA QNDFIMLNLM
110 120 130 140 150
HETTDKNLSP DGQYVPRIMF VDPSLTVRAD ITGRYSNRLY TYEPQDLPML
160
VDNMKKALRL IQSEL
Length:165
Mass (Da):19,081
Last modified:June 1, 2002 - v1
Checksum:i39FBC7DCB36E122C
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A7NSI2A7NSI2_MOUSE
Anterior gradient protein 3
Agr3
35Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti90A → E in BAC35297 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK053177 mRNA Translation: BAC35297.1
CT030196 Genomic DNA No translation available.
BC023499 mRNA Translation: AAH23499.1
CCDSiCCDS25880.1
RefSeqiNP_997414.2, NM_207531.3
UniGeneiMm.190508

Genome annotation databases

EnsembliENSMUST00000042101; ENSMUSP00000049212; ENSMUSG00000036231
GeneIDi403205
KEGGimmu:403205
UCSCiuc007njl.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK053177 mRNA Translation: BAC35297.1
CT030196 Genomic DNA No translation available.
BC023499 mRNA Translation: AAH23499.1
CCDSiCCDS25880.1
RefSeqiNP_997414.2, NM_207531.3
UniGeneiMm.190508

3D structure databases

ProteinModelPortaliQ8R3W7
SMRiQ8R3W7
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ8R3W7
PhosphoSitePlusiQ8R3W7

Proteomic databases

MaxQBiQ8R3W7
PaxDbiQ8R3W7
PeptideAtlasiQ8R3W7
PRIDEiQ8R3W7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000042101; ENSMUSP00000049212; ENSMUSG00000036231
GeneIDi403205
KEGGimmu:403205
UCSCiuc007njl.2 mouse

Organism-specific databases

CTDi155465
MGIiMGI:2685734 Agr3

Phylogenomic databases

eggNOGiENOG410IWAH Eukaryota
ENOG4111K70 LUCA
GeneTreeiENSGT00530000063273
HOGENOMiHOG000231100
HOVERGENiHBG006516
InParanoidiQ8R3W7
KOiK20357
OMAiAQNNFIM
OrthoDBiEOG091G0RHV
PhylomeDBiQ8R3W7
TreeFamiTF321449

Miscellaneous databases

PROiPR:Q8R3W7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036231 Expressed in 41 organ(s), highest expression level in saccule of membranous labyrinth
CleanExiMM_AGR3
ExpressionAtlasiQ8R3W7 baseline and differential
GenevisibleiQ8R3W7 MM

Family and domain databases

InterProiView protein in InterPro
IPR036249 Thioredoxin-like_sf
SUPFAMiSSF52833 SSF52833, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAGR3_MOUSE
AccessioniPrimary (citable) accession number: Q8R3W7
Secondary accession number(s): A7NSI1, Q8BW95
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: June 1, 2002
Last modified: November 7, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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