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Protein

Endophilin-B2

Gene

Sh3glb2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Endophilin-B2
Alternative name(s):
SH3 domain-containing GRB2-like protein B2
Gene namesi
Name:Sh3glb2
Synonyms:Kiaa1848
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2385131 Sh3glb2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001467561 – 400Endophilin-B2Add BLAST400

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei10PhosphoserineBy similarity1
Modified residuei400PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ8R3V5
PaxDbiQ8R3V5
PeptideAtlasiQ8R3V5
PRIDEiQ8R3V5

2D gel databases

REPRODUCTION-2DPAGEiQ8R3V5

PTM databases

iPTMnetiQ8R3V5
PhosphoSitePlusiQ8R3V5

Expressioni

Gene expression databases

BgeeiENSMUSG00000026860 Expressed in 275 organ(s), highest expression level in cerebellum
CleanExiMM_SH3GLB2
ExpressionAtlasiQ8R3V5 baseline and differential
GenevisibleiQ8R3V5 MM

Interactioni

Subunit structurei

Homodimer, and heterodimer with SH3GLB1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ8R3V5, 2 interactors
MINTiQ8R3V5
STRINGi10090.ENSMUSP00000028214

Structurei

3D structure databases

ProteinModelPortaliQ8R3V5
SMRiQ8R3V5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 287BARPROSITE-ProRule annotationAdd BLAST264
Domaini340 – 400SH3PROSITE-ProRule annotationAdd BLAST61

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 27Membrane-binding amphipathic helixBy similarityAdd BLAST27

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili205 – 234Sequence analysisAdd BLAST30

Sequence similaritiesi

Belongs to the endophilin family.Curated

Keywords - Domaini

Coiled coil, SH3 domain

Phylogenomic databases

eggNOGiKOG3725 Eukaryota
ENOG410XPA6 LUCA
GeneTreeiENSGT00550000074464
HOGENOMiHOG000232056
HOVERGENiHBG054448
InParanoidiQ8R3V5
KOiK21269
PhylomeDBiQ8R3V5
TreeFamiTF313281

Family and domain databases

CDDicd11944 SH3_Endophilin_B2, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR004148 BAR_dom
IPR035640 Endophilin_B2_SH3
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR028500 SH3GLB2
PANTHERiPTHR44071:SF2 PTHR44071:SF2, 1 hit
PfamiView protein in Pfam
PF03114 BAR, 1 hit
PF14604 SH3_9, 1 hit
SMARTiView protein in SMART
SM00721 BAR, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF103657 SSF103657, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS51021 BAR, 1 hit
PS50002 SH3, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 2 (identifier: Q8R3V5-4) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDFNMKKLAS DAGIFFTRAV QFTEEKFGQA EKTELDAHFE NLLARADSTK
60 70 80 90 100
NWTERILRQT EVLLQPNPSA RVEEFLYEKL DRKVPSRVTN GELLAQYMAE
110 120 130 140 150
AASELGPSTP YGKTLIKVSE AEKRLGAAER DFIHTASLSF LTPLRNFLEG
160 170 180 190 200
DWKTISKERR LLQNRRLDLD ACKARLKKAK AAEAKATTVP DFQETRPRNY
210 220 230 240 250
ILSASASALW NDEVDKAEQE LRVAQTEFDR QAEVTRLLLE GISSTHVNHL
260 270 280 290 300
RCLHEFVKSQ TTYYAQCYRH MLDLQKQLGS SQGAIFPGTF VGTTEPASPP
310 320 330 340 350
LSSTSPTTTA ATMPVVPTGA VLAPPEEAAL CLEEVAPPAS GTRKARVLYD
360 370 380 390 400
YEAADSSELA LLADELITVY SLPGMDPDWL IGERGNKKGK VPVTYLELLS
Length:400
Mass (Da):44,503
Last modified:October 23, 2007 - v2
Checksum:i0614F451F4B4370F
GO
Isoform 1 (identifier: Q8R3V5-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     280-285: SSQGAI → R

Show »
Length:395
Mass (Da):44,116
Checksum:iC36C19585EE15DD8
GO
Isoform 3 (identifier: Q8R3V5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     188-208: Missing.

Note: No experimental confirmation available.
Show »
Length:379
Mass (Da):42,198
Checksum:i0FC6AEA93E40C276
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AWI7A2AWI7_MOUSE
Endophilin-B2
Sh3glb2
404Annotation score:
A2AWI9A2AWI9_MOUSE
Endophilin-B2
Sh3glb2 mCG_18298
374Annotation score:

Sequence cautioni

The sequence AAH28859 differs from that shown. Intron retention.Curated
The sequence BAC98265 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti7K → N in AAL24820 (Ref. 1) Curated1
Sequence conflicti332L → M in BAE31195 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_009280188 – 208Missing in isoform 3. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_028795280 – 285SSQGAI → R in isoform 1. 4 Publications6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF426314 mRNA Translation: AAL24820.1
AK129455 Transcribed RNA Translation: BAC98265.2 Different initiation.
AK152409 mRNA Translation: BAE31195.1
AK155248 mRNA Translation: BAE33146.1
AK167762 mRNA Translation: BAE39795.1
AL954388 Genomic DNA No translation available.
BC024477 mRNA Translation: AAH24477.1
BC028859 mRNA Translation: AAH28859.1 Sequence problems.
CCDSiCCDS15879.1 [Q8R3V5-1]
CCDS71020.1 [Q8R3V5-4]
RefSeqiNP_001276638.1, NM_001289709.1 [Q8R3V5-4]
NP_647463.1, NM_139302.2 [Q8R3V5-1]
XP_006498002.1, XM_006497939.1 [Q8R3V5-3]
UniGeneiMm.33343

Genome annotation databases

EnsembliENSMUST00000028214; ENSMUSP00000028214; ENSMUSG00000026860 [Q8R3V5-1]
ENSMUST00000100215; ENSMUSP00000097788; ENSMUSG00000026860 [Q8R3V5-4]
ENSMUST00000163668; ENSMUSP00000131545; ENSMUSG00000026860 [Q8R3V5-3]
GeneIDi227700
KEGGimmu:227700
UCSCiuc008jcc.2 mouse [Q8R3V5-1]
uc008jcd.2 mouse [Q8R3V5-4]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF426314 mRNA Translation: AAL24820.1
AK129455 Transcribed RNA Translation: BAC98265.2 Different initiation.
AK152409 mRNA Translation: BAE31195.1
AK155248 mRNA Translation: BAE33146.1
AK167762 mRNA Translation: BAE39795.1
AL954388 Genomic DNA No translation available.
BC024477 mRNA Translation: AAH24477.1
BC028859 mRNA Translation: AAH28859.1 Sequence problems.
CCDSiCCDS15879.1 [Q8R3V5-1]
CCDS71020.1 [Q8R3V5-4]
RefSeqiNP_001276638.1, NM_001289709.1 [Q8R3V5-4]
NP_647463.1, NM_139302.2 [Q8R3V5-1]
XP_006498002.1, XM_006497939.1 [Q8R3V5-3]
UniGeneiMm.33343

3D structure databases

ProteinModelPortaliQ8R3V5
SMRiQ8R3V5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8R3V5, 2 interactors
MINTiQ8R3V5
STRINGi10090.ENSMUSP00000028214

PTM databases

iPTMnetiQ8R3V5
PhosphoSitePlusiQ8R3V5

2D gel databases

REPRODUCTION-2DPAGEiQ8R3V5

Proteomic databases

MaxQBiQ8R3V5
PaxDbiQ8R3V5
PeptideAtlasiQ8R3V5
PRIDEiQ8R3V5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028214; ENSMUSP00000028214; ENSMUSG00000026860 [Q8R3V5-1]
ENSMUST00000100215; ENSMUSP00000097788; ENSMUSG00000026860 [Q8R3V5-4]
ENSMUST00000163668; ENSMUSP00000131545; ENSMUSG00000026860 [Q8R3V5-3]
GeneIDi227700
KEGGimmu:227700
UCSCiuc008jcc.2 mouse [Q8R3V5-1]
uc008jcd.2 mouse [Q8R3V5-4]

Organism-specific databases

CTDi56904
MGIiMGI:2385131 Sh3glb2
RougeiSearch...

Phylogenomic databases

eggNOGiKOG3725 Eukaryota
ENOG410XPA6 LUCA
GeneTreeiENSGT00550000074464
HOGENOMiHOG000232056
HOVERGENiHBG054448
InParanoidiQ8R3V5
KOiK21269
PhylomeDBiQ8R3V5
TreeFamiTF313281

Miscellaneous databases

ChiTaRSiSh3glb2 mouse
PROiPR:Q8R3V5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026860 Expressed in 275 organ(s), highest expression level in cerebellum
CleanExiMM_SH3GLB2
ExpressionAtlasiQ8R3V5 baseline and differential
GenevisibleiQ8R3V5 MM

Family and domain databases

CDDicd11944 SH3_Endophilin_B2, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR004148 BAR_dom
IPR035640 Endophilin_B2_SH3
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR028500 SH3GLB2
PANTHERiPTHR44071:SF2 PTHR44071:SF2, 1 hit
PfamiView protein in Pfam
PF03114 BAR, 1 hit
PF14604 SH3_9, 1 hit
SMARTiView protein in SMART
SM00721 BAR, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF103657 SSF103657, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS51021 BAR, 1 hit
PS50002 SH3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSHLB2_MOUSE
AccessioniPrimary (citable) accession number: Q8R3V5
Secondary accession number(s): Q3TIQ1
, Q3U2J4, Q3U824, Q8K140, Q91ZI7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: October 23, 2007
Last modified: November 7, 2018
This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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