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Protein

Syntaxin-binding protein 6

Gene

Stxbp6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Forms non-fusogenic complexes with SNAP25 and STX1A and may thereby modulate the formation of functional SNARE complexes and exocytosis.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-binding protein 6
Gene namesi
Name:Stxbp6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2384963 Stxbp6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002067832 – 210Syntaxin-binding protein 6Add BLAST209

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ8R3T5
PaxDbiQ8R3T5
PRIDEiQ8R3T5

PTM databases

iPTMnetiQ8R3T5
PhosphoSitePlusiQ8R3T5

Expressioni

Gene expression databases

CleanExiMM_STXBP6

Interactioni

Subunit structurei

Part of a ternary complex containing SNAP25 and STX1A that can be dissociated by NAPA and NSF. Interacts with STX4A (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000052639

Structurei

3D structure databases

ProteinModelPortaliQ8R3T5
SMRiQ8R3T5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini151 – 210v-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST60

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410INFF Eukaryota
ENOG410ZU11 LUCA
HOGENOMiHOG000132986
HOVERGENiHBG059039
InParanoidiQ8R3T5
PhylomeDBiQ8R3T5

Family and domain databases

CDDicd14681 PH-STXBP6, 1 hit
cd15892 R-SNARE_STXBP6, 1 hit
InterProiView protein in InterPro
IPR028258 Sec3-PIP2_bind
IPR037821 STXBP6_PH
IPR037822 STXBP6_SNARE
IPR001388 Synaptobrevin
PfamiView protein in Pfam
PF15277 Sec3-PIP2_bind, 1 hit
PF00957 Synaptobrevin, 1 hit
SMARTiView protein in SMART
SM01313 Sec3-PIP2_bind, 1 hit
PROSITEiView protein in PROSITE
PS50892 V_SNARE, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q8R3T5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAKSAISKE IFAPLDERML GAVQVKRRTK KKIPFLATGG QGEYLTYICL
60 70 80 90 100
SVTNKKPTQA SITKVKQFEG STSFVRRSQW MLEQLRQVNG IDPNRDSAEF
110 120 130 140 150
DLLFENAFDQ WVASTASEKC TFFQILHHTC QRYLTDRKPE FINCQSKIMG
160 170 180 190 200
GNSILHSAAD SVTSAVQKAS QALNERGERL GRAEEKTEDM KNSAQQFAET
210
AHKLAMKHKC
Length:210
Mass (Da):23,671
Last modified:June 1, 2002 - v1
Checksum:i7C116A9F7FAFC2D8
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3TYA4Q3TYA4_MOUSE
Syntaxin-binding protein 6
Stxbp6
210Annotation score:
B8JJ84B8JJ84_MOUSE
Syntaxin-binding protein 6
Stxbp6
89Annotation score:
D6RJ81D6RJ81_MOUSE
Syntaxin-binding protein 6
Stxbp6
59Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC024598 mRNA Translation: AAH24598.1
CCDSiCCDS25898.1
UniGeneiMm.285400

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC024598 mRNA Translation: AAH24598.1
CCDSiCCDS25898.1
UniGeneiMm.285400

3D structure databases

ProteinModelPortaliQ8R3T5
SMRiQ8R3T5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000052639

PTM databases

iPTMnetiQ8R3T5
PhosphoSitePlusiQ8R3T5

Proteomic databases

MaxQBiQ8R3T5
PaxDbiQ8R3T5
PRIDEiQ8R3T5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:2384963 Stxbp6

Phylogenomic databases

eggNOGiENOG410INFF Eukaryota
ENOG410ZU11 LUCA
HOGENOMiHOG000132986
HOVERGENiHBG059039
InParanoidiQ8R3T5
PhylomeDBiQ8R3T5

Miscellaneous databases

ChiTaRSiStxbp6 mouse
PROiPR:Q8R3T5
SOURCEiSearch...

Gene expression databases

CleanExiMM_STXBP6

Family and domain databases

CDDicd14681 PH-STXBP6, 1 hit
cd15892 R-SNARE_STXBP6, 1 hit
InterProiView protein in InterPro
IPR028258 Sec3-PIP2_bind
IPR037821 STXBP6_PH
IPR037822 STXBP6_SNARE
IPR001388 Synaptobrevin
PfamiView protein in Pfam
PF15277 Sec3-PIP2_bind, 1 hit
PF00957 Synaptobrevin, 1 hit
SMARTiView protein in SMART
SM01313 Sec3-PIP2_bind, 1 hit
PROSITEiView protein in PROSITE
PS50892 V_SNARE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSTXB6_MOUSE
AccessioniPrimary (citable) accession number: Q8R3T5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: June 1, 2002
Last modified: July 18, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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