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Protein

Exocyst complex component 1

Gene

Exoc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.By similarity

GO - Molecular functioni

  • GTP-Rho binding Source: GO_Central
  • phosphatidylinositol-4,5-bisphosphate binding Source: GO_Central

GO - Biological processi

Keywordsi

Biological processExocytosis, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-264876 Insulin processing
R-MMU-5620916 VxPx cargo-targeting to cilium

Names & Taxonomyi

Protein namesi
Recommended name:
Exocyst complex component 1
Alternative name(s):
Exocyst complex component Sec3
Gene namesi
Name:Exoc1
Synonyms:Sec3, Sec3l1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2445020 Exoc1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001189141 – 894Exocyst complex component 1Add BLAST894

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei470PhosphoserineCombined sources1
Modified residuei471PhosphothreonineBy similarity1
Modified residuei473PhosphoserineCombined sources1
Modified residuei487PhosphoserineBy similarity1
Modified residuei501PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8R3S6
MaxQBiQ8R3S6
PaxDbiQ8R3S6
PeptideAtlasiQ8R3S6
PRIDEiQ8R3S6

PTM databases

iPTMnetiQ8R3S6
PhosphoSitePlusiQ8R3S6

Expressioni

Gene expression databases

BgeeiENSMUSG00000036435 Expressed in 260 organ(s), highest expression level in female gonad
CleanExiMM_EXOC1
ExpressionAtlasiQ8R3S6 baseline and differential
GenevisibleiQ8R3S6 MM

Interactioni

Subunit structurei

The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi213768, 2 interactors
CORUMiQ8R3S6
IntActiQ8R3S6, 1 interactor
MINTiQ8R3S6
STRINGi10090.ENSMUSP00000109121

Structurei

3D structure databases

ProteinModelPortaliQ8R3S6
SMRiQ8R3S6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili152 – 199Sequence analysisAdd BLAST48
Coiled coili205 – 259Sequence analysisAdd BLAST55

Sequence similaritiesi

Belongs to the SEC3 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2148 Eukaryota
ENOG410XQEE LUCA
GeneTreeiENSGT00530000063494
HOGENOMiHOG000247048
HOVERGENiHBG056730
InParanoidiQ8R3S6
KOiK19983

Family and domain databases

InterProiView protein in InterPro
IPR028258 Sec3-PIP2_bind
IPR019160 Sec3_C
PfamiView protein in Pfam
PF15277 Sec3-PIP2_bind, 1 hit
PF09763 Sec3_C, 1 hit
SMARTiView protein in SMART
SM01313 Sec3-PIP2_bind, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q8R3S6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTAIKHALQR DIFTPNDERL LSIVNVCKAG KKKKNCFLCA TVTTERPVQV
60 70 80 90 100
KVVKVKKSDK GDFYKRQIAW ALRDLAVVDA KDAIKENPEF DLHFEKVYKW
110 120 130 140 150
VASSTAEKNA FISCIWKLNQ RYLRKKIDFV NVSSQLLEES VPSGENQSVA
160 170 180 190 200
GGDEEAVDEY QELNAREEQD IEIMMEGCEC AISNAEAFAE KLSRELQVLD
210 220 230 240 250
GANIQSIMAS EKQVNTLMQL LDEALTEVDQ IELKLSSYEE MLQSVKEQMD
260 270 280 290 300
QISESNHLIH LSNTNNVKLL SEIEFLVNHM DLAKGHIKAL QEGDLVSSRG
310 320 330 340 350
IEACTNAADA LLQCMNVALR PGHDMLLAVK QQQQRFSDLR EHFARRLASH
360 370 380 390 400
LNNVFVQQGH DQSSTLAQHS VELTLPNHHP FHRDLLRYAK LMEWLKSTDY
410 420 430 440 450
GKYEGLTKNY MDYLSRLYER EIKDFFEVAK MKMTGTSKES KKFATLPRKE
460 470 480 490 500
SAVKQETESL HGSSGKLTGS TSSLNKLSVQ SSGSRRSQSS SLLDMGNMSA
510 520 530 540 550
SDLDVADRTK FDKIFEQVLS ELEPLCLAEQ DFISKFFKLQ QHQNMSASMT
560 570 580 590 600
EAEDLDGGSL LRQHSSGTLL PVSSEKDMIR QMMIKIFRCI EPELNNLIAL
610 620 630 640 650
GDKVDSFNSL YMLVKMSHHV WTAQNVDPAS FLSTTLGNVL VTVKRNFDKC
660 670 680 690 700
ISNQIRQMEE VKISKKSKVG ILPFVAEFEE FAGLAESIFK NAERRGDLDK
710 720 730 740 750
AYTKLIRGVF INVEKVANES QKTPRDVVMM ENFHHIFATL SRLKISCLEA
760 770 780 790 800
EKKEAKQKYT DHLQSYVIYS LGQPLEKLNH FFEGVEARVA QGIREEEVSY
810 820 830 840 850
QLAFNKQELR KVIKEYPGKE VKKGLDNLYK KVDKHLCEEE NLLQVVWHSM
860 870 880 890
QDEFIRQYKH FEGLIARCYP GSGVTMEFTI QDILDYCSSI AQSH
Length:894
Mass (Da):101,889
Last modified:July 27, 2011 - v4
Checksum:i50CA79A8F56091E7
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q6P1Y9Q6P1Y9_MOUSE
Exocyst complex component 1
Exoc1 Sec3l1
901Annotation score:
Q5PPR2Q5PPR2_MOUSE
Exocyst complex component 1
Exoc1 SEC3, Sec3l1, Sec3p
879Annotation score:
G3UVW9G3UVW9_MOUSE
Exocyst complex component 1
Exoc1 mCG_130100
123Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti329V → I in AAH24678 (PubMed:15489334).Curated1
Sequence conflicti561L → S in AAH24678 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC127332 Genomic DNA No translation available.
BC024678 mRNA Translation: AAH24678.1
CCDSiCCDS71607.1
RefSeqiNP_001276699.1, NM_001289770.1
UniGeneiMm.403233

Genome annotation databases

EnsembliENSMUST00000087133; ENSMUSP00000084373; ENSMUSG00000036435
GeneIDi69940
KEGGimmu:69940
UCSCiuc008xva.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC127332 Genomic DNA No translation available.
BC024678 mRNA Translation: AAH24678.1
CCDSiCCDS71607.1
RefSeqiNP_001276699.1, NM_001289770.1
UniGeneiMm.403233

3D structure databases

ProteinModelPortaliQ8R3S6
SMRiQ8R3S6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi213768, 2 interactors
CORUMiQ8R3S6
IntActiQ8R3S6, 1 interactor
MINTiQ8R3S6
STRINGi10090.ENSMUSP00000109121

PTM databases

iPTMnetiQ8R3S6
PhosphoSitePlusiQ8R3S6

Proteomic databases

EPDiQ8R3S6
MaxQBiQ8R3S6
PaxDbiQ8R3S6
PeptideAtlasiQ8R3S6
PRIDEiQ8R3S6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000087133; ENSMUSP00000084373; ENSMUSG00000036435
GeneIDi69940
KEGGimmu:69940
UCSCiuc008xva.2 mouse

Organism-specific databases

CTDi55763
MGIiMGI:2445020 Exoc1

Phylogenomic databases

eggNOGiKOG2148 Eukaryota
ENOG410XQEE LUCA
GeneTreeiENSGT00530000063494
HOGENOMiHOG000247048
HOVERGENiHBG056730
InParanoidiQ8R3S6
KOiK19983

Enzyme and pathway databases

ReactomeiR-MMU-264876 Insulin processing
R-MMU-5620916 VxPx cargo-targeting to cilium

Miscellaneous databases

PROiPR:Q8R3S6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036435 Expressed in 260 organ(s), highest expression level in female gonad
CleanExiMM_EXOC1
ExpressionAtlasiQ8R3S6 baseline and differential
GenevisibleiQ8R3S6 MM

Family and domain databases

InterProiView protein in InterPro
IPR028258 Sec3-PIP2_bind
IPR019160 Sec3_C
PfamiView protein in Pfam
PF15277 Sec3-PIP2_bind, 1 hit
PF09763 Sec3_C, 1 hit
SMARTiView protein in SMART
SM01313 Sec3-PIP2_bind, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEXOC1_MOUSE
AccessioniPrimary (citable) accession number: Q8R3S6
Secondary accession number(s): E9QQ24
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: July 27, 2011
Last modified: September 12, 2018
This is version 112 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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